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Weighted Average Number of Shares Outstanding, Diluted Weighted Average Number of Shares Outstanding, Diluted Weighted-average shares outstanding used in computing net loss per share attributable to common stockholders, diluted Weighted-average shares of common stock outstanding used in computing net loss per common share, diluted Entity File Number Entity File Number Effective Income Tax Rate Reconciliation, Other Reconciling Items, Percent Other foreign jurisdictions Non Cash Lease Impairment Expense Non Cash Lease Impairment Expense Non Cash Lease Impairment Expense 2017 Convertible Notes Two Thousand Seventeen Convertible Notes [Member] 2017 convertible notes. Cover Cover [Abstract] Derecognition of noncurrent deferred liabilities Derecognition Of Noncurrent Deferred Liabilities Derecognition of noncurrent deferred liabilities. Accrued Research And Development Policy [Text Block] Accrued research and development. 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United States Income (Loss) from Continuing Operations before Income Taxes, Domestic Income Tax Expense (Benefit), Effective Income Tax Rate Reconciliation, Amount [Abstract] Amount Depreciation, Total Depreciation Depreciation Gross proceeds from issuance of common stock Gross Proceeds From Issuance Of Common Stock Gross proceeds from issuance of common stock. 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Tenant Improvement Allowance Payable Tenant Improvement Allowance Payable [Member] Tenant improvement allowance payable. Stock Conversion Description Stock Conversion Description [Axis] Facilities And Other Research And Development Expenses [Member] Facilities And Other Research And Development Expenses [Member] Facilities and other research and development expenses Proceeds from Stock Options Exercised Cash in-transit for stock option exercises Fair Value Disclosures [Abstract] Commitments and Contingencies Disclosure [Abstract] ABC Platform and other program expenses ABC Platform And Other Program Expenses [Member] ABC Platform And Other Program Expenses [Member] Lessee, Operating Lease, Liability, to be Paid, Year One 2026 Effective Income Tax Rate Reconciliation [Line Items] Debt Instrument Debt Instrument [Axis] Thereafter Lessee, Operating Lease, Liability, to be Paid, after Year Five Share-Based Payment Arrangement [Abstract] Percentage of repurchase of royalties Percentage Of Patients To Be Enrolled Percentage of patients to be enrolled. 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Maximum [Member] Maximum Statistical Measurement Statistical Measurement [Axis] Exercise price Exercised Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Common Stock, Value, Issued, Ending Balance Common Stock, Value, Issued, Beginning Balance Common Stock, Value, Issued, Total Common Stock, Value, Issued Common stock, $0.0001 par value -490,000,000 shares authorized; 61,758,454 and 52,726,916 shares issued and outstanding, respectively Options exercise price, percentage of estimated fair value of shares on grant date Share Based Compensation Arrangement By Share Based Payment Award Exercise Price Exercise price must be equal to at least 110% of the fair market value of the common stock on the grant date. Long-term deposit Long-term deposit Principles of Consolidation Consolidation, Policy [Policy Text Block] Performance Based Restricted Stock Units Performance Based Restricted Stock Unit [Member] Performance-based restricted stock unit. Deferred Tax Assets, Operating Loss Carryforwards, Total Net operating loss carryforwards Deferred Tax Assets, Operating Loss Carryforwards Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block] Tax Credit Carryforward Tax Credit Carryforward [Axis] Impairment of Long-Lived Assets Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block] Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent, Total Other Comprehensive Income (Loss), Available-for-Sale Securities Adjustment, Net of Tax, Portion Attributable to Parent Change in unrealized gains (losses) related to available-for-sale debt securities, net of tax Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent State taxes State income taxes, net of Federal income tax effect Marketable Securities [Line Items] Marketable Securities [Line Items] Entity Public Float Entity Public Float The Company The entire disclosure for the company. The Company [Text Block] Expected volatility Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate Preferred stock, shares authorized Preferred Stock, Shares Authorized Finite-Lived Intangible Assets by Major Class Finite-Lived Intangible Assets by Major Class [Axis] Cross-border tax laws Effective Income Tax Rate Reconciliation, Cross-Border Tax Effect, Percent Effective Income Tax Rate Reconciliation, Cross-Border Tax Effect, Percent, Total Related Party Transaction [Line Items] Related Party Transaction [Line Items] Employee Stock [Member] ESPP Registrant Name Entity Registrant Name Entity Registrant Name Effective Income Tax Rate Reconciliation Foreign Tax Effects Percent [Abstract] Effective Income Tax Rate Reconciliation Foreign Tax Effects Percent [Abstract] Foreign tax effects Non-employee Stock Options Non Employee Stock Option [Member] Non-employee stock option. Entity Voluntary Filers Entity Voluntary Filers Other income (expense), net Other Nonoperating Income (Expense), Total Other Nonoperating Income (Expense) Subsequent Events [Abstract] Cybersecurity Risk Management Positions or Committees Responsible [Flag] Income Tax Expense (Benefit) Total provision (benefit) for income taxes Effective tax rate Debt Securities, Available-for-Sale, Unrealized Loss Unrealized Losses, Current Measurement Frequency Measurement Frequency [Axis] Share Based Compensation Arrangement By Share Based Payment Award [Line Items] Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Concentration of Credit Risk Concentration Risk, Credit Risk, Policy [Policy Text Block] Two Thousand Twenty One Long-Term Performance Incentive Plan Two Thousand Twenty One Long-Term Performance Incentive Plan [Member] Two Thousand Twenty One Long-Term Performance Incentive Plan [Member] Payments to Acquire Property, Plant, and Equipment, Total Purchase of property and equipment Payments to Acquire Property, Plant, and Equipment Stock units, granted Granted Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period Total assets Assets Schedule Of Property Plant And Equipment [Table] Property, Plant and Equipment [Table] Third B L A Approval [Member] Third B L A Approval. Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term Shares exercisable Options exercisable as of December 31,2025 Income Statement [Abstract] Fair Value of Financial Instruments, Policy [Policy Text Block] Fair Value of Financial Instruments Stock-Based Compensation Share-Based Payment Arrangement [Policy Text Block] Stock issued during period Stock Issued During Period, Shares, New Issues Proceeds from public offering, net of offering costs, shares Lease, Cost [Abstract] Vested Awards vested Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period Earnings Per Share, Diluted Net loss per share attributed to common stockholders diluted Net loss per share common share, diluted Net loss per share common share, diluted Effective Income Tax Rate Reconciliation, Percent [Abstract] Percent Purchase Commitment, Excluding Long-term Commitment Purchase Commitment, Excluding Long-Term Commitment [Domain] Initial lease term Lessee Operating Lease Initial Term Of Contract Lessee operating lease initial term of contract. Property, Plant, and Equipment, Useful Life, Term, Description [Extensible Enumeration] City Area Code City Area Code U.S. Food and Drug Administration Department [Member] U.S. Food and Drug Administration Department. Auditor Name Auditor Name Cancellable Assignment and License Agreement Licensing Agreements [Member] Lease Agreements [Member] Schedule of Quarterly Financial Information Quarterly Financial Information [Table Text Block] Improvements allowance payable to be drawn Debt Instrument, Face Amount Lease Agreement on June 2020 Lease Agreement On June Two Thousand And Twenty [Member] Lease Agreement on June two thousand and twenty Deferred Tax Assets, Valuation Allowance, Change related To Continuing Operations Deferred Tax Assets, Valuation Allowance, Change related To Continuing Operations Change related to continuing operations Counterparty Name Counterparty Name [Domain] Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount Research and development tax credits Variable lease expenses Variable Lease, Cost Issuance of common stock pursuant to employee stock purchase plans Stock Issued During Period, Value, Employee Stock Purchase Plan Weighted-average remaining lease term (in years) Operating Lease, Weighted Average Remaining Lease Term Segment Reporting Information [Line Items] Lease term Lease Expiration Date Lease, Cost Total lease expense Cash and Cash Equivalents Cash and Cash Equivalents, Policy [Policy Text Block] Conversion of redeemable convertible preferred stock into common stock, shares Common Stock Issued Upon Conversion Of Preferred Stock Shares Common stock issued upon conversion of preferred stock, shares. Property, Plant and Equipment, Net, Ending Balance Property, Plant and Equipment, Net, Beginning Balance Property and equipment, net Property, Plant and Equipment, Net Total property and equipment, net Issuance of common stock upon vesting of restricted stock units, net of taxes withheld Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures, Total Issuance of restricted stock awards Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures Cash, cash equivalents and restricted cash, at beginning of period Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation Cash, cash equivalents and restricted cash, at end of period Total cash, cash equivalents and restricted cash Options Vested Options vested. Loss from operations Loss from operations Operating Income (Loss) Accumulated Deficit Retained Earnings [Member] 2021 LTPIP, 2018 Plan and 2015 Equity Incentive Plan [Member] Two Thousand Twenty One LTPIP Two Thousand Eighteen And Two Thousand Fifteen Equity Incentive Plan [Member] Two thousand twenty one LTPIP two thousand eighteen and two thousand fifteen equity incentive plan. Computer Software Computer Software [Member] Computer software. Computer Software and Hardware [Member] Share-based Payment Arrangement, Noncash Expense, Total Stock-based compensation Share-Based Payment Arrangement, Noncash Expense Interest charged Income Tax Examination, Interest Expense Unrecorded Unconditional Purchase Obligation, Total Cancelable and/ or non-cancelable contractual obligations, total Unrecorded Unconditional Purchase Obligation Intangible valuation Effective Income Tax Rate Reconciliation Intangible Valuation Amount Effective Income Tax Rate Reconciliation Intangible Valuation Amount Weighted-average discount rate Operating Lease, Weighted Average Discount Rate, Percent Operating lease liability, net of current portion Operating Lease, Liability, Noncurrent Long-term operating lease liability Fair Value, Inputs, Level 1 [Member] Fair Value Inputs Level 1 Class Of Stock [Line Items] Class of Stock [Line Items] Cash Provided by (Used in) Financing Activity, Including Discontinued Operation Net cash provided by financing activities Summary of Lessee, Weighted Average Remaining Lease Term and Weighted Average Discount Rates Lease, Cost [Table Text Block] Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent [Abstract] Nontaxable or nondeductible items Auditor Location Auditor Location Operational Milestone [Member] Operational Milestone [Member] Summary of Marketable Securities Held Marketable Securities [Table Text Block] Summary of Anti-dilutive Securities Excluded from Computation of Diluted Net Loss per Share Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Derivative Instruments Not Designated as Hedging Instruments, Liability, at Fair Value Fair Value of Derivative Instruments Income Tax Authority Income Tax Jurisdiction [Domain] Entity Interactive Data Current Entity Interactive Data Current Income Statement Location Statement of Income Location, Balance [Domain] Cash flows from operating activities Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract] Furniture and Fixtures [Member] Furniture and Fixtures [Member] Accrued clinical trial and related costs Accrued Clinical Trial And Related Costs Current Accrued clinical trial and related costs current. Accretion (Amortization) of Discounts and Premiums, Investments Net accretion of discount on marketable securities Two Thousand Eighteen And Two Thousand Fifteen Equity Incentive Plan And Two Thousand Twenty One Long Performance Incentive Plan [Member] Two Thousand Eighteen And Two Thousand Fifteen Equity Incentive Plan And Two Thousand Twenty One Long Performance Incentive Plan [Member] 2021 LTPIP, 2018 Plan and 2015 Plan Performance Based Stock Units (PSUs) Performance Based Stock Units [Member] Performance based stock units. Payment to acquire for fixed ssets Payments to Acquire Lease Receivables Issuance of common stock upon exercise of common stock warrants, shares Issuance Of Common Stock Upon Exercise Of Common Stock Warrants Shares Issuance of common stock upon exercise of common stock warrants, shares. Entity Tax Identification Number Entity Tax Identification Number Income Taxes [Table] Income Taxes [Table] Income taxes. Lease Agreement on April and June 2020 Lease Agreement On April And June Two Thousand And Twenty [Member] Lease agreement on April and June two thousand and twenty Long-term Debt, Type Long-Term Debt, Type [Axis] Effective Income Tax Rate Reconciliation Change In Valuation Allowance Amount Effective Income Tax Rate Reconciliation Change In Valuation Allowance Amount Change in valuation allowance Debt instrument term Debt Instrument, Term Income Tax Authority, Name Income Tax Authority, Name [Domain] Local Phone Number Local Phone Number Cumulative Earning Percentage Cumulative Earning Percentage Related Party Transaction Related Party Transaction [Domain] Debt Securities, Available-for-Sale, Unrealized Gain Unrealized Gains, Current Unrecognized stock-based compensation expense Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount Short-Term Lease, Cost Short-term lease expense Denominator: Weighted Average Number of Shares Outstanding, Diluted [Abstract] Auditor Opinion Auditor Opinion [Text Block] Accounting Policies [Abstract] Investments and Cash, Total Investments and Cash Cash, cash equivalents and marketable securities Options Granted to Non-employees Options Granted To Non Employees [Member] Options granted to non employees. Lessee, Operating Lease, Liability, to be Paid, Year Four 2029 Class of Stock Class of Stock [Domain] Commercial Paper Commercial Paper [Member] Number of shares available for grant Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant Unrecognized stock-based compensation weighted-average period expected for recognition Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition Principal payments of tenant improvement allowance payable Principal Payments Of Tenant Improvement Allowance Payable Principal payments of tenant improvement allowance payable. Schedule Of Stock By Class [Table] Stock, Class of Stock [Table] Entity Emerging Growth Company Entity Emerging Growth Company Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term Vested and expected to vest Annual suite fees payment. Annual Suite Fees Payment Lease area Area of Land Tax Credit Carryforward, Name Tax Credit Carryforward, Name [Domain]