Liability Related to Sale of Future Royalties - Additional Information (Details) - USD ($) $ in Thousands			12 Months Ended
	Feb. 04, 2020	Dec. 01, 2019	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023	Jul. 31, 2021	Feb. 29, 2020
Related Party Transaction [Line Items]
Liability related to sale of future royalties			$ 100,000	$ 100,000
Interest expense, liability related to sale of future royalties			0	0	$ 0
Funding Agreement
Related Party Transaction [Line Items]
Remaining funding amount			125,000
Baker Bros. Advisors LP \| Funding Agreement
Related Party Transaction [Line Items]
Capped percentage of royalty on future net sales		4.50%
Contractual obligation under funding agreement		$ 225,000
Percentage of repurchase of royalties		100.00%
Proceeds from sale of future royalties	$ 100,000
Funds to be payable upon enrollment of patients				$ 0		$ 125,000	$ 125,000
Percentage of repurchase of royalties							50.00%
Liability related to sale of future royalties			$ 100,000
Baker Bros. Advisors LP \| Funding Agreement \| Minimum
Related Party Transaction [Line Items]
Ownership percentage		5.00%