Exhibit 21.1
SIGNIFICANT SUBSIDIARIES OF THE REGISTRANT
The following are the significant subsidiaries of MDB Capital Holdings, LLC as of December 31, 2025 and the states or jurisdictions in which they are organized.
| Name | Location of Formation | Ownership | ||||
| MDB CG Management Company | Delaware | 100 | % | |||
| Public Ventures, LLC | Texas | 100 | % | |||
| PatentVest, Inc. | Delaware | 100 | % | |||
| MDB Minnesota One, Inc. | Delaware | 68 | % | |||
| eXoZymes Technologies, Inc. | Nevada | 47 | % | |||