0000001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink 0000002 - Document - Audit Information link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - Consolidated Statements of Operations and Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - Consolidated Statements of Operations and Comprehensive Loss (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - Consolidated Statements of Shareholders' Equity link:presentationLink link:calculationLink link:definitionLink 9952156 - Statement - Consolidated Statements of Shareholders' Equity (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952157 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 9952158 - Disclosure - Organization and Description of Business link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Revenue Recognition link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Fair Value of Financial Instruments link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - Balance Sheet Components link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Debt link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Program Termination Costs link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Share-based Compensation link:presentationLink link:calculationLink link:definitionLink 9952167 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - Segment Information link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - Subsequent Event link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Fair Value of Financial Instruments (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Balance Sheet Components (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Debt (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Commitments and Contingencies (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Program Termination Costs (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Share-based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Segment Information (Tables) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Organization and Description of Business (Details) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Summary of Significant Accounting Policies - Cash, Cash Equivalents, and Restricted Cash (Details) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Summary of Significant Accounting Policies - Segments (Details) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Summary of Significant Accounting Policies - Foreign Currency Translation (Details) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Summary of Significant Accounting Policies - Property and Equipment, Net (Details) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Summary of Significant Accounting Policies - Research and Development Tax Incentives (Details) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Summary of Significant Accounting Policies - Retirement Plans (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Summary of Significant Accounting Policies - Schedule of Antidilutive Securities Excluded from Computation of Diluted Weighted-Average Ordinary Shares Outstanding (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Revenue Recognition (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Fair Value of Financial Instruments - Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Fair Value of Financial Instruments - Schedule of Debt Securities, Fair Value of U.S. Treasury Securities and Money Market Fund (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Fair Value of Financial Instruments - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Balance Sheet Components - Schedule of Prepaid Expenses and Other Current Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Balance Sheet Components - Schedule of Accrued Expenses and Other Current Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Balance Sheet Components - Schedule of Property and Equipment, Net (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Debt - Schedule of Debt (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Debt - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Debt - Schedule of Future Principal Payments, Including the End of Term Charge (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Commitments and Contingencies - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Commitments and Contingencies - Schedule of Balance Sheet Information Related to Leases (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Commitments and Contingencies - Schedule of Supplemental Information Related to Leases (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Commitments and Contingencies - Schedule of Components of Lease Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Commitments and Contingencies - Schedule of Future Lease Payments under Non-Cancelable Operating Leases (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Commitments and Contingencies - Schedule of Future Lease Payments under Non-Cancelable Operating Leases (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Program Termination Costs - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Program Termination Costs - Schedule of Roll-Forward of the Program Termination Liability (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Share-based Compensation - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Share-based Compensation - Schedule of Share-Based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Share-based Compensation - Schedule of Stock Option Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955549 - Disclosure - Share-based Compensation - Schedule of Assumptions Used to Estimate Fair Value of Stock Option Awards (Details) link:presentationLink link:calculationLink link:definitionLink 9955550 - Disclosure - Share-based Compensation - Schedule of Restricted Stock and Restricted Stock Unit, Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955551 - Disclosure - Income Taxes - Schedule of Deferred Tax Assets and Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955552 - Disclosure - Income Taxes - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955553 - Disclosure - Income Taxes - Schedule of Components of Income (Loss) before Income Tax (Details) link:presentationLink link:calculationLink link:definitionLink 9955554 - Disclosure - Income Taxes - Schedule of Components of Income Tax Provision (Details) link:presentationLink link:calculationLink link:definitionLink 9955555 - Disclosure - Income Taxes - Schedule of Effective Income Tax Rate Reconciliation (Details) link:presentationLink link:calculationLink link:definitionLink 9955556 - Disclosure - Income Taxes - Schedule of Operating Loss Carryforwards and Research Tax Credits (Details) link:presentationLink link:calculationLink link:definitionLink 9955557 - Disclosure - Income Taxes - Schedule of Gross Unrecognized Tax Benefits (Details) link:presentationLink link:calculationLink link:definitionLink 9955558 - Disclosure - Segment Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955559 - Disclosure - Subsequent Event (Details) link:presentationLink link:calculationLink link:definitionLink