v3.26.1
Consolidated Statements of Operations and Comprehensive Loss - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Income Statement [Abstract]    
License and other revenue $ 15,000 $ 0
Operating expenses:    
Research and development 172,224 150,244
General and administrative 50,468 50,811
Loss from operations (207,692) (201,055)
Interest income 20,527 14,016
Interest expense (11,459) (10,090)
Loss on extinguishment of debt 0 (34,097)
Other non-operating income (expense), net 2,911 (1,687)
Loss before income taxes (195,713) (232,913)
Income tax expense 1,819 2,844
Net loss (197,532) (235,757)
Other comprehensive (loss) income:    
Foreign currency translation adjustments 1,045 1,223
Unrealized gain on available for sale securities, net of tax of $0.1 million in 2025 and $0.8 million in 2024 243 2,787
Reclassification adjustment for realized net gain on available for sale marketable securities included in net loss, net of tax of $0.8 million in 2025 and $0.4 million in 2024 (2,787) (1,290)
Other comprehensive (loss) income (1,499) 2,720
Total comprehensive (loss) income $ (199,031) $ (233,037)
Net loss per ordinary share - basic (in dollars per share) $ (1.46) $ (2.06)
Net loss per ordinary share - diluted (in dollars per share) $ (1.46) $ (2.06)
Weighted average ordinary shares outstanding - basic (in shares) 135,715,608 114,473,449
Weighted average ordinary shares outstanding - diluted (in shares) 135,715,608 114,473,449