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Cash And Cash Equivalents, At Carrying Value, Sufficient Funding Term

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Debt Instrument, Period To Draw Loan, Minimum

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Line Of Credit Facility, Additional Borrowing Capacity

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Line Of Credit Facility, Potential Additional Borrowing Capacity

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Sale of Stock, Maximum Consideration Receivable

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Sale Of Stock, Number Of Shares Issued Per Ordinary Share

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Face amount or stated value per share of common stock.

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Face (par) amount of debt instrument at time of issuance.

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Amount, before accumulated amortization, of debt issuance costs. Includes, but is not limited to, legal, accounting, underwriting, printing, and registration costs.

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The cash inflow during the period from additional borrowings in aggregate debt. Includes proceeds from short-term and long-term debt.

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Amount of cash outflow for short-term and long-term debt. Excludes payment of lease obligation.

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Amount of accumulated undistributed earnings (deficit).

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Cash received on stock transaction after deduction of issuance costs.

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The number of shares issued or sold by the subsidiary or equity method investee per stock transaction.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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Organization and Description of Business (Details) $ in Thousands		12 Months Ended		35 Months Ended
	Dec. 30, 2024 USD ($)	Dec. 31, 2025 USD ($) shares	Dec. 31, 2024 USD ($) shares	Dec. 31, 2025 USD ($) shares	Dec. 31, 2025 £ / shares	Dec. 31, 2025 USD ($) shares	Dec. 31, 2024 £ / shares	Dec. 31, 2024 USD ($) shares	Jan. 27, 2023 USD ($)
Subsidiary, Sale of Stock [Line Items]
Accumulated deficit						$ (1,186,234)		$ (988,702)
Repayments of debt		$ 0	$ 110,097
Ordinary shares, nominal value (in pound sterling per share) \| £ / shares					£ 0.002		£ 0.002
Cash and cash equivalents and short-term investments						$ 577,100
Sufficient funding term (at least)		12 months
ATM Program
Subsidiary, Sale of Stock [Line Items]
Sale of stock, consideration receivable (up to)									$ 250,000
Shares sold in offering (in shares) \| shares		372,538		4,663,354
Aggregate net proceeds from shares sold		$ 6,100		$ 36,600
Underwriter Offering
Subsidiary, Sale of Stock [Line Items]
Shares sold in offering (in shares) \| shares		13,372,093	29,932,626
Aggregate net proceeds from shares sold		$ 269,200	$ 349,900
Number of shares issued per ordinary share (in shares) \| shares						1		1
Ordinary shares, nominal value (in pound sterling per share) \| £ / shares					£ 0.002		£ 0.002
Secured Debt \| Line of Credit
Subsidiary, Sale of Stock [Line Items]
Debt issuance costs	$ (1,100)
Additional amount of loan proceeds	$ 40,000
Clinical milestone (in days)	90 days
Additional amount available to borrowers	$ 50,000
Term Loan Facility
Subsidiary, Sale of Stock [Line Items]
Aggregate principal amount	200,000
Proceeds from issuance of debt	110,000
Additional amount of loan proceeds	40,000
Additional amount available to borrowers	50,000
Repayments of debt	$ 110,000