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<!-- Created: Mon Mar 30 20:14:48 UTC 2026 -->
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        <link:definition>026 - Disclosure - Commitments and Contingencies</link:definition>
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        <link:definition>029 - Disclosure - Accounts Receivable</link:definition>
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        <link:definition>030 - Disclosure - Prepaid Expenses and Other Current Assets</link:definition>
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        <link:definition>032 - Disclosure - Segment Information</link:definition>
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        <link:definition>996000 - Disclosure - Accounting Policies, by Policy (Policies)</link:definition>
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        <link:definition>996001 - Disclosure - Organization (Tables)</link:definition>
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        <link:definition>996002 - Disclosure - Summary of Significant Accounting Policies (Tables)</link:definition>
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        <link:definition>996003 - Disclosure - Long-Term Investment (Tables)</link:definition>
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        <link:definition>996004 - Disclosure - Other Receivables and Prepayments (Tables)</link:definition>
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        <link:definition>996005 - Disclosure - Property and Equipment, Net (Tables)</link:definition>
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        <link:definition>996006 - Disclosure - Intangible Assets, Net (Tables)</link:definition>
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        <link:definition>996007 - Disclosure - Long-Term Deposits (Tables)</link:definition>
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      <link:roleType roleURI="http://aptorumgroup.com/role/AccountsPayableandAccruedExpensesTables" id="apm_r_AccountsPayableandAccruedExpensesTables">
        <link:definition>996008 - Disclosure - Accounts Payable and Accrued Expenses (Tables)</link:definition>
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        <link:definition>996009 - Disclosure - Income Taxes (Tables)</link:definition>
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        <link:definition>996011 - Disclosure - Lease (Tables)</link:definition>
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        <link:definition>996012 - Disclosure - Convertible Notes Payable (Tables)</link:definition>
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        <link:definition>996013 - Disclosure - Stockholders&#8217; Equity (Tables)</link:definition>
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        <link:definition>996014 - Disclosure - Share Based Compensation (Tables)</link:definition>
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        <link:definition>996015 - Disclosure - Net Loss Per Share (Tables)</link:definition>
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        <link:definition>996016 - Disclosure - Warrants (Tables)</link:definition>
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        <link:definition>996017 - Disclosure - Commitments and Contingencies (Tables)</link:definition>
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        <link:definition>996018 - Disclosure - Accounts Receivable (Tables)</link:definition>
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        <link:definition>996019 - Disclosure - Prepaid Expenses and Other Current Assets (Tables)</link:definition>
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        <link:definition>996020 - Disclosure - Segment Information (Tables)</link:definition>
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        <link:definition>996023 - Disclosure - Going Concern (Details)</link:definition>
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        <link:definition>996024 - Disclosure - Summary of Significant Accounting Policies (Details)</link:definition>
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  <xs:element name="ReversalOfDeferredCashBonus" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="apm_ReversalOfDeferredCashBonus"/>
  <xs:element name="RepaymentOfLoanAndInterestFromARelatedParty" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="apm_RepaymentOfLoanAndInterestFromARelatedParty"/>
  <xs:element name="ProceedsFromIssuanceOfClassAOrdinarySharesAndWarrant" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="apm_ProceedsFromIssuanceOfClassAOrdinarySharesAndWarrant"/>
  <xs:element name="PaymentsRelatedToOfferingCosts" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="apm_PaymentsRelatedToOfferingCosts"/>
  <xs:element name="ConvertibleNotesConvertedToClassAOrdinaryShares" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="apm_ConvertibleNotesConvertedToClassAOrdinaryShares"/>
  <xs:element name="RightofuseAssetsObtainedInExchangeForNewOperatingLeaseLiabilities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="apm_RightofuseAssetsObtainedInExchangeForNewOperatingLeaseLiabilities"/>
  <xs:element name="SettlementOfDeferredCashBonusByIssuanceOfShareOptionsOrShares" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="apm_SettlementOfDeferredCashBonusByIssuanceOfShareOptionsOrShares"/>
  <xs:element name="PaymentToDiscountsOnNotePayableToFounder" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="apm_PaymentToDiscountsOnNotePayableToFounder"/>
  <xs:element name="Deferredofferingcostsexpensed" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="apm_Deferredofferingcostsexpensed"/>
  <xs:element name="OrganizationTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_OrganizationTable"/>
  <xs:element name="OrganizationLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_OrganizationLineItems"/>
  <xs:element name="SummaryofSignificantAccountingPoliciesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_SummaryofSignificantAccountingPoliciesTable"/>
  <xs:element name="SummaryofSignificantAccountingPoliciesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_SummaryofSignificantAccountingPoliciesLineItems"/>
  <xs:element name="PropertyandEquipmentNetTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_PropertyandEquipmentNetTable"/>
  <xs:element name="PropertyandEquipmentNetLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_PropertyandEquipmentNetLineItems"/>
  <xs:element name="IntangibleAssetsNetTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_IntangibleAssetsNetTable"/>
  <xs:element name="IntangibleAssetsNetLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_IntangibleAssetsNetLineItems"/>
  <xs:element name="AccountsPayableandAccruedExpensesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_AccountsPayableandAccruedExpensesTable"/>
  <xs:element name="AccountsPayableandAccruedExpensesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_AccountsPayableandAccruedExpensesLineItems"/>
  <xs:element name="IncomeTaxesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_IncomeTaxesTable"/>
  <xs:element name="IncomeTaxesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_IncomeTaxesLineItems"/>
  <xs:element name="LeaseTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_LeaseTable"/>
  <xs:element name="LeaseLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_LeaseLineItems"/>
  <xs:element name="ConvertibleNoteTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_ConvertibleNoteTable"/>
  <xs:element name="ConvertibleNoteLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_ConvertibleNoteLineItems"/>
  <xs:element name="OrdinarySharesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_OrdinarySharesTable"/>
  <xs:element name="OrdinarySharesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_OrdinarySharesLineItems"/>
  <xs:element name="NetLossPerShareTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_NetLossPerShareTable"/>
  <xs:element name="NetLossPerShareLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_NetLossPerShareLineItems"/>
  <xs:element name="CommitmentsandContingenciesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_CommitmentsandContingenciesTable"/>
  <xs:element name="CommitmentsandContingenciesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_CommitmentsandContingenciesLineItems"/>
  <xs:element name="SubsequentEventsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_SubsequentEventsTable"/>
  <xs:element name="SubsequentEventsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_SubsequentEventsLineItems"/>
  <xs:element name="BasisofPresentationTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_BasisofPresentationTable"/>
  <xs:element name="AccountsReceivableTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_AccountsReceivableTable"/>
  <xs:element name="PrepaidExpensesandOtherCurrentAssetsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_PrepaidExpensesandOtherCurrentAssetsTable"/>
  <xs:element name="PrepaidExpensesandOtherCurrentAssetsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_PrepaidExpensesandOtherCurrentAssetsLineItems"/>
  <xs:element name="SegmentInformationTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_SegmentInformationTable"/>
  <xs:element name="AccountingPoliciesbyPolicyPoliciesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_AccountingPoliciesbyPolicyPoliciesTable"/>
  <xs:element name="AccountingPoliciesbyPolicyPoliciesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_AccountingPoliciesbyPolicyPoliciesLineItems"/>
  <xs:element name="NoncontrollingInterestsPolicyTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_NoncontrollingInterestsPolicyTextBlock"/>
  <xs:element name="OperatingLeasesPolicyTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_OperatingLeasesPolicyTextBlock"/>
  <xs:element name="WarrantLiabilitiesPolicyTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_WarrantLiabilitiesPolicyTextBlock"/>
  <xs:element name="IssuanceCostsPolicyTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_IssuanceCostsPolicyTextBlock"/>
  <xs:element name="RecentlyIssuedAccountingStandardsWhichHaveNotYetBeenAdoptedPolicyTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_RecentlyIssuedAccountingStandardsWhichHaveNotYetBeenAdoptedPolicyTextBlock"/>
  <xs:element name="RelatedPartiesPolicyTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_RelatedPartiesPolicyTextBlock"/>
  <xs:element name="PatentCostsPolicyTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_PatentCostsPolicyTextBlock"/>
  <xs:element name="PropertyPlantAndEquipmentUsefullLifeTableTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_PropertyPlantAndEquipmentUsefullLifeTableTextBlock"/>
  <xs:element name="SummaryofSignificantAccountingPoliciesTablesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_SummaryofSignificantAccountingPoliciesTablesTable"/>
  <xs:element name="SummaryofSignificantAccountingPoliciesTablesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_SummaryofSignificantAccountingPoliciesTablesLineItems"/>
  <xs:element name="PropertyandEquipmentNetTablesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_PropertyandEquipmentNetTablesTable"/>
  <xs:element name="PropertyandEquipmentNetTablesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_PropertyandEquipmentNetTablesLineItems"/>
  <xs:element name="ScheduleOfLongTermDepositsTableTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_ScheduleOfLongTermDepositsTableTextBlock"/>
  <xs:element name="AccountsPayableandAccruedExpensesTablesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_AccountsPayableandAccruedExpensesTablesTable"/>
  <xs:element name="AccountsPayableandAccruedExpensesTablesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_AccountsPayableandAccruedExpensesTablesLineItems"/>
  <xs:element name="ScheduleOfIncomeTaxesPaidTableTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_ScheduleOfIncomeTaxesPaidTableTextBlock"/>
  <xs:element name="IncomeTaxesTablesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_IncomeTaxesTablesTable"/>
  <xs:element name="ScheduleOfLeaseTermsAndAssumedDiscountRatesTableTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_ScheduleOfLeaseTermsAndAssumedDiscountRatesTableTextBlock"/>
  <xs:element name="LeaseTablesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_LeaseTablesTable"/>
  <xs:element name="LeaseTablesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_LeaseTablesLineItems"/>
  <xs:element name="ConvertibleNotesPayableTablesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_ConvertibleNotesPayableTablesTable"/>
  <xs:element name="StockholdersEquityTablesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_StockholdersEquityTablesTable"/>
  <xs:element name="NetLossPerShareTablesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_NetLossPerShareTablesTable"/>
  <xs:element name="NetLossPerShareTablesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_NetLossPerShareTablesLineItems"/>
  <xs:element name="ScheduleOfMilestonePaymentsAreToBeMadeUponAchievementsOfCertainConditionsTableTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_ScheduleOfMilestonePaymentsAreToBeMadeUponAchievementsOfCertainConditionsTableTextBlock"/>
  <xs:element name="AccountsReceivableTablesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_AccountsReceivableTablesTable"/>
  <xs:element name="AccountsReceivableTablesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_AccountsReceivableTablesLineItems"/>
  <xs:element name="PrepaidExpensesandOtherCurrentAssetsTablesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_PrepaidExpensesandOtherCurrentAssetsTablesTable"/>
  <xs:element name="PrepaidExpensesandOtherCurrentAssetsTablesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_PrepaidExpensesandOtherCurrentAssetsTablesLineItems"/>
  <xs:element name="SegmentInformationTablesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_SegmentInformationTablesTable"/>
  <xs:element name="SummaryofSignificantAccountingPoliciesScheduleofFairValueHierarchyoftheGroupsFinancialAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_SummaryofSignificantAccountingPoliciesScheduleofFairValueHierarchyoftheGroupsFinancialAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetailsTable"/>
  <xs:element name="LongTermInvestmentScheduleofCarryingValueoftheNonMarketableInvestmentsHeldDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_LongTermInvestmentScheduleofCarryingValueoftheNonMarketableInvestmentsHeldDetailsTable"/>
  <xs:element name="LongTermInvestmentScheduleofCarryingValueoftheNonMarketableInvestmentsHeldDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_LongTermInvestmentScheduleofCarryingValueoftheNonMarketableInvestmentsHeldDetailsLineItems"/>
  <xs:element name="UpwardAdjustments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="apm_UpwardAdjustments"/>
  <xs:element name="InvestmentofImpairment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="apm_InvestmentofImpairment"/>
  <xs:element name="ImpairmentLossOfLongtermInvestment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="apm_ImpairmentLossOfLongtermInvestment"/>
  <xs:element name="PrepaidServiceFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="apm_PrepaidServiceFee"/>
  <xs:element name="OtherDepositsCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="apm_OtherDepositsCurrent"/>
  <xs:element name="RentalDeposits" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="apm_RentalDeposits"/>
  <xs:element name="ResearchAndDevelopmentExpensesPayable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="apm_ResearchAndDevelopmentExpensesPayable"/>
  <xs:element name="IncomeTaxesScheduleofIncomeLossBeforeIncomeTaxExpenseDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_IncomeTaxesScheduleofIncomeLossBeforeIncomeTaxExpenseDetailsTable"/>
  <xs:element name="IncomeTaxesScheduleofIncomeLossBeforeIncomeTaxExpenseDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_IncomeTaxesScheduleofIncomeLossBeforeIncomeTaxExpenseDetailsLineItems"/>
  <xs:element name="EffectiveIncomeTaxRateNetLossBeforeTax" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_EffectiveIncomeTaxRateNetLossBeforeTax"/>
  <xs:element name="IncomeTaxesScheduleofIncomeTaxesPaidDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_IncomeTaxesScheduleofIncomeTaxesPaidDetailsTable"/>
  <xs:element name="IncomeTaxesScheduleofIncomeTaxesPaidDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_IncomeTaxesScheduleofIncomeTaxesPaidDetailsLineItems"/>
  <xs:element name="DeferredTaxAssetsDepreciationAndAmortization" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="apm_DeferredTaxAssetsDepreciationAndAmortization"/>
  <xs:element name="ValuationAllowanceDeferredTaxAssetIncrease" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="apm_ValuationAllowanceDeferredTaxAssetIncrease"/>
  <xs:element name="ValuationAllowanceDeferredTaxAssetDecreaseAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="apm_ValuationAllowanceDeferredTaxAssetDecreaseAmount"/>
  <xs:element name="SettlementOfLoanFromARelatedPartyThroughIssuanceOfConvertibleNote" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="apm_SettlementOfLoanFromARelatedPartyThroughIssuanceOfConvertibleNote"/>
  <xs:element name="ConsultantSecondmentManagementAndAdministrativeServicesFees" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="apm_ConsultantSecondmentManagementAndAdministrativeServicesFees"/>
  <xs:element name="ShareBasedCompensationScheduleoftheOptionActivityDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_ShareBasedCompensationScheduleoftheOptionActivityDetailsTable"/>
  <xs:element name="SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm"/>
  <xs:element name="CommitmentsandContingenciesScheduleofMilestonePaymentsthattheGroupisRequiredtoPayuptoDifferentAchievementsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_CommitmentsandContingenciesScheduleofMilestonePaymentsthattheGroupisRequiredtoPayuptoDifferentAchievementsDetailsTable"/>
  <xs:element name="ContingentMilestonePaymentsSubtotal" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="apm_ContingentMilestonePaymentsSubtotal"/>
  <xs:element name="SummaryofSignificantAccountingPoliciesScheduleofContractAssetsandDeferredRevenuesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_SummaryofSignificantAccountingPoliciesScheduleofContractAssetsandDeferredRevenuesDetailsTable"/>
  <xs:element name="PrepaidExpensesandOtherCurrentAssetsScheduleofPrepaidExpensesandOtherCurrentAssetsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_PrepaidExpensesandOtherCurrentAssetsScheduleofPrepaidExpensesandOtherCurrentAssetsDetailsTable"/>
  <xs:element name="PrepaidExpensesandOtherCurrentAssetsScheduleofPrepaidExpensesandOtherCurrentAssetsDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_PrepaidExpensesandOtherCurrentAssetsScheduleofPrepaidExpensesandOtherCurrentAssetsDetailsLineItems"/>
  <xs:element name="AccountsPayableandAccruedExpensesScheduleofAccountsPayableandAccruedExpensesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_AccountsPayableandAccruedExpensesScheduleofAccountsPayableandAccruedExpensesDetailsTable"/>
  <xs:element name="AccountsPayableandAccruedExpensesScheduleofAccountsPayableandAccruedExpensesDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_AccountsPayableandAccruedExpensesScheduleofAccountsPayableandAccruedExpensesDetailsLineItems"/>
  <xs:element name="ConvertibleNotesPayableScheduleofConvertibleNotesPayableDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_ConvertibleNotesPayableScheduleofConvertibleNotesPayableDetailsTable"/>
  <xs:element name="ConvertibleNotesPayableScheduleofInterestExpensesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="apm_ConvertibleNotesPayableScheduleofInterestExpensesDetailsTable"/>
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  <xs:element name="MergerOrConsolidationMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_MergerOrConsolidationMember"/>
  <xs:element name="MiosMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_MiosMember"/>
  <xs:element name="MiosPharmaceuticalsLimitedMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_MiosPharmaceuticalsLimitedMember"/>
  <xs:element name="NetSalesAmountMoreThanCertainThresholdInAYearMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_NetSalesAmountMoreThanCertainThresholdInAYearMember"/>
  <xs:element name="OctoberTwoThousandTwentyFiveOfferingMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_OctoberTwoThousandTwentyFiveOfferingMember"/>
  <xs:element name="OfficeAdministrativeMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_OfficeAdministrativeMember"/>
  <xs:element name="OtherJurisdictionsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_OtherJurisdictionsMember"/>
  <xs:element name="OtherRevenueMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_OtherRevenueMember"/>
  <xs:element name="PathsDiagnosticsPteLimitedMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_PathsDiagnosticsPteLimitedMember"/>
  <xs:element name="PathsInnovationsLimitedMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_PathsInnovationsLimitedMember"/>
  <xs:element name="PlacementAgentWarrantMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_PlacementAgentWarrantMember"/>
  <xs:element name="PlacementAgentWarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_PlacementAgentWarrantsMember"/>
  <xs:element name="PrepaidPatentedLicensesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_PrepaidPatentedLicensesMember"/>
  <xs:element name="RelatedPartiesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_RelatedPartiesMember"/>
  <xs:element name="SalariesAndBenefitsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_SalariesAndBenefitsMember"/>
  <xs:element name="ScipioLifeSciencesLimitedMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_ScipioLifeSciencesLimitedMember"/>
  <xs:element name="ScipioMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_ScipioMember"/>
  <xs:element name="SepTwoThousandTwentyThreeNotesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_SepTwoThousandTwentyThreeNotesMember"/>
  <xs:element name="SeriesDConvertiblePreferredStockMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_SeriesDConvertiblePreferredStockMember"/>
  <xs:element name="SeriesEConvertiblePreferredStockMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_SeriesEConvertiblePreferredStockMember"/>
  <xs:element name="ServiceRevenueMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_ServiceRevenueMember"/>
  <xs:element name="ShareExchangeAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_ShareExchangeAgreementMember"/>
  <xs:element name="ShareOptionPlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_ShareOptionPlanMember"/>
  <xs:element name="StockBasedCompensationMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_StockBasedCompensationMember"/>
  <xs:element name="StockOptionPlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_StockOptionPlanMember"/>
  <xs:element name="TalemMedicalGroupLimitedMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_TalemMedicalGroupLimitedMember"/>
  <xs:element name="ThirdPartyInvestorMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_ThirdPartyInvestorMember"/>
  <xs:element name="TwoThousandAndTwentyFourStockOptionPlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_TwoThousandAndTwentyFourStockOptionPlanMember"/>
  <xs:element name="TwoThousandFourteenStockOptionPlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_TwoThousandFourteenStockOptionPlanMember"/>
  <xs:element name="TwoThousandSeventeenShareOptionPlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="apm_TwoThousandSeventeenShareOptionPlanMember"/>
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</xs:schema>
