v3.26.1
Note 5 - Stockholders' Equity, Equity Incentive Plans, And Stock-Based Compensation (Tables)
12 Months Ended
Dec. 31, 2025
Notes Tables  
Common Stock, Capital Shares Reserved for Future Issuance [Table Text Block]

Shares underlying outstanding warrants

    5,442,508  

Shares reserved for future grants under the 2020 Equity Incentive Plan

    340,793  

Shares underlying outstanding stock options

    158,098  

Total common stock reserved for future issuance

    5,941,399  
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

Black-Scholes-Merton Inputs

               
   

Year Ended

December 31, 2025

   

Year Ended

December 31, 2024

 

Risk-free interest rate

    3.7% - 4.4 %     3.4% - 4.2 %

Expected term (in years)

    5.4 - 6.1       5.0 - 5.6  

Expected volatility

    110% - 130       111% - 118 %

Expected dividend yield

    %     %
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
   

Number of

Options

Outstanding

   

Weighted

Average

Exercise

price per

share

   

Weighted

Average

Remaining

Contractual

Term in Years

   

Aggregate

Intrinsic

Value

 

Balance, December 31, 2023

    79,028     $ 130.20       9.11     $ 300,969  

Granted*

    54,780       24.20              

Expired/Cancelled

    (5,837 )     205.40              

Balance, December 31, 2024

    127,971     $ 81.40       8.88     $ 683,016  

Granted

    47,627       34.60                  

Expired/Cancelled

    (17,500 )     67.80              

Balance, December 31, 2025

    158,098     $ 68.80       8.22     $  

Options vested and exercisable at December 31, 2025

    121,693     $ 76.80       8.05     $  
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
   

Year Ended December 31,

 
   

2025

   

2024

 

Research and development

  $ 839,015     $ 950,247  

General and administrative

    1,388,844       680,094  

Total stock-based compensation expense

  $ 2,227,859     $ 1,630,341