000 - Document - Document And Entity Information link:calculationLink link:definitionLink link:presentationLink 001 - Statement - Consolidated Balance Sheets link:calculationLink link:definitionLink link:presentationLink 002 - Statement - Consolidated Balance Sheets (Parentheticals) link:calculationLink link:definitionLink link:presentationLink 003 - Statement - Consolidated Statements of Operations and Comprehensive Loss link:calculationLink link:definitionLink link:presentationLink 004 - Statement - Consolidated Statements of Changes in Redeemable Convertible Preferred Stock and Stockholders' Equity (Deficit) link:calculationLink link:definitionLink link:presentationLink 005 - Statement - Consolidated Statements of Cash Flows link:calculationLink link:definitionLink link:presentationLink 995555 - Disclosure - Note 1 - Organization and Description of Business link:calculationLink link:definitionLink link:presentationLink 995556 - Disclosure - Note 2 - Summary of Significant Accounting Policies link:calculationLink link:definitionLink link:presentationLink 995557 - Disclosure - Note 3 - Other Current Assets link:calculationLink link:definitionLink link:presentationLink 995558 - Disclosure - Note 4 - Intangible Assets link:calculationLink link:definitionLink link:presentationLink 995559 - Disclosure - Note 5 - Accrued Liabilities link:calculationLink link:definitionLink link:presentationLink 995560 - Disclosure - Note 6 - Convertible Promissory Note Due to Novartis link:calculationLink link:definitionLink link:presentationLink 995561 - Disclosure - Note 7 - Promissory Notes Due to 3i, LP ("3i") link:calculationLink link:definitionLink link:presentationLink 995562 - Disclosure - Note 8 - Preferred Stock link:calculationLink link:definitionLink link:presentationLink 995563 - Disclosure - Note 9 - Warrant Liability link:calculationLink link:definitionLink link:presentationLink 995564 - Disclosure - Note 10 - Stockholders' Equity link:calculationLink link:definitionLink link:presentationLink 995565 - Disclosure - Note 11 - Stock-based Compensation link:calculationLink link:definitionLink link:presentationLink 995566 - Disclosure - Note 12 - License and Development Agreements link:calculationLink link:definitionLink link:presentationLink 995567 - Disclosure - Note 13 - Income Tax link:calculationLink link:definitionLink link:presentationLink 995568 - Disclosure - Note 14 - Commitments and Contingencies link:calculationLink link:definitionLink link:presentationLink 995569 - Disclosure - Note 15 - Subsequent Events link:calculationLink link:definitionLink link:presentationLink 995570 - Disclosure - Significant Accounting Policies (Policies) link:calculationLink link:definitionLink link:presentationLink 995571 - Disclosure - Note 2 - Summary of Significant Accounting Policies (Tables) link:calculationLink link:definitionLink link:presentationLink 995572 - Disclosure - Note 3 - Other Current Assets (Tables) link:calculationLink link:definitionLink link:presentationLink 995573 - Disclosure - Note 4 - Intangible Assets (Tables) link:calculationLink link:definitionLink link:presentationLink 995574 - Disclosure - Note 5 - Accrued Liabilities (Tables) link:calculationLink link:definitionLink link:presentationLink 995575 - Disclosure - Note 6 - Convertible Promissory Note Due to Novartis (Tables) link:calculationLink link:definitionLink link:presentationLink 995576 - Disclosure - Note 8 - Preferred Stock (Tables) link:calculationLink link:definitionLink link:presentationLink 995577 - Disclosure - Note 9 - Warrant Liability (Tables) link:calculationLink link:definitionLink link:presentationLink 995578 - Disclosure - Note 11 - Stock-based Compensation (Tables) link:calculationLink link:definitionLink link:presentationLink 995579 - Disclosure - Note 13 - Income Tax (Tables) link:calculationLink link:definitionLink link:presentationLink 995580 - Disclosure - Note 1 - Organization and Description of Business (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995581 - Disclosure - Note 2 - Summary of Significant Accounting Policies (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995582 - Disclosure - Note 2 - Summary of Significant Accounting Policies - Estimated Useful Life of Assets (Details) link:calculationLink link:definitionLink link:presentationLink 995583 - Disclosure - Note 2 - Summary of Significant Accounting Policies - Schedule of Antidilutive Securities (Details) link:calculationLink link:definitionLink link:presentationLink 995584 - Disclosure - Note 3 - Other Current Assets - Other Current Assets (Details) link:calculationLink link:definitionLink link:presentationLink 995585 - Disclosure - Note 4 - Intangible Assets (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995586 - Disclosure - Note 4 - Intangible Assets - Schedule of Intangible Assets (Details) link:calculationLink link:definitionLink link:presentationLink 995587 - Disclosure - Note 5 - Accrued Liabilities - Schedule of Accrued Liabilities (Details) link:calculationLink link:definitionLink link:presentationLink 995588 - Disclosure - Note 6 - Convertible Promissory Note Due to Novartis (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995589 - Disclosure - Note 6 - Convertible Promissory Note Due to Novartis - Convertible Debt (Details) link:calculationLink link:definitionLink link:presentationLink 995590 - Disclosure - Note 7 - Promissory Notes Due to 3i, LP ("3i") (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995591 - Disclosure - Note 8 - Preferred Stock (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995592 - Disclosure - Note 8 - Preferred Stock - Schedule of Valuation Inputs (Details) link:calculationLink link:definitionLink link:presentationLink 995593 - Disclosure - Note 9 - Warrant Liability (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995594 - Disclosure - Note 9 - Warrant Liability - Schedule of Derivative Liabilities and Fair Value (Details) link:calculationLink link:definitionLink link:presentationLink 995595 - Disclosure - Note 10 - Stockholders' Equity (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995596 - Disclosure - Note 11 - Stock-based Compensation (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995597 - Disclosure - Note 11 - Stock-based Compensation - Summary of Restricted Stock Unit Activity (Details) link:calculationLink link:definitionLink link:presentationLink 995598 - Disclosure - Note 11 - Stock-based Compensation - Schedule of Stock Option Activity (Details) link:calculationLink link:definitionLink link:presentationLink 995599 - Disclosure - Note 11 - Stock-based Compensation - Stock-based Compensation Expense (Details) link:calculationLink link:definitionLink link:presentationLink 995600 - Disclosure - Note 12 - License and Development Agreements (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995601 - Disclosure - Note 13 - Income Tax (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995602 - Disclosure - Note 13 - Income Tax - Income Tax Reconciliation (Details) link:calculationLink link:definitionLink link:presentationLink 995603 - Disclosure - Note 13 - Income Tax - Components of Net Loss Before Income Taxes (Details) link:calculationLink link:definitionLink link:presentationLink 995604 - Disclosure - Note 13 - Income Tax - Schedule of Income Tax Expense (Benefit) (Details) link:calculationLink link:definitionLink link:presentationLink 995605 - Disclosure - Note 13 - Income Tax - Schedule of Deferred Tax Assets and Liabilities (Details) link:calculationLink link:definitionLink link:presentationLink 995606 - Disclosure - Note 14 - Commitments and Contingencies (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995607 - Disclosure - Note 15 - Subsequent Events (Details Textual) link:calculationLink link:definitionLink link:presentationLink