75000 - Document - Cover Page
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75010 - Statement - Consolidated Balance Sheets
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75020 - Statement - Consolidated Balance Sheets (Parenthetical)
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75030 - Statement - Consolidated Statements of Operations and Comprehensive Loss
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75040 - Statement - Consolidated Statements of Stockholders' Equity
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75050 - Statement - Consolidated Statements of Convertible Preferred Stock and Stockholders' Equity (Deficit) (Parenthetical)
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75060 - Statement - Consolidated Statements of Cash Flows
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75070 - Disclosure - Cybersecurity Risk Management, Strategy and Governance
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995457 - Disclosure - Organization and Liquidity
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995467 - Disclosure - Summary of Significant Accounting Policies and Basis of Presentation
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995477 - Disclosure - Cash Equivalents and Marketable Securities
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995487 - Disclosure - Fair Value Measurements
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995497 - Disclosure - Debt
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995507 - Disclosure - Balance Sheet Components
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995517 - Disclosure - Acquisitions of Assets
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995527 - Disclosure - Commitments and Contingencies
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995537 - Disclosure - Strategic License and Research and Collaboration Agreements
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995547 - Disclosure - Stockholders' Equity
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995557 - Disclosure - Preferred Stock Warrants
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995567 - Disclosure - Stock-Based Compensation
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995577 - Disclosure - Income Taxes
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995587 - Disclosure - Net Loss Per Share
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995597 - Disclosure - Segment Reporting
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995607 - Disclosure - Related Party Transactions
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995617 - Disclosure - Defined Contribution Plan
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995627 - Disclosure - Summary of Significant Accounting Policies and Basis of Presentation (Policies)
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995637 - Disclosure - Cash Equivalents and Marketable Securities (Tables)
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995647 - Disclosure - Fair Value Measurements (Tables)
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995657 - Disclosure - Debt (Tables)
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995667 - Disclosure - Balance Sheet Components (Tables)
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995677 - Disclosure - Commitments and Contingencies (Tables)
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995687 - Disclosure - Stockholders' Equity (Tables)
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995697 - Disclosure - Stock-Based Compensation (Tables)
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995707 - Disclosure - Income Taxes (Tables)
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995717 - Disclosure - Net Loss Per Share (Tables)
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995727 - Disclosure - Segment Reporting (Tables)
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995737 - Disclosure - Summary of Significant Accounting Policies and Basis of Presentation - Additional Information (Details)
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995747 - Disclosure - Cash Equivalents and Marketable Securities - Summary of Amortized Cost and Fair Value of Cash Equivalents and Marketable Securities by Major Investment Category (Details)
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995757 - Disclosure - Cash Equivalents and Marketable Securities - Summary of Marketable Securities by Contractual Maturity (Details)
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995767 - Disclosure - Fair Value Measurements - Summary of Assets and Liabilities Measured at Fair Value on Recurring Basis (Details)
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995777 - Disclosure - Fair Value Measurements - Additional Information (Details)
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995787 - Disclosure - Debt - Additional Information (Details)
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995797 - Disclosure - Debt - Summary of Outstanding Debt (Details)
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995807 - Disclosure - Debt - Summary of Components of Interest Expense (Details)
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995817 - Disclosure - Debt - Summary of Future Principal Payments (Details)
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995827 - Disclosure - Balance Sheet Components - Schedule of Property and Equipment, Net (Details)
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995837 - Disclosure - Balance Sheet Components - Additional information (Details)
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995847 - Disclosure - Balance Sheet Components - Schedule of Accrued Liabilities (Details)
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995857 - Disclosure - Acquisitions of Assets - Additional Information (Details)
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995867 - Disclosure - Commitments and Contingencies - Additional Information (Details)
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995877 - Disclosure - Commitments and Contingencies - Supplemental Information on the Company's Operating Leases (Details)
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995887 - Disclosure - Strategic License and Research and Collaboration Agreements - Additional Information (Details)
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995897 - Disclosure - Stockholders' Equity - Additional Information (Details)
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995907 - Disclosure - Convertible Preferred Stock and Stockholders' Equity (Deficit) - Summary of Convertible Preferred Stock (Details)
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995917 - Disclosure - Stockholders' Equity - Schedule of Common Stock Reserved for Future Issuance (Details)
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995927 - Disclosure - Preferred Stock Warrants - Additional Information (Detail)
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995937 - Disclosure - Stock-Based Compensation - Additional Information (Detail)
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995947 - Disclosure - Stock-Based Compensation - Summary of Stock Option Activity (Detail)
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995957 - Disclosure - Stock-Based Compensation - Summary of Stock Option Activity 1 (Details)
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995967 - Disclosure - Stock-Based Compensation - Summary of Fair Value of Stock Options Granted (Details)
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995977 - Disclosure - Stock-Based Compensation - Summary of Restricted Stock Activity (Detail)
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995987 - Disclosure - Stock-Based Compensation - Summary of Stock-Based Compensation Expense Recognized (Details)
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995997 - Disclosure - Income Taxes - Schedule of Income Tax Expense (Details)
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996007 - Disclosure - Income Taxes - Additional Information (Details)
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996017 - Disclosure - Income Taxes - Summary of Reconciliation of Effective Income Tax Rate to the Statutory Federal Income Tax Rate (Details)
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996027 - Disclosure - Income Taxes - Summary of Deferred Tax Assets and Liabilities (Details)
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996037 - Disclosure - Income Taxes - Summary of NOL and Tax Credit Carryforwards (Details)
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996047 - Disclosure - Income Taxes - Summary of NOL and Tax Credit Carryforwards (Parenthetical) (Details)
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996057 - Disclosure - Income Taxes - Summary of Reconciliation of Unrecognized Tax Benefits (Details)
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996067 - Disclosure - Net Loss Per Share - Summary of Computation of Basic and Diluted Net Loss Per Share (Details)
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996077 - Disclosure - Net Loss Per Share - Summary of Outstanding Potentially Dilutive Common Stock Equivalents were Excluded from Computation of Diluted Net Loss Per Share (Details)
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996087 - Disclosure - Segment Reporting - Additional information (Details)
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996097 - Disclosure - Segment Reporting - Schedule of Segment Loss Including Significant Segment Expenses (Details)
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996107 - Disclosure - Related Party Transactions - Additional Information (Details)
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996117 - Disclosure - Defined Contribution Plan (Additional Information) (Details)
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996127 - Disclosure - Subsequent Events - Additional Information (Details)
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Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Vested, Weighted Average Grant Date Fair Value Per Share
Proceeds from sale of property and equipment
Proceeds from Sale of Property, Plant, and Equipment
Proceeds from Sale of Property, Plant, and Equipment, Total
Other Research and Development Expense
Other research and development costs
Other research and development costs
Entity Incorporation, State or Country Code
Preferred stock, issued
Preferred stock warrants, issued
Preferred stock, shares issued
Statement of Financial Position Location, Balance [Domain]
Defined Benefit Plan, Plan Assets, Contributions by Employer
Defined benefit plan, plan assets, contributions by employer
Tax credits
Effective Income Tax Rate Reconciliation, Tax Credit, Amount [Abstract]
Increase (Decrease) in Accounts Payable, Total
Increase (Decrease) in Accounts Payable
Accounts payable
Debt Securities, Available-for-Sale, Fair Value, Maturity, Allocated and Single Maturity Date, Year One
Within one year
Long-Term Debt, Excluding Current Maturities
Long-Term Debt, Excluding Current Maturities, Total
Long term debt, net
Plan Name [Axis]
Equity [Abstract]
Entity Current Reporting Status
Preferred stock warrants held by related party.
Preferred Stock Warrants Held By Related Party
Preferred stock warrants held by related party
Operating Expenses [Abstract]
Operating expenses:
California
California Franchise Tax Board [Member]
Fair Value, Inputs, Level 2 [Member]
Level 2
Total deferred tax assets less valuation allowance
Deferred Tax Assets, Net of Valuation Allowance
Commitments and Contingencies Disclosure [Text Block]
Commitments and Contingencies
Common Stock, Shares Authorized
Common stock shares authorized
Share-Based Payment Arrangement, Tranche Three [Member]
Tranche Three
Early exercise liability, current portion.
Early Exercise Liability Current Portion
Early exercise liability, current portion
Massachusetts
MASSACHUSETTS
Product and Service [Axis]
Document Fiscal Period Focus
Debt Instrument, Interest Rate, Stated Percentage
Interest rate
Entity Shell Company
Temporary Equity, Shares Outstanding
Balance at Beginning (in Shares)
Balance at Ending (in Shares)
Convertible preferred stock, Shares Outstanding
Convertible preferred stock, shares outstanding
Other Accrued Liabilities, Current
Other
Segment Reporting
Segment Reporting, Policy [Policy Text Block]
Cash and Cash Equivalents, at Carrying Value, Total
Cash and Cash Equivalent
Cash and cash equivalents
Related party transaction obligation with related party.
Related Party Transaction Obligation with Related Party
Related party transaction obligation with related party
Cybersecurity Risk Management, Strategy, and Governance [Abstract]
Collaboration agreement non-refundable quarterly payments.
Collaboration Agreement Non-refundable Quarterly Payments
Collaboration agreement non-refundable quarterly payments
Common stock, shares issued
Common Stock, Shares, Issued
Cybersecurity Risk Management Positions or Committees Responsible Report to Board [Flag]
Cybersecurity Risk Board of Directors Oversight [Text Block]
Asset Class [Domain]
Statement [Table]
Gross increases based on tax positions related to current year
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Right-of-use-asset in connection with new operating lease agreement
Operating lease liabilities arising from obtaining right-of-use assets
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Weighted-average grant date fair value
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted-average fair value of options granted
Payments to Acquire Businesses, Gross
Contingent consideration payable in cash
Share-Based Compensation Arrangement by Share-Based Payment Award, Purchase Price of Common Stock, Percent
Grants vest percentage
Investment Owned, Balance, Principal Amount
Outstanding principal term loan
Shares reserved for issuance under the plans.
Shares Reserved for Issuance under the Plans [Member]
Shares Reserved for Issuance Under the Plans
Operating Lease Liability in Connection With New Lease Agreement
Operating lease liability in connection with new lease agreement.
Operating lease liability in connection with new lease agreement
Contingent consideration, milestone payment settled in cash
Contingent Consideration, Milestone Payment Settled in Cash
Contingent consideration, milestone payment settled in cash
Statement [Line Items]
Business Combination [Domain]
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price
Weighted-Average Exercise Price Per Share, Expired
Entity Filer Category
Non Cash Interest Expense and Amortization of Debt Isuance costs
Amount of non-cash interest expense and amortization of debt issuance costs.
Non-cash interest expense and amortization of debt issuance costs
Liabilities and Equity
Total liabilities and stockholders' equity
Debt Instrument [Line Items]
Long-Term Debt, Current Maturities
Long-Term Debt, Current Maturities, Total
Gross proceeds
Payments to Acquire Marketable Securities
Purchases of marketable securities
Year ended December 31, 2028
Long-Term Debt, Maturity, Year Three
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Weighted-Average Exercise Price Per Share, Exercisable
Long-Lived Tangible Asset [Axis]
Increase in valuation allowance
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Cybersecurity Risk Third Party Oversight and Identification Processes [Flag]
Gross proceeds
Proceeds from Issuance of Debt
Less: valuation allowance
Less: valuation allowance
Deferred Tax Assets, Valuation Allowance
Extinguishment of Debt, Amount
Extinguishment of debt
Federal income taxes
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Income benefit at statutory federal rate, Percent
Subsequent Event [Line Items]
Cybersecurity Risk Management Third Party Engaged [Flag]
Documents Incorporated by Reference [Text Block]
Effective income tax rate
Effective income tax rate
Effective Income Tax Rate Reconciliation, Percent
Common Stock Options
Interest income
Investment Income, Interest
Income Tax Jurisdiction [Axis]
Geographical [Domain]
Restricted Cash
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Defined Contribution Plan [Abstract]
Additional Paid in Capital, Common Stock
Additional paid-in capital
Debt issuance cost
Debt Issuance Costs, Net
Debt Issuance Costs, Net, Total
Defined Contribution Plan
Defined Contribution Plan [Text Block]
Property, Plant and Equipment [Line Items]
Issuance of common stock upon achievement of milestone related to acquisition of assets
Issuance of Common Stock Value Upon Achievement of Milestone Related to Acquisition of Assets
Issuance of common stock value upon achievement of milestone related to acquisition of assets.
Advisors.
Advisors [Member]
Advisors
Vesting [Domain]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Granted, outstanding stock options
Cybersecurity Risk Management, Strategy, and Governance [Table]
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Summary of Computation of Basic and Diluted Net Loss Per Share
Increase (Decrease) in Other Operating Assets and Liabilities, Net, Total
Increase (Decrease) in Other Operating Assets and Liabilities, Net
Other assets
Nontaxable or nondeductible items
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Amount [Abstract]
Navacaprant (NMRA-511) program expenses
Navacaprant (NMRA-511) program expenses.
NMRA-511 program
NMRA-511 program
Investments Classified by Contractual Maturity Date [Table Text Block]
Summary of Marketable Securities by Contractual Maturity
Earnings Per Share, Basic, Total
Earnings Per Share, Basic
Net loss per share, basic
Effective Income Tax Rate Reconciliation, Prior Year Income Taxes, Percent
Changes in unrecognized tax benefits, Percent
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Beginning balance, Outstanding Stock Options
Ending balance, Outstanding Stock Options
Schedule of Available-for-Sale Securities Reconciliation [Table Text Block]
Summary of Amortized Cost and Fair Value of Cash Equivalents and Marketable Securities by Major Investment Category
Debt and Debt Issuance Costs
Debt, Policy [Policy Text Block]
Interest income
Interest Income (Expense), Nonoperating
Interest Income (Expense), Nonoperating, Total
Liabilities, Current
Total current liabilities
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities:
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Exercise Price
Stock options granted, exercise price
Principal Amount of Debt Extinguished upon Conversion to Common stock
Principal amount of debt extinguished upon conversion to common stock.
Principal amount of debt extinguished upon conversion to common stock
Federal income taxes paid net of refunds received
Income Tax Paid, Federal, after Refund Received
Income Tax Paid, Federal, after Refund Received, Total
Shares issued based on volume weighted average price per share prior to date milestone was met
Shares Issued Based on Volume Weighted Average Price Per Share Prior to Date Milestone Was Met
Shares issued based on volume weighted average price per share prior to date milestone was met.
Federal
Domestic Tax Jurisdiction [Member]
Tax credits
Effective Income Tax Rate Reconciliation, Tax Credit, Percent [Abstract]
Effective Income Tax Rate Reconciliation, Tax Credit, Other, Amount
Tax credits, Amount
Tax credits, Amount
Development milestones.
Development Milestones [Member]
Development Milestones
Issuance of common stock upon initial public offering, net of offering costs shares.
Issuance of Common Stock Upon Initial Public Offering, Net of Offering Costs Shares
Liquidity.
Liquidity [Member]
Liquidity
Accounting Standards Update [Axis]
Funds Provided For Pre-clinical Research And Development Activities
Funds provided for pre-clinical research and development activities.
Funds provided for preclinical research and development activities
Equity, Attributable to Parent [Abstract]
Stockholders' equity:
Entity Small Business
Accrued liabilities
Increase (Decrease) in Accrued Liabilities, Total
Increase (Decrease) in Accrued Liabilities
Second Vanderbilt Research Agreement
Second Vanderbilt sponsored research agreement [Member]
Second vanderbilt sponsored research agreement.
Retained Earnings (Accumulated Deficit), Total
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Compensation related
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Deferred Tax Assets, Tax Credit Carryforwards [Abstract]
Accretion of final payment fee
Accretion Expense
Preferred Stock [Member]
Preferred Stock
Entity Well-known Seasoned Issuer
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Canceled and forfeited, Outstanding Stock Options
Stock options, cancelled
Canceled and forfeited, Outstanding Stock Options
Preferred stock, amount outstanding
Preferred Stock, Value, Outstanding
Alairion Carveout Plan.
Alairion Carveout Plan [Member]
Alairion Carveout Plan
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Intrinsic value of stock options exercised
Intrinsic value of options exercised
Share-Based Payment Arrangement [Text Block]
Stock-Based Compensation
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Leases [Abstract]
Amendment Flag
Net Cash Proceeds from Financing Activities
Net cash proceeds from financing activities.
Net cash proceeds from financing activities
Product and Service [Domain]
Debt Issuance Costs Reclassified to Equity in Connection with Conversion
Debt issuance costs reclassified to equity in connection with conversion.
Debt issuance costs reclassified to equity in connection with conversion
Loss Contingencies [Line Items]
Number of license agreements.
Number of License Agreements
Number of license agreements
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
Income benefit at statutory federal rate, Amount
State and local income taxes, net of federal benefit , Amount
Percentage of future taxable income offsetting by NOL carryforward
Percentage of Future Taxable Income Offsetting By NOL
Percentage of future taxable income offsetting by NOL.
Series A-1 convertible preferred stock.
Series A-1 convertible preferred stock [Member]
Series A-1
Series A-1 Convertible Preferred Stock
Net Loss Per Share
Earnings Per Share, Policy [Policy Text Block]
Share-Based Compensation Arrangement By Share-Based Payment Award Options Vested in Period Incremental Expense Resulted in Modification
Total incremental expense resulted in modification
Share based compensation arrangement by share based payment award options vested in period incremental expense resulted in modification.
Liabilities and Equity [Abstract]
Liabilities and Stockholders' Equity
Entity Address, Postal Zip Code
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Net cash used in operating activities
Increase (Decrease) in Operating Lease Liability
Operating lease liabilities
Maximum Future Capital Stock Offerings Investment
Maximum future capital stock offerings investment.
Maximum future capital stock offerings investment
Segment Reporting, CODM, Profit (Loss) Measure, How Used, Description
Common Stock [Member]
Common Stock
Research agreement expiry date
Research Agreement Expiry Date
Research agreement expiry date.
Cybersecurity Risk Role of Management [Text Block]
Tax credits, Carryforwards
Tax Credit Carryforward, Amount
Long-Term Debt, Maturity, Year One
Year ended December 31, 2026
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Weighted-Average Exercise Price Per Share, Granted
Less: accumulated depreciation and amortization
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated depreciation
Amgen research and collaboration agreement.
Amgen Research And Collaboration Agreement [Member]
Amgen Research and Collaboration Agreement
Entity Address, Address Line One
Total deferred tax liabilities
Total deferred tax liabilities
Deferred Tax Liabilities, Gross
Fair Value Hierarchy and NAV [Axis]
Other noncash expenses
Other Noncash Expense
Series A-2 Convertible Preferred Stock.
Series A-2 Convertible Preferred Stock [Member]
Series A-2 Convertible Preferred Stock
Series A-2
Earnings Per Share [Abstract]
Income Taxes
Income Tax, Policy [Policy Text Block]
Emerging growth company status.
Emerging Growth Company Status [Policy Text Block]
Emerging Growth Company Status
Balance at Ending
Convertible preferred stock, $0.0001 par value; 50,000 and 820,349 shares authorized as of December 31, 2023 and December 31, 2022, respectively; no and 104,417 shares issued and outstanding as of December 31, 2023 and December 31, 2022, respectively
Temporary Equity, Carrying Amount, Attributable to Parent
Balance at Beginning
Convertible preferred stock, Carrying Value
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Flag]
Supplemental disclosure of cash flow information:
Supplemental Cash Flow Information [Abstract]
Statement of Financial Position Location, Balance [Axis]
Investment Type [Axis]
Right-of-use asset
Operating Lease, Right-of-Use Asset
Operating lease right-of-use assets
Total deferred tax assets
Deferred Tax Assets, Gross
Cybersecurity Risk Board Committee or Subcommittee Responsible for Oversight [Text Block]
Summary of Fair Value of Stock Options
Summary of Fair Value of Stock Options [Table Text Block]
Summary of fair value of stock options.
Accrued Royalties
Royalties due
Share Based Compensation Arrangement by Share Based Payment Award, Incremental Compensation Cost Related to Unvested Stock Options
Share based compensation arrangement by share based payment award, incremental compensation cost related to unvested stock options.
Incremental compensation cost related to unvested stock options
Collaboration agreement term.
Collaboration Agreement Term
Term of the agreement
Class of Warrant or Right [Axis]
Accrued clinical trial and preclinical costs.
Accrued Clinical Trial and Preclinical Costs
Accrued clinical trial and preclinical costs
Document Type
Cash paid for income taxes
Income Taxes Paid, Net
Income Taxes Paid, Net, Total
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Federal (Post-December 31, 2017) [Member]
Federal (Post-December 31, 2017).
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Entity Central Index Key
BlackThorn Therapeutics, Inc. member.
BlackThorn Therapeutics, Inc. [Member]
BlackThorn Therapeutics, Inc.
Liquidity [ Policy Text Block ]
Liquidity.
Liquidity
Conversion of convertible preferred stock into common stock upon initial public offering shares.
Conversion of Convertible Preferred Stock into Common Stock Upon Initial Public Offering Shares
Conversion of convertible preferred stock into common stock upon initial public offering, Shares
Cybersecurity Risk Process for Informing Board Committee or Subcommittee Responsible for Oversight [Text Block]
Components of cash and restricted cash:
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation
Net change in cash and cash equivalents and restricted cash
Subsequent Event Type [Domain]
Preferred stock warrants expired.
Preferred Stock Warrants Expired
Preferred stock warrants, expired
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Antidilutive securities excluded from computation of earnings per share amount
Balance Sheet Related Disclosures [Abstract]
APIC, Share-Based Payment Arrangement, Option, Increase for Cost Recognition
Stock-based compensation
Impairment of long-lived assets
Impairment of Long-Lived Assets to be Disposed of
Impairment on assets held for sale
Common Stock, Par or Stated Value Per Share
Common stock, par value
Accounting Standards Update [Domain]
Two Thousand Twenty Three Equity Incentive Plan [Member]
Two Thousand Twenty Three Equity Incentive Plan [Member]
2023 Equity Incentive Plan
Share-Based Payment Arrangement, Tranche One [Member]
Tranche One
Restricted common stock.
Restricted Common Stock [Member]
Restricted Common Stock
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Weighted-Average Remaining Contractual Term, Outstanding (Years)
Second Tranche
Tranche Two [Member]
Tranche two.
Expected volatility, Maximum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum
Asset Acquisition, Contingent Consideration, Liability, Total
Asset Acquisition, Contingent Consideration, Liability
Contingent consideration deemed due or payable
Debt Securities, Available-for-Sale, Amortized Cost, Total
Debt Securities, Available-for-Sale, Amortized Cost
Amortized Cost
Components of Deferred Tax Assets and Liabilities [Abstract]
Debt Securities, Available-for-Sale
Estimated Fair Value
Total marketable securities
Employee stock option and and restricted stock units.
Employee Stock Option and and Restricted Stock Units Member
Common Stock Options and Restricted Stock Units
Document Financial Statement Error Correction [Flag]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Issuance of common stock upon exercise of stock options, shares
Exercised, Outstanding Stock Options
Exercised, Outstanding Stock Options
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Nonvested, Number of Shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Nonvested, Number of Shares, Ending Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Nonvested, Number of Shares, Beginning Balance
Number of unvested stock awards
Debt Disclosure [Abstract]
Marketable securities.
Marketable securities [Member]
Marketable Securities
Fair Value Measurement and Measurement Inputs, Recurring and Nonrecurring [Text Block]
Fair Value Measurements
Conversion of Term Loan Principal to Common Stock
Conversion of term loan principal to common stock.
Conversion of term loan principal to common stock
Early exercised stock options subject to future vesting.
Early exercised stock options subject to future vesting [Member]
Early Exercised Stock Options Subject to Future Vesting
Term Loan Conversion Election [Member]
Term loan conversion election.
Term Loan Conversion Election
Accrued Liabilities, Current
Accrued liabilities
Total accrued liabilities
Research And Collaboration Agreement Quarterly Payments
Research And Collaboration Agreement Quarterly Payments
Research and collaboration agreement quarterly payments
Current Fiscal Year End Date
Schedule of Long-Term Debt Instruments [Table]
Navacaprant (NMRA-140) program
Navacaprant (NMRA-140) program expenses
Navacaprant (NMRA-140) program expenses.
Navacaprant (NMRA-140) program
Research and collaboration agreement quarterly payments for first two years.
Research And Collaboration Agreement Quarterly Payments For First Two Years
Research and collaboration agreement quarterly payments for first two year
California
CALIFORNIA
Entity Address, State or Province
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Shares or restricted stock remained outstanding and unvested
Outstanding and unvested, Shares at beginning balance
Outstanding and unvested, Shares at ending balance
Stock Issued During Period, Value, Conversion of Convertible Securities
Conversion of convertible debt
Issuance of common stock upon conversion of convertible debt
Asset Acquisition [Domain]
Preferred Stock, Shares Outstanding
Preferred Stock, Shares Outstanding, Ending Balance
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred stock, outstanding
Preferred stock, shares outstanding
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Comprehensive loss
Federal (Pre-January 1, 2018) [Member]
Federal (Pre-January 1, 2018).
Tax credits, Expiration Years
Tax Credit Carryforward, Limitations on Use
Research and Development Expense, Policy [Policy Text Block]
Research and Development Expenses and Related Prepaid Assets and Accrued Liabilities
Common Stock, Capital Shares Reserved for Future Issuance
Common stock reserved for future issuance
Shares reserved for potential future issuances
Class of Warrant or Right [Domain]
Geographical [Axis]
Line of Credit Facility, Lender [Domain]
Prepayment penalty
Prepayment penalty.
Alairion, Inc.
Alairion, Inc [Member]
Alairion, Inc
Marketable Securities, Current
Short-term marketable securities
Marketable securities
Term Loans
Term Loans [Member]
Term Loans.
State and local income taxes, net of federal benefit , Amount
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Summary of Stock-Based Compensation Expense Recognized
Stock Issued During Period, Value, Stock Options Exercised
Issuance of common stock upon exercise of stock options
Comprehensive Income, Policy [Policy Text Block]
Comprehensive Loss
Summary of Deferred Tax Assets and Liabilities
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Massachusetts
Massachusetts [Member]
Massachusetts.
Early exercise liability, net of current portion.
Early Exercise Liability Net Of Current Portion
Early exercise liability, net of current portion
Collaborative Arrangement Disclosure [Text Block]
Strategic License and Research and Collaboration Agreements
Equity Option [Member]
Stock Option
Other Comprehensive Income (Loss), Net of Tax [Abstract]
Other comprehensive loss:
Milestone payment due description.
Milestone Payment Due Description
Milestone payment due description
Performance Shares [Member]
Performance Stock Options
Subsequent Event [Member]
Subsequent Event
Marketable Securities, Policy [Policy Text Block]
Marketable Securities
Alairion Merger Agreement.
Alairion Merger Agreement [Member]
Alairion Merger Agreement
Deferred tax assets in capitalized license agreements.
Capitalized license agreements
Deferred Tax Assets In Capitalized License Agreements
Acquired in-process research and development
Acquired in-process research and development
Acquired in-process research and development
Acquired in-process research and development
Property, Plant and Equipment [Abstract]
Research and development credits
Deferred Tax Assets, Tax Credit Carryforwards, Research
Other Assets, Noncurrent
Other assets
Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net
Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net, Total
Unamortized debt issuance costs
Antidilutive Securities [Axis]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Expirations in Period
Expired, Outstanding Stock Options
Expired, Outstanding Stock Options
Basis of Presentation and Significant Accounting Policies [Text Block]
Summary of Significant Accounting Policies and Basis of Presentation
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Aggregate Intrinsic Value, Vested
Income Tax Paid, Foreign, after Refund Received
Income Tax Paid, Foreign, after Refund Received, Total
Foreign income taxes paid net of refunds received
Interest Expense, Debt
Total interest expense related to debt
K2HV
K2 HealthVentures LLC [Member]
K2 HealthVentures LLC.
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Abstract]
Debt Instrument, Convertible, Number of Equity Instruments
Conversion option
State
State and Local Jurisdiction [Member]
Related Party Transaction [Axis]
AOCI Attributable to Parent [Member]
Accumulated Other Comprehensive Gain (Loss)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions and Methodology [Abstract]
Minimum liquidity covenant percentage of outstanding obligations two
Minimum liquidity covenant percentage of outstanding obligations two.
Minimum liquidity covenant percentage of outstanding obligations two
Line of Credit Facility, Frequency of Payment and Payment Terms
Payment terms
Preferred stock, amount issued
Preferred Stock, Value, Issued
Preferred stock, $0.0001 par value; 50,000 shares authorized as of December 31, 2025 and December 31, 2024; no shares issued and outstanding as of December 31, 2025 and December 31, 2024.
Accounting Standards Update 470 [Member]
Accounting Standards Update 470 member.
ASC 470
Asset Acquisition, Consideration Transferred, Contingent Consideration
Contingent consideration
Debt Instrument, Maturity Date
Maturity date
Minimum [Member]
Minimum
Preferred stock warrants.
Preferred stock warrants [Member]
Preferred Stock Warrants
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Granted, Weighted Average Grant Date Fair Value Per Share
Financial Instrument [Axis]
Assets, Current [Abstract]
Current assets:
Fair Value, Inputs, Level 3 [Member]
Level 3
Proceeds from Long-Term Lines of Credit
Proceeds from term loan, net
Shares issued upon achievement of milestone
Shares issued upon achievement of milestone
Shares issued upon achievement of milestone.
Income Tax Expense (Benefit), Continuing Operations [Abstract]
Segment Reporting [Abstract]
Fixed assets
Fixed assets
Deferred Tax Liabilities, Property, Plant and Equipment
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Summary of Assets and Liabilities Measured at Fair Value on Recurring Basis
Business Combination [Policy Text Block]
Acquisitions
Liabilities, Current [Abstract]
Current liabilities:
Two thousand and fifteen TSRI license agreement.
Two Thousand And Fifteen TSRI License Agreement [Member]
2015 TSRI License Agreement
Share-based compensation arrangement by share-based payment award, per share of purchase price of offering period
Share-based compensation arrangement by share-based payment award, per share of purchase price of offering period.
Per share of purchase price of offering period
Related Party Transactions [Abstract]
Shares, Outstanding
Balance at Beginning (in Shares)
Balance at Ending (in Shares)
NOLs, Carryforwards
Operating Loss Carryforwards
Amortization of Debt Issuance Costs and Accretion of Final Payment Fee
Amortization of debt issuance costs and accretion of final payment fee.
Amortization of debt issuance costs and accretion of final payment fee
Noncash operating lease expense.
Noncash operating lease expense
Non-cash operating lease expense
Research and development personnel-related costs
Research and Development Personnel Related Costs
Research and development personnel related costs.
Restricted Cash and Cash Equivalent
Total cash and cash equivalents and restricted cash
Total cash and cash equivalents and restricted cash
Proceeds from employee stock purchase plan purchases
Proceeds from Stock Plans
First Amendment to the Loan Agreement
First Amendment To The Loan Agreement [Member]
First amendment to the loan agreement.
Loan Agreement
Navacaprant.
Navacaprant [Member]
navacaprant
Commitments and Contingencies
Commitments and contingencies
Leases
Lessee, Leases [Policy Text Block]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Outstanding and unvested, Weighted Average Grant Date Fair Value Per Share at beginning balance
Outstanding and unvested, Weighted Average Grant Date Fair Value Per Share at ending balance
General and Administrative Expense [Member]
General and Administrative
Auditor Firm ID
Variable interest rate
Debt Instrument, Basis Spread on Variable Rate
Stockholders' Equity, Reverse Stock Split
Reverse stock split
Awards with performance conditions.
Awards with Performance Conditions [Member]
Awards with Performance Conditions
Deferred Tax Assets Tax Credit Carryforwards [Table]
Deferred tax assets tax credit carryforwards.
Restricted Cash, Current
Restricted cash
Share based compensation arrangement by share based payment award milestones achieved.
Share Based Compensation Arrangement By Share Based Payment Award Milestones Achieved
Share based payment, milestones achieved
Series b convertible preferred stock.
Series B Convertible Preferred Stock [Member]
Series B Convertible Preferred Stock
Series B
Year ended December 31, 2027
Long-Term Debt, Maturity, Year Two
Convertible Preferred Stock Warrant Liability
Convertible Preferred Stock Warrant Liability [Policy Text Block]
Convertible preferred stock warrant liability policy text block.
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Changes in valuation allowance, Percent
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net loss
Deferred funding
Deferred Funding Current
Deferred funding current.
Long-Term Debt, Type [Domain]
Cybersecurity Risk Management Positions or Committees Responsible [Text Block]
Loss Contingencies [Table]
Weighted Average Number of Shares Outstanding, Basic, Total
Weighted Average Number of Shares Outstanding, Basic
Weighted-average shares outstanding, basic
Weighted-average common shares outstanding, basic
Net accretion of investments in marketable securities
Investment Income, Amortization of Discount
Syllable Life Sciences, Inc.
Syllable Life Sciences, Inc [Member]
Syllable Life Sciences, Inc
Temporary Equity [Abstract]
Additional Debt at Face Value Net of Debt Issuance Costs
Additional debt at face value net of debt issuance costs.
Additional debt at face value net of debt issuance costs
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Aggregate Intrinsic Value, Exercisable
Lab And Other Equipment [Member]
Lab and other equipment.
Lab and Other Equipment
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Summary of Reconciliation of Effective Income Tax Rate to the Statutory Federal Income Tax Rate
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Long-Lived Tangible Asset [Domain]
Cybersecurity Risk Process for Informing Management or Committees Responsible [Text Block]
Available for sale securities debt maturities after one through two years fair value
Available For Sale Securities Debt Maturities After One Through Two Years Fair Value
After one year through [two] years
After one year through two years
Total debt, long-term
Long-Term Debt
New debt
Total debt, long-term
Unrecognized Tax Benefits, Increase (decrease) Resulting from Prior Period Tax Positions
Unrecognized tax benefits, increase (decrease) resulting from prior period tax positions.
Gross decrease based on tax positions related to prior years
Related Party Transactions Disclosure [Text Block]
Related Party Transactions
Effective Income Tax Rate Reconciliation Transaction Costs
Effective income tax rate reconciliation transaction costs.
Transaction costs, Percent
Deferred Tax Assets Tax Credit Carryforwards [Line Items]
Deferred tax assets tax credit carryforwards.
Deferred offering costs.
Deferred Offering Costs [Policy Text Block]
Deferred Offering Costs
Milestone Payments
Milestone Payments
Milestone payments
Capitalized research and development expense
Deferred Tax Asset, In-Process Research and Development
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Changes in valuation allowance, Amount
Equity, Attributable to Parent
Balance at Beginning
Balance at Ending
Total stockholders' equity
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value
Two Thousand Twenty Three And Two Thousand Twenty Equity Incentive Plan [Member]
2023 And 2020 Equity incentive plan.
2023 And 2020 Equity Incentive Plan
Interest Income and Interest Expense Disclosure [Table Text Block]
Summary of Components of Interest Expense
Basis of Accounting, Policy [Policy Text Block]
Basis of Presentation and Consolidation
Discretionary Tranche
Discretionary Tranche [Member]
Discretionary tranche member.
Statement of Stockholders' Equity [Abstract]
Share-Based Payment Arrangement, Tranche Two [Member]
Tranche Two
Share-Based Compensation Arrangement By Share-Based Payment Award Options Grant Date Fair Value
Grant date fair value
Share based compensation arrangement by share based payment award options grant date fair value.
Cash Equivalents [Member]
Cash Equivalents
Sale and Issuance of Common Stock Share
Sale and Issuance of Common Stock Share
Sale and issuance of common stock, Shares
Use of Estimates, Policy [Policy Text Block]
Use of Estimates
Unaudited interim condensed consolidated financial statements.
Unaudited Interim Condensed Consolidated Financial Statements [Policy Text Block]
Unaudited Interim Condensed Consolidated Financial Statements
Entity Address, Address Line Two
Shares Reserved For Future Issuance Under The Employee Stock Purchase Plan [Member]
Shares reserved for future issuance under the employee stock purchase plan.
Shares Reserved for Future Issuance Under the Employee Stock Purchase Plan
Minimum liquidity covenant percentage of outstanding obligations one
Minimum liquidity covenant percentage of outstanding obligations one.
Minimum liquidity covenant percentage of outstanding obligations one
Award modification.
Award Modification [Member]
Award Modification
Schedule of Accrued Liabilities [Table Text Block]
Schedule of Accrued Liabilities
Debt Instrument, Name [Domain]
Supplemental disclosure of noncash investing and financing activities:
Long-Term Debt, Maturity, Year Four
Year ended December 31, 2029
Vesting of restricted common stock, shares
Stock Issued During Period Shares Vesting Of Restricted Stock
Stock issued during period shares vesting of restricted stock.
Summary of Reconciliation of Unrecognized Tax Benefits
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]
Plan Name [Domain]
Interest Expense, Operating and Nonoperating
Interest Expense, Operating and Nonoperating, Total
Cash interest expense
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Credit Facility [Axis]
Stock Issued During Period, Value, Other
Issuance of common stock
Right-of-use asset derecognized
Right-of-use Asset Derecognized
Right-of-use asset derecognized.
Impairment, Long-Lived Asset, Held-for-Use
Impairment, Long-Lived Asset, Held-for-Use, Total
Impairment of held for sale assets
Current State and Local Tax Expense (Benefit)
State
Cybersecurity Risk Management Expertise of Management Responsible [Text Block]
Case two.
Case Two [Member]
Case Two
Certificates of Deposit [Member]
Certificates of Deposit
Amgen Inc. Licenses.
Amgen Inc. Licenses [Member]
Amgen Inc. Licenses
Warrants outstanding
Class of Warrant or Right, Outstanding
Other, Amount
Effective Income Tax Rate Reconciliation, Other Adjustments, Amount
Effective Income Tax Rate Reconciliation, Prior Year Income Taxes, Amount
Changes in unrecognized tax benefits, Amount
Achievement of specified commercialization events.
Achievement of Specified Commercialization Events [Member]
Achievement of Specified Commercialization Events
Preferred stock warrants exercised.
Preferred Stock Warrants Exercised
Preferred stock warrants, exercised
Property and Equipment, Net
Property, Plant and Equipment, Policy [Policy Text Block]
Entity Address, City or Town
Business Combination, Contingent Consideration, Liability, Total
Business Combination, Contingent Consideration, Liability
Milestone payment due
Milestone due
Area of office facility
Area of Office Facility
Area of office facility.
Security Exchange Name
Maximum repayment obligation
Maximum Repayment Obligation
Maximum repayment obligation.
Credit Facility [Domain]
Uncertain tax positions description
Uncertain Tax Positions Description
Uncertain tax positions description.
Total principal payments including final fee
Long-Term Debt, Gross
Other, Percent
Effective Income Tax Rate Reconciliation, Other Adjustments, Percent
Total property and equipment
Property, Plant and Equipment, Gross
Property, Plant and Equipment, Gross, Ending Balance
Property, Plant and Equipment, Gross, Beginning Balance
Total property and equipment
Temporary Equity [Table Text Block]
Summary of Convertible Preferred Stock
Performance restricted stock.
Performance Restricted Stock [Member]
Performance Restricted Stock
Deferred Offering Costs
Deferred offering costs
Net loss before income taxes
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
pre-tax net losses
Black Thorn.
Black Thorn [Member]
Black Thorn
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Vested, outstanding stock options
Repurchase of unvested early exercised stock options.
Repurchase of unvested early exercised stock options
Repurchase of unvested early exercised stock options
Case one.
Case One [Member]
Case One
Service conditions.
Service Conditions [Member]
Service Conditions
Issuance of common stock upon early exercise of stock options.
Issuance of common stock upon early exercise of stock options
Antidilutive Securities, Name [Domain]
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Percent
Permanent differences, Percent
Executive Officer [Member]
Executives
Interest expense
Interest Paid, Excluding Capitalized Interest, Operating Activity
Interest expense
Statistical Measurement [Domain]
Assets, Current
Total current assets
Share-Based Payment Arrangement, Expense
Share based compensation recognized
Total stock-based compensation
Document Period End Date
Laboratory Equipment
Laboratory Equipment [Member]
Laboratory equipment.
Title and Position [Axis]
Fair Value Hierarchy and NAV [Domain]
ICFR Auditor Attestation Flag
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Exercisable, Outstanding Stock Options
Gain (Loss) on Disposition of Property Plant Equipment
Gain (Loss) on Disposition of Property Plant Equipment, Total
Loss on disposal of property and equipment
Share-Based Compensation Arrangement by Share-Based Payment Award, Shares Purchased for Award
Stock options granted to purchase
Statement of Financial Position [Abstract]
Restricted Stock Units (RSUs) [Member]
Unvested Restricted Stock Awards
Restricted Stock Units
Loss Contingency Nature [Axis]
Loss Contingency, Nature [Domain]
Antidilutive Security, Excluded EPS Calculation [Table]
Vesting [Axis]
Class of Stock [Axis]
Cybersecurity Risk Management, Strategy, and Governance [Line Items]
M4 PAM programs
M4 PAM Programs Expenses
M4 PAM programs expenses.
M4 PAM programs
Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Percent
Tax law change, Percent
Liabilities
Total liabilities
Services agreement.
Services Agreement [Member]
Services Agreement
US Government Debt Securities [Member]
U.S. Government Securities
Financial Instruments [Domain]
Restricted Cash, Total
Restricted Cash
Restricted Stock [Member]
Restricted Stock
Restricted Common Stock
Cash and Cash Equivalent [Table]
Weighted Average Number of Shares Outstanding, Diluted, Total
Weighted Average Number of Shares Outstanding, Diluted
Weighted-average shares outstanding, diluted
Weighted-average common shares outstanding, diluted
Research and collaboration agreement quarterly payments for third year.
Research And Collaboration Agreement Quarterly Payments For Third Year
Research and collaboration agreement quarterly payments for third year
Securities Act File Number
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Unrealized gain (loss) on marketable debt securities
Unrealized gain (loss) on marketable securities
Cover [Abstract]
Deferred income taxes:
Deferred Federal, State and Local, Tax Expense (Benefit) [Abstract]
Expected volatility, Minimum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum
Prepaid Expense and Other Assets, Current
Prepaid expenses and other current assets
Prepaid research and development costs
Total prepaid expenses and other current assets
Canceled, Shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Share based compensation forfeited
Amortization And Write Off Of Deferred Debt Issuance Costs
Amortization and write off of deferred debt issuance costs.
Amortization and write-off of deferred debt issuance costs
Investments [Domain]
Supplemental Balance Sheet Disclosures [Text Block]
Balance Sheet Components
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized
Number of shares of common stock available for issuance
Number of Operating Segments
Number of operating segments
Sale of Stock [Domain]
Segment Reporting Disclosure [Text Block]
Segment Reporting
General and Administrative Expense, Total
General and Administrative Expense
General and administrative
General and administrative expense
General and administrative expense
Series B Preferred Stock [Member]
Series B Preferred Stock
Business Combination and Asset Acquisition [Abstract]
Business Combination and Asset Acquisition [Abstract]
Temporary Equity, Liquidation Preference
Convertible preferred stock, Liquidation Preference
Number of options vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested, Number of Shares
Subsequent Event [Table]
Other
Deferred Tax Assets, Other
Collaboration agreement termination description.
Collaboration Agreement Termination Description
Collaboration agreement termination description
Current tax provision
Current tax provision
Stock Issued During Period, Shares, Other
Issuance of common stock, Shares
Percentage of annual increase of outstanding shares of common stock
Share-Based Compensation Arrangement by Share-Based Payment Award Percentage of Anuual Increase
Share-based compensation arrangement by share-based payment award percentage of anuual increase.
Debt Instrument, Convertible, Conversion Price
Conversion price
Line of Credit Facility, Interest Rate During Period
Effective interest rate of term loan
Incremental stock compensation expense
Employee Stock Ownership Plan (ESOP), Compensation Expense
Issuance of common stock value as noncash consideration related to an acquisition of assets.
Issuance of common stock value as noncash consideration related to an acquisition of assets
Issuance of common stock as noncash consideration related to an acquisition of assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Weighted-Average Exercise Price Per Share, Vested
Nature of Operation, Product Information, Concentration of Risk [Table]
Amgen Inc.
Amgen Inc [Member]
Amgen Inc.
Estimated useful lives of assets
Property, Plant and Equipment, Useful Life
New Accounting Pronouncements, Policy [Policy Text Block]
Recent Accounting Pronouncements
Summary of Maturity of the Company's Operating Lease Liabilities
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Stock Issued During Period, Shares, Conversion of Convertible Securities
Conversion of convertible debt
Issuance of common stock upon conversion of convertible debt, shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Share based compensation granted under plan vested period
Share based compensation forfeited under unvested plan
Risk-free interest rate, Minimum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum
Income Tax Expense (Benefit), Effective Income Tax Rate Reconciliation, Amount [Abstract]
Depreciation
Depreciation, Total
Depreciation expense
Common stock, shares outstanding
Common Stock, Shares, Outstanding
Common Stock, Shares, Outstanding, Ending Balance
Common Stock, Shares, Outstanding, Beginning Balance
Less: Operating lease liabilities, current portion
Operating Lease, Liability, Current
Operating lease liabilities, current portion
Two thousand twenty equity incentive plan.
Two Thousand Twenty Equity Incentive Plan [Member]
2020 Equity Incentive Plan
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Depreciation and amortization expense
Depreciation, Depletion and Amortization, Total
Depreciation, Depletion and Amortization
Depreciation and amortization
Shares reserved for options and restricted stock unitsissued underthe plans.
Shares Reserved For Options And Restricted Stock UnitsIssued UnderThe Plans [Member]
Shares Reserved for Options and Restricted Stock Units Issued Under the Plans
Summary of Future Principal Payments
Contractual Obligation, Fiscal Year Maturity [Table Text Block]
Cybersecurity Risk Management Processes Integrated [Flag]
Document Transition Report
Net deferred tax assets
Deferred Tax Assets, Net
Tranche One [Member]
Tranche one.
First Tranche
Operating Expenses
Total operating expenses
Total Operating Expense
Accrued Liabilities, Current [Abstract]
NOLs, Expiration Years
Operating Loss Carryforwards, Limitations on Use
Research and Development Expense, Total
Research and development
Research and development expenses
Research and development personnel-related costs
Convertible Preferred Stock [Member]
Convertible Preferred Stock
Summary of Components of Interest Expense
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]
Schedule of Income Tax Expense
Additional shares of capital stock member.
Additional Shares of Capital Stock [Member]
Additional Shares of Capital Stock
Statement of Cash Flows [Abstract]
Current Federal Tax Expense (Benefit)
Federal
Stock Issued During Period, Value, New Issues
Issuance of common stock upon initial public offering and at the market offering, net of offering costs
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Summary of Stock Option Activity
Additional space added to area of office and laboratory as per amendment
Additional space added to area of office and laboratory as per amendment
Additional space added to area of office and laboratory as per amendment.
Stock-based compensation, Percent
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent
Equity [Text Block]
Stockholders' Equity
Earnings Per Share [Text Block]
Net Loss Per Share
Temporary Equity [Line Items]
Carol Suh [Member]
Carol Suh.
Carol Suh
Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]
Summary of Restricted Stock Activity
Cybersecurity Risk Management Processes Integrated [Text Block]
Sale of Stock, Consideration Received Per Transaction
Aggregate gross sales proceeds
Net loss
Net loss
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Aggregate Intrinsic Value, Outstanding
Aggregate Intrinsic Value, Outstanding
Acquisition date fair value of shares transferred
Acquisition Date Fair Value of Shares Transferred
Acquisition date fair value of shares transferred
Income Tax Contingency [Line Items]
Expected dividend yield
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Upfront cash payment.
Upfront Cash Payment
Upfront cash payment
Available-for-Sale Securities, Debt Maturities [Abstract]
Final payment fee, percentage of principal drawn
Final Payment Fee, Percentage of Principal Drawn
Final payment fee, percentage of principal drawn.
Cash paid for operating lease agreements (in thousands)
Operating Lease, Payments
Assets [Abstract]
Assets
Income Tax Authority, Name [Axis]
Supplemental Information on the Company's Operating Leases
Supplemental Information on the Company's Operating Leases [Table Text Block]
Supplemental information on the company's operating leases.
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk-free rate
Construction in Progress
Construction in Progress [Member]
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid expenses and other current assets
Amortization of debt issuance costs
Amortization of Debt Issuance Costs and Discounts, Total
Long-Term Debt, Fiscal Year Maturity [Abstract]
Payments For Execution Of Agreement
Payments for execution of agreement.
Payments for execution of agreement
Document Fiscal Year Focus
Incremental compensation cost related to vested stock options
Share Based Compensation Arrangement by Share Based Payment Award, Incremental Compensation Cost Related to Vested Stock Options
Share based compensation arrangement by share based payment award, incremental compensation cost related to vested stock options.
Debt Conversion, Converted Instrument, Shares Issued
Issuance of shares of common stock, conversion of debt
Commercial milestone payments.
Commercial Milestone Payments
Commercial milestone payments
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract]
Investing activities:
Accounts Payable, Current, Total
Accounts Payable, Current
Accounts payable
Aggregate grant-date fair value of options
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested in Period, Fair Value
Aggregate grant-date fair value of options vested
Interest Expense, Nonoperating
Interest Expense, Nonoperating, Total
Interest expense
Interest expense
Research and Development Expense [Member]
Research and Development
Matching employer contribution
Defined Contribution Plan, Employer Matching Contribution, Percent of Match
Deferred Federal Income Tax Expense (Benefit)
Federal
Schedule of Prepaid Expenses and Other Current Assets
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Table Text Block]
Research and Development
Research Tax Credit Carryforward [Member]
Operating lease right-of-use assets
Operating lease right-of-use assets
Deferred Tax Liabilities Operating Lease Right Of Use Assets
Deferred tax liabilities operating lease right of use assets.
Deferred tax assets:
Components of Deferred Tax Assets [Abstract]
Debt Conversion, Converted Instrument, Amount
Debt conversion amount
Third Tranche
Tranche Three [Member]
Tranche three.
Gross value of sale or disposed of property equipment
Property, Plant and Equipment, Disposals
Proceeds from Stock Options Exercised
Proceeds from exercise of stock options
Fair Value Disclosures [Abstract]
Commitments and Contingencies Disclosure [Abstract]
Forfeiture of unvested restricted common stock
Forfeiture of Unvested Restricted Common Stock, Shares
Forfeiture of unvested restricted common stock, shares.
Convertible Preferred Stock
Convertible Preferred Stock, Policy [Policy Text Block]
Convertible preferred stock, policy policy text block.
Deferred Debt Issuance Cost, Writeoff
Write-off of deferred debt issuance costs
Sale of Stock, Consideration Received on Transaction
Debt Instrument [Axis]
Funds received upon execution of agreement
Funds Received Upon Execution Of Agreement
Funds received upon execution of agreement.
Asset acquisition compensation recognized and paid
Asset Acquisition, Consideration Transferred, Equity Interest Issued and Issuable
Share-Based Payment Arrangement [Abstract]
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
Unrecognized stock-based compensation
Assets, Fair Value Disclosure, Total
Assets, Fair Value Disclosure
Total assets measured at fair value
Issuance of Series B convertible preferred stock, net of issuance costs
Temporary Equity, Stock Issued During Period, Value, New Issues
Sale of Stock [Axis]
Early exercise of employee stock options.
Early Exercise of Employee Stock Options [Member]
Early Exercise of Employee Stock Options
Sales-based milestones.
Sales Based Milestones [Member]
Sales-based Milestones
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
Net cash provided by (used in) investing activities
Title of 12(b) Security
Computer and Software
Computer and Software [Member]
Computer and software.
Vanderbilt sponsored research agreement.
Vanderbilt Sponsored Research Agreement [Member]
Vanderbilt Research Agreement
Stock-based compensation, Amount
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Amount
BlackThorn Carveout Plan.
BlackThorn Carveout Plan [Member]
BlackThorn Carveout Plan
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Weighted-Average Exercise Price Per Share, Canceled and forfeited
Cash paid for interest
Cash Paid For Interest
Cash paid for interest.
Money Market Funds [Member]
Money Market Funds
Income Taxes
Income Tax Disclosure [Text Block]
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Convertible preferred stock, shares issued
Temporary Equity, Shares Issued
Convertible preferred stock, Shares Issued
Parkinsons Research Ventures Funding Agreement [Member]
Parkinsons research ventures funding agreement.
Parkinson's Research Ventures Funding Agreement
Accounts Payable [Member]
Accounts payable
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]
Changes in operating assets and liabilities:
Schedule of Property and Equipment, Net
Property, Plant and Equipment [Table Text Block]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Weighted-Average Exercise Price Per Share, Outstanding, beginning of period
Weighted-Average Exercise Price Per Share, Outstanding, end of period
Preferred Stock [Text Block]
Preferred Stock Warrants
Income Tax Disclosure [Abstract]
Fair Value, Recurring and Nonrecurring [Table]
Business Combination [Text Block]
Acquisitions of Assets
Ending balance of unrecognized tax benefits
Beginning balance of unrecognized tax benefits
Unrecognized Tax Benefits
Additional Paid-in Capital [Member]
Additional Paid-in Capital
First Vanderbilt Research Agreement
First Vanderbilt sponsored research agreement [Member]
First Vanderbilt sponsored research agreement [Member]
Cash equivalents and marketable securities.
Cash Equivalents and Marketable Securities [Abstract]
Measurement Frequency [Domain]
Statement of Income Location, Balance [Axis]
Trading Symbol
Related Party Transaction [Table]
Risk-free interest rate, Maximum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum
Subsequent Event Type [Axis]
Employee-related Liabilities, Current, Total
Employee-related Liabilities, Current
Compensation and benefits
Two thousand twenty three employee share purchase plan.
Two Thousand Twenty Three Employee Share Purchase Plan [Member]
2023 Employee Share Purchase Plan
Financing activities:
Vanderbilt License Agreement member.
Vanderbilt License Agreement [Member]
Vanderbilt License Agreement
Expected term (years)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Fair Value, Recurring [Member]
Fair Value Recurring
Entity Ex Transition Period
Operating lease liability derecognized
Operating Lease Liability Derecognized
Operating lease liability derecognized.
Research and development tax credits
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent
Federal research and development credit, Percent
Additional borrowing capacity
Line of Credit Facility, Additional Borrowing Capacity
Line of credit facility, additional borrowing capacity.
Issuance of common stock upon achievement of milestone related to acquisition of assets, shares
Issuance of Common Stock Shares Upon Achievement of Milestone Related to Acquisition of Assets
Issuance of common stock shares upon achievement of milestone related to acquisition of assets.
Equity Components [Axis]
Total current provision
Current Federal, State and Local, Tax Expense (Benefit)
Nonoperating Income (Expense)
Total other income
Equity Component [Domain]
Asset Class [Axis]
Document Annual Report
Other segment items
Other Segment Items
Other segment items.
Other segment items
Business Combination [Axis]
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures, Total
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures
Forfeiture of restricted stock subject to repurchase
Vesting of restricted stock
Stock Issued During Period Value Through At The Market Transactions Net of Offering Costs
Stock Issued During Period Value Through At The Market Transactions Net of Offering Costs
Issuance of common stock through at-the-market transactions net of offering costs
IPO [Member]
Initial Public Offering
Issuance of common stock under employee stock purchase plan, shares
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Share based compensation, term of plan
Maximum [Member]
Maximum
Conversion ratio
Debt Instrument, Convertible, Conversion Ratio
Statistical Measurement [Axis]
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Weighted-Average Exercise Price Per Share, Exercised
Common Stock, Value, Issued
Common stock, $0.0001 par value; 700,000 shares authorized as of December 31, 2025 and December 31, 2024; 174,260 and 161,710 shares issued and outstanding as of December 31, 2025 and December 31, 2024, respectively.
Shares Reserved for Future Issuance Under the Plans
Shares reserved for future issuance under the plans [Member]
Shares reserved for future issuance under the plans.
Sale and issuance of common stock.
Sale and Issuance of Common Stock
Sale and issuance of common stock
Cash and Cash Equivalents [Abstract]
Commercial milestone payment.
Commercial Milestone Payment [Member]
Commercial Milestone Payment
Income Tax Contingency [Table]
Development and regulatory approval milestones.
Development and Regulatory Approval Milestones [Member]
Development and Regulatory Approval Milestones
Net operating losses
Deferred Tax Assets, Operating Loss Carryforwards
Deferred Tax Assets, Operating Loss Carryforwards, Total
Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block]
Tax Credit Carryforward [Axis]
Impairment of Long-Lived Assets
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Cash and Cash Equivalents [Line Items]
State income taxes, net of federal benefit
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
State and local income taxes, net of federal benefit, Percent
Amortization of debt issuance costs
Amortization of deferred debt issuance costs
Debt Instrument, Covenant Description
Debt instrument, covenant description
Vanderbilt License.
Vanderbilt License [Member]
Vanderbilt License
Entity Public Float
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Expected volatility
Preferred Stock, Shares Authorized
Preferred stock, shares authorized
Proceeds from Issuance of Common Stock In At-The-Market Transactions
Proceeds from issuance of common stock in at-the-market transactions.
Proceeds from issuance of common stock in at-the-market transactions, net of commissions and offering costs
Syllable Merger Agreement.
Syllable Merger Agreement [Member]
Syllable Merger Agreement
Schedule of Debt [Table Text Block]
Summary of Outstanding Debt
Contingent consideration, milestone payment.
Contingent Consideration, Milestone Payment
Contingent consideration, milestone payment
Lender Name [Axis]
Related Party Transaction [Line Items]
Employee Stock [Member]
Employee Stock Purchase Plan
Issuance of Series A-1 convertible preferred stock upon exercise of warrants
Issuance of Stock Upon Exercise of Warrants
Issuance of stock upon exercise of warrants.
Business Combination [Table]
Entity Registrant Name
Debt Disclosure [Text Block]
Debt
Achievement of specified development events.
Achievement of Specified Development Events [Member]
Achievement of Specified Development Events
Stock purchase right.
Stock Purchase Right [Member]
Stock Purchase Right
Entity Voluntary Filers
Cash paid for acquisition of assets
Payments to Acquire in Process Research and Development
Other Nonoperating Income (Expense), Total
Other Nonoperating Income (Expense)
Other expense, net
Deferred State and Local Income Tax Expense (Benefit)
State
Milestones achieved.
Milestones Achieved
Milestones achieved
Subsequent Events [Abstract]
Effective Income Tax Rate Reconciliation, Officers compensation Amount
Effective income tax rate reconciliation, officers compensation amount.
Officers compensation,/ Executive compensation, Amount
Cybersecurity Risk Management Positions or Committees Responsible [Flag]
Provision for income taxes
Provision for income taxes
Income tax expense
Income Tax Expense (Benefit)
Provision benefit for income taxes
Debt Securities, Available-for-Sale, Unrealized Loss
Gross Unrealized Loss
Measurement Frequency [Axis]
Business Combination, Contingent Consideration, Type [Axis]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Entity Common Stock, Shares Outstanding
Concentrations of Credit Risk
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Maximum additional financing in equity securities.
Maximum additional financing in equity securities
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated other comprehensive income
Issuance of Series B convertible preferred stock, net of issuance costs (in shares)
Temporary Equity, Stock Issued During Period, Shares, New Issues
Temporary equity, stock issued during period, shares, new issues.
Stock Issued During Period Shares Through At The Market Transactions Net of Offering Costs
Stock issued during period shares through at the market transactions net of offering costs.
Issuance of common stock through at-the-market transactions net of offering costs, shares
Research and collaboration agreement payments
Research And Collaboration Agreement Payments
Research and collaboration agreement payments.
Net Asset Value Per Share, Beginning Balance
Net Asset Value Per Share, Ending Balance
Net Asset Value Per Share
Net asset value per share
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Unvested shares repurchased
Granted, Shares
Temporary Equity, by Class of Stock [Table]
Assets
Total assets
Property, Plant and Equipment [Table]
Income Tax Paid, State and Local, after Refund Received
Income Tax Paid, State and Local, after Refund Received, Total
State and local income taxes, net of refunds received
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Weighted-Average Remaining Contractual Term, Exercisable
Income Statement [Abstract]
Vanderbilt IPR&D Assets.
Vanderbilt IPR&D Assets [Member]
Vanderbilt IPR&D Assets
Fair Value of Financial Instruments, Policy [Policy Text Block]
Fair Value of Financial Instruments
Schedule of common stock reserved for future issuance.
Schedule of common stock reserved for future issuance [Table Text Block]
Schedule of Common Stock Reserved for Future Issuance
Share-Based Payment Arrangement [Policy Text Block]
Stock-Based Compensation
Cash, Cash Equivalent, and Marketable Security [Text Block]
Cash Equivalents and Marketable Securities
Sale of Stock, Number of Shares Issued in Transaction
Common stock sold in initial public offering
At The Market Equity Offering Program [Member]
At the market equity offering program.
At The Market Equity Offering Program
Market Based Tranches
Share Based Compensation Award Tranche Four [Member]
Share Based Compensation Award Tranche Four.
Stock Issued During Period, Shares, New Issues
Issuance of common stock upon initial public offering and at the market offering, net of offering costs, shares
Convertible preferred stock, shares authorized
Temporary Equity, Shares Authorized
Convertible preferred stock, Shares Authorized
Fund Received Upon Completion Of Certain Development Milestone
Fund received upon completion of certain development milestone.
Fund received upon completion of certain development milestone
Preferred Stock Exercise Price Per Share
Preferred stock warrants, exercise price
Preferred stock exercise price per share.
Upfront consideration transferred shares.
Upfront Consideration Transferred Shares
Upfront consideration transferred shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Vested, Shares
Vested, Shares
Issuance of common stock as noncash consideration related to an acquisition of assets.
Issuance of common stock as noncash consideration related to an acquisition of assets
Issuance of common stock as noncash consideration related to an acquisition of assets, shares
Earnings Per Share, Diluted, Total
Earnings Per Share, Diluted
Net loss per share, diluted
Outstanding principal under the Term Loan converted into common stock
Debt Conversion, Original Debt, Amount
Schedule of Segment Loss Including Significant Segment Expenses
Schedule of Segment Reporting Information, by Segment [Table Text Block]
Effective Income Tax Rate Reconciliation, Percent [Abstract]
Title and Position [Domain]
Asset Acquisition [Axis]
City Area Code
Rent expense
Payments for Rent
Operating lease liabilities
Deferred Tax Assets Operating Lease Liabilities
Deferred tax assets operating lease liabilities.
Issuance of Series A-1 convertible preferred stock upon exercise of warrants (in shares)
Issuance of Stock Upon Exercise of Warrants, Shares
Issuance of stock upon exercise of warrants, shares.
Auditor Name
Debt Instrument, Fee Amount
Payment fee
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Cancelled In Period
Share based compensation arrangement by share based payment award equity instruments other than options cancelled in period.
Cancelled, Shares
Loan and security agreement.
Loan and Security Agreement [Member]
Loan Agreement
Executive compensation
Effective Income Tax Rate Reconciliation Executive Compensation.
Effective income tax rate reconciliation executive compensation.
Officers compensation/ Executive compensation, Percentage
Principal amount
Line of Credit Facility, Maximum Borrowing Capacity
NMRA-511.
NMRA-511 [Member]
NMRA-511
Business Combination [Line Items]
Preclinical programs expenses
Preclinical programs expenses.
Preclinical programs
Preclinical programs
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount
Federal research and development credit, Amount
Federal research and development credit, Amount
Area of office and laboratory facility
Area of Office and Laboratory Facility
Area of office and laboratory facility.
Variable costs
Variable Lease, Cost
Number of milestone achieved.
Number of Milestone Achieved
Number of milestone achieved
Stock Issued During Period, Value, Employee Stock Purchase Plan
Issuance of common stock under employee stock purchase plan
Weighted average remaining lease term (in years)
Operating Lease, Weighted Average Remaining Lease Term
Summary of NOL and Tax Credit Carryforwards
Summary of Tax Credit Carryforwards [Table Text Block]
Stock Issued During Period, Shares, Restricted Stock Award, Gross
Issuance of restricted common stock subject to repurchase
Effective Income Tax Rate Reconciliation, Tax Credit, Other, Percent
Tax credits, Percent
Tax credits, Percent
Cash and Cash Equivalents
Cash and Cash Equivalents, Policy [Policy Text Block]
Conversion Percentage
Conversion percentage.
Conversion percentage
Property, Plant and Equipment, Net
Property and equipment, net
Total property and equipment
Fund eligible to receive upon completion of certain development milestone
Fund Eligible To Receive Upon Completion Of Certain Development Milestone
Fund eligible to receive upon completion of certain development milestone.
Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures, Total
Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures
Vesting of restricted common stock
Number of tranches
Number of tranches.
Accreted Final Payment Fee
Accreted final payment fee.
Accreted final payment fee.
Accretion of final payment fee
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation
Cash and cash equivalents and restricted cash at beginning of year
Cash and cash equivalents and restricted cash at end of period
Operating Income (Loss), Total
Operating Income (Loss)
Loss from operations
Retained Earnings [Member]
Accumulated Deficit
Business Combination, Contingent Consideration, Type [Domain]
Share-Based Payment Arrangement, Noncash Expense, Total
Share-Based Payment Arrangement, Noncash Expense
Stock-based compensation
Issuance / Offering costs
Payments of Stock Issuance Costs
Issuance of Series B convertible preferred stock, issuance costs
Payments for deferred offering costs
Risks and uncertainties.
Risks and Uncertainties [Policy Text Block]
Risks and Uncertainties
Weighted-average discount rate
Operating Lease, Weighted Average Discount Rate, Percent
Operating Lease, Liability, Noncurrent
Operating lease liabilities, noncurrent
Fair Value, Inputs, Level 1 [Member]
Level 1
Class of Stock [Line Items]
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
Net cash provided by financing activities
Nontaxable or nondeductible items
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent [Abstract]
Unamortized debt issuance costs
Unamortized Debt Issuance Expense
Unamortized debt issuance costs
Auditor Location
Nonoperating Income (Expense) [Abstract]
Other income (expense):
Tranche Four [Member]
Tranche four.
Fourth Tranche
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Summary of Outstanding Potentially Dilutive Common Stock Equivalents were Excluded from Computation of Diluted Net Loss Per Share
Corporate Debt Securities [Member]
Corporate Debt Securities
Income Tax Jurisdiction [Domain]
Entity Interactive Data Current
Statement of Income Location, Balance [Domain]
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]
Operating activities:
Furniture and Fixtures
Furniture and Fixtures [Member]
Convertible Preferred Stock, Shares Issued upon Conversion
Converted shares
Number of convertible preferred stock automatically converted into shares of common stock
Term loan facility fee
Term Loan Facility Fee
Term loan facility fee
Acquired in-process research and developed expense
Acquired in-process Research and Developed Expense
Acquired in-process research and developed expense.
Deferred tax liabilities:
Components of Deferred Tax Liabilities [Abstract]
Total deferred income taxes
Deferred Federal, State and Local, Tax Expense (Benefit)
Borrowing capacity
Line of Credit Facility, Current Borrowing Capacity
Stock Issued During Period Value Vesting Of Common Stock Subject To Repurchase
Stock issued during period value vesting of common stock subject to repurchase.
Vesting of common stock subject to repurchase
Entity Tax Identification Number
BlackThorn Merger Agreement.
BlackThorn Merger Agreement [Member]
BlackThorn Merger Agreement
Development and regulatory milestone payments.
Development And Regulatory Milestone Payments
Development and regulatory milestone payments
Long-Term Debt, Type [Axis]
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Summary of Significant Accounting Policies and Basis of Presentation
Organization and Liquidity
Income Tax Authority, Name [Domain]
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Cancelled In Period Weighted Average Grant Date Fair Value
Share based compensation arrangement by share based payment award equity instruments other than options cancelled in period weighted average. Grant Date Fair Value
Cancelled, Weighted Average Grant Date Fair Value Per Share
Proceeds from equity financing
Aggregate gross sales proceeds
Proceeds from Issuance or Sale of Equity
Proceeds from Issuance or Sale of Equity, Total
Local Phone Number
Related Party Transaction [Domain]
Debt Securities, Available-for-Sale, Unrealized Gain
Gross Unrealized Gain
Conversion of convertible preferred stock into common stock upon initial public offering value.
Conversion of Convertible Preferred Stock into Common Stock Upon Initial Public Offering Value
Conversion of convertible preferred stock into common stock upon initial public offering
Short term lease expense
Short-Term Lease, Cost
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Denominator:
Auditor Opinion [Text Block]
Leerink Partners LLC [Member]
Leerink Partners LLC.
Leerink Partners LLC
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs
Offering costs
Interest rate description
Line of Credit Facility, Interest Rate Description
Proceeds From Maturities Of Marketable Securities
Proceeds from maturities of marketable securities.
Proceeds from maturities of marketable securities
Maximum Repayment Amount Agreed To Pay
Maximum repayment amount agreed to pay.
Maximum repayment amount agreed to pay
Accounting Policies [Abstract]
Market award.
Market Award [Member]
Market Award
Net Income (Loss) Attributable to Parent [Abstract]
Numerator:
Class of Stock [Domain]
Commercial Paper [Member]
Commercial Paper
Commercial Paper
Shares available for future issuance
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Issuance of Common Stock Upon Initial Public Offering, Net of Offering Costs
Issuance of common stock upon initial public offering, net of offering costs .
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Weighted-average remaining service period
Accrued Professional Fees, Current
Professional services
Matching employee contribution
Defined Contribution Plan, Maximum Annual Contributions Per Employee, Percent
Estimated fair value of available for sale debt securities fair value.
Estimated Fair Value Of Available For Sale Debt Securities Fair Value
Total marketable securities
Stock, Class of Stock [Table]
Entity Emerging Growth Company
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Weighted-Average Remaining Contractual Term, Vested
Weighted-Average Remaining Contractual Term, Outstanding (Years)
Tax Credit Carryforward, Name [Domain]