v3.26.1
Strategic License and Research and Collaboration Agreements - Additional Information (Details)
£ in Millions
1 Months Ended 12 Months Ended
Nov. 30, 2025
USD ($)
Oct. 31, 2025
USD ($)
Jan. 31, 2025
USD ($)
May 31, 2024
USD ($)
Mar. 31, 2024
USD ($)
Oct. 31, 2023
USD ($)
Feb. 28, 2022
USD ($)
Nov. 30, 2015
USD ($)
Dec. 31, 2025
USD ($)
Dec. 31, 2025
GBP (£)
Dec. 31, 2024
USD ($)
May 31, 2025
USD ($)
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Prepaid research and development costs                 $ 8,007,000   $ 5,264,000  
Research and development expenses                 176,065,000   200,927,000  
Fund received upon completion of certain development milestone     $ 1,500                  
2015 TSRI License Agreement                        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Milestone Payments           $ 300,000            
Accrued Royalties                 $ 0      
2015 TSRI License Agreement | Maximum                        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Development and regulatory milestone payments               $ 1,500,000        
Commercial milestone payments               $ 3,500,000        
Amgen Research and Collaboration Agreement                        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Collaboration agreement termination description                 The Amgen Collaboration Agreement automatically terminated upon its third anniversary in September 2024. The Amgen Collaboration Agreement automatically terminated upon its third anniversary in September 2024.    
Related party transaction obligation with related party                 $ 0   6,300,000 $ 6,300,000
Research and development expenses                 $ 6,300,000   12,500,000  
Vanderbilt Research Agreement                        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Research and collaboration agreement quarterly payments             $ 1,700,000          
Research agreement expiry date                 2023-09 2023-09    
Second Vanderbilt Research Agreement                        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Research agreement expiry date                 2024-11 2024-11    
Second Vanderbilt Research Agreement | Maximum                        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Research and collaboration agreement payments       $ 600,000                
Parkinson's Research Ventures Funding Agreement                        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Research and development expenses                 $ 1,600,000   $ 800,000  
Payments for execution of agreement $ 1,700,000       $ 1,100,000              
Deferred funding                 1,700,000      
Maximum repayment obligation   $ 6,600,000                    
Maximum Repayment Amount Agreed To Pay | £                   £ 8.4    
Parkinson's Research Ventures Funding Agreement | Maximum                        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                        
Funds provided for preclinical research and development activities   $ 3,300,000             $ 2,600,000