v3.26.1
Income Taxes - Summary of Net Operating Loss Carryforwards (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Operating Loss Carryforwards [Line Items]    
Pre-tax income (loss), Domestic $ (16,284) $ (62,760)
Loss before income taxes (114,201) (147,791)
Income taxes paid net of refunds received 0 0
UNITED KINGDOM    
Operating Loss Carryforwards [Line Items]    
NOL carryforwards 195,997  
UNITED KINGDOM | Research and Development Tax Credits    
Operating Loss Carryforwards [Line Items]    
Tax credit carryforwards 5,900  
UNITED KINGDOM | Orphan Drug Tax Credit    
Operating Loss Carryforwards [Line Items]    
Tax credit carryforwards 27,200  
United States    
Operating Loss Carryforwards [Line Items]    
Pre-tax income (loss), Foreign (65,531) (57,580)
United States, Federal    
Operating Loss Carryforwards [Line Items]    
NOL carryforwards 163,464  
Carryforward tax losses, subject to expiration 200  
United States, State/City    
Operating Loss Carryforwards [Line Items]    
NOL carryforwards 23,432  
Carryforward tax losses, subject to expiration 21,900  
Ireland    
Operating Loss Carryforwards [Line Items]    
NOL carryforwards 118,071  
Pre-tax income (loss), Foreign (30,193) (25,762)
Other    
Operating Loss Carryforwards [Line Items]    
NOL carryforwards 36,698  
Pre-tax income (loss), Foreign $ (2,193) $ (1,689)