v3.26.1
Income Taxes (Tables)
12 Months Ended
Dec. 31, 2025
Income Taxes  
Summary of Net Operating Loss Carryforwards

Federal

State/City

United Kingdom

$

195,997

$

United States

$

163,464

$

23,432

Ireland

$

118,071

$

Other

$

36,698

$

Schedule of Company's Pre-Tax Earnings

  ​ ​ ​

December 31, 2025

  ​ ​ ​

December 31, 2024

United Kingdom

$

(16,284)

$

(62,760)

United States

 

(65,531)

 

(57,580)

Ireland

(30,193)

(25,762)

Other

(2,193)

(1,689)

$

(114,201)

$

(147,791)

Schedule of Reconciliation of Income Tax Benefit with Amounts at the UK Statutory Income Tax Rate

  ​ ​ ​

December 31, 2025

  ​ ​ ​

December 31, 2024

  ​ ​ ​

U.K. Statutory Tax Rate

$

(26,827)

25.00%

$

(36,948)

25.00%

Foreign Tax Effects

United States

Statutory tax rate difference between United States and United Kingdom

1,945

(1.81)%

1,621

(1.10)%

State and Local Income Taxes, Net of Federal Income Tax Effect

(188)

0.18%

(634)

0.43%

Research and development tax credits

(4,253)

3.96%

(3,352)

2.27%

Change in valuation allowance

12,694

(11.83)%

11,405

(7.72)%

U.S. state change in ETR

1,832

(1.71)%

(309)

0.21%

Section 162(m) Adj.

2,226

(2.07)%

1,568

(1.06)%

Share based compensation shortfall

1,467

(1.37)%

2,221

(1.50)%

Other

660

(0.62)%

1,875

(1.27)%

Ireland

Statutory tax rate difference between Ireland and United Kingdom

3,265

(3.04)%

3,134

(2.12)%

Change in valuation allowance

3,265

(3.04)%

3,134

(2.12)%

Other

1,018

(0.95)%

172

(0.12)%

Other Foreign Countries

Statutory tax rate difference between other foreign countries and United Kingdom

1

0.00%

(5)

0.00%

Change in valuation allowance

938

(0.87)%

155

(0.11)%

Other

(357)

0.33%

272

(0.18)%

Tax Credits

(3,539)

3.30%

6,476

(4.38)%

Change in Valuation Allowances

4,395

(4.10)%

9,344

(6.32)%

Nontaxable or Nondeductible Items

Nondeductible interest

0.00%

(4,105)

2.78%

Other

837

(0.78)%

1,456

(0.99)%

Other Adjustments

621

(0.58)%

2,520

(1.70)%

Actual income tax benefit effective tax rate

$

 

0.00%

$

 

0.00%

Schedule of Expense/(Benefit) for Income Taxes from Continuing Operations

  ​ ​ ​

December 31, 2025

  ​ ​ ​

December 31, 2024

Current Tax Expense/(Benefit)

 

  ​

 

  ​

United Kingdom

 

$

 

$

United States

 

 

Ireland

 

Other

Total Current

 

$

 

$

Deferred Tax Expense/(Benefit)

 

  ​

 

  ​

United Kingdom

 

$

(4,395)

 

$

(9,344)

United States

 

(12,694)

 

(11,405)

Ireland

(3,265)

(3,134)

Other

(938)

(155)

Total Deferred

 

(21,292)

 

(24,038)

Change in Valuation Allowance

 

21,292

 

24,038

Total Income Tax Expense/(Benefit)

 

$

 

$

Schedule of Deferred Tax Assets and Liabilities

December 31, 2025

December 31, 2024

Deferred Tax Assets:

Net operating loss carryforwards

$

108,960

$

85,308

Interest expense

11,657

6,736

Capitalized research and development

15,289

26,312

Share-based compensation

 

11,700

11,921

R&D credit

 

30,417

22,160

Lease liability

3,397

2,767

Deferred tax assets

 

181,420

 

155,204

Less: valuation allowance

 

(174,808)

 

(149,382)

Deferred Tax Liabilities:

Depreciation

(2,729)

(2,192)

Right of use assets

 

(2,696)

(2,099)

Other

 

(1,187)

(1,531)

Net deferred tax liability

$

$

Schedule of Unrecognized Tax Benefits

  ​ ​ ​

December 31, 2025

  ​ ​ ​

December 31, 2024

Unrecognized tax benefits as of January 1

 

$

2,249

 

$

2,029

Gross increases/(decreases) related to current year

 

459

 

505

Gross increases/(decreases) related to prior years

 

13

 

(285)

Unrecognized tax positions as of December 31

 

$

2,721

 

$

2,249