Income Taxes (Tables)
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12 Months Ended |
Dec. 31, 2025 |
| Income Taxes |
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| Summary of Net Operating Loss Carryforwards |
| | | | | | | | | Federal | | State/City | United Kingdom | | $ | 195,997 | | $ | — | United States | | $ | 163,464 | | $ | 23,432 | Ireland | | $ | 118,071 | | $ | — | Other | | $ | 36,698 | | $ | — |
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| Schedule of Company's Pre-Tax Earnings |
| | | | | | | | | December 31, 2025 | | December 31, 2024 | United Kingdom | | $ | (16,284) | | $ | (62,760) | United States | | | (65,531) | | | (57,580) | Ireland | | | (30,193) | | | (25,762) | Other | | | (2,193) | | | (1,689) | | | $ | (114,201) | | $ | (147,791) |
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| Schedule of Reconciliation of Income Tax Benefit with Amounts at the UK Statutory Income Tax Rate |
| | | | | | | | | | | | | | December 31, 2025 | | | | | December 31, 2024 | | | U.K. Statutory Tax Rate | | $ | (26,827) | | 25.00% | | | $ | (36,948) | | 25.00% | Foreign Tax Effects | | | | | | | | | | | | United States | | | | | | | | | | | | Statutory tax rate difference between United States and United Kingdom | | | 1,945 | | (1.81)% | | | | 1,621 | | (1.10)% | State and Local Income Taxes, Net of Federal Income Tax Effect | | | (188) | | 0.18% | | | | (634) | | 0.43% | Research and development tax credits | | | (4,253) | | 3.96% | | | | (3,352) | | 2.27% | Change in valuation allowance | | | 12,694 | | (11.83)% | | | | 11,405 | | (7.72)% | U.S. state change in ETR | | | 1,832 | | (1.71)% | | | | (309) | | 0.21% | Section 162(m) Adj. | | | 2,226 | | (2.07)% | | | | 1,568 | | (1.06)% | Share based compensation shortfall | | | 1,467 | | (1.37)% | | | | 2,221 | | (1.50)% | Other | | | 660 | | (0.62)% | | | | 1,875 | | (1.27)% | Ireland | | | | | | | | | | | | Statutory tax rate difference between Ireland and United Kingdom | | | 3,265 | | (3.04)% | | | | 3,134 | | (2.12)% | Change in valuation allowance | | | 3,265 | | (3.04)% | | | | 3,134 | | (2.12)% | Other | | | 1,018 | | (0.95)% | | | | 172 | | (0.12)% | Other Foreign Countries | | | | | | | | | | | | Statutory tax rate difference between other foreign countries and United Kingdom | | | 1 | | 0.00% | | | | (5) | | 0.00% | Change in valuation allowance | | | 938 | | (0.87)% | | | | 155 | | (0.11)% | Other | | | (357) | | 0.33% | | | | 272 | | (0.18)% | Tax Credits | | | (3,539) | | 3.30% | | | | 6,476 | | (4.38)% | Change in Valuation Allowances | | | 4,395 | | (4.10)% | | | | 9,344 | | (6.32)% | Nontaxable or Nondeductible Items | | | | | | | | | | | | Nondeductible interest | | | — | | 0.00% | | | | (4,105) | | 2.78% | Other | | | 837 | | (0.78)% | | | | 1,456 | | (0.99)% | Other Adjustments | | | 621 | | (0.58)% | | | | 2,520 | | (1.70)% | Actual income tax benefit effective tax rate | | $ | — | | 0.00% | | | $ | — | | 0.00% |
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| Schedule of Expense/(Benefit) for Income Taxes from Continuing Operations |
| | | | | | | | | December 31, 2025 | | December 31, 2024 | Current Tax Expense/(Benefit) | | | | | | | United Kingdom | | $ | — | | $ | — | United States | | | — | | | — | Ireland | | | — | | | — | Other | | | — | | | — | Total Current | | $ | — | | $ | — | Deferred Tax Expense/(Benefit) | | | | | | | United Kingdom | | $ | (4,395) | | $ | (9,344) | United States | | | (12,694) | | | (11,405) | Ireland | | | (3,265) | | | (3,134) | Other | | | (938) | | | (155) | Total Deferred | | | (21,292) | | | (24,038) | Change in Valuation Allowance | | | 21,292 | | | 24,038 | Total Income Tax Expense/(Benefit) | | $ | — | | $ | — |
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| Schedule of Deferred Tax Assets and Liabilities |
| | | | | | | | | December 31, 2025 | | December 31, 2024 | Deferred Tax Assets: | | | | | | | Net operating loss carryforwards | | $ | 108,960 | | $ | 85,308 | Interest expense | | | 11,657 | | | 6,736 | Capitalized research and development | | | 15,289 | | | 26,312 | Share-based compensation | | | 11,700 | | | 11,921 | R&D credit | | | 30,417 | | | 22,160 | Lease liability | | | 3,397 | | | 2,767 | Deferred tax assets | | | 181,420 | | | 155,204 | Less: valuation allowance | | | (174,808) | | | (149,382) | Deferred Tax Liabilities: | | | | | | | Depreciation | | | (2,729) | | | (2,192) | Right of use assets | | | (2,696) | | | (2,099) | Other | | | (1,187) | | | (1,531) | Net deferred tax liability | | $ | — | | $ | — |
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| Schedule of Unrecognized Tax Benefits |
| | | | | | | | | December 31, 2025 | | December 31, 2024 | Unrecognized tax benefits as of January 1 | | $ | 2,249 | | $ | 2,029 | Gross increases/(decreases) related to current year | | | 459 | | | 505 | Gross increases/(decreases) related to prior years | | | 13 | | | (285) | Unrecognized tax positions as of December 31 | | $ | 2,721 | | $ | 2,249 |
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