v3.26.1
Insider Trading Arrangements
3 Months Ended
Dec. 31, 2025
shares
Trading Arrangements, by Individual  
Material Terms of Trading Arrangement

On November 18, 2025, Alexandria Forbes, Ph.D., our President and Chief Executive Officer, adopted a Rule 10b5-1 trading arrangement that is intended to satisfy the affirmative defense of Rule 10b5-1(c) for the sale of up to 496,000 of the Company’s ordinary shares until January 20, 2028.

On November 18, 2025, Richard Giroux, our Chief Financial Officer and Chief Operating Officer, adopted a Rule 10b5-1 trading arrangement that is intended to satisfy the affirmative defense of Rule 10b5-1(c) for the sale of up to 448,000 of the Company’s ordinary shares until January 20, 2028.

On December 9, 2025, Stuart Naylor, Ph.D., our Chief Development Officer, adopted a Rule 10b5-1 trading arrangement that is intended to satisfy the affirmative defense of Rule 10b5-1(c) for the sale of up to 221,274 of the Company’s ordinary shares until March 23, 2028.

Alexandria Forbes  
Trading Arrangements, by Individual  
Name Alexandria Forbes, Ph.D
Title President and Chief Executive Officer
Rule 10b5-1 Arrangement Adopted true
Adoption Date November 18, 2025
Expiration Date January 20, 2028
Aggregate Available 496,000
Richard Giroux  
Trading Arrangements, by Individual  
Name Richard Giroux
Title Chief Financial Officer and Chief Operating Officer
Rule 10b5-1 Arrangement Adopted true
Adoption Date November 18, 2025
Expiration Date January 20, 2028
Aggregate Available 448,000
Stuart Naylor  
Trading Arrangements, by Individual  
Name Stuart Naylor
Title Chief Development Officer,
Rule 10b5-1 Arrangement Adopted true
Adoption Date December 9, 2025
Expiration Date March 23, 2028
Aggregate Available 221,274