a
a
Country
Shares
a
Value
a
a
a
a
a
a
Common
Stocks
97.7%
Biotechnology
76.5%
a
Abivax
SA
,
ADR
....................................
France
164,591
$
18,294,290
a,b
Achieve
Life
Sciences,
Inc.
............................
United
States
1,575,682
6,586,351
a
Acumen
Pharmaceuticals,
Inc.
.........................
United
States
826,400
2,148,640
a,b
Adicet
Bio,
Inc.
.....................................
United
States
225,186
1,799,236
a
Alnylam
Pharmaceuticals,
Inc.
..........................
United
States
66,908
22,618,918
Amgen,
Inc.
.......................................
United
States
143,458
49,045,421
a
Apogee
Therapeutics,
Inc.
.............................
United
States
82,737
5,420,101
a
Arcutis
Biotherapeutics,
Inc.
...........................
United
States
505,651
12,828,366
a
Argenx
SE
,
ADR
....................................
Netherlands
48,962
41,152,561
a,b
ARS
Pharmaceuticals,
Inc.
............................
United
States
901,810
9,009,082
a,b
Artiva
Biotherapeutics,
Inc.
............................
South
Korea
192,871
750,268
a
Ascendis
Pharma
A/S
,
ADR
...........................
Denmark
129,742
29,334,666
a
Assembly
Biosciences,
Inc.
............................
United
States
27,877
718,530
a,b
Aura
Biosciences,
Inc.
................................
United
States
765,617
4,287,455
a
Benitec
Biopharma,
Inc.
..............................
Australia
995,152
12,120,951
a
BeOne
Medicines
Ltd.
,
ADR
...........................
United
States
14,276
4,859,265
a
Bicara
Therapeutics,
Inc.
..............................
United
States
387,402
6,508,354
a
Bridgebio
Pharma,
Inc.
...............................
United
States
207,858
16,061,188
a,b
Cardiff
Oncology,
Inc.
................................
United
States
438,961
768,182
a,c
Carmot
Therapeutics,
Inc.
.............................
United
States
83,100
531,572
a
Centessa
Pharmaceuticals
plc
,
ADR
.....................
United
States
614,165
15,090,034
a
CG
oncology,
Inc.
...................................
United
States
221,481
11,528,086
a
Cytokinetics,
Inc.
....................................
United
States
53,272
3,366,258
a
Dianthus
Therapeutics,
Inc.
............................
United
States
203,063
10,841,534
a
Dyne
Therapeutics,
Inc.
..............................
United
States
519,232
9,289,060
a
Engene
Holdings,
Inc.
................................
Canada
272,359
2,595,581
a,b
Engene
Holdings,
Inc.
................................
Canada
214,220
2,041,517
Gilead
Sciences,
Inc.
................................
United
States
443,663
62,977,963
a
GRAIL,
Inc.
........................................
United
States
46,433
4,542,076
a
Ideaya
Biosciences,
Inc.
..............................
United
States
81,852
2,634,816
a,b
Immix
Biopharma,
Inc.
...............................
United
States
357,034
2,081,508
a,b
IN8bio,
Inc.
........................................
United
States
332,083
654,203
a
Insmed,
Inc.
.......................................
United
States
188,633
29,590,859
a,b
Inventiva
SACA
,
ADR
................................
France
908,000
5,593,280
a
Ionis
Pharmaceuticals,
Inc.
............................
United
States
205,400
16,980,418
a
Mineralys
Therapeutics,
Inc.
...........................
United
States
623,239
19,251,853
a
Mirum
Pharmaceuticals,
Inc.
...........................
United
States
215,190
22,211,912
a
Neurocrine
Biosciences,
Inc.
...........................
United
States
135,273
18,405,244
a
Newamsterdam
Pharma
Co.
NV
........................
Netherlands
187,726
5,842,033
a
Nuvalent,
Inc.
,
A
....................................
United
States
75,535
7,771,796
a
Olema
Pharmaceuticals,
Inc.
...........................
United
States
554,385
14,258,782
a
ORIC
Pharmaceuticals,
Inc.
...........................
United
States
524,519
5,381,565
a
Oruka
Therapeutics,
Inc.
..............................
United
States
335,994
11,501,075
a,b
Palisade
Bio,
Inc.
...................................
United
States
2,119,910
3,158,666
a
Praxis
Precision
Medicines,
Inc.
........................
United
States
97,972
30,763,208
a
PTC
Therapeutics,
Inc.
...............................
United
States
369,527
27,910,374
Regeneron
Pharmaceuticals,
Inc.
.......................
United
States
61,019
45,242,538
a
Revolution
Medicines,
Inc.
.............................
United
States
202,430
19,625,588
a
Satellos
Bioscience,
Inc.
..............................
Canada
96,830
1,100,106
a,b
Sionna
Therapeutics,
Inc.
.............................
United
States
60,891
2,573,254
a
Soleno
Therapeutics,
Inc.
.............................
United
States
181,503
6,998,756
a
Solid
Biosciences,
Inc.
...............................
United
States
745,930
4,818,708
a
Spyre
Therapeutics,
Inc.
..............................
United
States
396,281
12,673,066
a
Syndax
Pharmaceuticals,
Inc.
..........................
United
States
544,055
11,049,757
a,b
Tango
Therapeutics,
Inc.
..............................
United
States
491,884
5,710,773
a
Ultragenyx
Pharmaceutical,
Inc.
........................
United
States
108,067
2,601,173
a
uniQure
NV
........................................
Netherlands
270,640
6,148,941
a
Vaxcyte,
Inc.
.......................................
United
States
145,674
7,803,756