0000001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink 0000002 - Document - Audit Information link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - Consolidated Statements of Operations link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - Consolidated Statements of Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - Consolidated Statements of Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 9952156 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 9952157 - Disclosure - Organization and Description of the Business link:presentationLink link:calculationLink link:definitionLink 9952158 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Available-for-Sale Securities link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Balance Sheet Components link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - Lease link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Debt link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Stock-Based Compensation link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Everest Collaboration link:presentationLink link:calculationLink link:definitionLink 9952167 - Disclosure - Commitments & Contingencies link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - License Agreement link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - Defined Contribution Plan link:presentationLink link:calculationLink link:definitionLink 9952170 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 9952171 - Disclosure - Net Loss Per Share link:presentationLink link:calculationLink link:definitionLink 9952172 - Disclosure - Restructuring and Impairment Charges link:presentationLink link:calculationLink link:definitionLink 9952173 - Disclosure - Segment Reporting link:presentationLink link:calculationLink link:definitionLink 9952174 - Disclosure - Subsequent Event link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Fair Value Measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Available-for-Sale Securities (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Balance Sheet Components (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Lease (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Debt (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Stock-Based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Net Loss Per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Restructuring and Impairment Charges (Tables) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Segment Reporting (Tables) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Organization and Description of the Business (Details) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Summary of Significant Accounting Policies (Details) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Fair Value Measurements - Summary of Financial Assets Measured at Fair Value on Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Fair Value Measurements - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Available-for-Sale Securities - Summary of Available-For-Sale Securities Recorded in Cash and Cash Equivalents or Marketable Securities (Details) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Available-for-Sale Securities - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Available-for-Sale Securities - Summary of Gross Unrealized Losses and Fair Value by Major Security Type for Available-For-Sale Securities in Unrealized Loss Position (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Balance Sheet Components - Summary of Prepaid Expenses And Other Current Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Balance Sheet Components - Summary of Property and Equipment, Net (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Balance Sheet Components - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Balance Sheet Components - Summary of Other Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Balance Sheet Components - Summary of Accrued Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Lease - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Lease - Summary of Lease Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Lease - Summary of Maturities of Lease Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Lease - Summary of Maturities of Lease Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Lease - Summary of Operating Lease Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Debt - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Debt - Summary of Long-term Debt Balance (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Debt - Summary of Long-term Debt Balance (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Stockholders' Equity (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Stock-Based Compensation - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Stock-Based Compensation - Summary of Activity under Stock Option Plans and Related Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Stock Based Compensation - Summary of RSU Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Stock-Based Compensation - Summary of Stock-Based Compensation Expense Recognized (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Stock-Based Compensation - Summary of Fair Value of Stock Options Granted is Calculated Using Black Scholes Option Pricing Model with Range of Assumptions (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Everest Collaboration (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - License Agreement (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Defined Contribution Plan (Details) link:presentationLink link:calculationLink link:definitionLink 9955549 - Disclosure - Income Taxes - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955550 - Disclosure - Income Taxes - Summary of Domestic and Foreign Components of Net Loss (Details) link:presentationLink link:calculationLink link:definitionLink 9955551 - Disclosure - Income Taxes - Summary of Components of Income Tax Expense (Benefit) (Details) link:presentationLink link:calculationLink link:definitionLink 9955552 - Disclosure - Income Taxes - Summary of Effective Tax Rate (Details) link:presentationLink link:calculationLink link:definitionLink 9955553 - Disclosure - Income Taxes - Summary of Components of Deferred Tax Assets and Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955554 - Disclosure - Income Taxes - Summary of Reconciliation of Unrecognized Tax Benefits (Details) link:presentationLink link:calculationLink link:definitionLink 9955555 - Disclosure - Net Loss Per Share - Summary of Calculation of Basic and Diluted Net Loss per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955556 - Disclosure - Net Loss Per Share - Summary of Anti-dilutive Outstanding Shares of Common Stock Equivalents Excluded from Computation of Diluted Net Loss per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955557 - Disclosure - Restructuring and Impairment Charges - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955558 - Disclosure - Restructuring and Impairment Charges - Summary of Restructuring and Impairment Charges (Details) link:presentationLink link:calculationLink link:definitionLink 9955559 - Disclosure - Restructuring and Impairment Charges - Summary of Accrual Activity and Payments Relating to Restructuring and Impairment Charge (Details) link:presentationLink link:calculationLink link:definitionLink 9955560 - Disclosure - Segment Reporting - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955561 - Disclosure - Segment Reporting - Summary of Financial Information for Segment (Details) link:presentationLink link:calculationLink link:definitionLink 9955562 - Disclosure - Subsequent Event (Details) link:presentationLink link:calculationLink link:definitionLink