0000001 - Document - Cover Page link:presentationLink link:calculationLink link:definitionLink 0000002 - Document - Audit Information link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - Consolidated Statements of Operations and Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - Consolidated Statements of Stockholders' Equity (Deficit) link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 9952156 - Disclosure - Organization and Description of Business link:presentationLink link:calculationLink link:definitionLink 9952157 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 9952158 - Disclosure - Strategic Agreements link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Prepaid Expenses and Other Current Assets link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Property and Equipment, Net link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Accrued Expenses link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - Vendor Concentration link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Stock-Based Compensation link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Leased Properties link:presentationLink link:calculationLink link:definitionLink 9952167 - Disclosure - Royalty Interest Financing link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - Royalty Purchase Agreements link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 9952170 - Disclosure - Grant Awards link:presentationLink link:calculationLink link:definitionLink 9952171 - Disclosure - Segment Information link:presentationLink link:calculationLink link:definitionLink 9952172 - Disclosure - Subsequent Events link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Prepaid Expenses and Other Current Assets (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Property and Equipment, Net (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Accrued Expenses (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Stockholders' Equity (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Stock-based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Leased Properties (Tables) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Royalty Interest Financing (Tables) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Segment Information (Tables) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Organization and Description of Business (Details) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies - Financial Assets and Liabilities Remeasured on a Recurring Basis Level - 2 (Details) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Strategic Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Prepaid Expenses and Other Current Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Property and Equipment, Net - Schedule of Property and Equipment, Net (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Property and Equipment, Net - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Accrued Expenses - Schedule of Accounts Payable and Accrued Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Vendor Concentration (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Income Taxes - Summary of Components of Loss from Continuing Operations Before Provision for Income Taxes (Detail) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Income Taxes - Reconciliation of Provision (Benefit) (Detail) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Income Taxes - Reconciliation of Provision (Benefit) for Income Taxes and Amount Computed by Applying U.S. Federal Income Tax Rate (Detail) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Income Taxes - Summary of Major Components of Company's Deferred Tax Assets (Detail) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Income Taxes - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Income Taxes - Summary of Reconciliation of Beginning and Ending Amount of Uncertain Tax Benefits (Detail) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Stockholders' Equity - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Stockholders' Equity - Schedule of Warrant Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Stockholders' Equity - Schedule of Common Stock Reserved for Future Issuance (Detail) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Stock-based compensation - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Stock-based Compensation - Summary of Stock Option Activity (Detail) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Stock-based Compensation - Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Stock-based Compensation - Summary of Assumptions Used in Black-Scholes Option-Pricing Model for Stock Options Granted to Employees and Non-Employee Directors (Detail) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Leased Properties - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Leased Properties - Schedule of Lease Cost (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Leased Properties - Schedule of Finance and Operating Lease Liabilities Maturity (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Leased Properties - Schedule of Finance and Operating Lease Liabilities Maturity (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Leased Properties - Schedule of Finance and Operating Lease Liabilities Maturity (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Leased Properties - Schedule of Weighted Average Remaining Lease Terms and Discount Rates (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Leased Properties - Schedule of Supplemental Cash Flows Information Related to Leases (Details) link:presentationLink link:calculationLink link:definitionLink 9955549 - Disclosure - Royalty Interest Financing - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955550 - Disclosure - Royalty Interest Financing - Schedule of Changes in the Liability Related to the Sale of Future Royalties (Details) link:presentationLink link:calculationLink link:definitionLink 9955551 - Disclosure - Royalty Purchase Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 9955552 - Disclosure - Commitments and Contingencies (Details) link:presentationLink link:calculationLink link:definitionLink 9955553 - Disclosure - Grant Awards (Details) link:presentationLink link:calculationLink link:definitionLink 9955554 - Disclosure - Segment Information - Summary of Segment's Financial Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955555 - Disclosure - Subsequent Events (Details) link:presentationLink link:calculationLink link:definitionLink