Commitments and Contingent Liabilities - Additional Information (Details) - USD ($) |
12 Months Ended | |
|---|---|---|
Dec. 31, 2025 |
Dec. 31, 2024 |
|
| Lessee, Lease, Description [Line Items] | ||
| Accounts payable | $ 5,306,000 | $ 4,624,000 |
| Milestone payments achieved or probable | 0 | 0 |
| Royalties due | 0 | 0 |
| Accrued loss contingency | $ 0 | $ 0 |
| Operating lease, description | As of December 31, 2025, the Company leased office and laboratory space in Emeryville, California under operating leases (the “Emeryville Lease”) which have terms through February 2027. The lease includes an option to extend the lease for an additional 36 months. The Company does not believe that the option to extend the lease is reasonably certain of being exercised, and therefore did not include it in the computations of the present value of the remaining lease payments at lease commencement. In addition to the base rent, which includes escalating payments over the lease term, the Company pays variable costs related to operating expenses and taxes, which are recognized as incurred.On February 27, 2026, the Company entered into a lease amendment to reduce total office and lab space in the same building commencing around July 1, 2026. The term of the Emeryville Lease, together with this amendment, has been extended through August 31, 2030. Base rent payments under the lease amendment are approximately $0.2 million per month. | |
| Operating lease option to extend | option to extend the lease for an additional 36 months. | |
| Operating lease weighted average lease term | 1 year 1 month 6 days | 2 years 1 month 6 days |
| Operating lease weighted average discount rate | 9.00% | 9.00% |
| Finance lease weighted average lease term | 9 months 18 days | 1 year 1 month 6 days |
| Finance lease weighted average discount rate | 10.00% | 11.00% |
| NIH Agreement | ||
| Lessee, Lease, Description [Line Items] | ||
| Accounts payable | $ 0 | $ 600,000 |
| NIH Agreement | Research and Development Expense | ||
| Lessee, Lease, Description [Line Items] | ||
| Benchmark royalties | $ 0 | $ 600,000 |
| Office and Laboratory | ||
| Lessee, Lease, Description [Line Items] | ||
| Operating lease term month and year | 2027-02 | |
| Laboratory Equipment | ||
| Lessee, Lease, Description [Line Items] | ||
| Finance lease term of contract | 36 months | |