<?xml version="1.0" encoding="ASCII"?><xs:schema targetNamespace="http://canfite.com/20251231" attributeFormDefault="unqualified" elementFormDefault="qualified" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:canf="http://canfite.com/20251231" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2024-01-31" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:us-gaap="http://fasb.org/us-gaap/2025" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:dtr="http://www.xbrl.org/dtr/type/2024-01-31" xmlns:srt="http://fasb.org/srt/2025" xmlns:cyd="http://xbrl.sec.gov/cyd/2025" xmlns:dei="http://xbrl.sec.gov/dei/2025" xmlns:country="http://xbrl.sec.gov/country/2025" xmlns:enum2="http://xbrl.org/2020/extensible-enumerations-2.0" xmlns:ecd-sub="http://xbrl.sec.gov/ecd-sub/2025">
  <xs:import namespace="http://www.xbrl.org/dtr/type/2024-01-31" schemaLocation="https://www.xbrl.org/dtr/type/2024-01-31/types.xsd" />
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" />
  <xs:import namespace="http://fasb.org/us-gaap/2025" schemaLocation="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd" />
  <xs:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" />
  <xs:import namespace="http://fasb.org/srt/2025" schemaLocation="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd" />
  <xs:import namespace="http://xbrl.sec.gov/cyd/2025" schemaLocation="https://xbrl.sec.gov/cyd/2025/cyd-2025.xsd" />
  <xs:import namespace="http://xbrl.sec.gov/dei/2025" schemaLocation="https://xbrl.sec.gov/dei/2025/dei-2025.xsd" />
  <xs:import namespace="http://xbrl.sec.gov/country/2025" schemaLocation="https://xbrl.sec.gov/country/2025/country-2025.xsd" />
  <xs:import namespace="http://xbrl.org/2020/extensible-enumerations-2.0" schemaLocation="https://www.xbrl.org/2020/extensible-enumerations-2.0.xsd" />
  <xs:import namespace="http://xbrl.sec.gov/ecd-sub/2025" schemaLocation="https://xbrl.sec.gov/ecd/2025/ecd-sub-2025.xsd" />
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="canf-20251231_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:title="Presentation link" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="canf-20251231_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:title="Label link" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="canf-20251231_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:title="Definition link" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="canf-20251231_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:title="Calculation link" xlink:type="simple" />
      <link:roleType roleURI="http://canfite.com/20251231/role/DocumentAndEntityInformation" id="DocumentAndEntityInformation">
        <link:definition>995300 - Document - Document And Entity Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/AuditInformation" id="AuditInformation">
        <link:definition>995301 - Document - Audit Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/ConsolidatedBalanceSheets" id="ConsolidatedBalanceSheets">
        <link:definition>995302 - Statement - Consolidated Balance Sheets</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/ConsolidatedBalanceSheetsParentheticals" id="ConsolidatedBalanceSheetsParentheticals">
        <link:definition>995303 - Statement - Consolidated Balance Sheets (Parentheticals)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/ConsolidatedStatementsofOperatingLoss" id="ConsolidatedStatementsofOperatingLoss">
        <link:definition>995304 - Statement - Consolidated Statements of Operating Loss</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/ConsolidatedStatementsofChangesinShareholdersEquity" id="ConsolidatedStatementsofChangesinShareholdersEquity">
        <link:definition>995305 - Statement - Consolidated Statements of Changes in Shareholders&#8217; Equity</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/ConsolidatedStatementsofChangesinShareholdersEquityParentheticals" id="ConsolidatedStatementsofChangesinShareholdersEquityParentheticals">
        <link:definition>995306 - Statement - Consolidated Statements of Changes in Shareholders&#8217; Equity (Parentheticals)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/ConsolidatedStatementsofCashFlows" id="ConsolidatedStatementsofCashFlows">
        <link:definition>995307 - Statement - Consolidated Statements of Cash Flows</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/General" id="General">
        <link:definition>995308 - Disclosure - General</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/SignificantAccountingPolicies" id="SignificantAccountingPolicies">
        <link:definition>995309 - Disclosure - Significant Accounting Policies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/PrepaidExpensesandOtherCurrentAssets" id="PrepaidExpensesandOtherCurrentAssets">
        <link:definition>995310 - Disclosure - Prepaid Expenses and Other Current Assets</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/PropertyPlantandEquipmentNet" id="PropertyPlantandEquipmentNet">
        <link:definition>995311 - Disclosure - Property, Plant and Equipment, Net</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/OtherAccountsPayable" id="OtherAccountsPayable">
        <link:definition>995312 - Disclosure - Other Accounts Payable</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/FairValueMeasurements" id="FairValueMeasurements">
        <link:definition>995313 - Disclosure - Fair Value Measurements</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/Revenues" id="Revenues">
        <link:definition>995314 - Disclosure - Revenues</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/ContingentLiabilitiesandCommitments" id="ContingentLiabilitiesandCommitments">
        <link:definition>995315 - Disclosure - Contingent Liabilities and Commitments</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/ShareholdersEquity" id="ShareholdersEquity">
        <link:definition>995316 - Disclosure - Shareholders' Equity</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/Leases" id="Leases">
        <link:definition>995317 - Disclosure - Leases</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/FinanceIncomeExpenseNet" id="FinanceIncomeExpenseNet">
        <link:definition>995318 - Disclosure - Finance Income (Expense), Net</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/SegmentReporting" id="SegmentReporting">
        <link:definition>995319 - Disclosure - Segment Reporting</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/TaxesonIncome" id="TaxesonIncome">
        <link:definition>995320 - Disclosure - Taxes on Income</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/SubsequentEvents" id="SubsequentEvents">
        <link:definition>995321 - Disclosure - Subsequent Events</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/CybersecurityRiskManagementandStrategyDisclosure" id="CybersecurityRiskManagementandStrategyDisclosure">
        <link:definition>995322 - Disclosure - Cybersecurity Risk Management and Strategy Disclosure</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/AccountingPoliciesbyPolicyPolicies" id="AccountingPoliciesbyPolicyPolicies">
        <link:definition>996323 - Disclosure - Accounting Policies, by Policy (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/SignificantAccountingPoliciesTables" id="SignificantAccountingPoliciesTables">
        <link:definition>996324 - Disclosure - Significant Accounting Policies (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/PrepaidExpensesandOtherCurrentAssetsTables" id="PrepaidExpensesandOtherCurrentAssetsTables">
        <link:definition>996325 - Disclosure - Prepaid Expenses and Other Current Assets (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/PropertyPlantandEquipmentNetTables" id="PropertyPlantandEquipmentNetTables">
        <link:definition>996326 - Disclosure - Property, Plant and Equipment, Net (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/OtherAccountsPayableTables" id="OtherAccountsPayableTables">
        <link:definition>996327 - Disclosure - Other Accounts Payable (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/FairValueMeasurementsTables" id="FairValueMeasurementsTables">
        <link:definition>996328 - Disclosure - Fair Value Measurements (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/ShareholdersEquityTables" id="ShareholdersEquityTables">
        <link:definition>996329 - Disclosure - Shareholders' Equity (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/LeasesTables" id="LeasesTables">
        <link:definition>996330 - Disclosure - Leases (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/FinanceIncomeExpenseNetTables" id="FinanceIncomeExpenseNetTables">
        <link:definition>996331 - Disclosure - Finance Income (Expense), Net (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/TaxesonIncomeTables" id="TaxesonIncomeTables">
        <link:definition>996332 - Disclosure - Taxes on Income (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/GeneralDetails" id="GeneralDetails">
        <link:definition>996333 - Disclosure - General (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/SignificantAccountingPoliciesDetails" id="SignificantAccountingPoliciesDetails">
        <link:definition>996334 - Disclosure - Significant Accounting Policies (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/SignificantAccountingPoliciesScheduleofDepreciableRatesofPropertyandEquipmentDetails" id="SignificantAccountingPoliciesScheduleofDepreciableRatesofPropertyandEquipmentDetails">
        <link:definition>996335 - Disclosure - Significant Accounting Policies - Schedule of Depreciable Rates of Property and Equipment (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/SignificantAccountingPoliciesScheduleofMajorCustomerDataasaPercentageDetails" id="SignificantAccountingPoliciesScheduleofMajorCustomerDataasaPercentageDetails">
        <link:definition>996336 - Disclosure - Significant Accounting Policies- Schedule of Major Customer Data as a Percentage (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/SignificantAccountingPoliciesScheduleofAntidilutiveSharesDetails" id="SignificantAccountingPoliciesScheduleofAntidilutiveSharesDetails">
        <link:definition>996337 - Disclosure - Significant Accounting Policies- Schedule of Antidilutive Shares (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/PrepaidExpensesandOtherCurrentAssetsScheduleofPrepaidExpensesandOtherCurrentAssetsDetails" id="PrepaidExpensesandOtherCurrentAssetsScheduleofPrepaidExpensesandOtherCurrentAssetsDetails">
        <link:definition>996338 - Disclosure - Prepaid Expenses and Other Current Assets - Schedule of Prepaid Expenses and Other Current Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/PropertyPlantandEquipmentNetDetails" id="PropertyPlantandEquipmentNetDetails">
        <link:definition>996339 - Disclosure - Property, Plant and Equipment, Net (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/PropertyPlantandEquipmentNetScheduleofPropertyPlantandEquipmentNetDetails" id="PropertyPlantandEquipmentNetScheduleofPropertyPlantandEquipmentNetDetails">
        <link:definition>996340 - Disclosure - Property, Plant and Equipment, Net - Schedule of Property, Plant and Equipment, Net (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/OtherAccountsPayableScheduleofOtherAccountsPayableDetails" id="OtherAccountsPayableScheduleofOtherAccountsPayableDetails">
        <link:definition>996341 - Disclosure - Other Accounts Payable - Schedule of Other Accounts Payable (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/FairValueMeasurementsScheduleofFinancialAssetsandLiabilitiesMeasuredatFairvalueRecurringBasisDetails" id="FairValueMeasurementsScheduleofFinancialAssetsandLiabilitiesMeasuredatFairvalueRecurringBasisDetails">
        <link:definition>996342 - Disclosure - Fair Value Measurements - Schedule of Financial Assets and Liabilities Measured at Fair value Recurring Basis (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/RevenuesDetails" id="RevenuesDetails">
        <link:definition>996343 - Disclosure - Revenues (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/ContingentLiabilitiesandCommitmentsDetails" id="ContingentLiabilitiesandCommitmentsDetails">
        <link:definition>996344 - Disclosure - Contingent Liabilities and Commitments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/ShareholdersEquityDetails" id="ShareholdersEquityDetails">
        <link:definition>996345 - Disclosure - Shareholders' Equity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/ShareholdersEquityScheduleofInformationRegardingOutstandingWarrantstoPurchaseSharesDetails" id="ShareholdersEquityScheduleofInformationRegardingOutstandingWarrantstoPurchaseSharesDetails">
        <link:definition>996346 - Disclosure - Shareholders' Equity - Schedule of Information Regarding Outstanding Warrants to Purchase Shares (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/ShareholdersEquityScheduleofCompanysOptionActivityDetails" id="ShareholdersEquityScheduleofCompanysOptionActivityDetails">
        <link:definition>996347 - Disclosure - Shareholders' Equity - Schedule of Company's Option Activity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/ShareholdersEquityScheduleofFairvalueofCompanysShareOptionsGrantedDetails" id="ShareholdersEquityScheduleofFairvalueofCompanysShareOptionsGrantedDetails">
        <link:definition>996348 - Disclosure - Shareholders' Equity - Schedule of Fair value of Company&#8217;s Share Options Granted (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/ShareholdersEquityScheduleofExpensesRecognizedFinancialStatementsDetails" id="ShareholdersEquityScheduleofExpensesRecognizedFinancialStatementsDetails">
        <link:definition>996349 - Disclosure - Shareholders' Equity - Schedule of Expenses Recognized Financial Statements (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/LeasesDetails" id="LeasesDetails">
        <link:definition>996350 - Disclosure - Leases (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/LeasesScheduleofWeightedAverageRemainingLeaseTermsandDiscountRateDetails" id="LeasesScheduleofWeightedAverageRemainingLeaseTermsandDiscountRateDetails">
        <link:definition>996351 - Disclosure - Leases-Schedule of Weighted Average Remaining Lease Terms and Discount Rate (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/LeasesScheduleofMaturitiesofLeaseLiabilitiesDetails" id="LeasesScheduleofMaturitiesofLeaseLiabilitiesDetails">
        <link:definition>996352 - Disclosure - Leases-Schedule of Maturities of Lease Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/FinanceIncomeExpenseNetScheduleofFinanceIncomeExpenseNetDetails" id="FinanceIncomeExpenseNetScheduleofFinanceIncomeExpenseNetDetails">
        <link:definition>996353 - Disclosure - Finance Income (Expense), Net-Schedule of Finance Income (Expense), Net (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/SegmentReportingDetails" id="SegmentReportingDetails">
        <link:definition>996354 - Disclosure - Segment Reporting (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/TaxesonIncomeDetails" id="TaxesonIncomeDetails">
        <link:definition>996355 - Disclosure - Taxes on Income (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/TaxesonIncomeScheduleofScheduleofDeferredTaxAssetsandLiabilitiesDetails" id="TaxesonIncomeScheduleofScheduleofDeferredTaxAssetsandLiabilitiesDetails">
        <link:definition>996356 - Disclosure - Taxes on Income- Schedule of Schedule of Deferred Tax Assets and Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/TaxesonIncomeScheduleofReconciliationStatutoryIsraeliIncomeTaxRateDetails" id="TaxesonIncomeScheduleofReconciliationStatutoryIsraeliIncomeTaxRateDetails">
        <link:definition>996357 - Disclosure - Taxes on Income - Schedule of Reconciliation Statutory Israeli Income Tax Rate  (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://canfite.com/20251231/role/SubsequentEventsDetails" id="SubsequentEventsDetails">
        <link:definition>996358 - Disclosure - Subsequent Events (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:element id="canf_WarrantsToPurchaseOrdinarySharesPolicyTextBlock" name="WarrantsToPurchaseOrdinarySharesPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="canf_GrossProceeds" name="GrossProceeds" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="canf_NumberOfOrdinaryShares" name="NumberOfOrdinaryShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xs:element id="canf_PercentageOfDepositsOnMonthlySalary" name="PercentageOfDepositsOnMonthlySalary" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="canf_PercentageOfRealizationOnUltimateSettlement" name="PercentageOfRealizationOnUltimateSettlement" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="canf_ShortTermBankDepositsYearlyInterestRatePercentage" name="ShortTermBankDepositsYearlyInterestRatePercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="canf_FairValueMeasurementsScheduleofFinancialAssetsandLiabilitiesMeasuredatFairvalueRecurringBasisDetailsTable" name="FairValueMeasurementsScheduleofFinancialAssetsandLiabilitiesMeasuredatFairvalueRecurringBasisDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_ScheduleOfFinancialAssetsAndLiabilitiesMeasuredAtFairValueRecurringBasisAbstract" name="ScheduleOfFinancialAssetsAndLiabilitiesMeasuredAtFairValueRecurringBasisAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_CashPlacementFee" name="CashPlacementFee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="canf_ClassOfWarrantOrRightPercentage" name="ClassOfWarrantOrRightPercentage" type="dtr:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xs:element id="canf_CommonWarrantsMember" name="CommonWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_GrantedExcessYears" name="GrantedExcessYears" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xs:element id="canf_IncreaseAuthorizedShareCapital" name="IncreaseAuthorizedShareCapital" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xs:element id="canf_InvestorsFromJuly2025OfferingMember" name="InvestorsFromJuly2025OfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_IssuanceOfOrdinarySharesDueToATMNetOfIssuanceCosts" name="IssuanceOfOrdinarySharesDueToATMNetOfIssuanceCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="canf_NewWarrantsMember" name="NewWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_PreFundedWarrantsMember" name="PreFundedWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_PurchaseAgreementMember" name="PurchaseAgreementMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_ShareholdersEquityDetailsTable" name="ShareholdersEquityDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_SpecialGeneralMeetingOfShareholdersMember" name="SpecialGeneralMeetingOfShareholdersMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_StockIssuedDuringPeriodSharesIssuanceOfOrdinarySharesDueToATM" name="StockIssuedDuringPeriodSharesIssuanceOfOrdinarySharesDueToATM" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="canf_StockIssuedDuringPeriodSharesReleaseOfOrdinarySharesThatWerePreviouslyHeldInAbeyance" name="StockIssuedDuringPeriodSharesReleaseOfOrdinarySharesThatWerePreviouslyHeldInAbeyance" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="canf_TwoThousandThirteenPlanMember" name="TwoThousandThirteenPlanMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_TwoThousandTwentyThreePlanMember" name="TwoThousandTwentyThreePlanMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_ScheduleOfFairValueOfCompanySShareOptionsGrantedAbstract" name="ScheduleOfFairValueOfCompanySShareOptionsGrantedAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionExercisePrice" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionExercisePrice" type="xbrli:pureItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="canf_ShareholdersEquityScheduleofFairvalueofCompanysShareOptionsGrantedDetailsTable" name="ShareholdersEquityScheduleofFairvalueofCompanysShareOptionsGrantedDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_ChongKunDangPharmaceuticalsCorpMember" name="ChongKunDangPharmaceuticalsCorpMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_CipherPharmaceuticalsMember" name="CipherPharmaceuticalsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_EwopharmaAGMember" name="EwopharmaAGMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_GebroHoldingGmbHMember" name="GebroHoldingGmbHMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_VetbiolixMember" name="VetbiolixMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_AdditionalRevenueReceivedForAchievedMilestone" name="AdditionalRevenueReceivedForAchievedMilestone" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="canf_CMSMedicalVentureInvestmentLimitedMember" name="CMSMedicalVentureInvestmentLimitedMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_EwopharmaMember" name="EwopharmaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_KyongboPharmCoLtdMember" name="KyongboPharmCoLtdMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_LiverCancerIndicationMember" name="LiverCancerIndicationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_MilestonePaymentPercentage" name="MilestonePaymentPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="canf_NASHMember" name="NASHMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_NonRefundablePayment" name="NonRefundablePayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="canf_EffectOfBenefittedIncomePreferredTechnologicalEnterpriseInIsraelAmount" name="EffectOfBenefittedIncomePreferredTechnologicalEnterpriseInIsraelAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="canf_DocumentAndEntityInformationAbstract" name="DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_BankCommissions" name="BankCommissions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="canf_ExchangeRateFluctuationsAndOthers" name="ExchangeRateFluctuationsAndOthers" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="canf_OtherGainFromShortTermInvestmentRemeasurement" name="OtherGainFromShortTermInvestmentRemeasurement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="canf_ScheduleOfExpensesRecognizedFinancialStatementsAbstract" name="ScheduleOfExpensesRecognizedFinancialStatementsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_StockIssuedDuringPeriodValueIssuanceOfShareCapitalAndWarrants" name="StockIssuedDuringPeriodValueIssuanceOfShareCapitalAndWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="canf_StockIssuedDuringPeriodShareIssuanceOfShareCapitalAndWarrants" name="StockIssuedDuringPeriodShareIssuanceOfShareCapitalAndWarrants" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="canf_LegalAndOtherContingenciesPolicyTextBlock" name="LegalAndOtherContingenciesPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="canf_PrepaidExpensesAndOtherCurrentAssetsPolicyTextBlock" name="PrepaidExpensesAndOtherCurrentAssetsPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="canf_RecentlyIssuedAccountingPronouncementsNotYetAdoptedPolicyTextBlock" name="RecentlyIssuedAccountingPronouncementsNotYetAdoptedPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="canf_SeverancePayPolicyTextBlock" name="SeverancePayPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="canf_ShorttermBankDepositsPolicyTextBlock" name="ShorttermBankDepositsPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="canf_ContingentLiabilitiesandCommitmentsDetailsTable" name="ContingentLiabilitiesandCommitmentsDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_PercentageOfNetSales" name="PercentageOfNetSales" type="dtr:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="canf_PhaseIIIStudiesMember" name="PhaseIIIStudiesMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_PhaseIIStudiesMember" name="PhaseIIStudiesMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_PhaseIStudiesMember" name="PhaseIStudiesMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_RegulatoryAuthorityMember" name="RegulatoryAuthorityMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_RoyaltyPaymentsPercentage" name="RoyaltyPaymentsPercentage" type="dtr:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="canf_AmericanDepositarySharesMember" name="AmericanDepositarySharesMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsWeightedAverageRemainingContractualTermsForfeitedexpired" name="SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsWeightedAverageRemainingContractualTermsForfeitedexpired" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="canf_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsTermsGrants" name="SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsTermsGrants" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="canf_EffectiveIncomeTaxRateReconciliationBenefittedIncomePreferredTechnologicalEnterpriseInIsrael" name="EffectiveIncomeTaxRateReconciliationBenefittedIncomePreferredTechnologicalEnterpriseInIsrael" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="canf_LaboratoryEquipmentMember" name="LaboratoryEquipmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_ScheduleOfUsefulLivesOfTheAssetTableTextBlock" name="ScheduleOfUsefulLivesOfTheAssetTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="canf_NetOfIssuanceCostsOfOrdinarySharesAndWarrants" name="NetOfIssuanceCostsOfOrdinarySharesAndWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="canf_PercentageOfRoyaltiesOnNetSales" name="PercentageOfRoyaltiesOnNetSales" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="canf_RegulatoryMilestonesMember" name="RegulatoryMilestonesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_SalesMilestonesMember" name="SalesMilestonesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_TransferPriceRate" name="TransferPriceRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="canf_UpfrontAndMilestonePaymentsPayable" name="UpfrontAndMilestonePaymentsPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="canf_UpfrontPayment" name="UpfrontPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="canf_NetOfIssuanceExpensesOfOrdinarySharesDueToExerciseOfWarrants" name="NetOfIssuanceExpensesOfOrdinarySharesDueToExerciseOfWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="canf_NetOfIssuanceCostsOrdinarySharesDueToATM" name="NetOfIssuanceCostsOrdinarySharesDueToATM" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="canf_NetOfIssuanceCostsOrdinarySharesAndWarrantsAndExerciseOfPreFundedWarrants" name="NetOfIssuanceCostsOrdinarySharesAndWarrantsAndExerciseOfPreFundedWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="canf_GovernmentAuthorities" name="GovernmentAuthorities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="canf_November2023Member" name="November2023Member" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_IssuanceDate" name="IssuanceDate" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="canf_December2021Member" name="December2021Member" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_April2025Member" name="April2025Member" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_NewWarrantSharesMember" name="NewWarrantSharesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_StockIssuedDuringPeriodSharesExercised" name="StockIssuedDuringPeriodSharesExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xs:element id="canf_StockIssuedDuringPeriodExerciseValue" name="StockIssuedDuringPeriodExerciseValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="canf_ExistingWarrantsMember" name="ExistingWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_ScheduleOfInformationRegardingOutstandingWarrantsToPurchaseSharesAbstract" name="ScheduleOfInformationRegardingOutstandingWarrantsToPurchaseSharesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_November2023AgentMember" name="November2023AgentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_July2025OneMember" name="July2025OneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_July2025Member" name="July2025Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_January2023AgentMember" name="January2023AgentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_August2024Member" name="August2024Member" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_August2024AgentMember" name="August2024AgentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_SubsequentEventsDetailsTable" name="SubsequentEventsDetailsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_ADSMember" name="ADSMember" type="dtr:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xs:element id="canf_ChangesInFairValueOfShortTermInvestment" name="ChangesInFairValueOfShortTermInvestment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xs:element id="canf_StockIssuedDuringPeriodValueReleaseOfOrdinarySharesThatWerePreviouslyHeldInAbeyance" name="StockIssuedDuringPeriodValueReleaseOfOrdinarySharesThatWerePreviouslyHeldInAbeyance" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xs:element id="canf_LeaseLiabilitiesArisingFromObtainingRightofuseassets" name="LeaseLiabilitiesArisingFromObtainingRightofuseassets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
</xs:schema>
