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Amount of the fee for available but unused credit capacity under the credit facility.

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Subsequent events - Additional Information (Details)		1 Months Ended
Subsequent events - Additional Information (Details)	Feb. 04, 2026 USD ($) TermLoan	Mar. 31, 2025	Mar. 25, 2026 shares	Dec. 31, 2025 shares	Dec. 31, 2024 shares
Subsequent Event [Line Items]
Common stock, shares, issued \| shares				49,335,551	2,446,864
Interest rate		4.50%
Hercules Term Loan Facility
Subsequent Event [Line Items]
Period additional term loan tranches available from closing date	60 months after the Closing Date
Subsequent Event \| Shionogi License Agreement \| Development And Regulatory Milestone
Subsequent Event [Line Items]
Milestone payment	$ 20,000,000
Subsequent Event \| Jefferies LLC
Subsequent Event [Line Items]
Sale of common stock maximum aggregate offering price	$ 200,000,000
Common stock, shares, issued \| shares			0
Subsequent Event \| Jefferies LLC \| Maximum
Subsequent Event [Line Items]
Commission for agent on sales	3.00%
Subsequent Event \| Hercules Term Loan Facility
Subsequent Event [Line Items]
Maturity date	Feb. 01, 2031
Proceeds from Issuance of Long-Term Debt, Total	$ 38,400,000
Debt default interest rate	4.00%
Cash and cash equivalents of percentage of outstanding loan amount	50.00%
Subsequent Event \| Hercules Term Loan Facility \| Debt Repaid on or Within 24 Months of Closing Date
Subsequent Event [Line Items]
Exit fee, percentage	3.95%
Subsequent Event \| Hercules Term Loan Facility \| Debt Repaid More Than 24 Months Less Than 48 Months after Closing Date
Subsequent Event [Line Items]
Exit fee, percentage	5.75%
Subsequent Event \| Hercules Term Loan Facility \| Debt Repayment After 48 Months of Closing Date
Subsequent Event [Line Items]
Exit fee, percentage	6.45%
Subsequent Event \| Hercules Term Loan Facility \| Debt Prepaid on or Within 12 Months of Closing Date
Subsequent Event [Line Items]
Term loan prepayment premium percentage	3.00%
Subsequent Event \| Hercules Term Loan Facility \| Debt Prepaid More Than 12 Months Less Than 24 Months After Closing Date
Subsequent Event [Line Items]
Term loan prepayment premium percentage	2.00%
Subsequent Event \| Hercules Term Loan Facility \| Debt Prepaid More Than 24 Months Less Than 36 Months after Closing Date
Subsequent Event [Line Items]
Term loan prepayment premium percentage	1.00%
Subsequent Event \| Hercules Term Loan Facility \| Debt Repayment After 36 Months of Closing Date
Subsequent Event [Line Items]
Term loan prepayment premium percentage	0.00%
Subsequent Event \| Hercules Term Loan Facility \| Market Capitalization Greater Than or Equal to $450.0 Million
Subsequent Event [Line Items]
Market capitalization	$ 450,000,000
Subsequent Event \| Hercules Term Loan Facility \| Market Capitalization Greater Than or Equal to $450.0 Million and Principal of Less Than or Equal to $85.0 Million Outstanding
Subsequent Event [Line Items]
Principal amount outstanding	85,000,000
Subsequent Event \| Hercules Term Loan Facility \| Market Capitalization Greater Than or Equal to $750.0 Million
Subsequent Event [Line Items]
Market capitalization	$ 750,000,000
Subsequent Event \| Hercules Term Loan Facility \| Minimum
Subsequent Event [Line Items]
Interest rate	7.95%
Decrease in cash and cash equivalents of percentage of outstanding loan amount	35.00%
Subsequent Event \| Hercules Term Loan Facility \| Maximum
Subsequent Event [Line Items]
Term Loan Facility	$ 200,000,000
Number of additional term loan tranches \| TermLoan	6
Additional term loan providing up to an aggregate	$ 160,000,000
Interest rate	9.25%
Decrease in cash and cash equivalents of percentage of outstanding loan amount	40.00%
Subsequent Event \| Hercules Term Loan Facility \| Tranche 1A [Member]
Subsequent Event [Line Items]
Initial term loan	$ 40,000,000
Subsequent Event \| Hercules Term Loan Facility \| final tranche [Member]
Subsequent Event [Line Items]
Final tranche	$ 50,000,000