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  <xsd:element name="DecreaseInFairValueOfShareBasedCompensationLiabilityIncreaseInAdditionalPaidInCapital" id="pmn_DecreaseInFairValueOfShareBasedCompensationLiabilityIncreaseInAdditionalPaidInCapital" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ShareBasedCompensationArrangementWeightedAverageFairValueOfOptions" id="pmn_ShareBasedCompensationArrangementWeightedAverageFairValueOfOptions" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CanadianDollarShareOptionsMember" id="pmn_CanadianDollarShareOptionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="UsDollarShareOptionsMember" id="pmn_UsDollarShareOptionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptions" id="pmn_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="January2026Member" id="pmn_January2026Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="January2027Member" id="pmn_January2027Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="July2029Member" id="pmn_July2029Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DeferredTaxAssetsRestrictedInterestAndFinancingExpenses" id="pmn_DeferredTaxAssetsRestrictedInterestAndFinancingExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="EmploymentAgreementAnnualBaseSalary" id="pmn_EmploymentAgreementAnnualBaseSalary" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="EmploymentAgreementPercentageOfTargetBonusOnAnnualBaseSalary" id="pmn_EmploymentAgreementPercentageOfTargetBonusOnAnnualBaseSalary" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="TerminationWithoutCauseMember" id="pmn_TerminationWithoutCauseMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ChangeInControlOfCompanyMember" id="pmn_ChangeInControlOfCompanyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="StockOptionPlan2015Member" id="pmn_StockOptionPlan2015Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ArrangementOptionInitialAwardMember" id="pmn_ArrangementOptionInitialAwardMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ShareBasedPaymentArrangementOptionPerformanceAwardsMember" id="pmn_ShareBasedPaymentArrangementOptionPerformanceAwardsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsThresholdTradingDaysVolumeWeightedAveragePrice" id="pmn_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsThresholdTradingDaysVolumeWeightedAveragePrice" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="EmploymentAgreementSeveranceAmountCalculationTerm" id="pmn_EmploymentAgreementSeveranceAmountCalculationTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsMultiplierForVolumeWeightedAveragePriceForCalculationOfExercisePrice" id="pmn_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsMultiplierForVolumeWeightedAveragePriceForCalculationOfExercisePrice" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="Pmn310DevelopmentProgramCosts" id="pmn_Pmn310DevelopmentProgramCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="OtherNonEmployeeResearchAndDevelopmentCosts" id="pmn_OtherNonEmployeeResearchAndDevelopmentCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="SegmentReportingOtherSegmentItemAmount" id="pmn_SegmentReportingOtherSegmentItemAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ReclassificationOfPipeWarrantsFromLiabilityToEquity" id="pmn_ReclassificationOfPipeWarrantsFromLiabilityToEquity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="VolumeWeightedAveragePriceThresholdTradingDays" id="pmn_VolumeWeightedAveragePriceThresholdTradingDays" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ThresholdVolumeWeightedAveragePriceOfCommonSharesStockPriceTrigger" id="pmn_ThresholdVolumeWeightedAveragePriceOfCommonSharesStockPriceTrigger" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueOfOptions" id="pmn_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueOfOptions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AggregateGrossProceeds" id="pmn_AggregateGrossProceeds" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="OfferingCostsAndAgentFee" id="pmn_OfferingCostsAndAgentFee" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="July2024PrivatePlacementMember" id="pmn_July2024PrivatePlacementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CommonShareUnitsMember" id="pmn_CommonShareUnitsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="TrancheaAndBWarrantsMember" id="pmn_TrancheaAndBWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="TrancheaCommonShareWarrantMember" id="pmn_TrancheaCommonShareWarrantMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="TrancheBCommonShareWarrantMember" id="pmn_TrancheBCommonShareWarrantMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="TrancheCCommonShareWarrantMember" id="pmn_TrancheCCommonShareWarrantMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PreFundedUnitsMember" id="pmn_PreFundedUnitsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ThresholdDaysAfterCompletionOfTrancheMilestoneEventsConsideredForExpiryTerm" id="pmn_ThresholdDaysAfterCompletionOfTrancheMilestoneEventsConsideredForExpiryTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ThresholdDaysToGetShareholdersApproval" id="pmn_ThresholdDaysToGetShareholdersApproval" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="July222025ExerciseOfDiscountedWarrantsAndPipeOfferingMember" id="pmn_July222025ExerciseOfDiscountedWarrantsAndPipeOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="July282025ExerciseOfDiscountedWarrantsAndPipeOfferingMember" id="pmn_July282025ExerciseOfDiscountedWarrantsAndPipeOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AtMarketOffering2024Member" id="pmn_AtMarketOffering2024Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AtMarketOffering2025Member" id="pmn_AtMarketOffering2025Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NetProceedsFromIssuanceOfWarrants" id="pmn_NetProceedsFromIssuanceOfWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DeferredDiscountForFairValueModificationOfWarrants" id="pmn_DeferredDiscountForFairValueModificationOfWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DeferredDiscountIssuanceCostRecognized" id="pmn_DeferredDiscountIssuanceCostRecognized" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="RegisteredDirectOfferingMember" id="pmn_RegisteredDirectOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="July2030Member" id="pmn_July2030Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="WarrantExercisePriceUsd50.50Member" id="pmn_WarrantExercisePriceUsd50.50Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="WarrantExercisePriceUsd315.00Member" id="pmn_WarrantExercisePriceUsd315.00Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="WarrantExercisePriceUsd240.00Member" id="pmn_WarrantExercisePriceUsd240.00Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="WarrantExercisePriceUsd187.50Member" id="pmn_WarrantExercisePriceUsd187.50Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="WarrantExercisePriceUsd152.50Member" id="pmn_WarrantExercisePriceUsd152.50Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="WarrantExercisePriceUsd43.75Member" id="pmn_WarrantExercisePriceUsd43.75Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="WarrantExercisePriceUsd62.50Member" id="pmn_WarrantExercisePriceUsd62.50Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="WarrantExercisePriceUsd31.25Member" id="pmn_WarrantExercisePriceUsd31.25Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="WarrantExercisePriceUsd0.25Member" id="pmn_WarrantExercisePriceUsd0.25Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CommonStockCapitalSharesReservedForFutureIssuanceAmount" id="pmn_CommonStockCapitalSharesReservedForFutureIssuanceAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="July222025DiscountedWarrantExerciseOfferMember" id="pmn_July222025DiscountedWarrantExerciseOfferMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="July222025DiscountedWarrantExerciseOfferTrancheMember" id="pmn_July222025DiscountedWarrantExerciseOfferTrancheMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="July222025DiscountedWarrantExerciseOfferTrancheBMember" id="pmn_July222025DiscountedWarrantExerciseOfferTrancheBMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="July222025DiscountedWarrantExerciseOfferTrancheCMember" id="pmn_July222025DiscountedWarrantExerciseOfferTrancheCMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="July222025PipeOfferingMember" id="pmn_July222025PipeOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="July282025DiscountedWarrantExerciseOfferMember" id="pmn_July282025DiscountedWarrantExerciseOfferMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="July282025DiscountedWarrantExerciseOfferTrancheMember" id="pmn_July282025DiscountedWarrantExerciseOfferTrancheMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="July282025DiscountedWarrantExerciseOfferTrancheBMember" id="pmn_July282025DiscountedWarrantExerciseOfferTrancheBMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="July282025DiscountedWarrantExerciseOfferTrancheCMember" id="pmn_July282025DiscountedWarrantExerciseOfferTrancheCMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="July282025PipeOfferingMember" id="pmn_July282025PipeOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ProceedsFromIssuanceOfCommonStockAndWarrants" id="pmn_ProceedsFromIssuanceOfCommonStockAndWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="StockIssuedDuringPeriodSharesDiscountedWarrantExercise" id="pmn_StockIssuedDuringPeriodSharesDiscountedWarrantExercise" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="BeneficialOwnershipLimitation" id="pmn_BeneficialOwnershipLimitation" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="WarrantJuly222025Member" id="pmn_WarrantJuly222025Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PreModificationMember" id="pmn_PreModificationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PostModificationMember" id="pmn_PostModificationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="WarrantJuly282025Member" id="pmn_WarrantJuly282025Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ClassOfWarrantOrRightExercisedDiscountedExercisePrice" id="pmn_ClassOfWarrantOrRightExercisedDiscountedExercisePrice" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ProceedsFromPreFundedWarrantExercises" id="pmn_ProceedsFromPreFundedWarrantExercises" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationReturnToAdjustmentsAmount" id="pmn_EffectiveIncomeTaxRateReconciliationReturnToAdjustmentsAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationReturnToAdjustmentsPercent" id="pmn_EffectiveIncomeTaxRateReconciliationReturnToAdjustmentsPercent" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="January2026PrivatePlacementMember" id="pmn_January2026PrivatePlacementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="January2026PrivatePlacementIssuePriceOneMember" id="pmn_January2026PrivatePlacementIssuePriceOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="January2026PrivatePlacementIssuePriceTwoMember" id="pmn_January2026PrivatePlacementIssuePriceTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="January2026PrivatePlacementIssuePriceThreeMember" id="pmn_January2026PrivatePlacementIssuePriceThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CommonShareWarrantsMember" id="pmn_CommonShareWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CommonShareWarrantsIssuePriceOneMember" id="pmn_CommonShareWarrantsIssuePriceOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CommonShareWarrantsIssuePriceTwoMember" id="pmn_CommonShareWarrantsIssuePriceTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CommonShareWarrantsIssuePriceThreeMember" id="pmn_CommonShareWarrantsIssuePriceThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DirectorsAndManagementMember" id="pmn_DirectorsAndManagementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ThresholdDaysAfterCompletionOfMilestoneEventsConsideredForExpiryTerm" id="pmn_ThresholdDaysAfterCompletionOfMilestoneEventsConsideredForExpiryTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="StockOptionAndIncentivePlan2025Member" id="pmn_StockOptionAndIncentivePlan2025Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
</xsd:schema>
