75000 - Document - Document and Entity Information
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75010 - Statement - Consolidated Balance Sheets
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75020 - Statement - Consolidated Balance Sheets (Parenthetical)
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75030 - Statement - Consolidated Statements of Loss and Comprehensive Loss
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75040 - Statement - Consolidated Statements of Loss and Comprehensive Loss 2
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75050 - Statement - Consolidated Statements of Stockholder's Equity
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75060 - Statement - Consolidated Statements of Cash Flows
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995457 - Disclosure - Cybersecurity Risk Management, Strategy, and Governance
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995467 - Disclosure - Nature of Business, Basis of Presentation and Liquidity Risk
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995477 - Disclosure - Accounting Policies
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995487 - Disclosure - Financial Instruments and Risk
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995497 - Disclosure - Government Grant
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995507 - Disclosure - Intangibles
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995517 - Disclosure - License Agreements
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995527 - Disclosure - Fair Value Measurements
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995537 - Disclosure - Property and Equipment
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995547 - Disclosure - Convertible Debt
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995557 - Disclosure - Income Tax
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995567 - Disclosure - Common Stock
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995577 - Disclosure - Related Party Transactions
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995587 - Disclosure - Commitments and Contingencies
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995597 - Disclosure - Subsequent Events
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995607 - Disclosure - Accounting Policies (Policies)
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995617 - Disclosure - Accounting Policies (Tables)
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995627 - Disclosure - Intangibles (Tables)
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995637 - Disclosure - Fair Value Measurements (Tables)
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995647 - Disclosure - Property and Equipment (Tables)
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995657 - Disclosure - Convertible Debt (Tables)
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995667 - Disclosure - Income Tax (Tables)
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995677 - Disclosure - Common Stock (Tables)
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995687 - Disclosure - Commitments and Contingencies (Tables)
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995697 - Disclosure - Nature of Business, Basis of Presentation and Liquidity Risk - Additional Information (Detail)
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995707 - Disclosure - Accounting Policies - Additional Information (Detail)
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995717 - Disclosure - Accounting Policies - Summary of Depreciation on Property and Equipment (Detail)
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995727 - Disclosure - Financial Instruments and Risk - Additional Information (Detail)
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995737 - Disclosure - Government Grant - Additional Information (Details)
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995747 - Disclosure - Intangibles - Additional Information (Detail)
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995757 - Disclosure - Intangibles - Components of Intangible Assets (Detail)
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995767 - Disclosure - Intangibles - Estimated Future Amortization Expense Related to Intangible Assets (Detail)
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995777 - Disclosure - License Agreements - Additional Information (Detail)
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995787 - Disclosure - Fair Value Measurements - Additional Information (Detail)
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995797 - Disclosure - Fair Value Measurements - Summary of Assets and Liabilities Measured at Fair Value on Recurring Basis (Detail)
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995807 - Disclosure - Fair Value Measurements - Summary of Cash, Cash Equivalents and Restricted Cash (Detail)
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995817 - Disclosure - Fair Value Measurements - Schedule of Corporate Bonds and Commercial Paper (Details)
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995827 - Disclosure - Fair Value Measurements - Schedule of Aggregate Fair Value of Principal Amount of Convertible Debt (Detail)
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995837 - Disclosure - Fair Value Measurements - Schedule of Changes in Fair Value of Level 3 Financial Liabilities (Details)
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995847 - Disclosure - Property and Equipment - Summary of Property and Equipment (Detail)
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995857 - Disclosure - Convertible Debt - Additional Information (Details)
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995867 - Disclosure - Convertible Debt - Schedule of Convertible Term Loan Balance Including Convertible Debt Balance (Details)
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995877 - Disclosure - Income Tax - Additional Information (Detail)
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995887 - Disclosure - Income Tax - Summary of U.S. and Foreign Components of Income (Loss) before Income Taxes (Detail)
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995897 - Disclosure - Income Tax - Reconciliation of Income Tax Attributable to Operations (Detail)
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995907 - Disclosure - Income Tax - Summary of Tax Effects of Temporary Differences and Carryforwards Rise to Deferred Tax Assets and Liabilities (Detail)
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995917 - Disclosure - Income Tax - Summary of Components of Cash Income Taxes Paid Net of Refunds (Details)
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995927 - Disclosure - Income Tax - Reconciliation of Unrecognized Tax Benefits of Uncertain Tax Positions (Detail)
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995937 - Disclosure - Income Tax - Summary of Years Open to Examination under Different Jurisdiction (Detail)
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995947 - Disclosure - Common Stock - Authorized - Additional Information (Detail)
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995957 - Disclosure - Common Stock - Issued and Outstanding Shares - Additional Information (Detail)
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995967 - Disclosure - Common Stock - Open Market Sale Agreement - Additional Information (Detail)
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995977 - Disclosure - Common Stock- Public Offering - Additional Information (Details)
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995987 - Disclosure - Common Stock - Equity Awards - Additional Information (Detail)
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995997 - Disclosure - Common Stock - Summary of Fair Value of Option Awards (Detail)
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996007 - Disclosure - Common Stock - Summary of Stock-Based Compensation Expense (Detail)
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996017 - Disclosure - Common Stock - Summary of Stock Options Activity (Detail)
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996027 - Disclosure - Common Stock - Summary of Stock Options Outstanding Regarding Number of Common Shares Issuable upon Exercise of Outstanding Options (Detail)
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996037 - Disclosure - Common Stock - Summary of Stock Options Outstanding Regarding Number of Common Shares Issuable upon Exercise of Vested Options (Detail)
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996047 - Disclosure - Common Stock - Restricted Stock Unit Awards - Additional Information (Detail)
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996057 - Disclosure - Common Stock - Summary of Restricted Stock Unit Award Activity (Detail)
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996067 - Disclosure - Common Stock - Employee Stock Purchase Plan - Additional Information (Detail)
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996077 - Disclosure - Common Stock - Summary of Outstanding Warrants (Detail)
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996087 - Disclosure - Common Stock - Stock Warrants - Additional Information (Detail)
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996097 - Disclosure - Common Stock - Computation of Basic and Diluted Net Loss Attributable to Common Shareholders Per Share (Detail)
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996107 - Disclosure - Common Stock - Loss Per Common Share - Additional Information (Detail)
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996117 - Disclosure - Related Party Transactions (Additional Information) (Details)
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996127 - Disclosure - Commitments and Contingencies - Summary of Contractual Obligations (Detail)
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996137 - Disclosure - Commitments and Contingencies - Additional Information (Detail)
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996147 - Disclosure - Commitments and Contingencies - Summary of Future Minimum Annual Lease Payments (Detail)
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996157 - Disclosure - Commitments and Contingencies - Summary of Other Information Related to Leases (Detail)
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996167 - Disclosure - Subsequent Events - Additional Information (Detail)
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Weighted-Average Grant Date Fair Value, Released
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Schedule of Cash Flow, Supplemental Disclosures [Table Text Block]
Summary of Components of Cash Income Taxes Paid Net of Refunds
Restricted Cash And Other Assets
Restricted cash and other assets.
Restricted cash and other assets [note 6 and note 7]
August 2020 Public Offering [Member]
August Two Thousand Twenty Public Offering [Member]
August two thousand twenty public offering.
Foreign
Income (Loss) from Continuing Operations before Income Taxes, Foreign
Share-Based Compensation Arrangement by Share-Based Payment Award, Non-Option Equity Instruments, Outstanding, Number, Ending Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Non-Option Equity Instruments, Outstanding, Number, Beginning Balance
Restricted shares reserved for issuance under incentive plan
Share-Based Compensation Arrangement by Share-Based Payment Award, Non-Option Equity Instruments, Outstanding, Number
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Preferred stock, shares issued
Preferred Stock, Shares Issued
Share purchase agreement contingent consideration.
Share Purchase Agreement Contingent Consideration [Policy Text Block]
Share Purchase Agreement Contingent Consideration
Expenses related to indemnification issues
Indemnification Expense
Indemnification expense.
Amendment to the University of Bristol License Agreement [Member]
Amendment To License Agreement [Member]
Amendment to license agreement.
Business Combination, Contingent Consideration, Change in Contingent Consideration, Liability, Increase (Decrease)
Loss on contingent consideration
Change in fair value of contingent consideration [note 4 and note 5]
Change in fair value of contingent consideration [note 5 and note 6]
Plan Name
Plan Name [Axis]
Equity [Abstract]
Entity Current Reporting Status
Entity Current Reporting Status
Pike [Member]
Pike [Member]
Pike.
Proceeds from Warrant Exercises
Proceeds from exercise of warrants
Proceeds from exercise of warrants [note 10[g]]
Warrants Issued In June Two Thousand Twenty Five [Member]
Warrants issued in June two thousand twenty five.
Warrants Issued in June 2025 [Member]
Level 2 [Member]
Fair Value, Inputs, Level 2 [Member]
Deferred Tax Assets, Net of Valuation Allowance
Net deferred tax assets
Restricted cash [Member]
Restricted Cash [Member]
Restricted cash.
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Common stock, shares authorized
Common Stock, Shares Authorized
Finite-Lived Intangible Asset, Expected Amortization, Year Four
2029
Fair Value by Liability Class [Domain]
Liablilty Class
Document Fiscal Period Focus
Document Fiscal Period Focus
Convertible debt compound interest
Debt Instrument, Interest Rate, Stated Percentage
Convertible debt, stated rate
Entity Shell Company
Entity Shell Company
Total
Contractual Obligation
Accrued liabilities other
Other Accrued Liabilities, Current
Convertible Indebtedness [Member]
Convertible Debt [Member]
Convertible Debt [Member]
Forfeiture rate
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Forfeiture Rate
Share based compensation arrangement by share based payment award fair value assumptions expected forfeiture rate.
Segment Information
Segment Reporting, Policy [Policy Text Block]
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value, Total
Cash and cash equivalents [note 3 and note 6]
Cash and cash equivalents, amortized cost and estimated fair value
Regulatory Agency
Regulatory Agency [Domain]
Cybersecurity Risk Management, Strategy, and Governance [Abstract]
Common stock, shares issued
Common Stock, Shares, Issued
Cybersecurity Risk Management Positions or Committees Responsible Report to Board [Flag]
Cybersecurity Risk Board of Directors Oversight [Text Block]
Lease agreement
Lessee, Operating Lease, Description
Kristen Slaoui [Member]
Kristen Slaoui.
Asset Class
Asset Class [Domain]
Statement [Table]
Statement [Table]
Operating leases
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Share-Based Payment Arrangement, Disclosure [Abstract]
Business Combination, Contingent Consideration, Liability, Measurement Input [Extensible Enumeration]
Weighted average fair value of stock options granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Inventory Costs for Contracts or Programs, Policy [Policy Text Block]
Inventory Costs
Series A Convertible Preferred Stock [Member]
Series A Convertible Preferred Stock [Member]
Series A convertible preferred stock.
Share-Based Payment Arrangement, Option, Exercise Price Range, Outstanding, Weighted Average Exercise Price, Ending Balance
Share-Based Payment Arrangement, Option, Exercise Price Range, Outstanding, Weighted Average Exercise Price, Beginning Balance
Exercise Price Range, Weighted Average Exercise Price
Share-Based Payment Arrangement, Option, Exercise Price Range, Outstanding, Weighted Average Exercise Price
Research And Development To Related Parties
Research and development to related parties.
Research and development - related parties [note 11]
Area of office space leased
Area Of Office Space Leased
Area of office space leased.
Statement [Line Items]
Statement [Line Items]
Maturity period of securities
Maturity Period Of Securities
Maturity period of securities.
Weighted Average Exercise Price, Expired
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price
Warrant [Member]
Warrant [Member]
Entity Filer Category
Entity Filer Category
Liabilities and Equity
Total liabilities and stockholders' equity
Debt Instrument [Line Items]
Increase (Decrease) in Employee Related Liabilities, Total
Accrued compensation
Increase (Decrease) in Employee Related Liabilities
Effective Income Tax Rate Reconciliation, Tax Contingency, Percent
Effective Income Tax Rate Reconciliation, Tax Contingency, Percent, Total
Changes in unrecognized tax benefits, Percent
Related Party Consulting Fee Incurred
Related party consulting fee incurred.
Consulting fees incurred
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Axis]
Increase in allowance considered deferred tax assets
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Income Tax Expense Benefit Excluding Adjustment For Reversal Of Deferred Tax Liability
Income tax expense (benefit) excluding adjustment for reversal of deferred tax liability.
Income tax expense/(recovery), Amount
Cybersecurity Risk Third Party Oversight and Identification Processes [Flag]
Financial Instruments and Risk
Financial Instruments Disclosure [Text Block]
Latest Tax Year [Member]
Latest Tax Year [Member]
Employees and Consultants [Member]
Employees And Consultants [Member]
Employees and consultants.
Exercise Price Range
Exercise Price Range [Axis]
Valuation allowance
Deferred Tax Assets, Valuation Allowance
Income tax rate assumed for both State and Foreign deferred tax calculations
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Income tax recovery at U.S. federal statutory income tax rate, Percent
Common stock, price per share
Shares Issued, Price Per Share
Cybersecurity Risk Management Third Party Engaged [Flag]
Documents Incorporated by Reference
Documents Incorporated by Reference [Text Block]
Goodwill
Goodwill, Ending Balance
Goodwill, Beginning Balance
Goodwill, Total
Goodwill
Effective Income Tax Rate Reconciliation, Percent
Income tax expense/(recovery), Percent
Income tax expense/(recovery), Percent
Interest income
Investment Income, Interest
Accretion of discount on modification of debt
Accretion of Discount On Modification Debt
Accretion of discount on modification debt.
Income Tax Authority
Income Tax Jurisdiction [Axis]
May 2021 Public Offering [Member]
May2021 Public Offering [Member]
May 2021 public offering.
Convertible Debt [Table]
Convertible Debt [Table]
Convertible debt.
Proceeds from Convertible Debt
Receipt of 2024 SVB convertible term loan less transaction costs [note 6 and note 8]
Accounting Policies [Table]
Accounting Policies [Table]
Accounting Policies.
Geographical
Geographical [Domain]
Income Tax Examination [Table]
Income Tax, Examination [Table]
Pre Funded Warrants [Member]
Pre-funded warrants.
Pre-Funded Warrants
Additional paid-in capital
Additional Paid in Capital, Common Stock
Debt Issuance Costs, Net, Total
Debt Issuance Costs, Net
Transaction costs
Tax basis in excess of book value of assets
Deferred Tax Assets, Property, Plant and Equipment
Related Party [Member]
Adare Pharma Solutions [Member]
Related Parties [Member]
Accounting Policies
Significant Accounting Policies [Text Block]
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Intangible assets, Useful life
Finite-Lived Intangible Asset, Useful Life
Concentration Risk [Table]
Grant awarded
Grant Awarded
Grant awarded.
2023 Non Employee Director Equity Incentive Plan [Member]
Two Thousand Twenty Three Non Employee Director Equity Incentive Plan [Member]
Two Thousand Twenty Three Non Employee Director Equity Incentive Plan.
Drawn amount
Debt Instrument Withdrawal Amount
Debt instrument withdrawal amount.
Nonrelated Party [Member]
Nonrelated Party [Member]
Number of shares granted
Number of Optioned Common Shares, Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Cybersecurity Risk Management, Strategy, and Governance [Table]
Computation of Basic and Diluted Net Loss Attributable to Common Shareholders Per Share
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Earnings Per Share, Basic, Total
Net loss per common share, basic
Earnings Per Share, Basic
Basic net loss per common share [note 10 [i]]
Common stock available for sale under offering
Common Stock Shares Available For Future Grant
Common stock, shares available for future grant.
Other Comprehensive Income (Loss), before Tax [Abstract]
OTHER COMPREHENSIVE INCOME (LOSS)
Percentage of Outstanding Shares of Common Stock
Percentage of outstanding shares of common stock.
Percentage of outstanding shares of common stock
Common shares reserved for options currently outstanding
Number of Optioned Common Shares, Beginning Balance
Number of Optioned Common Shares, Ending Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
February Two Thousand Twenty Four Private Placement [Member]
February two thousand twenty four private placement.
February 2024 Private Placement [Member]
Reimbursements received
Reimbursements Received
Reimbursements received.
Total current liabilities
Liabilities, Current
Proceeds from Sale of Equity Securities, FV-NI
Net cash proceeds from the sale and issuance of equity securities
Deferred Tax Assets Capitalized Research And Development Expenses
Deferred tax assets capitalized research and development expenses.
Capitalized R&D expenses
Federal
Income Tax Paid, Federal, after Refund Received
Income Tax Paid, Federal, after Refund Received, Total
US [Member]
Federal [Member]
Domestic Tax Jurisdiction [Member]
Effective Income Tax Rate Reconciliation, Tax Credit, Other, Amount
Other, Amount
Other, Amount
Maximum beneficial ownership percentage of outstanding common stock for warrant holders
Maximum Beneficial Ownership Percentage Of Outstanding Common Stock For Warrant Holders
Maximum beneficial ownership percentage of outstanding common stock for warrant holders.
Effective Income Tax Rate Reconciliation [Table]
Accounting Standards Update
Accounting Standards Update [Axis]
Income Tax Examination [Line Items]
Income Tax Examination [Line Items]
Stockholders' equity:
Equity, Attributable to Parent [Abstract]
Entity Small Business
Entity Small Business
Range six [Member]
Share Based Compensation Shares Authorized Under Stock Option Plans By Exercise Price Range Six [Member]
Share based compensation shares authorized under stock option plans by exercise price range six.
Retained Earnings (Accumulated Deficit), Total
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Stock based compensation
ASU 2016-02 [Member]
Accounting Standards Update 2016-02 [Member]
Other Commitments [Line Items]
Other Commitments [Line Items]
Preferred Stock [Member]
Preferred Stock [Member]
Effective Income Tax Rate Reconciliation, Cross-Border Tax Effect, Amount
Effective Income Tax Rate Reconciliation, Cross-Border Tax Effect, Amount, Total
Effect of cross-border laws, Amount
Grant receivable [note 4]
Grant receivable
Grants Receivable, Current
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Number of Optioned Common Shares, Forfeited
Number of Shares, Cancelled/Forfeited
Number of Optioned Common Shares, Forfeited
Sale of Stock, Price Per Share
Sale of common stock and warrant, public offering price
Aggregate intrinsic value of options exercised
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Reduction in R&D expense
Research And Development Expenses Increase Decrease
Research and development expenses increase (decrease).
Registration Rights Agreement [Member]
Registration rights agreement.
Registration Rights Agreement [Member]
Exercise Price Range, Weighted Average Remaining Contractual Life
Share-Based Payment Arrangement, Option, Exercise Price Range, Outstanding, Weighted Average Remaining Contractual Term
Debt instrument, repayment terms
Debt Instrument, Payment Terms
Amendment Flag
Amendment Flag
Security Owned and Sold, Not yet Purchased, at Fair Value [Axis]
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
Income tax recovery at U.S. federal statutory income tax rate, Amount
Proceeds from Sale, Maturity and Collection of Investments
Proceeds from Sale, Maturity and Collection of Investments, Total
Maturities of investments
Warrants to purchase common stock
Warrants to purchase common stock
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Loss per Common Share
Earnings Per Share, Policy [Policy Text Block]
Concentration Risk [Line Items]
LIABILITIES AND STOCKHOLDERS' EQUITY
Liabilities and Equity [Abstract]
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Board of Directors [Member]
Board Of Directors [Member]
Board of directors.
Net cash used in operating activities
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Net cash used in operating activities
Direct Offering [Member]
Direct Offering [Member]
Direct offering.
Segment Reporting, CODM, Profit (Loss) Measure, How Used, Description
Range ten [Member]
Share Based Compensation Shares Authorized Under Stock Option Plans By Exercise Price Range Ten [Member]
Share based compensation shares authorized under stock option plans by exercise price range ten.
Common stock [Member]
Common Stock [Member]
Common Stock [Member]
Cybersecurity Risk Role of Management [Text Block]
Tax credit carryforwards
Tax Credit Carryforward, Amount
Weighted Average Exercise Price, Granted
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Government Grant [Line Items]
Government Grant [Line Items]
Government grant.
Business Combination, Contingent Consideration, Liability, Measurement Input
Measurement input
Entity Address, Address Line One
Entity Address, Address Line One
Deferred Tax Liabilities, Gross, Total
Total deferred tax liabilities
Deferred Tax Liabilities, Gross
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Summary of Fair Value of Option Awards
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Maximum number of shares authorized to purchased
Share Based Compensation Maximum Number Of Shares Authorized To Purchased
Share based compensation, maximum number of shares authorized to purchased.
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Axis]
Government Grant [Table]
Government Grant [Table]
Government grant.
2010 Performance Incentive Plan [Member]
Two Thousands And Ten Performance Incentive Plan [Member]
Information pertaining to 2010 performance incentive plan.
Earnings Per Share [Abstract]
Income Taxes
Income Tax, Policy [Policy Text Block]
November 2022 Private Placement [Member]
November2022 Private Placement [Member]
November2022 Private Placement.
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Flag]
Reporting Currency and Foreign Currency Translation
Foreign Currency Transactions and Translations Policy [Policy Text Block]
Right-of-use assets
Right-of-use assets [note 12]
Operating Lease, Right-of-Use Asset
Total deferred tax assets
Deferred Tax Assets, Gross
Cybersecurity Risk Board Committee or Subcommittee Responsible for Oversight [Text Block]
Indemnification obligations
Guarantor Obligations, Current Carrying Value
Schedule of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Return Roll Forward [Table Text Block]
Schedule of unrecognized tax benefits, excluding amounts pertaining to examined tax return roll forward.
Reconciliation of Unrecognized Tax Benefits of Uncertain Tax Positions
Right-of-use asset
Deffered tax liabilities, right of use assets
Deffered Tax Liabilities, Right of Use Assets
Debt Instrument, Redemption, Period
Debt Instrument, Redemption, Period [Axis]
Class of Warrant or Right
Class of Warrant or Right [Axis]
Document Type
Document Type
Income Taxes Paid, Net
Total
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Public Offering [Member]
Public Offering.
Public Offering [Member]
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Entity Central Index Key
Entity Central Index Key
June Twenty Twenty Five Public Offering [Member]
June twenty twenty five public offering.
June 2025 Public Offering [Member]
Underwriting discounts
Underwriting Discounts
Underwriting discounts.
Cybersecurity Risk Process for Informing Board Committee or Subcommittee Responsible for Oversight [Text Block]
Unrecognized Tax Benefits Increases Decrease Resulting From Current Period Tax Positions
Unrecognized tax benefits increases decrease resulting from current period tax positions,
Additions (reductions) from tax positions taken in the current year
Net increase (decrease) in cash, cash equivalents and restricted cash
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation
Subsequent Event Type
Subsequent Event Type [Domain]
Percentage of exercise price exceeds in measurement period
Percentage Of Exercise Price Exceeds In Measurement Period
Percentage of exercise price exceeds in measurement period.
Anti-dilutive securities excluded from earning per share computation
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Pre-Funded Warrants Issued in August 2020 [Member]
Warrants Issued In August Two Thousand Twenty [Member]
Warrants issued in August two thousand twenty.
Sopharma
Sopharma [Member]
Common stock, par value
Common Stock, Par or Stated Value Per Share
Accounting Standards Update
Accounting Standards Update [Domain]
Operating Costs and Expenses
Operating Costs and Expenses, Total
Expenses incurred
Amortized Cost
Debt Securities, Available-for-Sale, Amortized Cost
Amortized Cost
Income Taxes [Line Items]
Income Taxes [Line Items]
Income taxes.
Debt Securities, Available-for-Sale
Estimated Fair Value
Estimated Fair Value
Range seven [Member]
Share Based Compensation Shares Authorized Under Stock Option Plans By Exercise Price Range Seven [Member]
Share based compensation shares authorized under stock option plans by exercise price range seven.
Document Financial Statement Error Correction [Flag]
Stock option exercises, Shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Debt Disclosure [Abstract]
Unrecognized Tax Benefits, Decrease Resulting from Settlements with Taxing Authorities
Tax settlements
Amortization of Transaction Costs
Amortization of transaction costs.
Amortization of transaction costs
Accrued Liabilities, Current
Accrued Liabilities, Current, Total
Accrued liabilities
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Ownership [Domain]
Current Fiscal Year End Date
Current Fiscal Year End Date
Schedule of Long-Term Debt Instruments [Table]
Lease, security deposit, annual payment
Lease Security Deposit Annual Payment
Lease security deposit annual payment.
Receivables [Abstract]
Fair Value By Balance Sheet Grouping [Table]
Fair Value, by Balance Sheet Grouping [Table]
Entity Address, State or Province
Entity Address, State or Province
Number of Shares, Beginning Balance
Number of Shares, Ending Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Unclaimed tax deductions related to scientific research and experimental development expenditures
Unclaimed Tax Deductions Related To Scientific Research And Experimental Development Expenditures
Unclaimed tax deductions related to scientific research and experimental development expenditures.
Accrued liabilities other
Increase (Decrease) in Other Accrued Liabilities
Threshold consecutive trading days
Debt Instrument, Convertible, Threshold Consecutive Trading Days
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding, Ending Balance
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Comprehensive loss
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Gross Unrealized Gains
Research and Development Costs
Research and Development Expense, Policy [Policy Text Block]
Class of Warrant or Right
Class of Warrant or Right [Domain]
Geographical
Geographical [Axis]
Line of Credit Facility, Lender
Line of Credit Facility, Lender [Domain]
Marketable Securities, Current
Marketable securities [note 6]
Summary of Stock Options Outstanding Regarding Number of Common Shares Issuable upon Exercise of Outstanding Options
Share-Based Payment Arrangement, Option, Exercise Price Range [Table Text Block]
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount
Domestic state & local income tax, net of federal income tax effect, Amount
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Summary of Stock-Based Compensation Expense
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Amount
Other, Amount
Comprehensive Income (Loss)
Comprehensive Income, Policy [Policy Text Block]
Lease, security deposit payment remaining amount
Lease Security Deposit Thereafter
Lease security deposit thereafter.
Summary of Tax Effects of Temporary Differences and Carryforwards Rise to Deferred Tax Assets and Liabilities
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
License Agreements
Collaborative Arrangement Disclosure [Text Block]
Range four [Member]
Share Based Compensation Shares Authorized Under Stock Option Plans By Exercise Price Range Four [Member]
Share based compensation shares authorized under stock option plans by exercise price range four.
2018 Equity Incentive Plan [Member]
Two Thousand And Eighteen Equity Incentive Plan [Member]
Two thousand and eighteen equity incentive plan.
Subsequent Events [Member]
Subsequent Event [Member]
Marketable Securities, Policy [Policy Text Block]
Marketable Securities
June 2025 Public Offering [Member]
June 2025 public offering.
June 2025 Public Offering [Member]
Realized gain on investments
Proceeds from Realized Gain on Investments
Proceeds from Realized Gain on Investments.
Property, Plant and Equipment [Abstract]
Share holding percentage of shares issued and outstanding
Share Holding Percentage Of Shares Issued And Outstanding
Share holding percentage of shares issued and outstanding.
Deferred Tax Assets, Tax Credit Carryforwards, Research
Research and development credits
Antidilutive Securities
Antidilutive Securities [Axis]
Number of Optioned Common Shares, Expired
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Expirations in Period
Intangible Assets
Goodwill and Intangible Assets, Intangible Assets, Policy [Policy Text Block]
Income Tax Paid, Foreign, after Refund Received
Income Tax Paid, Foreign, after Refund Received, Total
Foreign
Warrants
Warrants Policy [Text Block]
Disclosure of accounting policy for warrants.
More than 5 years
Contractual Obligation, to be Paid, after Year Five
Accrued Interest On S V B Convertible Debt
Accrued interest on SVB convertible debt.
Accrued interest on SVB convertible debt [note 8]
Seattle Lease Arrangement [Member]
Seattle Office Operating Lease [Member]
Seattle office operating lease.
Schedule Of Share Based Compensation Shares Authorized Under Stock Option Plans By Exercise Price Range [Table]
Share-Based Payment Arrangement, Option, Exercise Price Range [Table]
Range five [Member]
Share Based Compensation Shares Authorized Under Stock Option Plans By Exercise Price Range Five [Member]
Share based compensation shares authorized under stock option plans by exercise price range five.
Lease agreement commencement date
Lease Agreement Commencement Date
Lease agreement commencement date.
Accumulated other comprehensive income (loss) [Member]
AOCI Attributable to Parent [Member]
Finite-Lived Intangible Assets, Major Class Name
Finite-Lived Intangible Assets, Major Class Name [Domain]
Cash and Cash Equivalents [Domain]
Other Commitments [Table]
Other Commitments [Table]
Convertible Debt, Current
Current portion of convertible debt [note 6 and note 8]
Convertible preferred stock, value
Preferred Stock, Value, Issued
Share-Based Payment Arrangement, Option, Exercise Price Range, Shares Exercisable, Ending Balance
Share-Based Payment Arrangement, Option, Exercise Price Range, Shares Exercisable, Beginning Balance
Exercise Price Range, Number of Vested Options
Share-Based Payment Arrangement, Option, Exercise Price Range, Shares Exercisable
Maturity date
Debt Instrument, Maturity Date
Shares issued as settlement with trade vendor
Shares Issued As Settlement With Trade Vendor As Non Monetary Transaction
Shares issued as settlement with trade vendor as non-monetary transaction.
Minimum [Member]
Minimum [Member]
Weighted-Average Grant Date Fair Value, Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Financial Instrument [Axis]
Current assets:
Assets, Current [Abstract]
License agreement amortization expense
Amortization of Intangible Assets
Level 3 [Member]
Fair Value, Inputs, Level 3 [Member]
Liabilities
Liabilities, Fair Value Disclosure [Abstract]
Tax credit carryforwards expiration year
Tax Credit Carry Forward Expiration Year
Tax credit carry forward expiration year.
Summary of Assets and Liabilities Measured at Fair Value on Recurring Basis
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Tax Period
Tax Period [Domain]
Fair Value, Assets Measured on Recurring Basis [Table Text Block]
Schedule of Corporate Bonds and Commercial Paper
Current liabilities:
Liabilities, Current [Abstract]
New Convertible Term Loan [Member]
New Convertible Term Loan [Member]
New Convertible Term Loan Member
Placement agent fees and offering expenses
Placement Agent Fees And Offering Expenses
Placement agent fees and offering expenses.
Related Party Transactions [Abstract]
Operating loss carryforwards
Operating Loss Carryforwards
Lessee, Operating Lease, Renewal Term
Operating lease, extension term
Restricted Cash and Cash Equivalents, Total
Restricted cash, amortized cost and estimated fair value
Restricted Cash and Cash Equivalent
Proceeds from Stock Plans
Proceeds from employee stock purchase plan [note 10[e]]
Commitments and contingencies [note 12]
Commitments and Contingencies
Leases
Lessee, Leases [Policy Text Block]
Restricted stock unit settlements withheld and retired to treasury, Shares
Stock Issued During Period Shares Restricted Stock Unit Settlement Withheld And Retired To Treasury
Stock issued during period shares restricted stock unit settlement withheld and retired to treasury.
Weighted-Average Grant Date Fair Value, Beginning Balance
Weighted-Average Grant Date Fair Value, Ending Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Debt Prepayment Fee Percentage On Or After First Anniversary
Debt prepayment fee percentage on or after first anniversary.
Prepayment fee percentage on or after first anniversary
General and administrative [Member]
General and Administrative Expense [Member]
Operating Lease, Liability, Total
Operating lease liability
Operating Lease, Liability
Auditor Firm ID
Auditor Firm ID
Convertible debt, interest rate
Debt Instrument, Basis Spread on Variable Rate
Discount on modification of debt
Discount On Modification of Debt
Discount on modification of debt.
Convertible Debt [Line Items]
Convertible Debt [Line Items]
Convertible debt.
Cash paid for amounts included in the measurement of lease liabilities:
Cash Flow, Operating Activities, Lessee [Abstract]
Computer software.
Computer software [Member]
Computer Software [Member]
Equity Instrument Convertible Beneficial Ownership Percentage for Exercise Option
Equity instrument convertible beneficial ownership percentage for exercise option.
Equity instrument, convertible beneficial ownership percentage for exercise by holder
Receipt of SVB LoanTranche
Receipt of SVB loan tranche.
Receipt of SVB loan tranche
Commercial Paper Cash Equivalents [Member]
Commercial paper cash equivalents.
Commercial paper (cash equivalents) [Member]
Commercial Paper (Cash Equivalents) [Member]
Changes in valuation allowance, Percent
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Gross proceeds
Proceeds From Issuance Of Common Stock Gross
Proceeds from issuance of common stock gross.
Average daily trading volume for measurement period
Average Daily Trading Volume For Measurement Period
Average daily trading volume for measurement period.
Stock Units Description
Stock Units Description
Description of stock units issued
Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Effect of exchange rate changes on cash
Effect of Exchange Rate on Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Unrecognized Tax Benefits Increases Decrease Resulting From Prior Period Tax Positions
Unrecognized tax benefits increases decrease resulting from prior period tax positions.
Additions (reductions) from tax positions taken in prior years
Income Tax Examination, Penalties and Interest Accrued, Total
Tax penalties or accrued interest recorded
Income Tax Examination, Penalties and Interest Accrued
Equipment under capital lease [Member]
Assets Held under Capital Leases [Member]
Jefferies Open Market Sale Agreement [Member]
Jefferies Open Market Sale Agreement [Member]
Jefferies open market sale agreement.
NIDA
National Institute On Drug Abuse [Member]
National Institute on Drug Abuse.
Long-Term Debt, Type
Long-Term Debt, Type [Domain]
Cybersecurity Risk Management Positions or Committees Responsible [Text Block]
Weighted Average Number of Shares Outstanding, Basic, Total
Weighted Average Number of Shares Outstanding, Basic
Weighted average number of common shares outstanding, basic
Shares used in computation of basic net loss per common share [note 10 [i]]
ORCA-V1 Clinical Study Costs
O R C A V1 Clinical Study Costs [Member]
ORCA-V1 Clinical study costs.
Document Information [Line Items]
Aggregate intrinsic value of the exercisable outstanding options
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Additional Number of Securities Called by Warrants or Rights
Additional number of securities called by warrants or rights.
Additional number of shares to be issued accompanying warrants
General and administrative - related parties [note 11]
General And Administrative To Related Parties
General and administrative to related parties.
Reconciliation of Income Tax Attributable to Operations
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Schedule Of Operating Leased Assets [Table]
Schedule of Operating Leased Assets [Table]
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Domain]
Adjustment of fractional shares on reverse stock split
Stock Issued During Period, Shares, Reverse Stock Splits
Accrued paid-in-kind interest
Interest Payable
Cybersecurity Risk Process for Informing Management or Committees Responsible [Text Block]
Proceeds from Issuance of Private Placement
Proceeds from private placement, net of issuance costs [note 10[b]]
Deferred tax assets
Deferred Tax Assets, Net [Abstract]
Subsequent Events
Subsequent Events [Text Block]
Related Party Transactions Disclosure [Text Block]
Related Party Transactions
Cash
Cash
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition, Total
Stock-based compensation expense
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Business Combination, Contingent Consideration, Liability, Current
Current contingent consideration [note 5 and note 6]
Variable Rate
Variable Rate [Domain]
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Change in valuation allowance, Amount
Total stockholders' equity
Beginning Balance
Ending Balance
Equity, Attributable to Parent
Purchase of investments
Payments to Acquire Investments
Payments to Acquire Investments, Total
Purchase of investments
Preferred stock, par value
Preferred Stock, Par or Stated Value Per Share
Lessee, Operating Lease, Existence of Option to Extend [true false]
Lessee, Operating Lease, Existence of Option to Extend [true false]
Debt Prepayment Fee Percentage On Original Aggregate Principal
Debt Prepayment Fee Percentage On Original Aggregate Principal
Prepayment fee percentage on original aggregate principal
Statement of Stockholders' Equity [Abstract]
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Percentage of outstanding shares acquired.
Percentage of Outstanding Shares Acquired
Percentage of outstanding shares acquired
Leasehold improvements and equipment under capital lease [Member]
Leaseholds and Leasehold Improvements [Member]
Leasehold improvements [Member]
Leasehold Improvements [Member]
Entity Address, Address Line Two
Entity Address, Address Line Two
Fair Value Measurements
Fair Value Disclosures [Text Block]
2017 Equity Incentive Plan [Member]
Two Thousands And Seventeen Equity Incentive Plan [Member]
Information pertaining to 2017 equity incentive plan.
Earliest Tax Year [Member]
Earliest Tax Year [Member]
Average days to maturity of Company's portfolio of cash equivalents and marketable securities
Average Period To Maturity For Portfolio Of Cash And Marketable Securities
Average period to maturity for portfolio of cash and marketable securities.
Number of units issued in financing
Number Of Units Issued In Financing
Number of units issued in financing.
Security Owned and Sold, Not yet Purchased Fair Value, Security Name [Domain]
Debt Instrument, Name
Debt Instrument, Name [Domain]
Right-of-use assets obtained in exchange for lease obligations:
Right Of Use Assets Obtained In Exchange For Lease Obligations [Abstract]
Right-of-use assets obtained in exchange for lease obligations.
Measurement Input, Discount Rate [Member]
SVB [Member]
Silicon Valley Bank And S V B Innovation Credit Fund V I I I L P [Member]
Silicon Valley Bank and SVB Innovation Credit Fund VIII, L.P.
Proceeds from financing
Proceeds From Financing
Proceeds from financing.
Deferred tax assets liabilities, valuation allowance
Deferred Tax Assets Liabilities Valuation Allowance
Deferred tax assets liabilities valuation allowance.
Proceeds from Issuance Public Offering
Proceeds from issuance public offering.
Proceeds from June 2025 public offering, net of issuance costs [note 7b]
Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]
Deferred Costs, Noncurrent, Total
Deferred Costs, Noncurrent
Deferred payment
Lease, security deposit payment first anniversary
Lease Security Deposit Year One
Lease security deposit year one.
Plan Name
Plan Name [Domain]
Contingent Consideration.
Contingent Consideration [Member]
Contingent Consideration [Member]
Accounting Policies [Line Items]
Accounting Policies [Line Items]
Accounting policies.
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Entity
Entity [Domain]
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Text Block]
Warrants Issued in May 2019 [Member]
Warrants Issued In May Two Thousand Ninteen [Member]
WarrantsIssuedInMayTwoThousandNinteenMember.
Vancouver Lease Arrangement [Member]
Vancouver Office Operating Lease [Member]
Vancouver Office Operating Lease [Member]
Vancouver office operating lease.
Business Description and Basis of Presentation [Text Block]
Nature of Business, Basis of Presentation and Going Concern Uncertainty
Cybersecurity Risk Management Expertise of Management Responsible [Text Block]
Total Outstanding and Exercisable
Class of Warrant or Right, Outstanding
Tax Period
Tax Period [Axis]
Measurement input, probability of success.
Measurement Input, Probability of Success [Member]
Related and Nonrelated Parties [Axis]
Effective Income Tax Rate Reconciliation, Other Adjustments, Amount
Other, Amount
Class Of Warrant Or Right [Table]
Class of Warrant or Right [Table]
Convertible Debt, Fair Value
Convertible Debt, Fair Value Disclosures
Canada [Member]
Foreign Tax Jurisdiction [Member]
Foreign Tax Jurisdiction [Member]
Income Tax Reconciliation Impact Of Tax Attribute Expirations
Income tax reconciliation impact of tax attribute expirations.
Impact of tax attribute expirations, Amount
Property and Equipment
Property, Plant and Equipment, Policy [Policy Text Block]
February 2024 Registered Direct Offering [Member]
February 2024 registered direct offering.
Accounting Standards Update [Extensible Enumeration]
Research and development tax credits.
Income Tax Reconciliation Tax Credits Research And Development
Research and development tax credits, Amount
Entity Address, City or Town
Entity Address, City or Town
Increase Decrease In Grants Receivable
Increase decrease in grants receivable.
Grant receivable
Business Combination, Contingent Consideration, Liability, Total
Business Combination, Contingent Consideration, Liability
Fair value of the contingent consideration
Contigent consideration [note 6 and note 7]
Security Exchange Name
Security Exchange Name
Regulatory Agency
Regulatory Agency [Axis]
Other, Percent
Effective Income Tax Rate Reconciliation, Other Adjustments, Percent
Property, Plant and Equipment, Gross, Ending Balance
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Total
Cost
Property, Plant and Equipment, Gross
Range eight [Member]
Share Based Compensation Shares Authorized Under Stock Option Plans By Exercise Price Range Eight [Member]
Share based compensation shares authorized under stock option plans by exercise price range eight.
Investments, All Other Investments [Abstract]
Intangibles
Intangible Assets Disclosure [Text Block]
Counterparty Name
Counterparty Name [Axis]
Income (loss) before income taxes
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Additional paid-in capital [Member]
Common Stock Including Additional Paid in Capital [Member]
Conversion Price Percentage Of Average Closing Sale Price
Conversion price percentage of Average closing sale price.
Conversion price percentage of average closing sale price
Measurement Input Type [Domain]
Impairment of Long-Lived Assets
Impairment or Disposal of Long-Lived Assets, Including Intangible Assets, Policy [Policy Text Block]
Antidilutive Securities, Name
Antidilutive Securities, Name [Domain]
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Percent
Other foreign jurisdictions, Percent
Contingent Convertible Debt Agreement [Member]
Contingent Convertible Debt Agreement [Member]
Contingent convertible debt agreement.
Range nine [Member]
Share Based Compensation Shares Authorized Under Stock Option Plans By Exercise Price Range Nine [Member]
Share based compensation shares authorized under stock option plans by exercise price range nine.
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Statistical Measurement
Statistical Measurement [Domain]
Exercise price per Share
Class of Warrant or Right, Exercise Price of Warrants or Rights
Exercise price per share of warrant
Total current assets
Assets, Current
Stock based compensation expense
Share-Based Payment Arrangement, Expense
Document Period End Date
Document Period End Date
Warrants Issued in November 2022 [Member]
Warrants Issued In November Two Thousand Twenty Two [Member]
Warrants Issued In November Two Thousand Twenty Two.
Title of Individual
Title and Position [Axis]
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Domain]
Related Party Transaction Amounts Payable
Related party transaction amounts payable.
Amounts payable
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Percentage Of Voting Power
Percentage of voting power.
Percentage of voting power
December 2020 Public Offering [Member]
December 2020 Public Offering [Member]
December Two Thousand Twenty Public Offering [Member]
December two thousand twenty public offering.
Statement of Financial Position [Abstract]
NIDA/NIH
National Institute On Drug Abuse And National Institutes Of Health [Member]
National institute on drug abuse and national institutes of health.
Maximum maturity period of cash and cash equivalents
Maximum Maturity Period Of Cash And Cash Equivalents
Maximum maturity period of cash and cash equivalents.
Restricted Stock Unit Awards [Member]
Restricted Stock Units (RSUs) [Member]
Restricted Stock Units (RSUs) [Member]
Convertible Debt Agreement [Member]
Convertible Debt Agreement [Member]
Convertible Debt Agreement.
Class of Stock
Class of Stock [Axis]
Deferred Tax Liabilities, Net
Deferred Tax Liabilities, Net
Net deferred tax liabilities
Intellectual Property
In Process Research and Development, Policy [Policy Text Block]
Proceeds from June 2025 public offering exercise of overallotment option, net of issuance costs [note 10b]
Proceeds From Exercise Of Overallotment Option Net Of Issuance Costs
Proceeds from exercise of overallotment option, net of issuance costs.
Cybersecurity Risk Management, Strategy, and Governance [Line Items]
Expiration date
Warrants and Rights Outstanding, Maturity Date
Enactment of new tax laws, Percent
Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Percent
Total liabilities
Liabilities
Intangible assets, Fair Value
Finite-Lived Intangible Assets, Fair Value Disclosure
US Government Securities [Member]
US Government Debt Securities [Member]
Range three [Member]
Share Based Compensation Shares Authorized Under Stock Option Plans By Exercise Price Range Three [Member]
Share based compensation shares authorized under stock option plans by exercise price range three.
Financial Instruments [Domain]
At-the-Market Sales Agreement [Member]
At Market Sales Agreement [Member]
At-the-Market Sales Agreement.
Loss on disposal of property and equipment
Payments on Loss on Disposal of Property and Equipment
Payments on loss on disposal of property and equipment.
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Amount
Other foreign jurisdictions, Amount
Lessee, Operating Lease, Liability, to be Paid, Year Two
2027
Variable Rate
Variable Rate [Axis]
Finite-Lived Intangible Assets, Gross, Total
Intangible assets, Gross Carrying Value
Finite-Lived Intangible Assets, Gross
May 2023 Private Placement [Member]
May 2023 private placement.
Grant.
Government Grants
Grant Policy [Text Block]
Weighted Average Number of Shares Outstanding, Diluted, Total
Weighted Average Number of Shares Outstanding, Diluted
Weighted average number of common shares outstanding, diluted
Shares used in computation of Diluted net loss per common share [note 10 [i]]
Aggregate principal amount of term loan advances extended percentage
Extended Percentage Of Aggregate Principal Amount Of Term Loan Advances
Extended percentage of aggregate principal amount of term loan advances.
Entity File Number
Entity File Number
Accounting Standards Update 2023-07 [Member]
ASU 2023-07 [Member]
Cover [Abstract]
Cover
Measurement Input Type [Axis]
Prepaid expenses and other assets
Prepaid Expense and Other Assets, Current
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Number of Shares, Cancelled/Forfeited
Non-Convertible Term Loans [Member]
Non Convertible Term Loans [Member]
Non-convertible term loans.
Contractual Obligation Fiscal Year Maturity Schedule [Line Items]
Contractual Obligation Fiscal Year Maturity Schedule [Line Items]
Contractual obligation fiscal year maturity schedule.
Number of operating segments
Number of Operating Segments
Sale of Stock
Sale of Stock [Domain]
May 2023 Private Placement [Member]
May Twenty Twenty Three Private Placement [Member]
May twenty twenty three private placement.
Amortization of transaction costs
Amortization of Transaction Cost
Amortization of transaction cost.
Transaction costs
General and Administrative Expense, Total
General and administrative
General and Administrative Expense
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Noncash Item [Abstract]
Business Combination, Contingent Consideration, Liability, Noncurrent
Non-current contingent consideration [note 5 and note 6]
Accrued Liabilities Other To Related Parties Current
Accrued liabilities other to related parties current.
Accrued liabilities other - related parties [note 11]
Operating Leased Assets [Line Items]
Operating Leased Assets [Line Items]
Deferred Tax Assets, Other
Other, net
Short-Term Debt, Type [Domain]
Finite-Lived Intangible Assets, Net, Ending Balance
Finite-Lived Intangible Assets, Net, Beginning Balance
Intangible assets, Net Carrying Value
Finite-Lived Intangible Assets, Net
License agreement [note 4 and note 5]
Conversion price per share
Debt Instrument, Convertible, Conversion Price
Warrants Issued in December 2020 [Member]
Warrants Issued In December Two Thousand Twenty [Member]
Warrants issued In December two thousand twenty.
Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Amount
Enactment of new tax laws, Amount
Consolidated rent and facilities expense
Operating Lease, Expense
Shares issued from purchase agreement with Virtu
Adjustments To Additional Paid In Capital Shares Issued Through At The Market Offering
Adjustments to additional paid in capital shares issued through at-the-market offering.
Gain (Loss) on Extinguishment of Debt
Gain (Loss) on Extinguishment of Debt, Total
Loss on extinguishment of 2023 SVB convertible term loan
Loss on extinguishment of 2023 SVB convertible term loan [note 8]
Loss on extinguishment of 2023 SVB convertible term loan [note 8]
Useful life
Property, Plant and Equipment, Useful Life
Short-Term Debt, Type [Axis]
New Accounting Pronouncements, Policy [Policy Text Block]
Recent Accounting Standards
Summary of Future Minimum Annual Lease Payments
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Dr. Slaoui.
Dr. Slaoui [Member]
Maturity period of liquid investments
Maturity Period Of Highly Liquid Investments To Be Considered As Cash Equivalent
Maturity period of highly liquid investments to be considered as cash equivalent.
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Percent
Other, Percent
Ownership [Axis]
Award vesting period
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Number of Securities Exercised Accompanying Warrants
Number of securities exercised accompanying warrants.
Number of securities exercised accompanying warrants
Percentage of principal amount to be repaid
Debt Instrument, Redemption Price, Percentage of Principal Amount Redeemed
U.S.
Income (Loss) from Continuing Operations before Income Taxes, Domestic
Contractual Obligation Fiscal Year Maturity Schedule [Table]
Contractual Obligation Fiscal Year Maturity Schedule [Table]
Contractual obligation fiscal year maturity schedule table.
Total unrecognized compensation expense related to the Company's restricted stock unit awards
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Debt Instrument, Convertible, Stock Price Trigger
Stock trigger price
Share purchase agreement.
Share Purchase Agreement [Member]
Operating lease, term of contract
Lessee, Operating Lease, Term of Contract
Common Stock, Shares, Outstanding, Ending Balance
Common Stock, Shares, Outstanding, Beginning Balance
Common stock, shares outstanding
Common Stock, Shares, Outstanding
Current portion of long-term obligations [note 12]
Operating Lease, Liability, Current
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Summary of Contractual Obligations
Contractual Obligation, Fiscal Year Maturity [Table Text Block]
Two Thousand Twenty Four Silicon Valley Bank Convertible Debt [Member]
Two thousand twenty four silicon valley bank convertible debt.
2024 SVB Convertible Debt
Cybersecurity Risk Management Processes Integrated [Flag]
Document Transition Report
Document Transition Report
Net deferred tax assets
Deferred tax assets
Deferred Tax Assets, Net
Research and Development Expense, Total
Research and development
Research and Development Expense
Common Stock and Warrants Member
Common stock and warrants.
Common Stock and Warrants [Member]
Lease obligation
Increase Decrease In Lease Obligations
Increase decrease in lease obligations.
Statement of Cash Flows [Abstract]
Expiration Date
Class Of Warrants Or Right Expiration Date
Class of warrants or right expiration date.
Monthly base rent, maximum annual increase
Monthly Base Rental Payments Maximum Annual Increase
Monthly base rental payments maximum annual increase.
Shares issued
Stock Issued During Period, Value, New Issues
Assets
Assets, Fair Value Disclosure [Abstract]
Sale of Stock, Additional Number of Shares to be Issued in Transaction
Sale of stock, additional number of shares to be issued in transaction.
Additional number of shares to be issued as option in part
Stock Based Compensation, Pecent
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent
Common Stock
Equity [Text Block]
Finite Lived Intangible Assets [Line Items]
Finite-Lived Intangible Assets [Line Items]
Beginning Balance, Shares
Ending Balance, Shares
Shares, Issued
Unrecognized tax benefits
Unrecognized Tax Benefits that Would Impact Effective Tax Rate
Summary of Restricted Stock Unit Award Activity
Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]
Other
Deferred Tax Liabilities, Other
Computer equipment [Member]
Computer Equipment [Member]
Cybersecurity Risk Management Processes Integrated [Text Block]
Net Loss
Net loss
Aggregate intrinsic value of the outstanding options
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Shares issued from purchase agreement with Virtu, Shares
Adjustments To Additional Paid In Capital Shares Issued Through At The Market Offering Shares
Adjustments to additional paid in capital shares issued through at-the-market offering shares.
Convertible Debt [Abstract]
Convertible Term Loan Information
Operating loss carryforwards indefinitely
Operating Loss Carryforwards Indefinitely
Operating loss carryforwards indefinitely.
Covenant compliance
Debt Instrument, Covenant Compliance
Warrants and Rights Outstanding, Term
Warrants term
Expected dividend yield
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Contractual Obligation, to be Paid, Year Two and Three, Total
1-3 years
Contractual Obligation, to be Paid, Year Two and Three
Other Address [Member]
Other Address
Operating cash flows from operating leases
Operating Lease, Payments
ASSETS
Assets [Abstract]
Risk-free interest rates
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid expenses and other assets
Related party transaction expenses expected to incur
Related party transaction expenses expected to incur.
Expenses expected to incur
Maximum amount payable under license agreement, tied to milestones
Maximum Required Payment Under License Agreement Upon Completion Of Various Milestones
Maximum required payment under license agreement upon completion of various milestones.
Document Fiscal Year Focus
Document Fiscal Year Focus
Exercise Price Range
Exercise Price Range [Domain]
Investing Activities:
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract]
Exercise Price Range, Upper Range Limit
Share-Based Payment Arrangement, Option, Exercise Price Range, Upper Range Limit
Accounts Payable, Current, Total
Accounts payable
Accounts Payable, Current
Interest Expense, Nonoperating
Interest Expense, Nonoperating, Total
Interest expense [note 8]
Reductions due to lapses of statute of limitations
Unrecognized Tax Benefits, Reduction Resulting from Lapse of Applicable Statute of Limitations
Summary of U.S. and Foreign Components of Income (Loss) before Income Taxes
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
Research and development [Member]
Research and Development Expense [Member]
Gross proceeds from issuance of common stock
Gross Proceeds From Issuance Of Common Stock
Gross proceeds from issuance of common stock.
Research and Development Tax Credits [Member]
Research Tax Credit Carryforward [Member]
Finite-Lived Intangible Asset, Expected Amortization, Year One
2026
Convertible debt
Convertible Debt, Carrying Value
Convertible Debt
Impact of tax attribute expirations, Percent
Effective Income Tax Rate Reconciliation Impact Of Tax Attribute Expirations
Effective income tax rate reconciliation impact of tax attribute expirations.
Accrued clinical liabilities
Accrued Liabilities Clinical Current
Accrued liabilities clinical current.
Conversion Price Percentage Of Closing Trading Share Price
Conversion Price Percentage Of Closing Trading Share Price
Conversion price percentage of closing trading share price
ASU 2020-06 [Member]
Accounting Standards Update 2020-06 [Member]
Fair Value Disclosures [Abstract]
Commitments and Contingencies Disclosure [Abstract]
Canada [Member]
CANADA
2023 SVB Convertible Debt
Two Thousand Twenty Three Silicon Valley Bank Convertible Debt [Member]
Two thousand twenty three silicon valley bank convertible debt.
Lessee, Operating Lease, Liability, to be Paid, Year One
2026
Effective Income Tax Rate Reconciliation [Line Items]
Outstanding balance
Long-Term Line of Credit, Total
Loan amount drawn
Long-Term Line of Credit
Debt Instrument
Debt Instrument [Axis]
Range two [Member]
Share Based Compensation Shares Authorized Under Stock Option Plans By Exercise Price Range Two [Member]
Share based compensation shares authorized under stock option plans by exercise price range two.
Share-Based Payment Arrangement [Abstract]
Receipt of SVB Convertible Term Loan Second Tranche
Receipt of SVB convertible term loan second tranche.
Receipt of 2024 SVB convertible term loan second tranche [note 6 and note 8]
Warrants Issued In February Two Thousand And Twenty Four [Member]
Warrants Issued In February Two Thousand And Twenty Four.
Warrants Issued in February 2024 [Member]
Assets, Fair Value Disclosure, Total
Total assets
Assets, Fair Value Disclosure
Sale of Stock
Sale of Stock [Axis]
Summary of Depreciation on Property and Equipment
Schedule Of Property Plant And Equipment Estimated Useful Life Table [Text Block]
Schedule of property plant and equipment estimated useful life.
Shares issued on conversion of preferred shares
Stock Issued During Period Value Preferred Share Conversion
Stock issued during period value preferred share conversion.
Prepayment fee percentage after second anniversary before maturity
Debt Prepayment Fee Percentage After Second Anniversary And Before Maturity
Debt prepayment fee percentage after second anniversary before maturity.
Net cash provided by (used in) investing activities
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
November 2022 Private Placement [Member]
Private Placement [Member]
Private Placement [Member]
Title of 12(b) Security
Title of 12(b) Security
Deferred tax liabilities
Deferred Tax Liabilities, Net [Abstract]
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Amount
Stock Based Compensation, Amount
Monthly base rental payments.
Monthly base rent
Monthly Base Rental Payments
Weighted Average Exercise Price, Forfeited
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Weighted Average Exercise Price, Cancelled/Forfeited
Weighted Average Exercise Price, Cancelled/Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Money market securities [Member]
Money market securities (cash equivalents) [Member]
Money Market Funds [Member]
Related and Nonrelated Parties [Domain]
Series B Convertible Preferred Stock [Member]
Series B Convertible Preferred Stock [Member]
Series A convertible preferred stock member.
Income Tax
Income Tax Disclosure [Text Block]
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Class of Warrant or Right [Line Items]
Class of Warrant or Right [Line Items]
Document Information [Table]
Debt Instrument, Redemption, Period
Debt Instrument, Redemption, Period [Domain]
Legal Entity
Legal Entity [Axis]
Changes in operating assets and liabilities:
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]
Accrued clinical liabilities
Increase Decrease In Accrued Clinical Liabilities
Increase decrease in accrued clinical liabilities.
Summary of Property and Equipment
Property, Plant and Equipment [Table Text Block]
Number Of Days Option Granted To Purchase Additional Shares
Number of days option granted to purchase additional shares.
Number of days option granted to purchase additional shares
Weighted Average Exercise Price, Beginning Balance
Weighted Average Exercise Price, Ending Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Income Tax Disclosure [Abstract]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value, Recurring and Nonrecurring [Table]
Unrecognized Tax Benefits
Gross unrecognized tax benefits, Beginning Balance
Gross unrecognized tax benefits, Ending Balance
Range one [Member]
Share Based Compensation Shares Authorized Under Stock Option Plans By Exercise Price Range One [Member]
Share based compensation shares authorized under stock option plans by exercise price range one.
UK [Member]
UNITED KINGDOM
Measurement Frequency
Measurement Frequency [Domain]
Income Statement Location
Statement of Income Location, Balance [Axis]
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Trading Symbol
Trading Symbol
Schedule Of Finite Lived Intangible Assets [Table]
Intangible Asset, Finite-Lived [Table]
Property and Equipment
Property, Plant and Equipment Disclosure [Text Block]
Liabilities, Fair Value Adjustment
Common stock aggregate maximum offering amount
Common Stock Aggregate Maximum Offering Amount
Common stock aggregate maximum offering amount.
Years open to examination
Open Tax Year
Related Party Transaction [Table]
Shares issued on exercise of warrants, Shares
Shares Issued On Exercise Of Warrants
Shares issued on exercise of warrants.
Regulatory Assets [Abstract]
Regulatory assets.
Subsequent Event Type
Subsequent Event Type [Axis]
Components of Intangible Assets
Schedule of Finite-Lived Intangible Assets [Table Text Block]
Employee-related Liabilities, Current, Total
Accrued compensation
Employee-related Liabilities, Current
Financing Activities:
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract]
Expected life
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Fair Value, Measurements, Recurring [Member]
Fair Value, Recurring [Member]
Finite-Lived Intangible Assets, Amortization Expense, Maturity Schedule [Abstract]
Finite-Lived Intangible Assets, Amortization Expense, Maturity Schedule [Abstract]
Total
Lessee, Operating Lease, Liability, to be Paid
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent
Research and development tax credits, Percent
Research and development tax credits, Percent
Equity Components
Equity Components [Axis]
Summary of Stock Options Outstanding Regarding Number of Common Shares Issuable upon Exercise of Vested Options
Schedule Of Share Based Compensation Shares Vested Under Stock Option Plans By Exercise Price Range Table [Text Block]
Schedule of share based compensation shares vested under stock option plans by exercise price range.
Nature Of Business And Basis Of Presentation [Table]
Nature Of Business And Basis Of Presentation [Table]
Nature of business and basis of presentation.
Nonoperating Income (Expense)
Total other income (expense)
Equity Component
Equity Component [Domain]
Asset Class
Asset Class [Axis]
Goodwill and Intangible Assets Disclosure [Abstract]
Address Type [Domain]
Contractual Obligation, to be Paid, Year Four and Five, Total
3-5 years
Contractual Obligation, to be Paid, Year Four and Five
Document Annual Report
Document Annual Report
Exercisable Subject to Certain Ownership Limitations [Member]
Exercisable Subject to Certain Ownership Limitations [Member]
Exercisable subject to certain ownership limitations.
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures, Total
Restricted stock unit settlements
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures
Restricted stock unit settlements, Shares
Machinery and equipment [Member]
Machinery and Equipment [Member]
Sweep Account [Member]
Sweep account.
Shares issued under employee share purchase plan, Shares
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Award expiration period
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Depreciation, Depletion and Amortization, Nonproduction, Total
Depreciation, Depletion and Amortization, Nonproduction
Depreciation and amortization [note 4]
Preferred stock, shares designated
Preferred Stock Shares Designated
Preferred stock shares designated.
Effective Income Tax Rate Reconciliation, Tax Contingency, Amount
Effective Income Tax Rate Reconciliation, Tax Contingency, Amount, Total
Changes in unrecognized tax benefits, Amount
Statement of Comprehensive Income [Abstract]
New exercise price per share
Class Of Warrant Or Right New Exercise Price Of Warrants Or Rights
Class of warrant or right new exercise price of warrants or rights.
Warrants issued in April two thousand twenty 1.
Warrants Issued in April 2020 [Member]
Warrants Issued In April Two Thousand Twenty1 [Member]
Maximum [Member]
Maximum [Member]
Entity Addresses, Address Type [Axis]
Debt instrument, liquidity ratio
Debt Instrument, Convertible, Conversion Ratio
Liabilities, Fair Value Disclosure
Total liabilities
Fair value of total financial liabilities
Fair value of total financial liabilities
Statistical Measurement
Statistical Measurement [Axis]
Intangible assets, Accumulated Amortization
Finite-Lived Intangible Assets, Accumulated Amortization
Common Stock, Value, Issued
Common stock, $0.001 par value, 150,000,000 shares authorized, 53,233,988 and 34,685,072 issued and outstanding at December 31, 2025 and December 31, 2024, respectively.
Shares issued on conversion of preferred shares, Shares
Stock Issued During Period Shares Preferred Share Conversion
Stock issued during period shares preferred share conversion.
Loan agreement expiration date
Line of Credit Facility, Expiration Date
Working capital
Working Capital Balance
The capital of a business which is used in its day-to-day trading operations, calculated as the current assets minus the current liabilities.
Number of shares agreed to issue and sell
Sale of Stock, Potential Number of Shares to be Issued in Transaction
Sale of stock, potential number of shares to be issued in transaction.
Deferred Tax Assets, Operating Loss Carryforwards, Total
Deferred Tax Assets, Operating Loss Carryforwards
Net operating loss carryforwards
Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block]
Tax Credit Carryforward
Tax Credit Carryforward [Axis]
University of Bristol [Member]
University Of Bristol [Member]
University of Bristol.
Net unrealized loss on securities
Other Comprehensive Income (Loss), Available-for-Sale Securities Adjustment, Net of Tax, Portion Attributable to Parent
Other Comprehensive Income (Loss), Available-for-Sale Securities Adjustment, Net of Tax, Portion Attributable to Parent, Total
Net unrealized gain (loss) on securities
December 2019 Public Offering [Member]
December2019 Public Offering [Member]
December 2019 public offering.
Domestic state & local income tax, net of federal income tax effect, Percent
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
Amortization of Debt Issuance Costs
Amortization of 2024 SVB convertible term loan transaction costs [note 8]
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]
Share-Based Payment Arrangement, Option, Exercise Price Range [Line Items]
Estimated Future Amortization Expense Related to Intangible Assets
Schedule of Finite-Lived Intangible Assets, Future Amortization Expense [Table Text Block]
Future enacted income tax rate assumed for both Federal and state deferred tax calculations
Future Income Tax Rate Assumed For Deferred Tax Calculations
Future income tax rate assumed for deferred tax calculations.
Warrants Issued in April 2020 [Member]
Warrants Issued In April Two Thousand Twenty [Member]
Warrants issued in April two thousand twenty.
Shares issued on exercise of warrants
Shares Issued On Exercise Of Warrants Value
Shares issued on exercise of warrants value.
Entity Public Float
Entity Public Float
Income Taxes Paid, Net [Abstract]
Non-capital loss carryforwards
Non Capital Gain Loss Carryforwards Amount
Non capital gain loss carryforwards amount.
Summary of Other Information Related to Leases
Schedule Of Supplemental Cash Flows Information Related To Leases Table [Text Block]
Schedule of supplemental cash flows information related to leases.
Lease, security deposit payment two anniversary
Lease Security Deposit Year Two
Lease security deposit year two.
Expected volatility
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Preferred stock, shares authorized
Preferred Stock, Shares Authorized
Total operating expenses
Costs and Expenses
Finite-Lived Intangible Assets by Major Class
Finite-Lived Intangible Assets by Major Class [Axis]
Accounts Payable To Related Parties Current
Accounts payable to related parties current.
Accounts payable - related parties [note 11]
Shares issued on exercise of warrants, Shares
Stock Issued During Period Shares Warrants Exercised
Stock issued during period shares warrants exercised.
Taxes paid related to net share settlement of equity awards
Payment, Tax Withholding, Share-Based Payment Arrangement
Lender Name
Lender Name [Axis]
Repayments of Convertible Debt
Repayment of 2023 SVB convertible term loan [note 7]
Repayment of 2023 SVB convertible term loan [note 6 and note 8]
Fair Value Balance Sheet Grouping Financial Statement Captions [Line Items]
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Cash, Cash Equivalent, and Investment [Table Text Block]
Summary of Cash, Cash Equivalents and Restricted Cash
Effective Income Tax Rate Reconciliation, Cross-Border Tax Effect, Percent
Effective Income Tax Rate Reconciliation, Cross-Border Tax Effect, Percent, Total
Effect of cross-border laws, Percent
Related Party Transaction [Line Items]
Employee Stock [Member]
Employee Stock Purchase Plan
Prepayment fee percentage occurs after first anniversary but on or prior to the second anniversary
Debt Prepayment Fee Percentage Occurs After First Anniversary But On Or Prior To The Second Anniversary
Debt prepayment fee percentage occurs after first anniversary but on or prior to the second anniversary.
Exercise Price Range, Lower Range Limit
Share-Based Payment Arrangement, Option, Exercise Price Range, Lower Range Limit
Entity Registrant Name
Entity Registrant Name
Accrued interest and penalties related to income taxes
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued, Total
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued
Convertible Debt
Debt Disclosure [Text Block]
After 18-Month Anniversary [Member]
After Eighteen Month Anniversary [Member]
After eighteen month anniversary.
Gross Unrealized Losses
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Gross Unrealized Losses
Number of required consecutive days weighted average trading price for cancelation or recall of warrants
Number of Required Consecutive Days Weighted Average Trading Price for Cancelation or Recall of Warrants
Number of required consecutive days weighted average trading price for cancelation or recall of warrants.
Entity Voluntary Filers
Entity Voluntary Filers
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Table]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table]
Finite-Lived Intangible Asset, Expected Amortization, Year Two
2027
Other Nonoperating Income (Expense), Total
Other Nonoperating Income (Expense)
Other income (expense)
Exercise Price Range, Weighted Average Vested Price
Share-Based Payment Arrangement, Option, Exercise Price Range, Exercisable, Weighted Average Exercise Price
Subsequent Events [Abstract]
Cybersecurity Risk Management Positions or Committees Responsible [Flag]
Finite-Lived Intangible Asset, Expected Amortization, Year Three
2028
Measurement Frequency
Measurement Frequency [Axis]
June 2025 public offering exercise of overallotment option [Member]
June 2025 public offering exercise of overallotment option [Member]
Proceeds from issuance of common stock
Proceeds from Issuance of Common Stock
Proceeds from offering, net of issuance costs [note 11[b]]
EXPENSES
Costs and Expenses [Abstract]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Restricted Stock Unit Awards
Compensation Related Costs, Policy [Policy Text Block]
Liability Class [Axis]
Liability Class
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Accumulated other comprehensive income
Accumulated Other Comprehensive Income (Loss), Net of Tax
Schedule of Aggregate Fair Value of Principal Amount of Convertible Debt
Convertible Debt [Table Text Block]
Payments under license agreement
Payments Under License Agreement
Payments under license agreement.
Payments to Acquire Property, Plant, and Equipment, Total
Purchase of property and equipment
Payments to Acquire Property, Plant, and Equipment
Number of Shares, Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Total assets
Assets
Schedule Of Property Plant And Equipment [Table]
Property, Plant and Equipment [Table]
Income Tax Paid, State and Local, after Refund Received
Income Tax Paid, State and Local, after Refund Received, Total
State and local
Underwriting Member
Underwriting.
Underwriting [Member]
Fair Value of Financial Instruments
Fair Value of Financial Instruments, Policy [Policy Text Block]
Exercise Price Range, Weighted Average Remaining Contractual Term
Share-Based Payment Arrangement, Option, Exercise Price Range, Exercisable, Weighted Average Remaining Contractual Term
Stock-Based Compensation
Share-Based Payment Arrangement [Policy Text Block]
Subscription Agreements Executed In November Two Thousand Twenty Two [Member]
Subscription Agreements Executed In November Two Thousand Twenty Two [Member]
Subscription Agreements Executed In November Two Thousand Twenty Two.
Common stock, shares issued
Shares issued, Shares
Stock Issued During Period, Shares, New Issues
Number of Shares, Released
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Earnings Per Share, Diluted, Total
Net loss per common share, diluted
Earnings Per Share, Diluted
Diluted net loss per common share [note 10 [i]]
Accounts payable
Increase (Decrease) in Accounts Payable, Trade
Title of Individual
Title and Position [Domain]
Property, Plant, and Equipment, Useful Life, Term, Description [Extensible Enumeration]
City Area Code
City Area Code
Schedule of Changes in Fair Value of Liabilities [Table Text Block]
Schedule of changes in fair value of liabilities.
Schedule of Changes in Fair Value of Level 3 Financial Liabilities
Before 18-Month Anniversary [Member]
Before Eighteen Month Anniversary [Member]
Before eighteen month anniversary.
2024 Equity Inducement Plan [Member]
Two Thousand Twenty Four Equity Incentive Plan [Member]
Two thousand twenty four equity incentive plan.
Annual rent expense
Payments for Rent
Other comprehensive income
Other Comprehensive Income (Loss), Net of Tax
Total other comprehensive income (loss)
Auditor Name
Auditor Name
Nature Of Business And Basis Of Presentation [Line Items]
Nature Of Business And Basis Of Presentation [Line Items]
Nature of business and basis of presentation.
License Agreements [Member]
Licensing Agreements [Member]
Convertible debt principal amount
Convertible Debt, Principal Amount
Debt Instrument, Face Amount
Prepaid Expenses And Other Assets Related Parties Current
Prepaid expenses and other assets related parties current.
Prepaid expenses and other assets - related parties [note 11]
Counterparty Name
Counterparty Name [Domain]
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount
Research and development tax credits, Amount
Research and development tax credits, Amount
Commercial Paper Marketable Securities [Member]
Commercial paper marketable securities.
Commercial paper (marketable securities) [Member]
Convertible Debt, Noncurrent
Non-current portion of convertible debt [note 6 and note 8]
Number of Days Prior Notice to Increase or Decrease Ownership Limitation on Warrants
Number of days prior notice to increase or decrease ownership limitation on warrants.
Number of days prior notice to increase or decrease ownership limitation on warrants
Shares issued under employee share purchase plan
Stock Issued During Period, Value, Employee Stock Purchase Plan
Costs relating to financing and purchase agreement
Adjustments To Additional Paid In Capitals Additional Costs To Financings Charged To A P I C
Adjustments to additional paid in capitals additional costs to financings charged to APIC.
Weighted Average Remaining Lease Term Operating leases
Operating Lease, Weighted Average Remaining Lease Term
Silicon Valley Bank And Lender [Member]
Silicon Valley Bank And Lender [Member]
SVB and Lender [Member]
Warrants issued in April two thousand twenty 2.
Warrants Issued in April 2020 [Member]
Warrants Issued In April Two Thousand Twenty2 [Member]
Initial term of lease expiration date
Lease Expiration Date
Other, Percent
Effective Income Tax Rate Reconciliation, Tax Credit, Other, Percent
Other, Percent
Common stock, price per unit
Common Stock Price Per Unit
Common stock price per unit
Cash Equivalents
Cash and Cash Equivalents, Policy [Policy Text Block]
Net Book Value
Property, Plant and Equipment, Net
Goodwill
Goodwill and Intangible Assets, Goodwill, Policy [Policy Text Block]
Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures, Total
Restricted stock unit settlements
Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures
Impairment of intangible assets
Impairment of Intangible Assets, Finite-Lived
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Cash, cash equivalents and restricted cash at beginning of year
Cash, cash equivalents and restricted cash at end of year
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation
Corporate Bond Securities [Member]
Corporate Bonds [Member]
Accretion Of Discount On Modification Of Debt
Accretion of discount on modification of debt.
Accretion of discount on modification of debt [note 8]
Summary of Years Open to Examination Under Different Jurisdiction
Summary of Income Tax Examinations [Table Text Block]
Accumulated deficit [Member]
Retained Earnings [Member]
Cash and Cash Equivalents [Axis]
Share-Based Payment Arrangement, Noncash Expense, Total
Total stock-based compensation
Share-Based Payment Arrangement, Noncash Expense
Stock-based compensation [note 10[c], note 10[d], note 10[e]] and note 10[f]]
Operating loss carryforwards expiration year
Operating Loss Carryforwards Expiration Year
Operating loss carryforwards expiration year.
Financing costs relating to purchase agreement with Lincoln Park Capital
Payments of Stock Issuance Costs
Placement agent fees and offering expenses
Government Grant
Government Grants [Text Block]
Government grants.
Minimum market capitalization
Minimum Market Capitalization
Minimum market capitalization.
Weighted Average Discount Rate Operating leases
Operating Lease, Weighted Average Discount Rate, Percent
Long-term obligations [note 12]
Operating Lease, Liability, Noncurrent
Level 1 [Member]
Fair Value, Inputs, Level 1 [Member]
Net cash provided by financing activities
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
Proceeds from Issuance of Registered Direct Offering
Proceeds from issuance of registered direct offering.
Proceeds from registered direct offering, net of issuance costs
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Auditor Location
Auditor Location
Rule10b51ArrModifiedFlag
Rule10b51ArrModifiedFlag
Summary of Outstanding Warrants
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
OTHER INCOME (EXPENSE)
Nonoperating Income (Expense) [Abstract]
Convertible Term Loan [Member]
Convertible Term Loan [Member]
Convertible term loan.
Income Tax Authority
Income Tax Jurisdiction [Domain]
Entity Interactive Data Current
Entity Interactive Data Current
Income Statement Location
Statement of Income Location, Balance [Domain]
Restricted stock unit settlements withheld and retired to treasury
Stock Issued During Period Value Restricted Stock Unit Settlement Withheld And Retired To Treasury
Stock issued during period value restricted stock unit settlement withheld and retired to treasury.
Operating Activities:
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]
Furniture and fixtures [Member]
Furniture and Fixtures [Member]
Vancouver, British Columbia [Member]
BRITISH COLUMBIA
Cash Equivalents, at Carrying Value, Total
Cash equivalents, amortized cost and estimated fair value
Cash equivalents
Cash Equivalents, at Carrying Value
Entity Tax Identification Number
Entity Tax Identification Number
Prepaid Expenses Related Party
Prepaid expenses related party.
Prepayment of expenses
Lincoln Park Capital Fund L L C
Lincoln Park Capital Fund L L C [Member]
Lincoln Park Capital Fund, LLC.
NonRule10b51ArrModifiedFlag
NonRule10b51ArrModifiedFlag
Long-Term Debt, Type
Long-Term Debt, Type [Axis]
SVB convertible debt refinancing discount
Adjustment to Additional Paid in Capital Convertible Debt Refinancing Discount
Adjustment to additional paid in capital convertible debt refinancing discount.
Number of development agreements
Number of development agreements.
Summary of Stock Options Activity
Schedule of Stock Options Roll Forward [Table Text Block]
Local Phone Number
Local Phone Number
Income taxes.
Income Taxes [Table]
Income Taxes [Table]
Share-Based Payment Arrangement, Option, Exercise Price Range, Shares Outstanding, Ending Balance
Share-Based Payment Arrangement, Option, Exercise Price Range, Shares Outstanding, Beginning Balance
Exercise Price Range, Number of Outstanding Options
Share-Based Payment Arrangement, Option, Exercise Price Range, Shares Outstanding
Debt Instrument Convertible Threshold Percentage Of Conversion Amount Of Debt
Debt instrument convertible threshold percentage of conversion amount of debt.
Threshold percentage of conversion amount of debt
Prime Rate Minus 1.0% [Member]
Prime Rate Minus One Percentage [Member]
Prime rate minus one percentage.
Unrecognized compensation expense related to stock options granted
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Denominator
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Auditor Opinion [Text Block]
Auditor Opinion
New Employee Inducement Grants [Member]
New Employee Inducement Grants [Member]
New employee inducement grants.
Accounting Policies [Abstract]
Numerator
Net Income (Loss) Attributable to Parent [Abstract]
Additional Number of Securities Underwriters Exercised by Warrants or Rights
Additional Number of Securities Underwriters Exercised by Warrants or Rights
Additional number of securities underwriters exercised by warrants or rights in part
Cash and Cash Equivalents [Member]
Class of Stock
Class of Stock [Domain]
Debt Conversion, Description
Debt conversion description
Commercial Paper [Member]
Commercial Paper [Member]
Commercial paper (short term investments) [Member]
Common shares reserved for issuance under incentive plan
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Weighted-average period, restricted stock awards
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Cash, Cash Equivalents, and Short-Term Investments
Cash, Cash Equivalents, and Short-Term Investments, Total
Cash, cash equivalents and short-term investments
Warrants Issued in December 2019 [Member]
Warrants Issued In December Two Thousand Nineteen [Member]
Warrants issued in december two thousand nineteen.
Less than 1 year
Contractual Obligation, to be Paid, Year One
Entity Emerging Growth Company
Entity Emerging Growth Company
Tax Credit Carryforward, Name
Tax Credit Carryforward, Name [Domain]