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Note 8 - Stockholders' Equity (Details Textual) $ / shares in Units, $ in Millions								1 Months Ended			12 Months Ended		18 Months Ended
	Sep. 10, 2025 USD ($) $ / shares shares	Apr. 02, 2025 USD ($) $ / shares shares	Jun. 24, 2024 shares	May 31, 2024 shares	Jan. 22, 2024 USD ($) shares	Jan. 17, 2024 USD ($) $ / shares shares	Jun. 16, 2020 shares	Oct. 31, 2025 USD ($) $ / shares shares	Sep. 30, 2025 $ / shares shares	Jan. 31, 2011 shares	Dec. 31, 2025 $ / shares shares	Dec. 31, 2024 $ / shares shares	Dec. 31, 2023 shares	Sep. 07, 2025 $ / shares	Dec. 29, 2022 $ / shares	Dec. 31, 2011
Stock, Shares Authorized (in shares)											210,000,000
Common Stock, Shares Authorized (in shares)											200,000,000	200,000,000
Common Stock, Par or Stated Value Per Share (in dollars per share) \| $ / shares		$ 0.001									$ 0.001	$ 0.001		$ 0.001
Preferred Stock, Shares Authorized (in shares)											10,000,000
Preferred Stock, Par or Stated Value Per Share (in dollars per share) \| $ / shares											$ 0.001
Preferred Stock, Shares Issued (in shares)											0
Preferred Stock, Shares Outstanding (in shares)											0
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number											2,610,477	1,786,900	893,321
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross											919,781	1,053,612
Restricted Stock Units (RSUs) [Member]
Share-Based Payment Arrangement, Shares Withheld for Tax Withholding Obligation (in shares)													0
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period											158,966	176,768
2011 Equity Incentive Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other Than Options, Outstanding (in shares)										93,750,000,000
Stock Option Plan Option Reserve Annual Increase as Percentage of Outstanding Shares Allowed																4.00%
The 2020 Equity Incentive Plan [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized (in shares)							275,000
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized			1,400,000
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant											1,954,964
Inducement Grant [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized (in shares)				217,000
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross				185,000
Inducement Grant [Member] \| Restricted Stock Units (RSUs) [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period				32,000
Employee Stock Purchase Plan (ESPP) [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized (in shares)							245,000,000,000
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized			100,000
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant			445,000
Maximum [Member] \| 2011 Equity Incentive Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares to be Added (in shares)							744,608
Maximum [Member] \| The 2020 Equity Incentive Plan [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized (in shares)			4,561,395
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period							10 years
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number			744,608
September 2025 Prefunded Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)	5,845,455								5,845,455
Class of Warrant or Right, Issued During Period, Price Per Warrant (in dollars per share) \| $ / shares	$ 0.549								$ 0.549
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) \| $ / shares	$ 0.001								$ 0.001						$ 0.001
Pre-funded Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)		4,999,316						1,706,484
Class of Warrant or Right, Issued During Period, Price Per Warrant (in dollars per share) \| $ / shares		$ 0.585						$ 0.585
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) \| $ / shares		$ 0.001						$ 0.001
Prefunded 2024 Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)					7,792,208
Proceeds from Issuance of Warrants \| $					$ 6.0
Prefunded 2024 Warrants [Member] \| Maximum [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) \| $ / shares						$ 1.11
Prefunded 2024 Warrants [Member] \| Minimum [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) \| $ / shares						$ 0.77
September 2025 Private Placement, First Closing [Member]
Stock Issued During Period, Shares, New Issues (in shares)	25,036,360
Shares Issued, Price Per Share (in dollars per share) \| $ / shares	$ 0.55
Proceeds from Issuance or Sale of Equity \| $	$ 17.0
September 2025 Purchasers [Member] \| Scenario, Plan [Member]
Proceeds from Issuance or Sale of Equity \| $	$ 12.0
September 2025 Private Placement, Second Closing [Member] \| Scenario, Plan [Member]
Private Placement, Covenant to Trigger Sale, Share Price (in dollars per share) \| $ / shares	$ 0.6875
April 2025 Private Placement, First Closing [Member]
Stock Issued During Period, Shares, New Issues (in shares)		3,405,118
Shares Issued, Price Per Share (in dollars per share) \| $ / shares		$ 0.586
Proceeds from Issuance or Sale of Equity \| $		$ 4.9
April 2025 Private Placement, Second Closing [Member]
Stock Issued During Period, Shares, New Issues (in shares)								1,023,890
Shares Issued, Price Per Share (in dollars per share) \| $ / shares								$ 0.586
Proceeds from Issuance or Sale of Equity \| $								$ 1.6
Private Placement, Covenant to Trigger Sale, Share Price (in dollars per share) \| $ / shares											$ 0.7325
Private Placement, Covenant to Trigger Sale, Patients Enrolled											17
April 2025 Private Placement, Second Closing [Member] \| Maximum [Member]
Proceeds from Issuance or Sale of Equity \| $								4.1
April 2025 Private Placement, Third Closing [Member]
Private Placement, Covenant to Trigger Sale, Share Price (in dollars per share) \| $ / shares											$ 0.7325
Private Placement, Covenant to Trigger Sale, Patients Enrolled											35
April 2025 Private Placement, Third Closing [Member] \| Maximum [Member]
Proceeds from Issuance or Sale of Equity \| $								$ 4.1
The January 2024 Private Placement [Member]
Proceeds from Issuance or Sale of Equity \| $						$ 6.0
Additional Proceeds from Issuance of Equity Pending Positive Clinical Trial \| $						10.0
Additional Proceeds from Issuance of Equity Pending Share Price Milestone \| $						2.0
The January 2024 Private Placement [Member] \| Pivotal Trail Milestone [Member]
Proceeds from Issuance of Common Stock \| $						10.0
The January 2024 Private Placement [Member] \| Pivotal Share Price Milestone [Member]
Proceeds from Issuance of Common Stock \| $						$ 2.0
Sale of Equity, Share Price Milestone \| $ / shares						$ 0.92
The January 2024 Private Placement [Member] \| Prefunded 2024 Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)						7,792,208
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) \| $ / shares						$ 0.001
The January 2024 Private Placement [Member] \| Prefunded 2024 Warrants [Member] \| Pivotal Trail Milestone [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)						12,987,013
The January 2024 Private Placement [Member] \| Prefunded 2024 Warrants [Member] \| Pivotal Share Price Milestone [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)						2,597,402