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Equity Incentive Plans, Equity Inducement Plans, Employee Stock Purchase Plan and Stock-Based Compensation - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands			12 Months Ended
	Sep. 26, 2018	Sep. 25, 2018	Dec. 31, 2025	Dec. 31, 2024	May 31, 2025	Jan. 01, 2025	Feb. 28, 2023	Aug. 31, 2022	Aug. 04, 2021
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Reserved common stock			2,094,228	1,760,456
Expected dividend			0.00%
Weighted-average estimated grant-date fair value of employee stock options granted			$ 6.08	$ 30.73
Restricted Stock Units
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares vesting period			4 years
2018 Equity Incentive Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Reserved common stock		230,000
Annual increase period of common stock reserved for issuance		10 years
Maximum number of shares issuable						412,632
2018 Equity Incentive Plan \| Employee Stock Option
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Total unrecognized compensation cost related to unvested granted			$ 3,300
Remaining unrecognized compensation cost expected to be recognized over weighted-average period			2 years 8 months 12 days
2018 Equity Incentive Plan \| Restricted Stock Units
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Total unrecognized compensation cost related to unvested granted			$ 6,300
Remaining unrecognized compensation cost expected to be recognized over weighted-average period			2 years 1 month 6 days
2018 Equity Incentive Plan \| Employee Stock Purchase Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Unrecognized stock-based compensation expense			$ 26,000
2018 Equity Incentive Plan \| Maximum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Increase in stock reserved for issuance as percentage of capital stock outstanding on last day of preceding year		5.00%
2018 Employee Stock Purchase Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Reserved common stock	23,000
Annual increase period of common stock reserved for issuance	10 years
Maximum number of shares issuable	305,000		52,277	56,517
Shares available for grant			69,816
Shares available for grant, increase						75,000
2018 Employee Stock Purchase Plan \| Maximum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Increase in stock reserved for issuance as percentage of capital stock outstanding on last day of preceding year	1.00%
2021 Equity Inducement Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Reserved common stock									75,000
2018 Equity Incentive Plan and 2021 Equity Inducement Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares available for grant			676,072
Amended and Restated 2021 Equity Inducement Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Reserved common stock			425,000		225,000		50,000	75,000