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Organization and Principal Activities - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands		1 Months Ended	12 Months Ended
	Feb. 09, 2026	Apr. 30, 2024	Dec. 31, 2025	Dec. 31, 2024
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Date of incorporation			Apr. 21, 2003
Reverse stock split			0.1
Accumulated deficit			$ 977,955	$ 786,869
Proceeds from issuance of common stock			0	$ 25,000
Unrestricted cash, cash equivalents and marketable securities			$ 141,400
Headquartered in			South San Francisco
Headquartered in state			CA
Employee Severance \| March and September 2025 Restructuring Plan
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Restructuring plan, percentage of workforce reduction			0.6667%
Minimum
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Period from issuance date of unaudited interim condensed financial statements			12 months
Common Stock
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Shares of common stock				482,738
Common Stock \| BofA Securities, Inc
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Shares of common stock		1,447,876
Offering price		$ 51.79
Proceeds from issuance of common stock		$ 75,000
Common Stock \| Leerink Partners LLC and TD Securities (USA) LLC
Organization Consolidation And Presentation Of Financial Statements [Line Items]
Shares of common stock	7,868,383
Offering price	$ 13.98
Proceeds from issuance of common stock	$ 110,000