Property and equipment, net, consists of the following:


	December 31,
	2025			2024
	(in thousands)
Computer equipment and software	$	1,475		$	1,623
Furniture and office equipment		110			244
Laboratory equipment		23,921			40,251
Leasehold improvements		12,343			24,205
Construction in progress		151			497
Total		38,000			66,820
Less accumulated depreciation and amortization		(27,352	)		(48,630	)
Total property and equipment, net	$	10,648		$	18,190

Depreciation and amortization expense amounted to $7.3 million and $7.2 million for the years ended December 31, 2025 and 2024, respectively.

The Company recognized impairment charges of $0.2 million for the leasehold improvements at its San Carlos facility and a $0.5 million loss on assets held for sales related to property plant and equipment for the year ended December 31, 2025. See Note 11 for additional information.