v3.26.1
Stockholders’ Equity and Stock-Based Compensation - Additional Information (Details)
 1 Months Ended 3 Months Ended 10 Months Ended 12 Months Ended
Feb. 02, 2026
$ / shares
shares
Sep. 16, 2025
USD ($)
$ / shares
shares
Mar. 14, 2025
$ / shares
shares
Feb. 21, 2025
shares
Jan. 15, 2025
Jan. 03, 2025
USD ($)
$ / shares
shares
Oct. 30, 2024
USD ($)
$ / shares
shares
Jul. 04, 2024
USD ($)
$ / shares
shares
Jun. 03, 2024
Installment
$ / shares
shares
Apr. 04, 2024
USD ($)
$ / shares
shares
Mar. 09, 2023
USD ($)
Oct. 06, 2021
shares
Mar. 23, 2021
USD ($)
Aug. 31, 2018
shares
Jan. 31, 2025
USD ($)
shares
Mar. 31, 2026
USD ($)
$ / shares
shares
Dec. 31, 2025
USD ($)
$ / shares
shares
Dec. 31, 2025
USD ($)
$ / shares
shares
Dec. 31, 2024
USD ($)
$ / shares
shares
Dec. 31, 2023
$ / shares
Dec. 31, 2022
Nov. 05, 2025
shares
Jan. 24, 2025
$ / shares
Jan. 01, 2025
USD ($)
$ / shares
Nov. 21, 2022
shares
Aug. 31, 2020
shares
Class of Stock [Line Items]                                                    
Common stock, shares authorized (in shares)                                 400,000,000 400,000,000 400,000,000              
Common stock, par value (in dollars per share) | $ / shares           $ 0.001   $ 0.001   $ 0.001             $ 0.0001 $ 0.0001 $ 0.0001              
Preferred stock, shares authorized (in shares)                                 10,000,000 10,000,000 10,000,000              
Preferred stock, par value (in dollars per share) | $ / shares                                 $ 0.0001 $ 0.0001 $ 0.0001              
Preferred stock, shares outstanding (in shares)                                 0 0 0              
Preferred stock, shares issued (in shares)                                 0 0 0              
Offering price per unit (in dollars per share) | $ / shares                                 $ 3.06 $ 3.06 $ 46.4         $ 18.94    
Reverse stock split, conversion ratio         0.0166                                          
Reverse stock split, multiplier, per share (in dollars per share) | $ / shares                                             $ 9.75      
Number of shares sold (in shares)                             100,000   3,000,000   500,000              
Gross proceeds | $                             $ 1,900,000   $ 9,200,000   $ 21,400,000              
Debt issuance costs | $                                 $ 300,000 $ 300,000 600,000         $ 50,000.00    
Issue stock for employee stock purchase plan (in shares)                                   1,000                
Exercised | $                                   $ 0 0              
Granted (in shares)                                   150,000                
Granted (in dollars per share) | $ / shares                                   $ 3.49                
Historical stock volatility in the expected volatility                                 100.00% 100.00%                
Unrecognized compensation cost | $                                 $ 2,500,000 $ 2,500,000                
Unrecognized compensation cost related to outstanding employee options, period for recognition (in years)                                   1 year 2 months 12 days                
Offering expenses on sale of common stock and warrants | $                                   $ 2,122,000 $ 2,953,000              
Warrants to purchase, fair value preferred stock (in dollars per share) | $ / shares                                 $ 13.22 $ 13.22 $ 91.34 $ 262.61            
Warrant expiration period                                 5 years 5 years                
Proceeds from offering | $   $ 10,000,000                                                
Reverse stock split, description                                   On January 15, 2025, the Company held a Special Meeting of Stockholders (the “2025 Special Meeting”), and obtained stockholder approval for the issuance of the shares of common stock issuable upon exercise of the October Purchase Warrants and approval, at the discretion of the Company’s board of directors, of a reverse stock split of the Company’s common stock at a ratio of between 1-for-25 and 1-for-75. On January 15, 2025, the Company’s board of directors approved a reverse stock split at a ratio of 1-for-60, and on January 24, 2025, the Company filed a certificate of amendment to effect the reverse split ratio chosen by the Company’s board of directors as further described above under the section “Reverse Stock Splits.”                
Pre-Funded Warrant                                                    
Class of Stock [Line Items]                                                    
Warrants to purchase shares (in shares)   50,000                                                
Sale of stock, price per share (in dollars per share) | $ / shares   $ 1.9999                                                
Warrants to purchase, fair value preferred stock (in dollars per share) | $ / shares   $ 0.0001                                                
Series A Warrants                                                    
Class of Stock [Line Items]                                                    
Warrant anniversary period                                 24 months 24 months                
Warrant expiration period                                 60 days 60 days                
Series B Warrants                                                    
Class of Stock [Line Items]                                                    
Warrant anniversary period                                 5 years 5 years                
Warrant expiration period                                 6 months 6 months                
Series C Warrants                                                    
Class of Stock [Line Items]                                                    
Warrant expiration period                                 5 years 5 years                
Series D Warrants                                                    
Class of Stock [Line Items]                                                    
Warrant expiration period                                 18 months 18 months                
Series E Warrants                                                    
Class of Stock [Line Items]                                                    
Gross proceeds | $   $ 20,000,000                                                
Warrants to purchase, fair value preferred stock (in dollars per share) | $ / shares   $ 2                                                
Expected life (in years)   5 years                                                
Series F Warrants                                                    
Class of Stock [Line Items]                                                    
Gross proceeds | $   $ 20,000,000                                                
Warrants to purchase, fair value preferred stock (in dollars per share) | $ / shares   $ 2                                                
Expected life (in years)   18 months                                                
Common Stock                                                    
Class of Stock [Line Items]                                                    
Shares issued in public offering (in shares)                                   8,496,600 968,600              
Number of shares sold (in shares)   4,925,000           195,000                                    
Issue stock for employee stock purchase plan (in shares)                                     500              
Common Stock | Pre-Funded Warrant                                                    
Class of Stock [Line Items]                                                    
Warrants to purchase shares (in shares)   75,000           97,000                           25,000        
Sale of stock, price per share (in dollars per share) | $ / shares   $ 2       15.119   $ 34.259                                    
Common Stock | Subsequently Purchased Warrants                                                    
Class of Stock [Line Items]                                                    
Sale of stock, price per share (in dollars per share) | $ / shares           $ 15.12   $ 34.26                                    
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right           1                                        
Common Stock | Series E Warrants                                                    
Class of Stock [Line Items]                                                    
Warrants to purchase shares (in shares)   5,000,000                                                
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right   1                                                
Common Stock | Series F Warrants                                                    
Class of Stock [Line Items]                                                    
Warrants to purchase shares (in shares)   5,000,000                                                
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right   1                                                
Employee Stock Option                                                    
Class of Stock [Line Items]                                                    
Vested and exercisable (in dollars per share) | $ / shares                                   $ 3.14 $ 39.48              
Vested and expected to vest (in years)                                   10 years                
Vesting period (in years)                                   4 years                
Share-based compensation arrangement by vested and exercisable (in years)                 4 years                                  
RSUs                                                    
Class of Stock [Line Items]                                                    
Vesting period (in years)                 48 months                     4 years 2 years          
Granted (in shares)                                   0                
Share-based compensation arrangement by vested and exercisable (in years)                 4 years                                  
Fair value, vested | $                                   $ 500,000 $ 700,000              
Weighted average remaining contractual term (in years)                                   2 years 1 month 6 days                
PSUs                                                    
Class of Stock [Line Items]                                                    
Vesting period (in years)                                       4 years            
Granted (in shares)                                   0                
Weighted average remaining contractual term (in years)                                       0 years            
2018 Employee Stock Purchase Plan                                                    
Class of Stock [Line Items]                                                    
Common stock initially reserved for future issuance (in shares)                           300                        
Incremental rate at which the shares reserved for issuance increase (as a percent)                           1.00%                        
2018 Employee Stock Purchase Plan | Maximum                                                    
Class of Stock [Line Items]                                                    
Common stock initially reserved for future issuance (in shares)                           400                        
Registered Direct Offering                                                    
Class of Stock [Line Items]                                                    
Sale of stock, consideration received per transaction | $                   $ 10,000,000                                
Sale of stock, consideration received on transaction | $                   9,300,000                                
Offering expenses on sale of common stock and warrants | $                   $ 700,000                                
Registered Direct Offering | Pre-Funded Warrant                                                    
Class of Stock [Line Items]                                                    
Ownership percentage limit (as a percent)                   4.99%                                
Ownership percentage limit, election of holder (as a percent)                   9.99%                                
Registered Direct Offering | Common Stock                                                    
Class of Stock [Line Items]                                                    
Number of shares sold (in shares)           382,000 165,000     109,000                                
Registered Direct Offering | Common Stock | Pre-Funded Warrant                                                    
Class of Stock [Line Items]                                                    
Warrants to purchase shares (in shares)                   37,000                                
Sale of stock, price per share (in dollars per share) | $ / shares                   $ 68.64                                
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right               1   1                                
Warrants to purchase, fair value preferred stock (in dollars per share) | $ / shares               $ 0.001   $ 0.001                                
Registered Direct Offering | Common Stock | Subsequently Purchased Warrants                                                    
Class of Stock [Line Items]                                                    
Warrants to purchase shares (in shares)                   146,000                                
Sale of stock, price per share (in dollars per share) | $ / shares             $ 18.234     $ 68.7                                
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right             1 1   1                                
Warrants to purchase, fair value preferred stock (in dollars per share) | $ / shares                   $ 61.2                                
Expected life (in years)                   5 years                                
Registered Direct Offering | Common Stock | Series C Warrants                                                    
Class of Stock [Line Items]                                                    
Warrants to purchase shares (in shares)           280,000 165,000                                      
Registered Direct Offering | Common Stock | Series D Warrants                                                    
Class of Stock [Line Items]                                                    
Warrants to purchase shares (in shares)           661,000 165,000                                      
Private Placement                                                    
Class of Stock [Line Items]                                                    
Sale of stock, consideration received per transaction | $           $ 10,000,000   $ 10,000,000                                    
Sale of stock, consideration received on transaction | $             $ 3,000,000 9,300,000                                    
Offering expenses on sale of common stock and warrants | $               $ 700,000                                    
Private Placement | Common Stock | Series A Warrants                                                    
Class of Stock [Line Items]                                                    
Warrants to purchase shares (in shares)               292,000                                    
Private Placement | Common Stock | Series B Warrants                                                    
Class of Stock [Line Items]                                                    
Warrants to purchase shares (in shares)               292,000                                    
Private Placement | Maximum                                                    
Class of Stock [Line Items]                                                    
Sale of stock, consideration received on transaction | $           $ 10,000,000 $ 6,000,000 $ 20,000,000                                    
2018 Equity Incentive Plan                                                    
Class of Stock [Line Items]                                                    
Common stock initially reserved for future issuance (in shares)                           2,500                        
Number of new shares issued under plan (in shares)                           1,700                        
Incremental rate at which the shares reserved for issuance increase (as a percent)                                   5.00%                
2020 Inducement Plan | Common Stock                                                    
Class of Stock [Line Items]                                                    
Common stock reserved for issuance (in shares)                                                 6,900 3,500
Additional common stock reserved for issuance (in shares)                       1,700                            
Forecast                                                    
Class of Stock [Line Items]                                                    
Offering price per unit (in dollars per share) | $ / shares                               $ 1.3                    
Number of shares sold (in shares)                               400,000                    
Gross proceeds | $                               $ 600,000                    
Debt issuance costs | $                               $ 20,000.00                    
Cowen                                                    
Class of Stock [Line Items]                                                    
Aggregate offering price | $                     $ 200,000,000   $ 350,000,000                          
Commission fee (as a percent)                         3.00%                          
Wainwright                                                    
Class of Stock [Line Items]                                                    
Commission fee (as a percent)       3.00%                                            
Number of shares sold (in shares)       75,000,000                                            
Authorized for future stock awards, option grants, or employee stock purchase program | 2018 Equity Incentive Plan                                                    
Class of Stock [Line Items]                                                    
Common stock initially reserved for future issuance (in shares)                                 14,000 14,000                
Authorized for future stock awards, option grants, or employee stock purchase program | 2020 Inducement Plan                                                    
Class of Stock [Line Items]                                                    
Common stock initially reserved for future issuance (in shares)                                 35,000 35,000                
Executive Officer                                                    
Class of Stock [Line Items]                                                    
Granted (in shares)     41,000           8,000                                  
Granted (in dollars per share) | $ / shares     $ 3.47           $ 55.8                                  
Executive Officer | Employee Stock Option                                                    
Class of Stock [Line Items]                                                    
Vesting period (in years)                 48 months                                  
Executive Officer | RSUs                                                    
Class of Stock [Line Items]                                                    
Granted (in dollars per share) | $ / shares                 $ 55.8                                  
Granted (in shares)                 2,000                                  
Number of successive annual installments | Installment                 3                                  
Executive Officer | Subsequent Event                                                    
Class of Stock [Line Items]                                                    
Granted (in shares) 162,000                                                  
Granted (in dollars per share) | $ / shares $ 1.27