v3.26.1
Fair Value Measurements - Narrative (Details)
 3 Months Ended 12 Months Ended
Mar. 28, 2024
USD ($)
Dec. 31, 2025
USD ($)
Dec. 31, 2024
USD ($)
Dec. 31, 2022
USD ($)
Dec. 31, 2025
USD ($)
Dec. 31, 2024
USD ($)
Dec. 31, 2023
USD ($)
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]              
Initial valuation of warrant liability           $ 194,901,000  
Contingent consideration   $ 18,000,000 $ 8,480,000   $ 18,000,000 8,480,000 $ 5,550,000
Derivative liability   18,000,000 8,480,000   18,000,000 8,480,000  
Change in fair value of warrant liability         0 (121,611,000)  
Change in fair value     79,300,000   (9,520,000) 118,681,000  
Warrant liability | Private Placement              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]              
Potential proceeds from future exercise of warrants   0 0   0 0  
Warrant liability   0 0   0 0  
Series C preferred stock | Private Placement              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]              
Net proceeds $ 115,600,000   115,600,000        
AVTX-501              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]              
Maximum aggregate milestone payment       $ 20,000,000.0      
AVTX-007 | Milestone One              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]              
Maximum aggregate milestone payment       6,250,000      
AVTX-007 | Milestone Two              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]              
Maximum aggregate milestone payment       $ 67,500,000      
Royalty payments period       10 years      
AVTX-611              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]              
Maximum aggregate milestone payment       $ 20,000,000.0      
Derivative liability              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]              
Initial valuation of warrant liability           0  
Contingent consideration   18,000,000 8,480,000   18,000,000 8,480,000 5,550,000
Change in fair value         (9,520,000) (2,930,000)  
Derivative liability | AVTX-501              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]              
Initial valuation of warrant liability       $ 3,500,000      
Derivative liability | AVTX-501 | Measurement Input, Probability Of Success              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]              
Derivative liability, measurement input       0.01      
Derivative liability | AVTX-007              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]              
Initial valuation of warrant liability       $ 1,300,000      
Contingent consideration   18,000,000.0     $ 18,000,000.0    
Derivative liability | AVTX-007 | Measurement Input, Probability Of Success              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]              
Derivative liability, measurement input       0.41      
Derivative liability | AVTX-007 | Measurement Input, Sales Forecast Peak              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]              
Change in fair value of warrant liability       $ 1,700,000,000      
Derivative liability | AVTX-007 | Measurement Input, Expected Term              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]              
Derivative liability, measurement input term       6 years 6 months      
Derivative liability | AVTX-501 And AVTX-007              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]              
Initial valuation of warrant liability       $ 4,800,000      
Change in fair value of derivative liability   $ (9,500,000)          
Warrant liability              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]              
Initial valuation of warrant liability $ 194,900,000         194,901,000  
Contingent consideration     $ 0     0 $ 0
Change in fair value           $ 121,611,000  
ES | Derivative liability              
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]              
Initial valuation of warrant liability       $ 5,000,000.0