v3.26.1
Insider Trading Arrangements
 3 Months Ended 12 Months Ended
Dec. 31, 2025
shares
Dec. 31, 2025
shares
Trading Arrangements, by Individual    
Material Terms of Trading Arrangement
During the three months ended December 31, 2025, the following directors and officers had adopted contracts, instructions or written plans for the purchase or sale of our securities as follow:

Name and TitleType of Trading ArrangementAction Taken (Date of Action)Duration or End Date
Aggregate Numbers of Securities to be Sold(1)
Description of Trading Arrangement
Mitchell Chan, DirectorTrading plan intended to satisfy the affirmative defense conditions of Securities Exchange Act Rule 10b5-1(c)Adoption (November 19, 2025)November 30, 2026
42,833(2)
Exercises of vested stock options and sales of shares of the Company’s common stock pursuant to terms of the trading plan
Mittie Doyle, Chief Medical OfficerTrading plan intended to satisfy the affirmative defense conditions of Securities Exchange Act Rule 10b5-1(c)Adoption (November 13, 2025)October 31, 2026186,999Exercises of vested stock options and sales of shares of the Company’s common stock pursuant to terms of the trading plan
Jennifer Riley, Chief Strategy OfficerTrading plan intended to satisfy the affirmative defense conditions of Securities Exchange Act Rule 10b5-1(c)Adoption (November 12, 2025)November 30, 202612,000Exercises of vested stock options and sales of shares of the Company’s common stock pursuant to terms of the trading plan
Christopher Sullivan, Chief Financial OfficerTrading plan intended to satisfy the affirmative defense conditions of Securities Exchange Act Rule 10b5-1(c)Adoption (November 12, 2025)November 30, 2026
138,115(3)
Exercises of vested stock options and sales of shares of the Company’s common stock pursuant to terms of the trading plan
Paul Varki, Chief Legal OfficerTrading plan intended to satisfy the affirmative defense conditions of Securities Exchange Act Rule 10b5-1(c)Adoption (November 12, 2025)June 30, 202692,771Exercises of vested stock options and sales of shares of the Company’s common stock pursuant to terms of the trading plan
(1)Represents the maximum number of shares that may be sold pursuant to the 10b5-1 arrangement. The number of shares sold is dependent on the satisfaction of certain conditions as set forth in the trading plans.
(2)
These shares reflect the aggregate maximum of shares underlying vested stock options and RSUs, including 3,166 RSUs that are expected to vest during the term of the trading plan.
(3)
These shares reflect the aggregate maximum of shares underlying vested stock options and RSUs, including 24,200 RSUs that are expected to vest during the term of the trading plan prior to expected share withholding or sell-to-cover to satisfy tax withholding obligations associated with the expected RSU vest.
  
Non-Rule 10b5-1 Arrangement Adopted false  
Rule 10b5-1 Arrangement Terminated   false
Non-Rule 10b5-1 Arrangement Terminated false  
Mitchell Chan [Member]    
Trading Arrangements, by Individual    
Name Mitchell Chan, Director  
Title Mitchell Chan, Director  
Rule 10b5-1 Arrangement Adopted true  
Adoption Date Adoption (November 19, 2025)  
Expiration Date November 30, 2026  
Arrangement Duration 376 days  
Aggregate Available 42,833 42,833
Mittie Doyle [Member]    
Trading Arrangements, by Individual    
Name Mittie Doyle, Chief Medical Officer  
Title Mittie Doyle, Chief Medical Officer  
Rule 10b5-1 Arrangement Adopted true  
Adoption Date Adoption (November 13, 2025)  
Expiration Date October 31, 2026  
Arrangement Duration 352 days  
Aggregate Available 186,999 186,999
Jennifer Riley [Member]    
Trading Arrangements, by Individual    
Name Jennifer Riley, Chief Strategy Officer  
Title Jennifer Riley, Chief Strategy Officer  
Rule 10b5-1 Arrangement Adopted true  
Adoption Date Adoption (November 12, 2025)  
Expiration Date November 30, 2026  
Arrangement Duration 383 days  
Aggregate Available 12,000 12,000
Christopher Sullivan [Member]    
Trading Arrangements, by Individual    
Name Christopher Sullivan, Chief Financial Officer  
Title Christopher Sullivan, Chief Financial Officer  
Rule 10b5-1 Arrangement Adopted true  
Adoption Date Adoption (November 12, 2025)  
Expiration Date November 30, 2026  
Arrangement Duration 383 days  
Aggregate Available 138,115 138,115
Paul Varki [Member]    
Trading Arrangements, by Individual    
Name Paul Varki, Chief Legal Officer  
Title Paul Varki, Chief Legal Officer  
Rule 10b5-1 Arrangement Adopted true  
Adoption Date Adoption (November 12, 2025)  
Expiration Date June 30, 2026  
Arrangement Duration 230 days  
Aggregate Available 92,771 92,771
Aggregate Maximum Of Shares Underlying Vested Stock Options And RSUs [Member] | Mitchell Chan [Member]    
Trading Arrangements, by Individual    
Aggregate Available 3,166 3,166
Aggregate Maximum Of Shares Underlying Vested Stock Options And RSUs [Member] | Christopher Sullivan [Member]    
Trading Arrangements, by Individual    
Aggregate Available 24,200 24,200