​Exhibit 24.1​ ​LIMITED POWER OF ATTORNEY​ ​FOR SECTION 16 REPORTING OBLIGATIONS​ ​Know all by these presents, that the undersigned hereby makes, constitutes and appoints each of​ ​Yvonne Tran, Donald Shum, and Elizabeth Schauber signing singly and each acting individually, as the​ ​undersigned's true and lawful attorney-in-fact with full power and authority as hereinafter described to:​ ​(1)​ ​execute for and on behalf of the undersigned, in the undersigned's capacity as an​ ​executive officer of Schrödinger, Inc. (the “Company”), Forms 3, 4, and 5 (including any amendments​ ​thereto) in accordance with Section 16(a) of the Securities Exchange Act of 1934, as amended, and the​ ​rules thereunder (the “Exchange Act”);​ ​(2)​ ​do and perform any and all acts for and on behalf of the undersigned which may be​ ​necessary or desirable to prepare, complete and execute any such Form 3, 4, or 5, prepare, complete and​ ​execute any amendment or amendments thereto, and timely deliver and file such form with the United​ ​States Securities and Exchange Commission (the “SEC”) and any stock exchange or similar authority,​ ​including without limitation the filing of a Form ID, Update Passphrase, or any other application​ ​materials to enable the undersigned to gain or maintain access to the Electronic Data Gathering, Analysis​ ​and Retrieval system of the SEC;​ ​(3)​ ​seek or obtain, as the undersigned’s representative and on the undersigned’s behalf,​ ​information regarding transactions in the Company’s securities from any third party, including brokers,​ ​employee benefit plan administrators and trustees, and the undersigned hereby authorizes any such person​ ​to release any such information to such attorney-in-fact and approves and ratifies any such release of​ ​information; and​ ​(4)​ ​take any other action of any type whatsoever in connection with the foregoing which, in​ ​the opinion of such attorney-in-fact, may be of benefit to, in the best interest of, or legally required by, the​ ​undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the​ ​undersigned pursuant to this Power of Attorney shall be in such form and shall contain such terms and​ ​conditions as such attorney-in-fact may approve in such attorney-in-fact's discretion.​ ​The undersigned hereby grants to each such attorney-in-fact full power and authority to do and​ ​perform any and every act and thing whatsoever requisite, necessary, or proper to be done in the exercise​ ​of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned​ ​might or could do if personally present, with full power of substitution or revocation, hereby ratifying and​ ​confirming all that such attorney-in-fact, or such attorney-in-fact's substitute or substitutes, shall lawfully​ ​do or cause to be done by virtue of this power of attorney and the rights and powers herein granted. The​ ​undersigned acknowledges that the foregoing attorneys-in-fact, in serving in such capacity at the request​ ​of the undersigned, are not assuming nor relieving, nor is the Company assuming nor relieving, any of the​ ​undersigned's responsibilities to comply with Section 16 of the Exchange Act. The undersigned​ ​acknowledges that neither the Company nor the foregoing attorneys-in-fact assume (i) any liability for the​ ​undersigned’s responsibility to comply with the requirements of the Exchange Act, (ii) any liability of the​ ​undersigned for any failure to comply with such requirements, or (iii) any obligation or liability of the​ ​undersigned for profit disgorgement under Section 16(b) of the Exchange Act.​ ​This Power of Attorney shall remain in full force and effect until the undersigned is no longer​ ​required to file Forms 3, 4, and 5 with respect to the undersigned's holdings of and transactions in​ ​securities issued by the Company, unless earlier revoked by the undersigned in a signed writing delivered​ ​to the foregoing attorneys-in-fact.​ ​IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as​ ​of this 10​​th​ ​day of March, 2026.​ ​/s Therese Abrams​ ​Name: Therese Abrams​