FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person * Sharma Mani (Last) (First) (Middle) C/O ASTRAZENECA PLC 1 FRANCIS CRICK AVENUE CAMBRIDGE BIOMEDICAL CAMPUS (Street) CAMBRIDGE CB2 0AA (City) (State) (Zip)	2. Date of Event Requiring Statement (Month/Day/Year) 03/18/2026	3. Issuer Name and Ticker or Trading Symbol ASTRAZENECA PLC [ AZN ]
		4. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director 10% Owner X Officer (give title below) Other (specify below) See Remarks	5. If Amendment, Date of Original Filed (Month/Day/Year)
			6. Individual or Joint/Group Filing (Check Applicable Line) X Form filed by One Reporting Person Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Ordinary Shares	31,153.4659	D

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Restricted Stock Units	(1)	(1)	Ordinary Shares	2,996.308	(1)	D
Dividend Equivalent Rights	(2)	(2)	Ordinary Shares	31.297	(2)	D
Employee Stock Option (right to buy)	12/01/2028	06/01/2029	Ordinary Shares	195	123.98 (3)	D

Explanation of Responses:

1. Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer. The RSUs vest on November 16, 2028. Vested ordinary shares will be delivered to the reporting person on November 17, 2028.

2. Dividend equivalent rights accrue on the reporting person's RSUs when and as dividends are paid on the Issuer's ordinary shares and vest along with the RSUs on which they accrued. Each dividend equivalent right converts into one ordinary share of the Issuer on the date of vesting.

3. The exercise price for these options under the Issuer's Savings Related Share Option Scheme is denominated in British pounds sterling at a price of GBP93.64 per ordinary share. The exercise price reported herein was converted from British pounds sterling to United States dollars at a conversion rate of GBP1.0000 to $1.3240 on March 13, 2026 as published by the Board of Governors of the Federal Reserve System. The exercise price is the actual British pounds sterling amount regardless of the exchange rate on the date of exercise.

Remarks:

SVP, Group Controller and Head of Global Finance Services

	/s/ Mani Sharma	03/19/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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