75000 - Document - Document and Entity Information
link:presentationLink
link:calculationLink
link:definitionLink
75010 - Statement - Consolidated Balance Sheets
link:presentationLink
link:calculationLink
link:definitionLink
75020 - Statement - Consolidated Balance Sheets (Parenthetical)
link:presentationLink
link:calculationLink
link:definitionLink
75030 - Statement - Consolidated Statements of Operations
link:presentationLink
link:calculationLink
link:definitionLink
75040 - Statement - Consolidated Statements of Comprehensive Loss
link:presentationLink
link:calculationLink
link:definitionLink
75050 - Statement - Consolidated Statements of Stockholders' Equity
link:presentationLink
link:calculationLink
link:definitionLink
75060 - Statement - Consolidated Statements of Stockholders' Equity (Parenthetical)
link:presentationLink
link:calculationLink
link:definitionLink
75070 - Statement - Consolidated Statements of Cash Flows
link:presentationLink
link:calculationLink
link:definitionLink
75080 - Disclosure - Cybersecurity Risk Management, Strategy, and Governance Disclosure
link:presentationLink
link:calculationLink
link:definitionLink
995457 - Disclosure - Organization and Description of Business Operations
link:presentationLink
link:calculationLink
link:definitionLink
995467 - Disclosure - Significant Accounting Policies
link:presentationLink
link:calculationLink
link:definitionLink
995477 - Disclosure - Fair Value Measurements
link:presentationLink
link:calculationLink
link:definitionLink
995487 - Disclosure - Supplemental Financial Information
link:presentationLink
link:calculationLink
link:definitionLink
995497 - Disclosure - Leases
link:presentationLink
link:calculationLink
link:definitionLink
995507 - Disclosure - Term Loans
link:presentationLink
link:calculationLink
link:definitionLink
995517 - Disclosure - Astellas Agreements
link:presentationLink
link:calculationLink
link:definitionLink
995527 - Disclosure - Research, Collaboration and License Agreements
link:presentationLink
link:calculationLink
link:definitionLink
995537 - Disclosure - Stock-Based Compensation
link:presentationLink
link:calculationLink
link:definitionLink
995547 - Disclosure - Warrants
link:presentationLink
link:calculationLink
link:definitionLink
995557 - Disclosure - Net Loss Per Common Share
link:presentationLink
link:calculationLink
link:definitionLink
995567 - Disclosure - Income Taxes
link:presentationLink
link:calculationLink
link:definitionLink
995577 - Disclosure - Commitments and Contingencies
link:presentationLink
link:calculationLink
link:definitionLink
995587 - Disclosure - Strategic Reprioritization
link:presentationLink
link:calculationLink
link:definitionLink
995597 - Disclosure - Retirement Plan
link:presentationLink
link:calculationLink
link:definitionLink
995607 - Disclosure - Segment Information
link:presentationLink
link:calculationLink
link:definitionLink
995617 - Disclosure - Subsequent Events
link:presentationLink
link:calculationLink
link:definitionLink
995627 - Disclosure - Significant Accounting Policies (Policies)
link:presentationLink
link:calculationLink
link:definitionLink
995637 - Disclosure - Fair Value Measurements (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995647 - Disclosure - Supplemental Financial Information (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995657 - Disclosure - Leases (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995667 - Disclosure - Term Loans (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995677 - Disclosure - Astellas Agreements (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995687 - Disclosure - Stock-Based Compensation (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995697 - Disclosure - Warrants (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995707 - Disclosure - Net Loss Per Common Share (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995717 - Disclosure - Income Taxes (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995727 - Disclosure - Commitments and Contingencies (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995737 - Disclosure - Strategic Reprioritization (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995747 - Disclosure - Segment Information (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995757 - Disclosure - Organization and Description of Business Operations - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995767 - Disclosure - Significant Accounting Policies - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995777 - Disclosure - Significant Accounting Policies - Additional Information (Details 1)
link:presentationLink
link:calculationLink
link:definitionLink
995787 - Disclosure - Fair Value Measurements - Schedule of Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995797 - Disclosure - Supplemental Financial Information - Schedule of Property, Plant and Equipment Net (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995807 - Disclosure - Supplemental Financial Information - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995817 - Disclosure - Supplemental Financial Information - Schedule of Accrued Expenses and Other Current Liabilities (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995827 - Disclosure - Supplemental Financial Information - Schedule of Prepaid Expenses and Other Current Assets (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995837 - Disclosure - Leases - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995847 - Disclosure - Leases - Schedule of Lease Cost (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995857 - Disclosure - Leases - Supplemental Information Related to Remaining Lease Term and Discount Rate (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995867 - Disclosure - Leases - Schedule of Supplemental Cash Flow Information Related to Operating Leases (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995877 - Disclosure - Leases - Schedule of Future Minimum Commitments Under Company's Operating and Finance Leases (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995887 - Disclosure - Leases - Schedule of Future Minimum Commitments Under Company's Operating and Finance Leases (Details) 3
link:presentationLink
link:calculationLink
link:definitionLink
995897 - Disclosure - Leases - Schedule of Aggregate Lease Commitments (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995907 - Disclosure - Term Loans - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995917 - Disclosure - Term Loans - Schedule of Future Principal Debt Payments on Term Loan Agreement (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995927 - Disclosure - Term Loans - Schedule of Reconcile of Change in Fair Value of Debt (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995937 - Disclosure - Astellas Agreements - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995947 - Disclosure - Astellas Agreements - Summary of Allocation for Transaction Price to the Three Performance Obligations (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995957 - Disclosure - Research, Collaboration and License Agreements - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995967 - Disclosure - Stock-Based Compensation - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995977 - Disclosure - Stock-Based Compensation - Schedule of Share Based Compensation Available for Grant under Incentive Plans (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995987 - Disclosure - Stock-Based Compensation - Schedule of Assumptions Used to Estimate Fair Value of Stock Options (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995997 - Disclosure - Stock-Based Compensation - Schedule of Stock Option Activity (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996007 - Disclosure - Stock-Based Compensation - Schedule of Restricted Stock Units Activity (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996017 - Disclosure - Stock-Based Compensation - Schedule of Restricted Stock Awards Activity (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996027 - Disclosure - Stock-Based Compensation - Schedule of Total Stock-Based Compensation Expense for Stock Options, ESPP and RSUs (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996037 - Disclosure - Warrants - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996047 - Disclosure - Warrants - Schedule of Fair Value Method to Allocate Net Proceeds Received from Sale of Common Stock and Pre-funded Warrants (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996057 - Disclosure - Warrants - Schedule of Assumptions Used to Estimate Fair Value of Warrants (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996067 - Disclosure - Warrants - Schedule of Warrant Liability (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996077 - Disclosure - Net Loss Per Common Share - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996087 - Disclosure - Net Loss Per Common Share - Schedule of Calculation of Basic and Diluted Net Loss Per Common Share (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996097 - Disclosure - Net Loss Per Common Share - Schedule of Common Stock Equivalents Outstanding Excluded from Computation of Diluted Net Loss Per Share Attributable to Common Stockholders (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996107 - Disclosure - Income Taxes - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996117 - Disclosure - Income Taxes - Schedule of Reconciliation of Federal Statutory Income Tax Rate (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996127 - Disclosure - Income Taxes - Schedule of Significant Components of Net Deferred Tax Asset (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996137 - Disclosure - Strategic Reprioritization - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996147 - Disclosure - Strategic Reprioritization - Summary of Accrued Severance Activity Recorded (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996157 - Disclosure - Retirement Plan - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996167 - Disclosure - Segment Information - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996177 - Disclosure - Segment Information - Summary of Significant Segment Expenses (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996187 - Disclosure - Subsequent Events - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Vested, Weighted Average Grant Date Fair Value per Share
TSHA-120
Acquisition Of Worldwide Rights For T S H A120 For Treatment Of Giant Axonal Neuropathy [Member]
Acquisition of worldwide rights for TSHA 120 for treatment of giant axonal neuropathy.
Schedule of Revenues from External Customers and Long-Lived Assets [Table]
Finance Lease, Liability
Total lease liabilities
Total lease liabilities
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Finance Lease, Liability, to be Paid, Year Four
2028
Preferred Stock, Shares Issued
Preferred stock, shares issued
Preferred stock, shares issued
Preferred Stock, Shares Issued, Total
Tax Credits:
Effective Income Tax Rate Reconciliation, Tax Credit, Amount [Abstract]
Increase (Decrease) in Accounts Payable
Accounts payable
Increase (Decrease) in Accounts Payable, Total
Success Fees
Success fees.
Success fees
Operating Leases, Future Minimum Payments, Remainder of Fiscal Year
2022
Long-Term Debt, Excluding Current Maturities
Term loan, net
Long-term Debt, Excluding Current Maturities, Total
Plan Name [Axis]
Plan Name
Research and Development Expense [Abstract]
Research and development program expense
Entity Current Reporting Status
Entity Current Reporting Status
Share based compensation arrangement by share based payment award options grants in period intrinsic value.
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Intrinsic Value
Options granted, Aggregate Intrinsic Value
Proceeds from term loan.
Proceeds From Term Loan
Proceeds from term loan
Proceeds from Warrant Exercises
Proceeds from exercise of warrants
Two Thousand Twenty Three Trinity Term Loan Agreement [Member]
Two Thousand Twenty Three Trinity Term Loan Agreement.
2023 Trinity Term Loan Agreement
License For GAN
License For GAN [Member]
Option to obtain license for GAN
Operating Expenses [Abstract]
Operating expenses:
Less:
Level 2
Fair Value, Inputs, Level 2 [Member]
Commitments and Contingencies Disclosure [Text Block]
Commitments and Contingencies
Share based compensation arrangement by share based payment award number of shares available for grant cancelled in period.
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant Cancelled In Period
Forfeitures
Common Stock, Shares Authorized
Common stock, shares authorized
Common stock, shares authorized
Share-Based Payment Arrangement, Tranche Three [Member]
Share-based Payment Arrangement, Tranche Three
Proceeds from Issuance of Common Stock and Pre-funded Warrants from Underwritten Public Offering, Net of Underwriting Discounts and Sales Commissions and Other Offering Costs
Proceeds from issuance of common stock and pre-funded warrants from underwritten public offering, net of underwriting discounts and sales commissions and other offering costs.
Proceeds from issuance of common stock and pre-funded warrants from underwritten public offering, net of underwriting discounts and sales commissions and other offering costs
Product and Service [Axis]
Product and Service
Document Fiscal Period Focus
Document Fiscal Period Focus
Finance Lease, Liability, to be Paid
Total lease payments
Debt Instrument, Interest Rate, Stated Percentage
Percentage of interest rate
ASU 2023-09
Accounting Standards Update 2023-09 [Member]
Entity Shell Company
Entity Shell Company
Inducement Plan
Inducement Plan [Member]
Inducement Plan.
Schedule Of Supplemental Cash Flow Information Related To Operating Leases
Schedule Of Supplemental Cash Flow Information Related To Operating Leases [Table Text Block]
Schedule of Supplemental Cash Flow Information Related to Operating Leases
Other Accrued Liabilities, Current
Other
Debt Instrument, Unamortized Discount, Noncurrent
Exit fee recorded as debt discount
Segment Reporting, Policy [Policy Text Block]
Segments
Cash and Cash Equivalent
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value, Total
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Schedule of Maturities of Long-Term Debt [Table Text Block]
Schedule of Future Principal Debt Payments on Term Loan Agreement
Impairment of long-lived assets
Deferred Tax Assets Impairment of Long-lived Assets
Deferred tax assets impairment of long-lived assets.
License and inventory purchase agreement sales related milestones payment.
License And Inventory Purchase Agreement Sales Related Milestones Payment
License and inventory purchase agreement sales related milestones payment
Abeona Therapeutics Inc.
Abeona Therapeutics Inc [Member]
Abeona
Cybersecurity Risk Management, Strategy, and Governance [Abstract]
Common Stock, Shares, Issued, Total
Common Stock, Shares, Issued
Common stock, shares issued
Cybersecurity Risk Management Positions or Committees Responsible Report to Board [Flag]
Change in fair value of term loan
Change in fair value of term loan
Change in fair value of term loan
Change in fair value of term loan.
Cybersecurity Risk Board of Directors Oversight [Text Block]
Percentage of principal amount of terms regarding fee
Percentage Of Principal Amount Of Terms Regarding Fee
Percentage of principal amount of terms regarding fee.
Statement [Table]
Statement [Table]
Restricted cash, noncurrent
Restricted cash
Restricted Cash, Noncurrent
Right-of-use assets obtained in exchange for lease liabilities
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Assets capitalized as finance leases.
Assets Capitalized as Finance Leases [Member]
Assets Capitalized as Finance Leases
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Share-based payment award, options, weighted-average grant date fair value
Emerging growth company.
Emerging Growth Company Policy [Text Block]
Emerging Growth Company
Statement [Line Items]
Statement [Line Items]
Underwriting agreement member.
Underwriting Agreement Member
Underwriting Agreement
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price
Options expired, Weighted Average Exercise Price
Build-to-suit lease liability.
Build To Suit Lease Liability
Build-to-suit lease liability
SSI Warrants
Warrant [Member]
Entity Filer Category
Entity Filer Category
Liabilities and Equity
Total liabilities and stockholders' equity
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Equipment purchases and build-out of leased facility.
Equipment Purchases And Build Out Of Leased Facility
Equipment purchases and build-out of leased Facility
2028
Long-Term Debt, Maturity, Year Three
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Options exercisable at December 31, 2025, Weighted Average Exercise Price
Restructuring Type [Axis]
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset
Severance Costs
Severance and termination-related costs
Severance paid
Finance Lease, Liability, to be Paid, Year Three
2027
Valuation allowance increased (decreased)
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Schedule of accrued severance activity table text block.
Schedule Of Accrued Severance Activity Recorded [Table Text Block]
Summary of Accrued Severance Activity Recorded
Income Tax Rate Reconciliation Worldwide Changes In Unrecognized Tax Benefits
Income tax rate reconciliation worldwide changes in unrecognized tax benefits.
Worldwide changes in unrecognized tax benefits
Cybersecurity Risk Third Party Oversight and Identification Processes [Flag]
May Twenty Twenty Five Pre Funded Warrants Option One [Member]
May 2025 Pre Funded Warrants Option One.
May 2025 Pre Funded Warrants Option One
Purchase of clinical materials and reimbursement incurred development costs.
Purchase Of Clinical Materials And Reimbursement Incurred Development Costs
Purchase of clinical materials and reimbursement incurred development costs
Cash equivalents - money market funds
Cash and Cash Equivalents, Fair Value Disclosure
Deferred Tax Assets, Valuation Allowance
Valuation allowance
Deferred Tax Assets, Valuation Allowance, Total
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
US Federal Statutory Tax Rate
Purchase price per share of common stock
Shares Issued, Price Per Share
Offering price per share of common stock
Share based compensation arrangement by share based payment award commencement date.
Share Based Compensation Arrangement By Share Based Payment Award Commencement Date
Share-based payment award, commencement date
Subsequent Event [Line Items]
Cybersecurity Risk Management Third Party Engaged [Flag]
Documents Incorporated by Reference [Text Block]
Documents Incorporated by Reference
Other
Other Noncash Income (Expense)
Other
Other Noncash Income (Expense), Total
Effective Income Tax Rate Reconciliation, Percent
Total
Stock Options
Finance Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]
Investment Income, Interest
Interest income
Interest Income
Income Tax Jurisdiction [Axis]
Income Tax Authority
Geographical
Geographical [Domain]
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Restricted Cash
Significant Change in Unrecognized Tax Benefits is Reasonably Possible, Amount of Unrecorded Benefit
Unrecognized tax benefits to change significantly over next 12 months
Trinity Term Loan Agreement
Trinity Term Loan Agreement [Member]
Trinity Term Loan Agreement
Debt instrument, Fair Value at Beginning of 2025 Success Fee
Debt instrument, fair Value at beginning of 2025 success fee.
Beginning fair value balance of 2025 Success Fee on August 7, 2025
Significant Accounting Policies [Text Block]
Significant Accounting Policies
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award, Terms of Award
Share-based payment award, terms of award issuance
Risk-free interest rate
Measurement Input, Risk Free Interest Rate [Member]
Vesting [Domain]
Vesting
Options granted, Stock Options
Share-based payment award, options granted
Options granted for purchase an aggregate share of common stock
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Schedule of Calculation of Basic and Diluted Net Loss Per Common Share
Closing Date through November 13, 2024
Closing Date through November 13, 2024 [Member]
Closing Date through November 13, 2024.
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Amount [Abstract]
Nondeductible items:
Reduced uncertain tax positions related to prior year positions
Decreases Resulting From Prior Period Tax Positions Unrecognized Tax Benefits
Decreases resulting from prior period tax positions unrecognized tax benefits.
Earnings Per Share, Basic, Total
Earnings Per Share, Basic
Net loss per common share, basic
Retirement Benefits [Text Block]
Retirement Plan
Organization and description of business operations.
Organization And Description Of Business Operations [Table]
Organization And Description Of Business Operations [Table]
Outstanding performance and market-based options
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Outstanding, Stock Options, Beginning Balance
Outstanding, Stock Options, Ending Balance
Debt, Policy [Policy Text Block]
Debt Issuance Costs
Liabilities, Current
Total current liabilities
Two Thousand Twenty Five Trinity Term Loan Agreement [Member]
Two Thousand Twenty Five Trinity Term Loan Agreement.
2025 Trinity Term Loan Agreement
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities:
Lessee, Operating Lease, Liability, to be Paid, Year Five
2030
Revenues from External Customers and Long-Lived Assets [Line Items]
Smaller Reporting Company Policy [TextBlock]
Smaller reporting company policy.
Smaller Reporting Company
Inflation Reduction Act, Corporate Alternative Minimum Tax Percentage on Some Large Corporations
Inflation reduction act, corporate alternative minimum tax percentage on some large corporations.
Corporate alternative minimum tax on large corporations
Shelf registration,term
Shelf Registration Term
Shelf Registration,term
Domestic Tax Jurisdiction [Member]
Federal
Tax Credits:
Effective Income Tax Rate Reconciliation, Tax Credit, Percent [Abstract]
Deferred Tax Assets, Tax Deferred Expense, Other
Other
Debt issuance costs for term loan
Payments of Debt Issuance Costs
Accounting Standards Update [Axis]
Accounting Standards Update
Restructuring and Related Cost, Number of Positions Eliminated, Period Percent
Percentage of headcount reduced
Equity, Attributable to Parent [Abstract]
Stockholders' equity
Entity Small Business
Entity Small Business
T S H A 120 For Treatment Of Giant Axonal Neuropathy [Member]
TSHA-120 for treatment of giant axonal neuropathy.
TSHA-120
Commitment fee
Line of Credit Facility, Commitment Fee Amount
Common stock and warrants fair value disclosure
Common Stock and Warrants Fair Value Disclosure
Common stock and warrants fair value disclosure.
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Accumulated deficit
Retained Earnings (Accumulated Deficit), Total
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Ending Balance
Stock and pre-funded warrants issued during period, value, new issues
Stock and pre-funded warrants issued during period, value, new issues.
Issuance of common stock and pre-funded warrants, upon closing of underwritten public offering, net of underwriting discounts and commissions, and other offering costs
Remaining Sales Agents
Remaining Sales Agents [Member]
Remaining Sales Agents.
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Operations Commenced Date
Operating lease commencement date
Options forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Options cancelled or forfeited, Stock Options
Option award, canceled
Two Thousand Twenty Three Success Fee Agreement [Member]
Two Thousand Twenty Three Success Fee Agreement.
2023 Success Fee Agreement
Prepaid clinical trial.
Prepaid Clinical Trial
Prepaid clinical trial
Offering price per share
Sale of Stock, Price Per Share
Warrants, measurement input
Warrants and Rights Outstanding, Measurement Input
Share-Based Payment Arrangement [Text Block]
Stock-Based Compensation
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Remaining balance of debt discount
Remaining Balance of Debt Discount
Remaining balance of debt discount.
Leases [Abstract]
Risks And Uncertainties Policy [Text Block]
Risks and Uncertainties
Risks and uncertainties.
Trinity Refinance Date through August 2026 [Member]
Trinity refinance date through August 2026.
Trinity Refinance Date through August 2026
Lessee, Lease, Description [Line Items]
Amendment Flag
Amendment Flag
Product and Service [Domain]
Product and Service
US Federal Statutory Tax Rate
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
Warrants issued
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Number of Additional Warrants Issued Upon Exercise of Underwriters Option
Number of additional warrants issued upon exercise of underwriters option.
Additional warrants sold upon exercise of underwriters option
Exit and disposal activities.
Exit And Disposal Activities [Member]
Exit and Disposal Activities
Liabilities and Equity [Abstract]
LIABILITIES AND STOCKHOLDERS' EQUITY
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Net cash used in operating activities
Research and development license expense
Research And Development License Expense
Research and development license expense.
Income Tax Payments, Net Of Refunds Received Maximum Percentage
Income tax payments, net of refunds received maximum percentage.
Income tax payments, net of refunds received
Warrants
Warrants Note Disclosure [Text Block]
Warrants note disclosure.
Segment Reporting, CODM, Profit (Loss) Measure, How Used, Description
PIPE Shares
Common Stock [Member]
Common Stock
Cybersecurity Risk Role of Management [Text Block]
Defined Contribution Plan, Employer Discretionary Contribution Amount
Contribution to retirement savings plan
2026
Long-Term Debt, Maturity, Year One
Options granted, Weighted Average Exercise Price
Share-based payment award, options granted, exercise price per share
Weighted-average exercise price
Lessee, Operating Lease, Liability, to be Paid, Year Three
2028
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
August 2023 Private Placement
August Two Thousand And Twenty Three Private Placement [Member]
August two thousand and twenty three private placement.
Escrow Deposit
Amount required to place in escrow account
Underwritten public offering.
Underwritten Public Offering [Member]
Underwritten Public Offering
Percentage of prepayment of facility.
Percentage Of Prepayment Of Facility
Percentage of prepayment of facility
Performance-Based Restricted Stock Units
Performance-Based Restricted Stock Units [Member]
Performance-Based Restricted Stock Units.
Entity Address, Address Line One
Entity Address, Address Line One
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Schedule of Assumptions Used to Estimate Fair Value of Stock Options
Debt issuance costs incurred
Debt Issuance Costs Incurred
Debt issuance costs incurred.
Fair Value Hierarchy and NAV [Axis]
Earnings Per Share [Abstract]
Debt issuance costs expensed under the fair value option
Debt Issuance Costs Expensed under Fair Value Option
Debt issuance costs expensed under fair value option.
Income Taxes
Income Tax, Policy [Policy Text Block]
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Flag]
Supplemental Cash Flow Information [Abstract]
Supplemental disclosure of cash flow information:
May Twenty Twenty Five Pre Funded Warrants Option Two [Member]
May 2025 Pre Funded Warrants Option Two.
May 2025 Pre Funded Warrants Option Two
Durham lease.
Durham Lease [Member]
Durham Lease
Expiration Period
Line of Credit Facility, Expiration Period
Prepayment of long term debt
Prepayment of Long Term Debt
Prepayment of long term debt.
Through March Thirty One Twenty Twenty Nine [Member]
Through March 31,2029.
Through March 31,2029
Share based compensation arrangement by share based payment award equity instruments other than options replacement units grants in period.
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Replacement Units Grants In Period
Replacement restricted units granted, Number of Shares
Number of shares awarded
Effective Income Tax Rate Reconciliation, Nondeductible Expense Change in Fair Value of Warrant Liability and Note
Effective income tax rate reconciliation, nondeductible expense change in fair value of warrant liability and note.
Change in fair value of Warrant Liability and note
Operating Lease, Right-of-Use Asset
Operating lease right-of-use assets
Finance Lease, Liability, Undiscounted Excess Amount
Less: imputed interest
Less: imputed interest
Share-Based Compensation Arrangement by Share-Based Payment Award, Maximum Number of Shares Per Employee
Maximum number of shares employees may purchase during offering period
Deferred Tax Assets, Gross
Total deferred tax assets
Cancelled options.
Cancelled Options [Member]
Cancelled Options
Cybersecurity Risk Board Committee or Subcommittee Responsible for Oversight [Text Block]
Class of Warrant or Right [Axis]
Document Type
Document Type
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Change in fair value
Change in Fair Value of Warrants
Change in fair value of warrants.
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative
Entity Central Index Key
Entity Central Index Key
Available for grant net of reserve - December 31, 2025
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant Net Of Reserve
Share based compensation arrangement by share based payment award number of shares available for grant net of reserve.
Cybersecurity Risk Process for Informing Board Committee or Subcommittee Responsible for Oversight [Text Block]
Build-to-suit lease.
Build To Suit Lease Policy [Text Block]
Build-to-Suit Lease
Build-to-Suit Lease
Net increase (decrease) in cash, cash equivalents and restricted cash
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation
Subsequent Event Type [Domain]
Change in fair value of warrant liability
Change in fair value of warrant liability
Fair Value Adjustment of Warrants
Warrant liability fair value adjustments
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Anti-dilutive securities excluded from computation of diluted net loss per share
Balance Sheet Related Disclosures [Abstract]
Impairment loss on asset held for sale
Impairment of Long-Lived Assets to be Disposed of
Common Stock, Par or Stated Value Per Share
Common stock, par value per share
Accounting Standards Update [Domain]
Accounting Standards Update
Tax credit carryforward expiration or due date year.
Tax Credit Carryforward Expiration Or Due Date Year
Tax credit carryforward expiration or due date year
Proceeds from Issuance of Warrants
Proceeds from issuance of common stock upon exercise of warrants
Share-Based Payment Arrangement, Tranche One [Member]
Share-based Payment Arrangement, Tranche One
Operating Lease, Right-of-Use Asset, Periodic Reduction
Non-cash lease expense
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Outstanding, Weighted Average Remaining Contractual Life
Pre-Funded Warrants
Pre Funded Warrants [Member]
Pre Funded Warrants.
Document Financial Statement Error Correction [Flag]
Operating Leases, Future Minimum Payments, Due in Four Years
2026
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Exercised, Stock Options
Exercised, Stock Options
Issuance of common stock upon exercise of stock options, shares
Debt Disclosure [Abstract]
Combined voting power beneficially owned
Percentage Of Combined Voting Power Beneficially Owned
Percentage of combined voting power beneficially owned.
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Current Fiscal Year End Date
Current Fiscal Year End Date
Schedule of Long-Term Debt Instruments [Table]
Debt Instrument [Table]
Organization and description of business operations.
Organization And Description Of Business Operations [Line Items]
Organization and Description of Business Operations [Line Items]
Percentage of Aggregate Shares Beneficially Owned
Percentage of aggregate shares beneficially owned.
Shares beneficially owned
Impairment Charge On Construction In Progress And Finance Lease Right Of Use Asset
Impairment charges to construction in process and finance lease right of use assets
Impairment Charge On Construction In Progress And Finance Lease Right Of Use Asset
Queen's agreement.
Queens Agreement [Member]
Queens Agreement
Share based compensation arrangement by share based payment award number of shares available for grant granted in period..
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant Granted In Period
Grants
Sales agent.
Sales Agent [Member]
Sales Agents
Entity Address, State or Province
Entity Address, State or Province
Income tax disclosure.
Income Tax Disclosure [Table]
Income Tax Disclosure [Table]
Outstsanding performance and market-based RSU's
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Nonvested, Number of Shares, Ending Balance
Nonvested, Number of Shares, Beginning Balance
Outstsanding performance and market-based RSU's and RSAs
Operating Leases, Future Minimum Payments, Due Thereafter
Thereafter
Preclinical activities period under sponsored research agreements.
Preclinical Activities Period Under Sponsored Research Agreements
Preclinical activities period under sponsored research agreements
T S H A120 Rett Syndrome [Member]
T S H A120 Rett Syndrome.
Rett Option
Debt issuance costs
Debt Issuance Costs, Gross
Preferred Stock, Shares Outstanding
Preferred stock, shares outstanding
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding, Ending Balance
Research and Development Expense, Policy [Policy Text Block]
Research and Development
Common Stock, Capital Shares Reserved for Future Issuance
Common stock reserved for future issuance
Class of Warrant or Right [Domain]
Geographical [Axis]
Geographical
Line of Credit Facility, Lender [Domain]
Operating Leases, Future Minimum Payments, Due in Three Years
2025
Underwriting discounts and commissions and other offering costs
Underwriting Discounts And Commissions and Other Offering Costs
Underwriting discounts and commissions and other offering costs.
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount
State and local income taxes, net of federal benefit
Schedule of Total Stock-Based Compensation Expense for Stock Options, ESPP, RSAs and RSUs
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Finance Lease, Liability, Statement of Financial Position [Extensible Enumeration]
Other
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Amount
Stock Issued During Period, Value, Stock Options Exercised
Stock options were exercised during the period
Issuance of common stock upon exercise of stock options
Two Thousand Twenty Three Trinity Term Loans [Member]
Two Thousand Twenty Three Trinity Term Loans.
2023 Trinity Term Loans
Comprehensive Income, Policy [Policy Text Block]
Comprehensive Loss
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Schedule of Significant Components of Net Deferred Tax Asset
Collaborative Arrangement Disclosure [Text Block]
Astellas Agreements
Performance Stock Options
Performance Shares [Member]
Schedule Of Assumptions Used To Estimate Fair Value Of Warrants [Table Text Block]
Schedule of assumptions used to estimate fair value of warrants.
Schedule of Assumptions Used to Estimate Fair Value of Warrants
Subsequent Events
Subsequent Event [Member]
Long-Term Debt, Maturity, Remainder of Fiscal Year
2025
Deferred Revenue, Current, Total
Deferred Revenue, Current
Deferred revenue
Research credits
Deferred Tax Assets, Tax Credit Carryforwards, Research
Percentage of sale price per share of common stock.
Percentage Of Sale Price Per Share Of Common Stock
Percentage of gross sales price per share of common stock
Other Assets, Noncurrent
Other non-current assets
Other Assets, Noncurrent, Total
Expected term (in years)
Measurement Input, Expected Term [Member]
November 13, 2025 through, but excluding, the Maturity Date
November 13, 2025 through, but excluding, the Maturity Date [Member]
November 13, 2025 through, but excluding, the Maturity Date.
Summary Of Transaction Price Allocation
Summary Of Transaction Price Allocation [Table Text Block]
Summary of Allocation for Transaction Price to the Three Performance Obligations
Antidilutive Securities [Axis]
Antidilutive Securities
Schedule of Warrant Liability
Schedule Of Warrant Liability [Table Text Block]
Schedule of warrant liability.
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Expirations in Period
Options expired, Stock Options
Outstanding payments due
Outstanding Payments Due
Outstanding payments due.
State and Local Jurisdiction [Member]
State
Sale-related milestones per licensed product and royalties on net sales of licensed products payable.
Sale Related Milestones Per Licensed Product And Royalties On Net Sales Of Licensed Products Payable
Sale-related milestones per licensed product and royalties on net sales of licensed products payable
Accumulated Other Comprehensive Loss
AOCI Attributable to Parent [Member]
Registration Payment Arrangement, Arrangement [Domain]
Issuance of Warrants
Issuance Of Warrant Liability
Issuance of warrant liability.
Cash and Cash Equivalents [Domain]
Lessee, Operating Lease, Option to Extend
Lease, option to extend description
Preferred Stock, Value, Issued
Preferred Stock, Value, Issued, Total
Preferred Stock, Value, Issued, Beginning Balance
Preferred Stock, Value, Issued, Ending Balance
Preferred stock, $0.00001 par value per share; 10,000,000 shares authorized and no shares issued and outstanding as of December 31, 2025 and December 31, 2024
Selling, General and Administrative Expense
Selling, General and Administrative Expense, Total
Rett program expenses
Significant accounting policies table.
Significant Accounting Policies [Table]
Significant Accounting Policies [Table]
Debt Instrument, Maturity Date
Debt instrument, maturity date
Minimum [Member]
Minimum [Member]
Minimum
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Restricted units/stock granted, Weighted Average Grant Date Fair Value per Share
Share-based payment award, RSU/RSA granted, weighted average grant date fair value
Term loan from january one twenty twenty two until september thirty twenty twenty two.
Term Loan From January One Twenty Twenty Two Until September Thirty Twenty Twenty Two [Member]
January 1, 2022 until September 30, 2022
Assets, Current [Abstract]
Current assets:
Two Thousand Twenty Stock Incentive Plan and Two Thousand Twenty Three Inducement Plan [Member]
Two thousand twenty stock incentive plan and two thousand twenty three inducement plan.
New Plan and Inducement Plan
Impairment loss on sale of assets
Gain (Loss) on Sale of Assets and Asset Impairment Charges
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right
Shares of common stock
Level 3
Fair Value, Inputs, Level 3 [Member]
November 13, 2024 through November 13, 2025
November 13, 2024 through November 13, 2025 [Member]
November 13, 2024 through November 13, 2025
Segment Reporting [Abstract]
Schedule of Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Term loan through august thirteen twenty twenty three.
Term Loan Through August Thirteen Twenty Twenty Three [Member]
Through August 13, 2023
Liabilities, Current [Abstract]
Current liabilities
End of term payment percentage
End of term payment percentage
End of term payment percentage
Net operating loss carryforward annual utilization limitation
Operating Loss Carryforward Annual Limitation Amount
Operating loss carryforward annual limitation amount.
Payroll and payroll-related costs.
Payroll And Payroll Related Costs [Member]
Payroll and Payroll Related Costs
Class of Warrant or Right, Unissued
Warrants exercised
Gross operating loss carryforward
Operating Loss Carryforwards
Operating Loss Carryforwards, Total
Lessee, Operating Lease, Renewal Term
Operating lease extend term of contract
Proceeds from Stock Plans
Proceeds from common stock issuances under ESPP
Offering to Astellas.
Offering to Astellas [Member]
Offering to Astellas
Commitments and contingencies - Note 13
Commitments and Contingencies
Lessee, Leases [Policy Text Block]
Leases
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits
Non-qualified stock options
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Total
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Nonvested, Weighted Average Grant Date Fair Value per Share, Ending Balance
Nonvested, Weighted Average Grant Date Fair Value per Share, Beginning Balance
General and Administrative Expense
General and Administrative Expense [Member]
Operating Lease, Liability
Total lease liabilities
Total lease liabilities
Auditor Firm ID
Auditor Firm ID
Debt Instrument, Basis Spread on Variable Rate
Debt instrument, basis spread on variable rate
Interest rate period
Interest rate period
Interest rate period
Cash Flow, Operating Activities, Lessee [Abstract]
August Through August [Member]
August Through August.
August, 2026 through August, 2027
Convertible preferred stock.
Convertible Preferred Stock Policy [Text Block]
Convertible Preferred Stock
Term loan from october one twenty twenty two until march thirty one twenty twenty three.
Term Loan From October One Twenty Twenty Two Until March Thirty One Twenty Twenty Three [Member]
October 1, 2022 until March 31, 2023
Restricted cash, current
Restricted cash
Restricted Cash, Current
Payment of exit fee
Payment of Exit Fee
Payment of exit fee.
2027
Long-Term Debt, Maturity, Year Two
Finance Lease, Liability, Current
Finance lease liabilities, current
Lessee, Lease, Description [Table]
Finance Lease, Weighted Average Discount Rate, Percent
Weighted average discount rate - Finance leases
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Change in valuation allowance
Percentage of calculated discounted cash flows of discount rate
Percentage Of Calculated Discounted Cash Flows Of Discount Rate
Percentage of calculated discounted cash flows of discount rate.
Significant accounting policies line items.
Significant Accounting Policies [Line Items]
Significant Accounting Policies [Line Items]
Capital Expenditures Incurred but Not yet Paid
Offering costs not yet paid
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net loss
Consolidated net loss
Transaction price.
Transaction Price
Transaction price
Transaction Price Allocation
Debt Instrument, Maturity Date Range, Start
Debt instrument, maturity start date
Long-Term Debt, Type [Domain]
Long-term Debt, Type
Cybersecurity Risk Management Positions or Committees Responsible [Text Block]
Weighted Average Number of Shares Outstanding, Basic, Total
Weighted Average Number of Shares Outstanding, Basic
Weighted average common shares outstanding, basic
Scenario [Axis]
Laboratory equipment.
Laboratory Equipment [Member]
Laboratory Equipment
Share based compensation arrangement by share based payment award equity instruments other than options replacement units grants in period weighted average grant date fair value.
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Replacement Units Grants In Period Weighted Average Grant Date Fair Value
Replacement restricted units granted, Weighted Average Grant Date Fair Value per Share
Additional Milestone payments.
Additional Milestone Payments
Additional milestone payments
January 1, 2022 until March 31, 2023
Term Loan From January One Twenty Twenty Two Until March Thirty One Twenty Twenty Three [Member]
Term loan from january one twenty twenty two until march thirty one twenty twenty three.
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Options exercisable at December 31, 2025, Aggregate Intrinsic Value
Property and equipment in accounts payable and accrued expenses.
Property And Equipment In Accounts Payable And Accrued Expenses
Property, plant and equipment in accounts payable and accrued expenses
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Schedule of Reconciliation of Federal Statutory Income Tax Rate
Deferred Tax Liabilities, Leasing Arrangements
Right-of-use assets
Right-of-use assets
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset
Share based compensation arrangement by share based payment award number of shares available for grant plan adjustments and amendments in period.
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant Plan Adjustments And Amendments In Period
Plan adjustments and amendments
Cybersecurity Risk Process for Informing Management or Committees Responsible [Text Block]
Proceeds from Issuance of Private Placement
Aggregate gross proceeds
Gross proceeds of Private Placement
Subsequent Events [Text Block]
Subsequent Events
Effective Income Tax Rate Reconciliation, Tax Credit, Percent, Total
Effective Income Tax Rate Reconciliation, Tax Credit, Percent
Corporate alternative minimum tax on large corporations
Debt outstanding
Long-Term Debt
Term Loan, net
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Stock-based compensation
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
Interest rate terms description
Debt Instrument, Interest Rate Terms
Deferred Tax Asset, In-Process Research and Development
R&E expenditures
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Change in valuation allowance
Equity, Attributable to Parent
Balance
Balance
Total stockholders’ equity
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value per share
Property Subject to or Available for Operating Lease, Number of Units
Number of operating lease landlord square feet manufacturing facility
Basis of Accounting, Policy [Policy Text Block]
Basis of Presentation
Program expense
Program Expense
Program expense.
Statement of Stockholders' Equity [Abstract]
Interest rate extension period
Interest rate extension period
Interest rate extension period
Warrant Liability Fair Value Disclosure
Warrant liability fair value disclosure.
Balance at January 1
Balance at December 31
Share-Based Payment Arrangement, Tranche Two [Member]
Share-based Payment Arrangement, Tranche Two
Probability of Option Exercise
Probability Of An Option Exercise
Probability of option exercise
SSI Strategy Holdings LLC
SSI Strategy Holdings LLC [Member]
SSI Strategy Holdings LLC.
Type of Restructuring [Domain]
Dallas lease amendment.
Dallas Lease Amendment [Member]
Dallas Lease Amendment
Consultants and contractors expense
Consultants and Contractors Expense
Consultants and contractors expense.
Use of Estimates, Policy [Policy Text Block]
Use of Estimates
2030
Long-Term Debt, Maturity, Year Five
Leasehold Improvements [Member]
Leasehold Improvements
Minimum licensed product to develop obtain regulatory approval for and commercialize.
Minimum Licensed Product To Develop Obtain Regulatory Approval For And Commercialize
Minimum licensed product to develop obtain regulatory approval for and commercialize
Entity Address, Address Line Two
Entity Address Address Line2
Fair Value Measurements
Fair Value Disclosures [Text Block]
UNITED STATES
United States
Warrants and Rights Note Disclosure [Abstract]
Trinity Term Loans
Trinity Term Loans
Trinity term loans
Sales Commissions and Other Offering Costs
Sales commissions and other offering costs.
Sales commissions and other offering costs
Entity Incorporation, Date of Incorporation
Date of incorporation
Debt Instrument, Name [Domain]
Debt Instrument, Name
Other Assets, Current
Other
Noncash Investing and Financing Items [Abstract]
Supplemental disclosure of noncash investing and financing activities:
Accrued Liabilities and Other Liabilities
Accrued expenses and other current liabilities
Total accrued expenses and other current liabilities
2029
Long-Term Debt, Maturity, Year Four
Accrued license fees current.
Accrued License Fees Current
Accrued license fees
Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]
Percentage of fully diluted common stock shares outstanding.
Percentage Of Fully Diluted Common Stock Shares Outstanding
Percentage of fully diluted common stock shares outstanding
Other segment expense
Segment Reporting, Other Segment Item, Amount
Plan Name [Domain]
Plan Name
Certain employees and consultants.
Certain Employees And Consultants [Member]
Certain Employees and Consultants
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Entity [Domain]
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Text Block]
Impairment, Long-Lived Asset, Held-for-Use
Impairment losses
Impairment, Long-Lived Asset, Held-for-Use, Total
Impairment of long-lived assets
License agreement commercial milestones payment.
License Agreement Commercial Milestones Payment
License agreement commercial milestones payment
Cybersecurity Risk Management Expertise of Management Responsible [Text Block]
Finance Lease, Liability, to be Paid, Year One
2025
Maximum construction allowance provided by landlord per rentable square foot.
Maximum Construction Allowance Provided By Landlord Per Rentable Square Foot
Maximum construction allowance provided by landlord per rentable square foot
Deferred Charges, Policy [Policy Text Block]
Deferred Offering Costs
Lessee, Operating Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract]
Operating Lease
Initial Options and Original Options
Initial Options and Original Options [Member]
Initial options and original options.
Restructuring Plan [Axis]
Class of Warrant or Right [Table]
2023 Pre-Funded Warrants
Twenty Twenty Three Pre Funded Warrants [Member]
Twenty twenty three pre funded warrants.
Value of voting and non-voting common stock held by non-affiliates
Value of Voting and Non-voting Common Stock Held by Non-Affiliates
Value of voting and non-voting common stock held by non-affiliates.
Property, Plant and Equipment, Policy [Policy Text Block]
Property Plant and Equipment, net
Entity Address, City or Town
Entity Address, City or Town
Payment of one-time upfront license fee.
Payment Of One Time Upfront License Fee
Payment of one-time upfront license fee
Trinity Refinance Date until March Thirty One Twenty Twenty Eight[Member]
Trinity Refinance Date until March 31, 2028.
Trinity Refinance Date Until March 31, 2028
Security Exchange Name
Security Exchange Name
Debt Instrument, Variable Interest Rate, Type [Extensible Enumeration]
Long-Term Debt, Gross
Total principal payments
Property, plant and equipment, gross
Property, Plant and Equipment, Gross
Property, Plant and Equipment, Gross, Total
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Ending Balance
Assets Held for Sale
Assets Held for Sale [Policy Text Block]
Assets held for sale.
Warrants
Warrants Policy [Policy Text Block]
Warrants policy.
Performance and Market-based Restricted Stock Units
Performance And Market-Based Stock Options [Member]
Performance and market-based stock options.
Deferred Offering Costs
Deferred offering costs
Counterparty Name [Axis]
Counterparty Name
Performance and market-based options vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Finance Lease, Liability, to be Paid, Year Five
2029
Research and experimentation expenditures amortized period.
Research and Experimentation Expenditures Amortized Period
Research and experimentation expenditures amortized period
Measurement Input Type [Domain]
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name
Accrued interest
Debt Instrument, Increase, Accrued Interest
Upfront payment.
Upfront Payment
Upfront payment
Deferred Tax Assets, Goodwill and Intangible Assets
Intangibles
Interest Paid, Excluding Capitalized Interest, Operating Activity
Cash paid for interest
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Statistical Measurement [Domain]
Statistical Measurement
Exercise price of warrants Per Share
Exercise price of warrants
Class of Warrant or Right, Exercise Price of Warrants or Rights
Assets, Current
Total current assets
Share-Based Payment Arrangement, Expense
Stock-based compensation expense
Document Period End Date
Document Period End Date
Option Agreement for GAN
Giant Axonal Neuropathy Agreement [Member]
Giant axonal neuropathy agreement.
Title and Position [Axis]
Title of Individual
Fair Value Hierarchy and NAV [Domain]
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Proceeds Allocated to Success Fee Liability
Proceeds allocated to success fee liability.
Proceeds allocated to Success Fee liability
Gain (Loss) on Disposition of Property Plant Equipment
Gain (Loss) on Disposition of Property Plant Equipment, Total
Gain on disposal of equipment
Finance Lease, Liability, Noncurrent, Statement of Financial Position [Extensible Enumeration]
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]
Statement of Financial Position [Abstract]
Restricted Stock Units (RSUs) [Member]
Restricted Stock Units
Unvested RSUs
Revenue [Policy Text Block]
Revenue Recognition
Antidilutive Security, Excluded EPS Calculation [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Issuance Of Common Stock Upon Exercise Of Pre-funded Warrants, Shares
Issuance of common stock upon exercise of pre-funded warrants, shares.
Issuance of common stock upon exercise of pre-funded warrants, shares
Regulatory related milestones obligation payable.
Regulatory Related Milestones Obligation Payable
Regulatory related milestones obligation payable
Vesting [Axis]
Vesting
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Other comprehensive income (loss):
Deferred Tax Liabilities, Net
Deferred tax liabilities
Total deferred tax liabilities
Total deferred tax liabilities
Finance Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract]
Finance Lease
Liabilities
Total liabilities
Change in Fair Value of Debt Instrument
Change in fair value of debt instrument.
Change in fair value
Change in fair value of warrant liability
Change in Fair Value of Warrant Liability
Change in fair value of warrant liability.
Abeona Rett Agreement
Abeona Rett Agreement [Member]
Abeona Rett agreement.
Rett research and development activities
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Requisite Service Period
Award requisite service vesting period
Two thousand twenty stock incentive plan.
Two Thousand Twenty Stock Incentive Plan [Member]
New Plan
Accruals and reserves
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Total
Lessee, Operating Lease, Liability, to be Paid, Year Two
2027
Restricted cash, noncurrent
Restricted Cash
Restricted cash
Restricted Cash, Total
Restricted Stock [Member]
Restricted Stock Awards
Unvested RSAs
Common stock shares issued and sold.
Common Stock Shares Issued And Sold
Common stock shares issued and sold
License For RETT
License For RETT [Member]
Option to obtain license for Rett
SSI Investors
SSI Investors [Member]
SSI investors.
Weighted average common shares outstanding, diluted
Weighted Average Number of Shares Outstanding, Diluted, Total
Weighted Average Number of Shares Outstanding, Diluted
Securities Act File Number
Entity File Number
ASU 2023-07
Accounting Standards Update 2023-07 [Member]
Cover [Abstract]
Measurement Input Type [Axis]
Issuance of common stock upon vesting and settlement of restricted stock units value.
Issuance Of Common Stock Upon Vesting And Settlement Of Restricted Stock Units Value
Issuance of common stock upon vesting and settlement of restricted stock units, net
Schedule of Reconcile of Change in Fair Value of Debt
Schedule of Carrying Values and Estimated Fair Values of Debt Instruments [Table Text Block]
Prepaid Expense and Other Assets, Current
Prepaid expenses and other current assets
Total prepaid expenses and other current assets
Performance and market-based restricted stock units of other option forfeited during period
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Cancelled or forfeited, Number of Shares
Supplemental Balance Sheet Disclosures [Text Block]
Supplemental Financial Information
Income tax disclosure.
Income Tax Disclosure [Line Items]
Income Tax Disclosure [Line Items]
Warrant liability
Warrant liability, Current
Warrant liabilities, current.
Option To Purchase Additional Number Of Common Shares
Option to purchase additional number of common shares.
Option to purchase additional number of common shares
Scenario [Domain]
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized
Number of shares authorized for issuance
Number of Operating Segments
Number of operating segment
Sale of Stock [Domain]
Sale of Stock
Segment Information
Segment Reporting Disclosure [Text Block]
General and Administrative Expense
General and administrative
General and Administrative Expense, Total
Nonvested Restricted Stock Shares Activity [Table Text Block]
Schedule of Restricted Stock Awards Activity
Existing Plan
Previous Plan
Two thousand twenty equity incentive plan.
Two Thousand Twenty Equity Incentive Plan [Member]
May Twenty Twenty Five Pre Funded Warrants [Member]
May 2025 Pre Funded Warrants.
May 2025 Pre Funded Warrants
Subsequent Event [Table]
Non-cash impact of exercise of liability classified warrants
Adjustments to Additional Paid in Capital, Warrant Issued
Payment of license fee.
Payment Of License Fee
License fee payment
Non-cash loss on debt extinguishment
Loss on debt extinguishment
Gain (Loss) on Extinguishment of Debt
Gain (Loss) on Extinguishment of Debt, Total
Trinity Term Loans
Trinity Term Loans [Member]
Trinity Term Loans
Property, Plant and Equipment, Useful Life
Property and equipment, useful life
New Accounting Pronouncements, Policy [Policy Text Block]
Recently Adopted Accounting Pronouncements
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Schedule of Aggregate Lease Commitments
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Percent
Other
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Award vesting period
Employee Severance [Member]
Employee Severance
Sales Agreement.
Sales Agreement [Member]
Sales Agreement
Issuance of Common Stock Upon Exercise of Warrants, Value
Issuance of common stock upon exercise of warrants, value.
Issuance of common stock upon exercise warrants
Income Tax Expense (Benefit), Effective Income Tax Rate Reconciliation, Amount [Abstract]
Amount
Depreciation
Depreciation expense
Depreciation, Total
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Share-based payment award, unvested RSU/RSA granted, compensation cost not yet recognized
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense
Interest and penalties associated with income tax positions
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense, Total
Term loan facility.
Term Loan Facility [Member]
Term Loan
Decrease in Liability Due to Exercise of Warrants
Decrease in liability due to exercise of warrants.
Exercise of SSI Warrants
Lessee, Operating Lease, Term of Contract
Operating lease term of contract
Share based compensation award tranche four.
Share Based Compensation Award Tranche Four [Member]
Share-based Payment Arrangement, Tranche Four
Common Stock, Shares, Outstanding
Balance, shares
Balance, shares
Common stock, shares outstanding
Operating Lease, Liability, Current
Operating lease liabilities, current
Lease liabilities, current portion
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Cybersecurity Risk Management Processes Integrated [Flag]
Document Transition Report
Document Transition Report
Deferred Tax Assets, Net
Net deferred taxes
Operating Expenses
Total operating expenses
Net operating loss carryforwards, limitations on use
Operating Loss Carryforwards, Limitations on Use
Research and Development Expense
Research and development
Research and Development Expense, Total
Asset Impairment Charges, Total
Asset Impairment Charges
Non-cash impairment charge
Lessee, Operating Leases [Text Block]
Leases
Accrued severance, Ending
Accrued severance, Beginning
Accrued severance balance.
Accrued Severance Balance
Stock and Pre-funded Warrants Issued During Period, Shares, New Issues
Stock and pre-funded warrants issued during period, shares, new issues.
Issuance of common stock and pre-funded warrants, upon closing of underwritten public offering, net of underwriting discounts and commissions, and other offering costs, shares
Comprehensive Income (Loss), Net of Tax, Including Portion Attributable to Noncontrolling Interest
Comprehensive loss
Accrued clinical trial current.
Accrued Clinical Trial Current
Accrued clinical trial
Statement of Cash Flows [Abstract]
Schedule of accrued expense and other current labilities.
Schedule Of Accrued Expense And Other Current Labilities Table [Text Block]
Schedule of Accrued Expenses and Other Current Labilities
Original Options
Original Options [Member]
Original Options.
Issuance of common stock, net of sales commissions and other offering costs
Stock Issued During Period, Value, New Issues
Operating Leases, Future Minimum Payments Due, Next 12 Months
2023
Stock-based compensation
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent
Earnings Per Share [Text Block]
Net Loss Per Common Share
Share-Based Compensation Arrangement By Share-Based Payment Award, Other Than Options, Grant Date Fair Value Not Yet Recognized
Share-based compensation arrangement by share-based payment award, other than options, grant date fair value not yet recognized.
Grant date fair value of issued units not yet recognized
Deferred Tax Liabilities, Other
Other
Other
Computer Equipment [Member]
Computer Equipment
Cybersecurity Risk Management Processes Integrated [Text Block]
Net loss
Net loss
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Outstanding, Aggregate Intrinsic Value, Ending Balance
Outstanding, Aggregate Intrinsic Value, Beginning Balance
Operating Lease, Cost
Operating lease cost
Accrued Severance
Accrued Severance
Accrued severance
Warrants and Rights Outstanding, Term
Warrants term
Schedule of supplemental information related to remaining lease term and discount rate.
Schedule Of Supplemental Information Related To Remaining Lease Term And Discount Rate [Table Text Block]
Schedule of Supplemental Information Related to Remaining Lease Term and Discount Rate
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend yield
Proceeds from (Payment for) Other Financing Activity
Other
License and inventory purchase agreement regulatory related milestones payment.
License And Inventory Purchase Agreement Regulatory Related Milestones Payment
License and inventory purchase agreement regulatory related milestones payment
Operating Lease, Payments
Operating cash flows for operating leases
Assets [Abstract]
ASSETS
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk-free interest rate
Construction in Progress [Member]
Construction in Progress
Prepaid expenses and other assets
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid expenses and other assets
Increase (Decrease) in Prepaid Expense and Other Assets, Total
Repayments of Debt
Repayment of 2023 Term Loan
Repayment of 2023 Term Loan
Restructuring and Related Activities [Abstract]
Document Fiscal Year Focus
Document Fiscal Year Focus
Underwriter Agreed To Purchase Share Price Of Per Share
Underwriter agreed to purchase share price of per share.
Underwriter agreed to purchase share price of per share
Proceeds from Issuance of Common Stock Pursuant to At The Market Offering, Net of Sales Commissions and Other Offering Costs
Proceeds from issuance of common stock pursuant to at the market offering, net of sales commissions and other offering costs.
Proceeds from issuance of common stock pursuant to at-the-market offering, net of sales commissions and other offering costs
Issuance of common stock upon vesting and settlement of restricted stock unit shares.
Issuance Of Common Stock Upon Vesting And Settlement Of Restricted Stock Unit Shares
Issuance of common stock upon vesting and settlement of restricted stock units, net, shares
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract]
Cash flows from investing activities
Securities purchase agreement member.
Securities Purchase Agreement [Member]
Securities Purchase Agreement
Retirement Benefits [Abstract]
Built-to-suit lease liability.
Built To Suit Lease Liability
Build-to-suit lease liability
Accounts Payable, Current
Accounts payable
Accounts Payable, Current, Total
Interest Expense, Nonoperating
Interest Expense, Nonoperating, Total
Interest expense
Interest Expense, Long-Term Debt
Interest expense related to term loan
Interest Expense, Long-term Debt, Total
Research and Development Expense [Member]
Research and Development Expense
ATM Agreement
At-The-Market (ATM) Agreement [Member]
At-The-Market (ATM) agreement.
Public Offering [Member]
Public Offering [Member]
Public Offering
Deferred Revenue, Total
Deferred Revenue
Deferred revenue
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Table Text Block]
Schedule of Prepaid Expenses and Other Current Assets
Astellas [Member]
Astellas [Member]
Astellas
Restructuring Cost and Reserve [Line Items]
June Twenty Twenty Four Pre Funded Warrants Option Two [Member]
June twenty twenty four pre-funded warrants option two.
June 2024 Pre-Funded Warrants Option Two
Components of Deferred Tax Assets [Abstract]
Property, Plant and Equipment, Disposals
Equipment disposal book value
Increase decrease in accrued expense and other liabilities.
Increase Decrease In Accrued Expense And Other Liabilities
Accrued expenses and other liabilities
Lessee, Operating Lease, Lease Not yet Commenced, Term of Contract
Term of contract, not yet commenced
Proceeds from Stock Options Exercised
Proceeds from stock option exercises
Build-to-suit lease.
Build To Suit Lease [Member]
Build-to-Suit Lease
Fair Value Disclosures [Abstract]
Commitments and Contingencies Disclosure [Abstract]
Market value of common stock (per share)
Measurement Input, Share Price [Member]
Lessee, Operating Lease, Liability, to be Paid, Year One
2026
License agreement for CLN7.
License Agreement For C L N7 [Member]
License Agreement for CLN7
Net Income (Loss) Available to Common Stockholders, Basic
Net loss
Net Income (Loss) Available to Common Stockholders, Basic, Total
Debt Instrument [Axis]
Debt Instrument
Lessee, Operating Lease, Liability, to be Paid, after Year Five
Thereafter
Share-Based Payment Arrangement [Abstract]
Difference of market value paid
Difference Of Market Value Paid
Difference of market value paid
Total assets
Assets, Fair Value Disclosure
Sale of Stock [Axis]
Sale of Stock
Pegasus Park, LLC.
Pegasus Park L L C [Member]
Pegasus Park L L C
Schedule of Nonvested Restricted Stock Units Activity [Table Text Block]
Schedule of Restricted Stock Units Activity
Ending fair value balance
Beginning fair value balance
Fair value of loan at issuance
Debt Instrument, Fair Value Disclosure
Debt Instrument, Fair Value Disclosure, Total
Revenues, Total
Revenues
Revenues
Revenue
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
Net cash used in investing activities
Private Placement [Member]
Private Placement
Finance Lease, Weighted Average Remaining Lease Term
Weighted average remaining lease term (in years) - Finance leases
Title of 12(b) Security
Title of 12(b) Security
Stock-based compensation
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Amount
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Options cancelled or forfeited, Weighted Average Exercise Price
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Cancelled or forfeited, Weighted Average Grant Date Fair Value per Share
Money Market Funds
Money Market Funds [Member]
Issuance of common stock upon exercise of warrants, shares.
Issuance of Common Stock upon Exercise of Warrants, Shares
Issuance of common stock upon exercise warrants, shares
Income Tax Disclosure [Text Block]
Income Taxes
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Class of Warrant or Right [Line Items]
Success fee liability at fair value
Success Fee Derivative liability
Success Fee Derivative liability
Success fee derivative liability
Business Combination, Integration, Restructuring, and Other Related Costs [Text Block]
Strategic Reprioritization
Debt Instrument, Maturity Date Range, End
Debt instrument, maturity end date
Other Liabilities, Noncurrent
Other non-current liabilities
Other Liabilities, Noncurrent, Total
Restructuring Plan [Domain]
Legal Entity [Axis]
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]
Changes in operating assets and liabilities:
Property, Plant and Equipment [Table Text Block]
Schedule of Property, Plant and Equipment Net
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Outstanding, Weighted Average Exercise Price, Ending balance
Outstanding, Weighted Average Exercise Price, Beginning balance
Regulatory milestone fee paid.
Regulatory Milestone Fee Paid
Regulatory milestone fee paid
Income Tax Disclosure [Abstract]
Fair Value, Recurring and Nonrecurring [Table]
Additional Paid-in Capital [Member]
Additional Paid-in Capital
Accrued property, plant and equipment
Accrued property, plant, and equipment current.
Accrued Property Plant And Equipment Current
Statement of Income Location, Balance [Axis]
Income Statement Location
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Trading Symbol
Trading Symbol
Former President and Chief Executive Officer
President and chief executive officer.
President And Chief Executive Officer [Member]
Percentage of automatic increase every year in common stock shares reserved for future issuance.
Percentage Of Automatic Increase Every Year In Common Stock Shares Reserved For Future Issuance
Percentage of automatic increase every year in common stock shares reserved for future issuance
License agreement sales-related milestones maximum amount payable.
License Agreement Sales Related Milestones Maximum Amount Payable
License agreement sales-related milestones maximum amount payable
Subsequent Event Type [Axis]
Modified Options
Modified Options [Member]
Modified Options.
Employee-related Liabilities, Current
Accrued compensation
Employee-related Liabilities, Current, Total
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract]
Cash flows from financing activities
Commitment fee percentage
Line of Credit Facility, Unused Capacity, Commitment Fee Percentage
Expected term (in years)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Entity Ex Transition Period
Entity Ex Transition Period
Lessee, Operating Lease, Liability, to be Paid
Total lease payments
Future minimum remianing lease payments
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Less: imputed interest
Less: imputed interest
Success Fee Agreement
Success Fee Agreement [Member]
Success fee agreement.
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent
Research and development tax credits
Research and development tax credits
Employee stock purchase plans.
Employee Stock Purchase Plans [Member]
Employee Stock Purchase Plan (ESPP)
Share-Based Compensation Arrangement by Share-Based Payment Award, Maximum Employee Subscription Rate
Percentage of common stock price purchased through payroll deductions
Research, collaboration and license agreements.
Research Collaboration And License Agreements [Abstract]
Number of distinct and active clinical stage.
Number Of Distinct And Active Clinical Stage
Number of distinct and active clinical stage
At the market offering.
At The Market Offering [Member]
At-the-Market Offering
Equity Components [Axis]
Equity Components
Operating Leases, Future Minimum Payments, Due in Two Years
2024
Nonoperating Income (Expense)
Total other income, net
Equity Component [Domain]
Equity Component
Share-Based Payment Arrangement, Activity [Table Text Block]
Schedule of Stock Option Activity
Recently issued accounting pronouncements policy.
Recently Issued Accounting Pronouncements Policy Policy [Text Block]
Recently Issued Accounting Pronouncements
Schedule of Future Minimum Rental Payments for Operating Leases [Table Text Block]
Schedule of Aggregate Lease Commitments
Document Annual Report
Document Annual Report
Prepaid Insurance
Prepaid insurance
August Through But Excluding The Maturity Date [Member]
August Through But Excluding The Maturity Date.
August, 2027 through, but Excluding, the Maturity Date
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Number of shares of common stock issued under ESPP
Issuance of common stock under ESPP, shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Share-based payment award, expiration period
Clinical, regulatory and commercial milestones to be received.
Clinical Regulatory And Commercial Milestones To Be Received
Clinical, regulatory and commercial milestones to be received
Statement of Comprehensive Income [Abstract]
License agreement regulatory milestones payment.
License Agreement Regulatory Milestones Payment
License agreement regulatory milestones payment
Term loan from april one twenty twenty three until december thirty one twenty twenty three.
Term Loan From April One Twenty Twenty Three Until December Thirty One Twenty Twenty Three [Member]
April 1, 2023 until December 31, 2023
Maximum [Member]
Maximum
Market Based Stock Options
Market Based Stock Options [Member]
Market based stock options.
Percentage of annual default interest rate.
Percentage Of Annual Default Interest Rate
Percentage of annual default interest rate
Total liabilities
Liabilities, Fair Value Disclosure
Statistical Measurement [Axis]
Statistical Measurement
Exercised, Weighted Average Exercise Price
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
June Twenty Twenty Four Pre-funded Warrants [Member]
June twenty twenty four pre-funded warrants.
June 2024 Pre-funded Warrants
Common Stock, Value, Issued
Common Stock, Value, Issued, Total
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Ending Balance
Common stock, $0.00001 par value per share; 700,000,000 shares authorized and 285,051,648 issued and outstanding as of December 31, 2025 and 400,000,000 shares authorized and 204,943,306 issued and outstanding as of December 31, 2024
Schedule of share based compensation available for grant.
Schedule Of Share Based Compensation Available For Grant [Table Text Block]
Schedule of Share Based Compensation Available for Grant under Incentive Plans
Excise tax rate percentage.
Excise Tax Rate Percentage
Excise tax rate on corporate buy-backs
Non-cash change in fair value of term loan
Non Cash Change In Fair Value Of Term Loan
Non cash change in fair value of term loan.
Consolidation, Policy [Policy Text Block]
Principles of Consolidation
Warrants and Rights Outstanding
Warrants associated with loan facility
Outstanding liability classified warrants
Deferred Tax Assets, Operating Loss Carryforwards
Net operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards, Total
Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block]
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Impairment of Long-Lived Assets
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
State and local income taxes, net of federal benefit
Success Fee Liability [Member]
Success fee liability.
Success Fees Liability
Research and development license not yet paid.
Research And Development License Not Yet Paid
Purchase of research and development license not yet paid
Aggregate offering price from sale of common stock.
Aggregate Offering Price From Sale Of Common Stock
Aggregate offering price from sale of common stock
Entity Public Float
Entity Public Float
Share-Based Compensation Arrangement by Share-Based Payment Award, Discount from Market Price, Offering Date
Percentage of payroll deductions of employee's compensation during offering period
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Expected volatility
Preferred Stock, Shares Authorized
Preferred stock, shares authorized
Convertible preferred stock, shares authorized
Two Thousand Twenty Five Trinity Term Loans [Member]
Two Thousand Twenty Five Trinity Term Loans.
2025 Trinity Term Loans
Lessee, operating and finance lease, liability, maturity .
Lessee, Operating And Finance Lease, Liability, Maturity [Table Text Block]
Schedule of Future Minimum Commitments Under Company's Operating and Finance Leases
Trinity Lenders
Trinity Lenders [Member]
Trinity Lenders
Lender Name [Axis]
Deferred tax assets lease liabilities.
Deferred Tax Assets Lease Liabilities
Lease liabilities
Entity Registrant Name
Entity Registrant Name
Term Loans
Debt Disclosure [Text Block]
Principal payments
Debt Instrument, Periodic Payment, Principal
Entity Voluntary Filers
Entity Voluntary Filers
Lessee Disclosure [Abstract]
Reclass of Pre-Funded Warrants to equity
Reclass of Pre-Funded Warrants to equity
Warrant liability reclassified into equity
Reclassification Of Warrant Liability Classified Pre-Funded Warrants To Equity Classified
Reclassification of warrant liability classified pre-funded warrants to equity classified.
Prepayment Of Two Thousand Twenty Three Trinity Term Loan
Prepayment of two thousand twenty three trinity term loan.
Prepayment of 2023 Trinity term loan
Other expense
Other Nonoperating Income (Expense)
Other Nonoperating Income (Expense), Total
Additional Paid in Capital
Additional paid-in capital
Additional Paid in Capital, Total
Additional Paid in Capital, Beginning Balance
Additional Paid in Capital, Ending Balance
Subsequent Events [Abstract]
Cybersecurity Risk Management Positions or Committees Responsible [Flag]
Third Parties [Member]
Third parties.
Third Parties
Accrued research and development current.
Accrued Research And Development Current
Accrued research and development
Income Tax Expense (Benefit)
Provision for income taxes
Total
Fair value of shares transferred value.
Fair Value Of Shares Transferred Value
Fair value of shares transferred, Value
Assets held for sale
Asset, Held-for-Sale, Not Part of Disposal Group, Current
Asset, Held-for-Sale, Not Part of Disposal Group, Current, Total
Gross proceeds from issuance of common stock
Proceeds from issuance of common stock from private placement
Net proceeds from issuance of common stock
Income Tax Rate Reconciliation, Nondeductible Expense Change In Fair Value Of Warrant Liability And Note
Income tax rate reconciliation, nondeductible expense change in fair value of warrant liability and note.
Change in fair value of Warrant Liability and note
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Concentrations of Credit Risk
Compensation Related Costs, Policy [Policy Text Block]
Stock-Based Compensation
Deferred revenue recognized
Deferred Revenue, Revenue Recognized
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Payments to Acquire Property, Plant, and Equipment
Purchase of property, plant and equipment
Payments to Acquire Property, Plant, and Equipment, Total
Payment for (Proceeds from) Other Investing Activity
Other
Other
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Restricted units/stock granted, Number of Shares
Share-based payment award, RSU/RSA granted
Assets
Total assets
Property, Plant and Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Options exercisable at December 31, 2025, Weighted Average Remaining Contractual Life
Income Statement [Abstract]
Beneficial ownership limitation notice period (in days)
Beneficial Ownership Limitation Notice Period
Beneficial ownership limitation notice period.
Restructuring Cost [Table]
Fair Value of Financial Instruments, Policy [Policy Text Block]
Fair Value of Financial Instruments
Gain Loss on Fair Value of Terms Loan Attributable to Instrument Specific Credit Risk
Gain loss on fair value of terms loan attributable to instrument specific credit risk.
Change in fair value reported in comprehensive loss
Change in fair value of term loan attributable to instrument specific credit risk
Issuance of common stock, net of sales commissions and other offering costs, shares
Number of shares issued
Number of shares issued or sell
Lease, Cost [Abstract]
Performance and market-based restricted stock units of other option vested during period
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Vested, Number of Shares
Earnings Per Share, Diluted, Total
Earnings Per Share, Diluted
Net loss per common share, diluted
Summary of Significant Segment Expenses
Schedule of Segment Reporting Information, by Segment [Table Text Block]
Percent
Effective Income Tax Rate Reconciliation, Percent [Abstract]
Title and Position [Domain]
Title of Individual
City Area Code
City Area Code
June Twenty Twenty Four Pre-Funded Warrants Option One [Member]
June twenty twenty four pre-funded warrants option one.
June 2024 Pre-Funded Warrants Option One
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Date
Share-based payment award, expiration date
Auditor Name
Auditor Name
Debt Instrument, Fee Amount
Debt instrument, fee amount
Finance Lease, Liability, Noncurrent
Finance, lease liabilities, non-current
Finance lease liabilities, non-current
End of term payment
End Of Term Payment
End of term payment.
Maximum borrowing capacity
Aggregate principal amount
Line of Credit Facility, Maximum Borrowing Capacity
Deferred Tax Assets, Tax Credit Carryforwards
Tax credit carryforwards
Deferred Tax Assets, Tax Credit Carryforwards, Total
Abeona CLN1 agreements.
Abeona C L N1 Agreements [Member]
Abeona CLN1 Agreements
Counterparty Name [Domain]
Counterparty Name
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount
Research and development tax credits
Research and development tax credits
Variable Lease, Cost
Variable lease cost
Stock Issued During Period, Value, Employee Stock Purchase Plan
Issuance of common stock under ESPP
Payments to acquire license right.
Payments To Acquire License Right
Cash payment to acquire license agreement
Operating Lease, Weighted Average Remaining Lease Term
Weighted average remaining lease term (in years) - Operating leases
Lease, Cost
Total lease cost
Cash and Cash Equivalents, Policy [Policy Text Block]
Cash and Cash Equivalents
Property, Plant and Equipment, Net
Property, plant and equipment, net
Property, plant and equipment, net
Property, Plant and Equipment, Net, Beginning Balance
Property, Plant and Equipment, Net, Ending Balance
Preferred stock tranche liability.
Preferred Stock Tranche Liability Policy [Text Block]
Preferred Stock Tranche Liability
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Number
Options exercisable at December 31, 2025
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation
Cash, cash equivalents and restricted cash at the end of the period
Cash, cash equivalents and restricted cash at the beginning of the period
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Operating Income (Loss)
Loss from operations
Proceeds from 2025 Trinity term loan, net
Proceeds From Two Thousand Twenty Five Trinity Term Loan Net
Proceeds from two thousand twenty five trinity term loan net.
Percentage of prepayment premium
Percentage Of Prepayment Premium
Percentage of prepayment premium
UT southwestern agreement.
U T Southwestern Agreement [Member]
UT Southwestern Agreement
Retained Earnings [Member]
Accumulated Deficit
Cash and Cash Equivalents [Axis]
Share-Based Payment Arrangement, Noncash Expense
Stock-based compensation
Share-based Payment Arrangement, Noncash Expense, Total
SSI Warrants
SSI Warrants [Member]
SSI Warrants [Member]
Expected volatility
Measurement Input, Price Volatility [Member]
Stock Issued During Period Value Gain (Loss) On Instrument Specific Credit Risk
Stock issued during period value gain (loss) on instrument specific credit risk.
Gain (loss) on instrument-specific credit risk
Operating Lease, Weighted Average Discount Rate, Percent
Weighted average discount rate - Operating leases
Operating Lease, Liability, Noncurrent
Operating lease liability, net of current portion
Operating lease liabilities, non-current
Level 1
Fair Value, Inputs, Level 1 [Member]
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
Net cash provided by financing activities
Prepaid bonus.
Prepaid Bonus
Prepaid bonus
Lease, Cost [Table Text Block]
Schedule of Lease Cost
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent [Abstract]
Nondeductible items:
Severance recorded
Severance Cost Recorded
Severance cost recorded.
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Auditor Location
Auditor Location
Nonoperating Income (Expense) [Abstract]
Other (expense) income:
Non-US [Member]
Outside the United States
Two Thousand Twenty Three And Two Thousand Twenty Five Trinity Term Loans Member
Two thousand twenty three and two thousand twenty five trinity term loans member.
2023 and 2025 Trinity Term Loans
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Schedule of Common Stock Equivalents Outstanding Excluded from Computation of Diluted Net Loss Per Share Attributable to Common Stockholders
Income Tax Jurisdiction [Domain]
Income Tax Authority
Entity Interactive Data Current
Entity Interactive Data Current
On Site Generation Lease
On Site Generation Lease [Member]
On-site generation lease.
Increase (Decrease) in Contract with Customer, Liability
Deferred revenue
Statement of Income Location, Balance [Domain]
Income Statement Location
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]
Cash flows from operating activities
Furniture and Fixtures [Member]
Furniture and Fixtures
SSI Warrant liability
SSI Warrants
SSI warrants.
Debt instrument, Fair Value at Beginning of 2025 Trinity Term Loan
Debt instrument, fair value at beginning of 2025 trinity term loan.
Beginning fair value balance of 2025 Trinity Term Loan on August 7, 2025
Cash Equivalents, at Carrying Value
Cash equivalents
Cash Equivalents, at Carrying Value, Total
Current borrowing capacity
Line of Credit Facility, Current Borrowing Capacity
Entity Tax Identification Number
Entity Tax Identification Number
Share Price
Preferred stock, issuing price per share
Share price
Share Based Compensation Arrangement By Share Based Payment Award Other Than Options Unvested And Outstanding Number
Share based compensation arrangement by share based payment award other than options unvested and outstanding number.
Unvested and Outstanding units
Long-Term Debt, Type [Axis]
Long-term Debt, Type
Amended Sales Agreement [Member]
Amended Sales Agreement.
Amended Sales Agreement
Worldwide changes in unrecognized tax benefits
Effective Income Tax Rate Reconciliation Worldwide Changes In Unrecognized Tax Benefits
Effective income tax rate reconciliation worldwide changes in unrecognized tax benefits.
Lease liability current.
Lease Liability Current
Lease liabilities, current portion
Increase or decrease in beneficial ownership limitation percentage
Increase or Decrease in Beneficial Ownership Limitation Percentage
Increase or decrease in beneficial ownership limitation percentage.
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Organization and Description of Business Operations
Percentage of remeasured calculated discounted cash flows of discount rate
Percentage Of Remeasured Calculated Discounted Cash Flows Of Discount Rate
Percentage of remeasured calculated discounted cash flows of discount rate.
Construction in Progress, Gross
Construction in progress
Local Phone Number
Local Phone Number
Term loan through december thirty one twenty twenty one.
Term Loan Through December Thirty One Twenty Twenty One [Member]
Through December 31, 2021
Net proceeds from issuance of common stock
Proceeds From Issuance Of Common Stock Net
Proceeds from issuance of common stock net.
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Share-based payment award, options, compensation cost not yet recognized
Auditor Opinion [Text Block]
Auditor Opinion
Finance Lease, Liability, to be Paid, Year Two
2026
Long-Lived Assets
Long-lived assets
Dallas lease.
Dallas Lease [Member]
Dallas Lease
Accounting Policies [Abstract]
License agreement regulatory related milestones maximum amount payable.
License Agreement Regulatory Related Milestones Maximum Amount Payable
License agreement regulatory related milestones maximum amount payable
Lessee, Operating Lease, Liability, to be Paid, Year Four
2029
Operating Leases, Future Minimum Payments Due
Total Lease Commitments
Increase (decrease) in gross unrecognized tax benefits.
Increase Decrease in Gross Unrecognized Tax Benefits
Increase in the amount of gross unrecognized tax benefits
Labor and Related Expense
Compensation expense
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Available for grant - December 31, 2024
Available for grant - January 1, 2024
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Share-based payment award, compensation cost not yet recognized, weighted-average period of recognition
Accrued Professional Fees, Current
Accrued professional and consulting fees
Prepaid research and development contracts.
Prepaid Research And Development Contracts
Prepaid research and development
Entity Emerging Growth Company
Entity Emerging Growth Company