v3.26.1
Document And Entity Information - USD ($)
$ in Millions
12 Months Ended
Dec. 31, 2025
Mar. 02, 2026
Jun. 30, 2025
Cover [Abstract]      
Document Type 10-K    
Document Period End Date Dec. 31, 2025    
Amendment Flag false    
Trading Symbol GLUE    
Entity Registrant Name Monte Rosa Therapeutics, Inc.    
Entity Central Index Key 0001826457    
Entity Current Reporting Status Yes    
Entity Voluntary Filers No    
Entity Well-known Seasoned Issuer Yes    
Current Fiscal Year End Date --12-31    
Document Fiscal Year Focus 2025    
Entity Filer Category Non-accelerated Filer    
Entity Small Business true    
Entity Emerging Growth Company true    
Entity Shell Company false    
Document Fiscal Period Focus FY    
Entity Public Float     $ 212
Entity Common Stock, Shares Outstanding   80,015,667  
Entity Ex Transition Period false    
ICFR Auditor Attestation Flag false    
Entity File Number 001-40522    
Entity Tax Identification Number 84-3766197    
Entity Address, Address Line One 321 Harrison Avenue    
Entity Address, Address Line Two Suite 900    
Entity Address, City or Town Boston    
Entity Address, State or Province MA    
Entity Address, Postal Zip Code 02118    
City Area Code 617    
Local Phone Number 949-2643    
Entity Interactive Data Current Yes    
Title of 12(b) Security Common stock, par value $0.0001 per share    
Security Exchange Name NASDAQ    
Entity Incorporation, State or Country Code DE    
Document Annual Report true    
Document Transition Report false    
Documents Incorporated by Reference

Portions of registrant's definitive proxy statement for its annual meeting of shareholders to be filed within 120 days after the close of the registrant's fiscal year are incorporated by reference to into Part III of this annual report on Form 10-K.

   
Document Financial Statement Error Correction [Flag] false    
Auditor Name Deloitte & Touche LLP    
Auditor Location Boston, Massachusetts    
Auditor Firm ID 34    
Auditor Opinion

Opinion on the Financial Statements

We have audited the accompanying consolidated balance sheets of Monte Rosa Therapeutics, Inc. and subsidiaries (the "Company") as of December 31, 2025 and 2024, the related consolidated statements of operations and comprehensive loss, stockholders' equity, and cash flows, for each of the two years in the period ended December 31, 2025, and the related notes (collectively referred to as the "financial statements"). In our opinion, the financial statements present fairly, in all material respects, the financial position of the Company as of December 31, 2025 and 2024, and the results of its operations and its cash flows for each of the two years in the period ended December 31, 2025, in conformity with accounting principles generally accepted in the United States of America.