v3.26.1
Income taxes (Tables)
12 Months Ended
Dec. 31, 2025
Income taxes  
Schedule of components of net loss before tax provision from income taxes

The components of net loss before income tax provision are as follows (in thousands):

Year Ended

December 31, 

  ​ ​ ​

2025

  ​ ​ ​

2024

  ​ ​ ​

2023

United Kingdom

$

(225,456)

$

(179,610)

$

(182,980)

United States

 

6,648

 

5,814

 

3,773

Total

$

(218,808)

$

(173,796)

$

(179,207)

Schedule of components of the benefit for income taxes

The components of the provision for (benefit from) income taxes are as follows (in thousands):

Year Ended

December 31, 

  ​ ​ ​

2025

  ​ ​ ​

2024

  ​ ​ ​

2023

Current income tax provision (benefit)

 

  ​

 

  ​

 

  ​

Federal - United States

$

690

$

283

$

(1,180)

State - United States

 

312

 

178

 

(669)

Total current income tax provision (benefit)

 

1,002

 

461

 

(1,849)

Deferred income tax (benefit) provision

 

  ​

 

  ​

 

  ​

Federal - United States

 

(1,304)

 

(3,772)

 

2,513

State - United States

 

454

 

(1,454)

 

793

Total deferred income tax (benefit) provision

 

(850)

 

(5,226)

 

3,306

Total provision for (benefit from) income taxes

$

152

$

(4,765)

$

1,457

Schedule of reconciliation of the provision (benefit) for income taxes

Year Ended

December 31, 2025

Amount ($)

  ​ ​ ​

Percent (%)

 

Provision for (benefit from) income taxes at U.K. federal statutory rate

$

(54,702)

25.0

%

Foreign tax effects

United States

 

(1,513)

0.7

%

Changes in valuation allowances

 

19,869

(9.1)

%

Nontaxable or nondeductible items

Net losses surrendered for research credit

21,626

(9.9)

%

Impact of foreign exchange rates

13,893

(6.3)

%

Other

979

(0.5)

%

Effective income tax rate

$

152

(0.1)

%

Year Ended

December 31,

  ​ ​ ​

2024

 

2023

(Benefit from) provision for income taxes at statutory rate

 

25.0

%

23.5

%

Increases (decreases) resulting from:

Tax credits

 

3.7

%

0.6

%

Change in valuation allowance

 

(11.2)

%

(14.8)

%

Net losses surrendered for research credit

 

(14.2)

%

(11.1)

%

Impact of statutory rate change

%

2.7

%

Impact of foreign exchange rates

(1.0)

%

(0.1)

%

Other

 

0.4

%

(1.6)

%

Effective income tax rate

 

2.7

%

(0.8)

%

Schedule of significant components of the Company's current and deferred tax assets

Year Ended

December 31, 2025

Amount ($)

  ​ ​ ​

Percent (%)

 

Provision for (benefit from) income taxes at U.K. federal statutory rate

$

(54,702)

25.0

%

Foreign tax effects

United States

 

(1,513)

0.7

%

Changes in valuation allowances

 

19,869

(9.1)

%

Nontaxable or nondeductible items

Net losses surrendered for research credit

21,626

(9.9)

%

Impact of foreign exchange rates

13,893

(6.3)

%

Other

979

(0.5)

%

Effective income tax rate

$

152

(0.1)

%

Year Ended

December 31,

  ​ ​ ​

2024

 

2023

(Benefit from) provision for income taxes at statutory rate

 

25.0

%

23.5

%

Increases (decreases) resulting from:

Tax credits

 

3.7

%

0.6

%

Change in valuation allowance

 

(11.2)

%

(14.8)

%

Net losses surrendered for research credit

 

(14.2)

%

(11.1)

%

Impact of statutory rate change

%

2.7

%

Impact of foreign exchange rates

(1.0)

%

(0.1)

%

Other

 

0.4

%

(1.6)

%

Effective income tax rate

 

2.7

%

(0.8)

%

Significant components of the Company’s deferred tax assets are as follows (in thousands):

December 31, 

  ​ ​ ​

2025

  ​ ​ ​

2024

Deferred tax assets:

Operating loss carryforwards

$

101,324

$

81,492

Research credit carryforwards

 

3,534

 

3,362

Operating lease liability

4,376

2,641

Share-based compensation

28,281

21,035

Depreciation & amortization

2,524

1,508

Accrued expenses and other

 

1,855

 

1,952

Total deferred tax assets

 

141,894

 

111,990

Deferred tax liabilities:

Operating lease right-of-use asset

(4,165)

(2,201)

Total deferred tax liabilities

 

(4,165)

 

(2,201)

Valuation allowance

 

(126,761)

 

(99,672)

Net deferred tax assets

$

10,968

$

10,117

Schedule of cash paid for income taxes

Year Ended

December 31, 

  ​ ​ ​

2025

Federal

$

State

Foreign

 

United States

(717)

Total

$

(717)