<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019cba95-f350-7447-bd3a-f1ec873e2c4a,g:c8e22a35-c929-41f6-9143-fdc172185841-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.colgate.com/role/Cover" xlink:type="simple" xlink:href="cl-20260317.xsd#Cover"/>
  <link:definitionLink xlink:role="http://www.colgate.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationLineItems_019cba95-f350-7855-b97d-548744340ebf" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationTable_019cba95-f350-76e3-8d0e-aa31c7e1cc0f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentInformationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dei_DocumentInformationLineItems_019cba95-f350-7855-b97d-548744340ebf" xlink:to="loc_dei_DocumentInformationTable_019cba95-f350-76e3-8d0e-aa31c7e1cc0f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019cba95-f350-7f3b-b9e9-1a8a6dfffb59" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_DocumentInformationTable_019cba95-f350-76e3-8d0e-aa31c7e1cc0f" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019cba95-f350-7f3b-b9e9-1a8a6dfffb59" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019cba95-f350-7f3b-b9e9-1a8a6dfffb59_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019cba95-f350-7f3b-b9e9-1a8a6dfffb59" xlink:to="loc_us-gaap_ClassOfStockDomain_019cba95-f350-7f3b-b9e9-1a8a6dfffb59_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019cba95-f350-7caf-9bf5-c1b9b800846a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019cba95-f350-7f3b-b9e9-1a8a6dfffb59" xlink:to="loc_us-gaap_ClassOfStockDomain_019cba95-f350-7caf-9bf5-c1b9b800846a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_019cba95-f350-7d0f-8c80-c0f8f4c694cc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019cba95-f350-7caf-9bf5-c1b9b800846a" xlink:to="loc_us-gaap_CommonStockMember_019cba95-f350-7d0f-8c80-c0f8f4c694cc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_A0.500NotesDue2026Member_019cba95-f350-793e-af73-5a32648bd49b" xlink:href="cl-20260317.xsd#cl_A0.500NotesDue2026Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019cba95-f350-7caf-9bf5-c1b9b800846a" xlink:to="loc_cl_A0.500NotesDue2026Member_019cba95-f350-793e-af73-5a32648bd49b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_A0300NotesDue2029Member_019cba95-f350-7df2-8631-3cf0b1097951" xlink:href="cl-20260317.xsd#cl_A0300NotesDue2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019cba95-f350-7caf-9bf5-c1b9b800846a" xlink:to="loc_cl_A0300NotesDue2029Member_019cba95-f350-7df2-8631-3cf0b1097951" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_A1.375NotesDue2034Member_019cba95-f350-7c61-af78-bcc71136682f" xlink:href="cl-20260317.xsd#cl_A1.375NotesDue2034Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019cba95-f350-7caf-9bf5-c1b9b800846a" xlink:to="loc_cl_A1.375NotesDue2034Member_019cba95-f350-7c61-af78-bcc71136682f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_A0.875Notesdue2039Member_019cba95-f350-7053-a921-de35f3bb938f" xlink:href="cl-20260317.xsd#cl_A0.875Notesdue2039Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019cba95-f350-7caf-9bf5-c1b9b800846a" xlink:to="loc_cl_A0.875Notesdue2039Member_019cba95-f350-7053-a921-de35f3bb938f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_A3.250NotesDue2035Member_019cba95-f350-7427-bc8c-dd9435134a2a" xlink:href="cl-20260317.xsd#cl_A3.250NotesDue2035Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019cba95-f350-7caf-9bf5-c1b9b800846a" xlink:to="loc_cl_A3.250NotesDue2035Member_019cba95-f350-7427-bc8c-dd9435134a2a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019cba95-f350-70b7-961f-ef4faef63aff" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019cba95-f350-7855-b97d-548744340ebf" xlink:to="loc_dei_Security12bTitle_019cba95-f350-70b7-961f-ef4faef63aff" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019cba95-f350-7d12-8369-68769b79b125" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019cba95-f350-7855-b97d-548744340ebf" xlink:to="loc_dei_TradingSymbol_019cba95-f350-7d12-8369-68769b79b125" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019cba95-f350-7a34-8025-8eea497bc68c" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019cba95-f350-7855-b97d-548744340ebf" xlink:to="loc_dei_SecurityExchangeName_019cba95-f350-7a34-8025-8eea497bc68c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019cba95-f350-7c66-a6fc-bd936215942a" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019cba95-f350-7855-b97d-548744340ebf" xlink:to="loc_dei_EntityCentralIndexKey_019cba95-f350-7c66-a6fc-bd936215942a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019cba95-f350-72fb-9651-d4e7c73e98f9" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019cba95-f350-7855-b97d-548744340ebf" xlink:to="loc_dei_AmendmentFlag_019cba95-f350-72fb-9651-d4e7c73e98f9" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019cba95-f350-773d-9948-a1702d52e1ed" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019cba95-f350-7855-b97d-548744340ebf" xlink:to="loc_dei_EntityEmergingGrowthCompany_019cba95-f350-773d-9948-a1702d52e1ed" xlink:type="arc" order="5"/>
  </link:definitionLink>
</link:linkbase>
