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  <xsd:element name="AssetAcquisitionsAndAcquiredInProcessResearchAndDevelopmentExpensePolicyTextBlock" id="zbio_AssetAcquisitionsAndAcquiredInProcessResearchAndDevelopmentExpensePolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="SingleReportableSegmentMember" id="zbio_SingleReportableSegmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ObexelimabMember" id="zbio_ObexelimabMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="UnallocatedMember" id="zbio_UnallocatedMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RightOfUseAssetObtainedUnderNewLeaseArrangement" id="zbio_RightOfUseAssetObtainedUnderNewLeaseArrangement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="CollaborativeArrangementSalesMilestonePaymentsReceivableMaximum" id="zbio_CollaborativeArrangementSalesMilestonePaymentsReceivableMaximum" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="CollaborativeArrangementTransactionPrice" id="zbio_CollaborativeArrangementTransactionPrice" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="LicenseAndOptionAgreementsRegulatoryMilestonePayable" id="zbio_LicenseAndOptionAgreementsRegulatoryMilestonePayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="LicenseAndOptionAgreementsSalesMilestonePayable" id="zbio_LicenseAndOptionAgreementsSalesMilestonePayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="PartneredRegionalProgramsZb001Zb005Member" id="zbio_PartneredRegionalProgramsZb001Zb005Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LicenseAndOptionAgreementsContractManufacturingOrganizationCosts" id="zbio_LicenseAndOptionAgreementsContractManufacturingOrganizationCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="LicenseAgreementsAbstract" id="zbio_LicenseAgreementsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LicenseAgreementsTextBlock" id="zbio_LicenseAgreementsTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ShortTermInvestmentsFairValueDisclosureAbstract" id="zbio_ShortTermInvestmentsFairValueDisclosureAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LongTermInvestmentsFairValueDisclosureAbstract" id="zbio_LongTermInvestmentsFairValueDisclosureAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="EmployeeStockPurchasePlanCommonSharesReservedForFutureIssuance" id="zbio_EmployeeStockPurchasePlanCommonSharesReservedForFutureIssuance" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="LicenseAgreementWithZaiLabsHongKongLimitedMember" id="zbio_LicenseAgreementWithZaiLabsHongKongLimitedMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="EmploymentInducementGrantsPlanMember" id="zbio_EmploymentInducementGrantsPlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CollaborativeAgreementUpfrontPaymentPaid" id="zbio_CollaborativeAgreementUpfrontPaymentPaid" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="RoyaltyPurchaseAgreementMember" id="zbio_RoyaltyPurchaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="Phase3TrialMilestoneMember" id="zbio_Phase3TrialMilestoneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FoodAndDrugAdministrationApprovalForIgg4RelatedDiseaseMember" id="zbio_FoodAndDrugAdministrationApprovalForIgg4RelatedDiseaseMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FoodAndDrugAdministrationApprovalForSystemicLupusErythematosusMember" id="zbio_FoodAndDrugAdministrationApprovalForSystemicLupusErythematosusMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PercentageOfRoyaltyOnNetSales" id="zbio_PercentageOfRoyaltyOnNetSales" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PercentageOfRoyaltyOnNetSalesByLicensees" id="zbio_PercentageOfRoyaltyOnNetSalesByLicensees" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PercentageOfRoyaltyOnIncomeEarnedFromLicensees" id="zbio_PercentageOfRoyaltyOnIncomeEarnedFromLicensees" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PercentageOfRoyaltyOnNonRoyaltyIncomeEarnedFromLicensees" id="zbio_PercentageOfRoyaltyOnNonRoyaltyIncomeEarnedFromLicensees" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="RoyaltyContingentMilestonePaymentsReceivable" id="zbio_RoyaltyContingentMilestonePaymentsReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="GrossProceedsFromIssuanceOfCommonStock" id="zbio_GrossProceedsFromIssuanceOfCommonStock" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="LicenseAgreementWithInnocarePharmaIncMember" id="zbio_LicenseAgreementWithInnocarePharmaIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CollaborativeAgreementUpfrontPaymentPayable" id="zbio_CollaborativeAgreementUpfrontPaymentPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CollaborativeAgreementUpfrontPaymentShares" id="zbio_CollaborativeAgreementUpfrontPaymentShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="CollaborativeAgreementContingentPaymentOnOccurrenceOfSpecifiedEvents" id="zbio_CollaborativeAgreementContingentPaymentOnOccurrenceOfSpecifiedEvents" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CollaborativeAgreementContingentSharesIssuableOnOccurrenceOfSpecifiedEvents" id="zbio_CollaborativeAgreementContingentSharesIssuableOnOccurrenceOfSpecifiedEvents" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="CollaborativeAgreementNearTermMilestonePaymentsPayable" id="zbio_CollaborativeAgreementNearTermMilestonePaymentsPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CollaborativeAgreementFutureRegulatoryAndCommercialMilestonePaymentsPayable" id="zbio_CollaborativeAgreementFutureRegulatoryAndCommercialMilestonePaymentsPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CollaborativeAgreementFutureDevelopmentRegulatoryAndCommercialMilestone" id="zbio_CollaborativeAgreementFutureDevelopmentRegulatoryAndCommercialMilestone" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CollaborativeAgreementRegulatoryMilestonePaymentsPayable" id="zbio_CollaborativeAgreementRegulatoryMilestonePaymentsPayable" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="DirectorsAndOfficersMember" id="zbio_DirectorsAndOfficersMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SaleOfStockCommonStockAuthorizedValue" id="zbio_SaleOfStockCommonStockAuthorizedValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="NoncashInterestExpenseOnRoyaltyObligation" id="zbio_NoncashInterestExpenseOnRoyaltyObligation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AtMarketOfferingMember" id="zbio_AtMarketOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PrivatePlacementAndAtOfferingMember" id="zbio_PrivatePlacementAndAtOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CommonStockReservedForFutureIssuance" id="zbio_CommonStockReservedForFutureIssuance" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="OrelabrutinibMember" id="zbio_OrelabrutinibMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ZenasBiopharmaHkLimitedMember" id="zbio_ZenasBiopharmaHkLimitedMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NoncashOrPartNoncashAcquisitionNoncashFinancialOrEquityInstrumentConsiderationSharesAmount" id="zbio_NoncashOrPartNoncashAcquisitionNoncashFinancialOrEquityInstrumentConsiderationSharesAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="OtherProgramsZb002Zb004Zb021Zb022Member" id="zbio_OtherProgramsZb002Zb004Zb021Zb022Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombination" id="zbio_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombination" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="RightsObtainedDevelopManufactureAndCommercializeNumberOfProducts" id="zbio_RightsObtainedDevelopManufactureAndCommercializeNumberOfProducts" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="InnocarePharmaInc.Member" id="zbio_InnocarePharmaInc.Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NumberOfSharesToBeIssued" id="zbio_NumberOfSharesToBeIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationNontaxableOrNondeductibleItemsAmount" id="zbio_EffectiveIncomeTaxRateReconciliationNontaxableOrNondeductibleItemsAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationNontaxableOrNondeductibleItemsPercentage" id="zbio_EffectiveIncomeTaxRateReconciliationNontaxableOrNondeductibleItemsPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="IncomeTaxPaidFederalStateAndLocalAfterRefundReceived" id="zbio_IncomeTaxPaidFederalStateAndLocalAfterRefundReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="InducementPlan2026Member" id="zbio_InducementPlan2026Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CommonStockToBeIssuedToRelatedPartyMember" id="zbio_CommonStockToBeIssuedToRelatedPartyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DeferredTaxLiabilitiesPrepaidAndOther" id="zbio_DeferredTaxLiabilitiesPrepaidAndOther" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="LicenseAndOptionAgreementsDevelopmentMilestonePassthroughObligation" id="zbio_LicenseAndOptionAgreementsDevelopmentMilestonePassthroughObligation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DebtInstrumentNumberOfTranches" id="zbio_DebtInstrumentNumberOfTranches" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="SecuredDebtInitialTrancheMember" id="zbio_SecuredDebtInitialTrancheMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SecuredDebtFutureTranchesMember" id="zbio_SecuredDebtFutureTranchesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DebtInstrumentInterestRateFloor" id="zbio_DebtInstrumentInterestRateFloor" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentMinimumLiquidityCovenant" id="zbio_DebtInstrumentMinimumLiquidityCovenant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DeferredTaxAssetsRoyaltyObligation" id="zbio_DeferredTaxAssetsRoyaltyObligation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DebtInstrumentInterestPaidInKindPercent" id="zbio_DebtInstrumentInterestPaidInKindPercent" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="DebtInstrumentInterestPaidInKindPeriod" id="zbio_DebtInstrumentInterestPaidInKindPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DebtInstrumentFeePercent" id="zbio_DebtInstrumentFeePercent" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="DebtInstrumentRepaymentsNumberOfEqualInstallments" id="zbio_DebtInstrumentRepaymentsNumberOfEqualInstallments" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
</xsd:schema>
