EXHIBIT 15.1

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CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We hereby consent to the incorporation by reference in the Registration Statements on Form F-3 (No. 333-227016, No. 333-249655 and No. 333-277940) and on Form S-8 (No. 333-216539, No. 333-213865 and No. 333-233019) of AC Immune SA of our report dated March 13, 2026 relating to the financial statements and the effectiveness of internal control over financial reporting, which appears in this Form 20-F.

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/s/ PricewaterhouseCoopers SA

Lausanne, Switzerland

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March 13, 2026

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