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Statement [Table] Statement [Table] 2015 Plan Replaced By The 2025 Plan [Member] 2015 Plan Replaced By The 2025 Plan [Member] 2015 Plan Replaced By The 2025 Plan Restricted cash Restricted Cash, Noncurrent Restricted cash Federal Internal Revenue Service (IRS) [Member] Weighted average grant date fair value per share of options granted to employees Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Statement [Line Items] Statement [Line Items] Revenue recognition Revenue from Contract with Customer [Policy Text Block] Warrant [Member] Warrant Warrants exercise price per share paid at closing of offering Class Of Warrant Or Right Exercise Price Of Warrants Paid At Closing Of Offering Class of warrant or right exercise price of warrants paid at closing of offering. Entity Filer Category Entity Filer Category Total liabilities and stockholders' equity Liabilities and Equity Payables and Accruals [Abstract] Weighted-average price, Exercisable Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price Long-Lived Tangible Asset Long-Lived Tangible Asset [Axis] Severance Costs Severance and related costs Increase in valuation allowance Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount Tenant improvement investment Tenant Improvement Investment Obligation The amount the lessee agrees to invest into a tenant improvement of a leased property. Cybersecurity Risk Third Party Oversight and Identification Processes [Flag] Plan 2015 Long Term Incentive Plan2015 [Member] Long Term Incentive Plan 2015. Cancelled stock awards Effective Income Tax Rate Reconciliation, Cancelled Stock Awards Amount Effective Income Tax Rate Reconciliation, Cancelled Stock Awards Amount Cash and Cash Equivalents, Fair Value Disclosure Estimated Fair Value 2025 Equity Incentive Award Plan [Member] 2025 Equity Incentive Award Plan [Member] 2025 Plan Balance at beginning of year Balance at end of year Valuation allowance Valuation allowance Deferred Tax Assets, Valuation Allowance U.S. federal statutory rate Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent U.S. federal statutory rate percent U.S. federal statutory rate Shares Issued, Price Per Share Related party transaction collaboration agreement, initial term Related party transaction collaboration agreement, initial term Related Party Transaction Collaboration Agreement Initial Term Related party transaction collaboration agreement, initial term. Subsequent Event [Line Items] Subsequent Event [Line Items] Cybersecurity Risk Management Third Party Engaged [Flag] Documents Incorporated by Reference Documents Incorporated by Reference [Text Block] Effective Income Tax Rate Reconciliation, Percent Effective income tax rate percent Income Taxes Paid Income Taxes Paid Total Income Tax Authority Income Tax Jurisdiction [Axis] Facility and All Other Costs [Member] Facility and All Other Costs [Member] Facility and all other costs Long-term marketable securities Debt Securities, Available-for-Sale, Noncurrent Restricted Cash Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block] Maximum matching contributions as a percentage of eligible compensation Defined Contribution Plan, Employer Matching Contribution, Percent of Employees' Gross Pay Fair market value change of warrant liability percent Effective Income Tax Rate Reconciliation, Nondeductible Expense, Change of Warrant Liability, Percent Effective Income Tax Rate Reconciliation, Nondeductible Expense, Change of Warrant Liability, Percent Schedule of Shares of Common Stock Reserved for Future Issuance Schedule Of Shares Of Common Stock Reserved For Future Issuance Table [Text Block] Schedule of shares of common stock reserved for future issuance. Research and development Accrued Research And Development Current Accrued research and development, current. Additional paid-in capital Additional Paid in Capital, Common Stock Property and equipment Deferred Tax Assets, Property, Plant and Equipment Summary of Significant Accounting Policies Significant Accounting Policies [Text Block] Property Plant And Equipment [Line Items] Property, Plant and Equipment [Line Items] Aggregate Purchase Per Share Aggregate Purchase Per Share Granted, Number of options Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross Cybersecurity Risk Management, Strategy, and Governance [Table] Schedule of Computation of Basic and Diluted Net Loss per Share Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Effective Income Tax Rate Reconciliation, Nondeductible Expense, Amount [Abstract] Nontaxable or nondeductible items Potential Shares Issuable Under ESPP Share-Based Payment Arrangement [Member] Net loss per share - basic and diluted Net loss per share - basic Earnings Per Share, Basic Earnings Per Share, Basic, Total Two thousand seventeen and two thousand fifteen equity incentive award plan. Two Thousand Seventeen And Two Thousand Fifteen Equity Incentive Award Plan [Member] 2017 Plan and 2015 Plan Repurchase of Common Stock (Treasury Stock) Payments for Repurchase of Equity Payments for Repurchase of Equity, Total Effective Income Tax Rate Reconciliation, Cancelled stock awards Effective Income Tax Rate Reconciliation, Cancelled stock awards Cancelled stock awards Outstanding Beginning balance, Number of options Outstanding Ending balance, Number of options Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number Summary of Available-for-Sale Securities Held Schedule of Available-for-Sale Securities Reconciliation [Table Text Block] Total current liabilities Liabilities, Current Options Exercisable to Purchase Common Stock Options Exercisable to Purchase Common Stock Options Exercisable To Purchase Common Stock [Member] Options exercisable to purchase common stock. Adjustments to reconcile net loss to net cash used in operating activities: Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract] Lessee, Operating Lease, Liability, to be Paid, Year Five 2028 Cancelled/Forfeited, Aggregate Intrinsic value Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures And Expirations In Period Intrinsic Value Share based compensation arrangement by share based payment award options forfeitures and expirations in period intrinsic value. Other Effective Income Tax Rate Reconciliation, Other ajustments other Percentage Effective Income Tax Rate Reconciliation, Other ajustments other Percentage Income Tax Paid, Federal, after Refund Received Income Tax Paid, Federal, after Refund Received, Total Federal Pledging Purpose [Axis] Upfront payments Upfront Payments Upfront payments. Operating And Variable Lease Cost Operating and variable lease cost. Total lease cost Existing Lease Obligations Existing lease obligations Existing lease obligations Existing Lease Obligations Accounting Standards Update [Axis] Stockholders' equity Equity, Attributable to Parent [Abstract] Entity Small Business Entity Small Business Accumulated deficit Accumulated deficit Retained Earnings (Accumulated Deficit), Total Retained Earnings (Accumulated Deficit) Equity compensation Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost Total research and development expense Research and Development Research and Development Preferred Stock [Member] Entity Well-known Seasoned Issuer Entity Well-known Seasoned Issuer Cancelled/Forfeited, Number of options Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period Sale of stock, price per share Sale of Stock, Price Per Share Exercised, Aggregate Intrinsic value Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value Equity-based Compensation and Equity Incentive Plans Share-Based Payment Arrangement [Text Block] Organization, Consolidation and Presentation of Financial Statements [Abstract] Leases [Abstract] Collaboration in research and development Anticipated Completion Of Research And Development Projects Period Anticipated completion period for research and development projects. 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Warrants to purchase shares of common stock Class of Warrant or Right, Number of Securities Called by Warrants or Rights Net Loss Per Share Earnings Per Share, Policy [Policy Text Block] Liabilities and Stockholders' Equity Liabilities and Equity [Abstract] Entity Address, Postal Zip Code Entity Address, Postal Zip Code Net cash used in operating activities Cash Provided by (Used in) Operating Activity, Including Discontinued Operation Operating lease liabilities Increase (Decrease) in Operating Lease Liability Common Stock $0.001 Par Value Common Stock Common Stock [Member] Cybersecurity Risk Role of Management [Text Block] Tax credit carryforwards Tax Credit Carryforward, Amount Employee contribution Defined Contribution Plan, Employer Discretionary Contribution Amount Income Tax Disclosure [Line Items] Income Tax Disclosure [Line Items] Income tax disclosure. 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Entity Central Index Key Entity Central Index Key Investments, Debt and Equity Securities [Abstract] Cybersecurity Risk Process for Informing Board Committee or Subcommittee Responsible for Oversight [Text Block] Available-for-Sale Securities Available For Sale Securities Disclosure [Text Block] Available for sale securities disclosure. 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Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] Current Fiscal Year End Date Current Fiscal Year End Date Former Headquarter [Member] Former Headquarter [Member] Former Headquarter Two Thousand Twenty Three Inducement Plan [Member] Two Thousand Twenty Three Inducement Plan [Member] 2023 Inducement Plan Entity Address, State or Province Entity Address, State or Province Beginning balance, Number of unvested shares/units Ending balance, Number of unvested shares/units Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number Comprehensive loss Comprehensive Income (Loss), Net of Tax, Attributable to Parent Research and Development Expense, Policy [Policy Text Block] Research and Development Costs Total Shares of Common Stock Reserved for Future Issuance Common Stock, Capital Shares Reserved for Future Issuance Class of Warrant or Right Class of Warrant or Right [Domain] Cowen and Company, LLC Cowen And Company L L C [Member] Cowen and company LLC. 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Total fair value of awards vested Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value Aggregate Intrinsic value, Vested or expected to vest at December 31, 2025 Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value Income Tax Disclosure [Table] Income Tax Disclosure [Table] Income tax disclosure. State State and Local Jurisdiction [Member] Percentage of shares outstanding Share Based Compensation Arrangement By Share Based Payment Award Percentage Of Shares Outstanding Share based compensation arrangement by share based payment award percentage of shares outstanding. Accumulated Other Comprehensive Income (Loss) AOCI Attributable to Parent [Member] Net operating loss carryforwards subject to expiration Operating Loss Carryforwards Subject To Expiration Operating loss carryforwards subject to expiration. 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Prepaid Expense, Noncurrent, Total Prepaid Expense, Noncurrent Non-current pre-paid research and development Income Tax Paid, by Individual Jurisdiction [Abstract] October 2023 Financing [Member] October 2023 Financing [Member] Commitments and Contingencies Commitments and contingencies (Note 12) Leases Lessee, Leases [Policy Text Block] Beginning balance, Unvested Grant date fair value Ending balance, Unvested Grant date fair value Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value General and Administrative Expense General and Administrative Expense [Member] Revenue, practical expedient, incremental cost of obtaining contract [true/false] Revenue, Practical Expedient, Incremental Cost of Obtaining Contract [true false] Total lease liabilities Operating Lease, Liability Auditor Firm ID Auditor Firm ID Stockholders' Equity, Reverse Stock Split Reverse Stock Split Decsription Computer and Office Equipment Computer And Office Equipment [Member] Computer and office equipment. 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Equity-Based Compensation Share-Based Payment Arrangement [Policy Text Block] Treasury stock, shares Treasury Stock Share Treasury Stock Share Sale of common stock, shares Proceeds from issuance of common stock, net of issuance costs, Shares Stock Issued During Period, Shares, New Issues Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period Vested Impairment for in-process research and development Restructuring, Settlement and Impairment Provisions Restructuring, Settlement and Impairment Provisions, Total Net loss per share - basic and diluted Net loss per share - diluted Earnings Per Share, Diluted Earnings Per Share, Diluted, Total Schedule of Segment Reporting Information, by Segment [Table Text Block] Schedule of Research and Development, General and Administrative Expenses, and Restructuring Charges are Significant Segment Expenses Effective Income Tax Rate Reconciliation, Percent [Abstract] Tax Rate Title of 12(g) Security Title of Individual Title and Position [Domain] Property, Plant, and Equipment, Useful Life, Term, Description [Extensible Enumeration] City Area Code City Area Code Milestone payments Milestone Payments Milestone Payments 2025 Plan and 2017 Plan Two Thousand Twenty Five And Two Thousand Seventeen Equity Incentive Award Plan [Member] Two Thousand Twenty Five And Two Thousand Seventeen Equity Incentive Award Plan [Member] Auditor Name Auditor Name Accured Restructuring cost Accured Restructuring cost Restructuring costs Transaction Costs Allocated To Warrant Liabilities Transaction Costs Allocated To Warrant Liabilities Transaction costs allocated to warrant liabilities Unbeneficial percentage of ownership after exercise of common stock outstanding effect to issuance Unbeneficial Percentage Of Ownership After Exercise Of Common Stock Outstanding Effect To Issuance Unbeneficial percentage of ownership after exercise of common stock outstanding effect to issuance. Letter of credit Line of Credit Facility, Maximum Borrowing Capacity Deferred Tax Assets, Tax Credit Carryforwards, Total Tax credit carryforwards Deferred Tax Assets, Tax Credit Carryforwards Treasury Stock Treasury Stock [Policy Text Block] The entire policy disclosure for treasury stock Impairment losses Impairment Losses Related to Real Estate Partnerships Counterparty Name Counterparty Name [Domain] Variable lease cost Variable Lease, Cost Issuance of common stock under employee stock purchase plan Stock Issued During Period, Value, Employee Stock Purchase Plan Operating Lease, Weighted Average Remaining Lease Term Weighted average remaining lease term (years) Segment Reporting Information [Line Items] Issuance of restricted stock, shares Stock Issued During Period, Shares, Restricted Stock Award, Gross Award Date [Axis] Letter of Credit Letter of Credit [Member] Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract] Cash Equivalents Cash and Cash Equivalents, Policy [Policy Text Block] The Binney Street [member] The Binney Street [member] The Binney Street Property and equipment, net Property and equipment, net Property, Plant and Equipment, Net Total cash, cash equivalents, and restricted cash shown in the consolidated statement of cash flows Cash, cash equivalents and restricted cash at beginning of period Cash, cash equivalents and restricted cash at end of period Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation Loss from operations Operating Income (Loss) Award Date [Domain] Deferred Tax Assets Amortizable Research Expenditures Deferred Tax Assets Amortizable Research Expenditures Amortizable research expenditures Accumulated Deficit Retained Earnings [Member] Consulting and professional services Consulting and Professional Services [Member] Consulting and Professional Services [Member] Cash and Cash Equivalents Cash and Cash Equivalents [Axis] Share-Based Payment Arrangement, Noncash Expense, Total Equity-based compensation expense Share-Based Payment Arrangement, Noncash Expense Reverse Stock Split [Policy Text Block] Reverse Stock Split [Policy Text Block] Reverse Stock Split Total long-term liabilities Liabilities, Noncurrent Operating Lease, Weighted Average Discount Rate, Percent Weighted average discount rate Long-term lease liabilities Lease liability - operating lease, net of current portion Operating Lease, Liability, Noncurrent Quoted Prices in Active Markets for Identical Assets (Level 1) Fair Value, Inputs, Level 1 [Member] Class Of Stock [Line Items] Class of Stock [Line Items] Cash Provided by (Used in) Financing Activity, Including Discontinued Operation Net cash provided by financing activities Components of Lease Cost for Operating Leases Lease, Cost [Table Text Block] Nontaxable or nondeductible items Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent [Abstract] Change in Accounting Principle, Accounting Standards Update, Adopted [true false] Change in accounting principle, accounting standards update, adopted [true false] Auditor Location Auditor Location Investments, Fair Value Disclosure, Total Short-term investments Investments, Fair Value Disclosure U.S. Government Agency Securities and Treasuries U S Treasury And Government Long Term Debt Securities [Member] US treasury and government long-term debt securities. Restructuring Charges [Member] Restructuring charges: expense acceleration ESPP Employee Stock Purchase Plan [Member] Employee Stock Purchase Plan [Member] Other income (expense): Nonoperating Income (Expense) [Abstract] Earnings Per Share Reconciliation [Abstract] Warrants Policy 1 [Policy Text Block] Warrants Policy 1 [Policy Text Block] Warrants Description of tax benefit likely to be realized upon settlement Income Tax Examination, Likelihood of Unfavorable Settlement Schedule of Potentially Common Shares Excluded from Calculation of Net Loss Per share Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Corporate Debt Securities Corporate debt securities Corporate Debt Securities [Member] Income Tax Authority Income Tax Jurisdiction [Domain] Clinical Research and External Costs [Member] Clinical Research and External Costs [Member] Clinical research and external costs Entity Interactive Data Current Entity Interactive Data Current Deferred revenue Increase (Decrease) in Contract with Customer, Liability Income Statement Location Statement of Income Location, Balance [Domain] Summary of Net Income Tax Paid of Refund Received [Table Text Block] Summary of Net Income Tax Paid of Refund Received [Table Text Block] Summary of Net Income Tax Paid of Refund Received Cash flows from operating activities: Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract] Furniture and Fixtures Furniture and Fixtures [Member] Accretion/amortization of investment securities Accretion (Amortization) of Discounts and Premiums, Investments Jefferies, LLC Jefferies L L C [Member] Jefferies, LLC Revenue, practical expedient, remaining performance obligation, description Revenue, Practical Expedient, Remaining Performance Obligation, Description Cash Equivalents, at Carrying Value, Total Cash equivalents Cash Equivalents, at Carrying Value Option Indexed to Issuer's Equity, Type Option Indexed to Issuer's Equity, Type [Domain] Entity Tax Identification Number Entity Tax Identification Number Access and use of space under agreement Access And Use Of Space Under Agreement Access and Use of space under agreement. Fair Value Asset Measured On Recurring Basis [Line Items] Fair Value Asset Measured On Recurring Basis [Line Items] Fair Value Asset Measured On Recurring Basis [Line Items] Nature of Business Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block] Income Tax Authority, Name Income Tax Authority, Name [Domain] Local Phone Number Local Phone Number Employee unrecognized compensation expense Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount Denominator: Weighted Average Number of Shares Outstanding, Diluted [Abstract] Auditor Opinion [Text Block] Auditor Opinion Operating leases Operating Lease Cost [Abstract] Operating lease cost. Right of use assets Deferred Tax Liabilities Right Of Use Assets Deferred tax liabilities, right of use assets. Right of use assets Accounting Policies [Abstract] Increase (Decrease) In Fair Value Warrant Liability Increase (Decrease) In Fair Value Warrant Liability Change in fair value warrant liability Noncash Purchase Of Property Plant And Equipment In Accounts Payable And Accrued Liabilities Adjustments Noncash purchase of property, plant and equipment in accounts payable and accrued liabilities adjustments. Property and equipment purchases included in accounts payable and accrued expenses Cancellation of restricted stock Stock Issued During Period, Shares, Restricted Stock Award, Forfeited ATM At The Market [Member] at the market. Lessee, Operating Lease, Liability, to be Paid, Year Four 2027 Cash and cash equivalents Cash and Cash Equivalents [Member] Class of Stock [Domain] Commercial Paper Commercial paper Commercial Paper [Member] Issuance costs included in accounts payable and accrued expenses Issuance Costs Included In Accounts Payable And Accrued Expenses Issuance costs included in accounts payable and accrued expenses. Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant Shares available for future grants Employee unrecognized compensation cost, period of recognition Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition Professional fees Accrued Professional Fees, Current Cash, Cash Equivalents, and Short-Term Investments, Total Cash, cash equivalents, and short-term marketable securities Cash, Cash Equivalents, and Short-Term Investments Employee contribution, percentage Defined Contribution Plan, Maximum Annual Contributions Per Employee, Percent Impairment Charge Impairment Charge on Reclassified Assets Numerator: Net Income (Loss) Available to Common Stockholders, Diluted [Abstract] Schedule Of Stock By Class [Table] Stock, Class of Stock [Table] Percentage Of Common Stock Ownership To Exercise Warrant Percentage Of Common Stock Ownership To Exercise Warrant Entity Emerging Growth Company Entity Emerging Growth Company Agreement expiration date Agreement Expiration Date Agreement expiration date. Weighted average remaining contractual term, Vested or expected to vest Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term Tax Credit Carryforward, Name Tax Credit Carryforward, Name [Domain]