<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:c64a3438-a589-4d3e-8f61-42701e2f974f,g:b04155ae-61d6-4e25-a070-b2b2d022cf0f-->
<xs:schema xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:dtil="http://precisionbiosciences.com/20251231" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2024-01-31" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" attributeFormDefault="unqualified" elementFormDefault="qualified" targetNamespace="http://precisionbiosciences.com/20251231">
  <xs:import namespace="http://fasb.org/srt/2025" schemaLocation="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd"/>
  <xs:import namespace="http://fasb.org/us-gaap/2025" schemaLocation="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/2024-01-31" schemaLocation="https://www.xbrl.org/dtr/type/2024-01-31/types.xsd"/>
  <xs:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/cyd-af-sub/2025" schemaLocation="https://xbrl.sec.gov/cyd/2025/cyd-af-sub-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei/2025" schemaLocation="https://xbrl.sec.gov/dei/2025/dei-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/ecd/2025" schemaLocation="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd"/>
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="dtil-20251231_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="dtil-20251231_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="dtil-20251231_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="dtil-20251231_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:type="simple"/>
      <link:roleType id="CoverPage" roleURI="http://precisionbiosciences.com/role/CoverPage">
        <link:definition>0000001 - Document - Cover Page</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AuditInformation" roleURI="http://precisionbiosciences.com/role/AuditInformation">
        <link:definition>0000002 - Document - Audit Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BALANCESHEETS" roleURI="http://precisionbiosciences.com/role/BALANCESHEETS">
        <link:definition>9952151 - Statement - BALANCE SHEETS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BALANCESHEETSParenthetical" roleURI="http://precisionbiosciences.com/role/BALANCESHEETSParenthetical">
        <link:definition>9952152 - Statement - BALANCE SHEETS (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STATEMENTSOFOPERATIONS" roleURI="http://precisionbiosciences.com/role/STATEMENTSOFOPERATIONS">
        <link:definition>9952153 - Statement - STATEMENTS OF OPERATIONS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STATEMENTSOFCHANGESINSTOCKHOLDERSEQUITY" roleURI="http://precisionbiosciences.com/role/STATEMENTSOFCHANGESINSTOCKHOLDERSEQUITY">
        <link:definition>9952154 - Statement - STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STATEMENTSOFCASHFLOWS" roleURI="http://precisionbiosciences.com/role/STATEMENTSOFCASHFLOWS">
        <link:definition>9952155 - Statement - STATEMENTS OF CASH FLOWS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DESCRIPTIONOFBUSINESSANDSUMMARYOFSIGNIFICANTACCOUNTINGPOLICIES" roleURI="http://precisionbiosciences.com/role/DESCRIPTIONOFBUSINESSANDSUMMARYOFSIGNIFICANTACCOUNTINGPOLICIES">
        <link:definition>9952156 - Disclosure - DESCRIPTION OF BUSINESS AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COLLABORATIONANDLICENSEAGREEMENTS" roleURI="http://precisionbiosciences.com/role/COLLABORATIONANDLICENSEAGREEMENTS">
        <link:definition>9952157 - Disclosure - COLLABORATION AND LICENSE AGREEMENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SHAREBASEDCOMPENSATION" roleURI="http://precisionbiosciences.com/role/SHAREBASEDCOMPENSATION">
        <link:definition>9952158 - Disclosure - SHARE-BASED COMPENSATION</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RETIREMENTPLAN" roleURI="http://precisionbiosciences.com/role/RETIREMENTPLAN">
        <link:definition>9952159 - Disclosure - RETIREMENT PLAN</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IMPAIRMENTCHARGES" roleURI="http://precisionbiosciences.com/role/IMPAIRMENTCHARGES">
        <link:definition>9952160 - Disclosure - IMPAIRMENT CHARGES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DISCONTINUEDOPERATIONS" roleURI="http://precisionbiosciences.com/role/DISCONTINUEDOPERATIONS">
        <link:definition>9952161 - Disclosure - DISCONTINUED OPERATIONS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EARNINGSPERSHARE" roleURI="http://precisionbiosciences.com/role/EARNINGSPERSHARE">
        <link:definition>9952162 - Disclosure - EARNINGS PER SHARE</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="PROPERTYEQUIPMENTANDSOFTWAREANDASSETSHELDFORSALE" roleURI="http://precisionbiosciences.com/role/PROPERTYEQUIPMENTANDSOFTWAREANDASSETSHELDFORSALE">
        <link:definition>9952163 - Disclosure - PROPERTY, EQUIPMENT AND SOFTWARE AND ASSETS HELD FOR SALE</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INTANGIBLEASSETS" roleURI="http://precisionbiosciences.com/role/INTANGIBLEASSETS">
        <link:definition>9952164 - Disclosure - INTANGIBLE ASSETS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTS" roleURI="http://precisionbiosciences.com/role/FAIRVALUEMEASUREMENTS">
        <link:definition>9952165 - Disclosure - FAIR VALUE MEASUREMENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ELOTRANSACTION" roleURI="http://precisionbiosciences.com/role/ELOTRANSACTION">
        <link:definition>9952166 - Disclosure - ELO TRANSACTION</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DEBT" roleURI="http://precisionbiosciences.com/role/DEBT">
        <link:definition>9952167 - Disclosure - DEBT</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="WARRANTS" roleURI="http://precisionbiosciences.com/role/WARRANTS">
        <link:definition>9952168 - Disclosure - WARRANTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSANDCONTINGENCIES" roleURI="http://precisionbiosciences.com/role/COMMITMENTSANDCONTINGENCIES">
        <link:definition>9952169 - Disclosure - COMMITMENTS AND CONTINGENCIES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXES" roleURI="http://precisionbiosciences.com/role/INCOMETAXES">
        <link:definition>9952170 - Disclosure - INCOME TAXES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SEGMENTREPORTING" roleURI="http://precisionbiosciences.com/role/SEGMENTREPORTING">
        <link:definition>9952171 - Disclosure - SEGMENT REPORTING</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SUBSEQUENTEVENTS" roleURI="http://precisionbiosciences.com/role/SUBSEQUENTEVENTS">
        <link:definition>9952172 - Disclosure - SUBSEQUENT EVENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DESCRIPTIONOFBUSINESSANDSUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESPolicies" roleURI="http://precisionbiosciences.com/role/DESCRIPTIONOFBUSINESSANDSUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESPolicies">
        <link:definition>9955511 - Disclosure - DESCRIPTION OF BUSINESS AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DESCRIPTIONOFBUSINESSANDSUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESTables" roleURI="http://precisionbiosciences.com/role/DESCRIPTIONOFBUSINESSANDSUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESTables">
        <link:definition>9955512 - Disclosure - DESCRIPTION OF BUSINESS AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SHAREBASEDCOMPENSATIONTables" roleURI="http://precisionbiosciences.com/role/SHAREBASEDCOMPENSATIONTables">
        <link:definition>9955513 - Disclosure - SHARE-BASED COMPENSATION (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DISCONTINUEDOPERATIONSTables" roleURI="http://precisionbiosciences.com/role/DISCONTINUEDOPERATIONSTables">
        <link:definition>9955514 - Disclosure - DISCONTINUED OPERATIONS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EARNINGSPERSHARETables" roleURI="http://precisionbiosciences.com/role/EARNINGSPERSHARETables">
        <link:definition>9955515 - Disclosure - EARNINGS PER SHARE (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="PROPERTYEQUIPMENTANDSOFTWAREANDASSETSHELDFORSALETables" roleURI="http://precisionbiosciences.com/role/PROPERTYEQUIPMENTANDSOFTWAREANDASSETSHELDFORSALETables">
        <link:definition>9955516 - Disclosure - PROPERTY, EQUIPMENT AND SOFTWARE AND ASSETS HELD FOR SALE (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INTANGIBLEASSETSTables" roleURI="http://precisionbiosciences.com/role/INTANGIBLEASSETSTables">
        <link:definition>9955517 - Disclosure - INTANGIBLE ASSETS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSTables" roleURI="http://precisionbiosciences.com/role/FAIRVALUEMEASUREMENTSTables">
        <link:definition>9955518 - Disclosure - FAIR VALUE MEASUREMENTS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="WARRANTSTables" roleURI="http://precisionbiosciences.com/role/WARRANTSTables">
        <link:definition>9955519 - Disclosure - WARRANTS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSANDCONTINGENCIESTables" roleURI="http://precisionbiosciences.com/role/COMMITMENTSANDCONTINGENCIESTables">
        <link:definition>9955520 - Disclosure - COMMITMENTS AND CONTINGENCIES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESTables" roleURI="http://precisionbiosciences.com/role/INCOMETAXESTables">
        <link:definition>9955521 - Disclosure - INCOME TAXES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SEGMENTREPORTINGTables" roleURI="http://precisionbiosciences.com/role/SEGMENTREPORTINGTables">
        <link:definition>9955522 - Disclosure - SEGMENT REPORTING (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DESCRIPTIONOFBUSINESSANDSUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESAdditionalInformationDetails" roleURI="http://precisionbiosciences.com/role/DESCRIPTIONOFBUSINESSANDSUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESAdditionalInformationDetails">
        <link:definition>9955523 - Disclosure - DESCRIPTION OF BUSINESS AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DESCRIPTIONOFBUSINESSANDSUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESScheduleofDepreciationandAmortizationPeriodsofPropertyEquipmentandSoftwareDetails" roleURI="http://precisionbiosciences.com/role/DESCRIPTIONOFBUSINESSANDSUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESScheduleofDepreciationandAmortizationPeriodsofPropertyEquipmentandSoftwareDetails">
        <link:definition>9955524 - Disclosure - DESCRIPTION OF BUSINESS AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - Schedule of Depreciation and Amortization Periods of Property, Equipment and Software (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COLLABORATIONANDLICENSEAGREEMENTSDetails" roleURI="http://precisionbiosciences.com/role/COLLABORATIONANDLICENSEAGREEMENTSDetails">
        <link:definition>9955525 - Disclosure - COLLABORATION AND LICENSE AGREEMENTS (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SHAREBASEDCOMPENSATIONAdditionalInformationDetails" roleURI="http://precisionbiosciences.com/role/SHAREBASEDCOMPENSATIONAdditionalInformationDetails">
        <link:definition>9955526 - Disclosure - SHARE-BASED COMPENSATION - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SHAREBASEDCOMPENSATIONScheduleofEmployeeandNonemployeeStockBasedCompensationExpenseDetails" roleURI="http://precisionbiosciences.com/role/SHAREBASEDCOMPENSATIONScheduleofEmployeeandNonemployeeStockBasedCompensationExpenseDetails">
        <link:definition>9955527 - Disclosure - SHARE-BASED COMPENSATION - Schedule of Employee and Nonemployee Stock-Based Compensation Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SHAREBASEDCOMPENSATIONScheduleofStockBasedCompensationExpenseDetails" roleURI="http://precisionbiosciences.com/role/SHAREBASEDCOMPENSATIONScheduleofStockBasedCompensationExpenseDetails">
        <link:definition>9955528 - Disclosure - SHARE-BASED COMPENSATION - Schedule of Stock-Based Compensation Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SHAREBASEDCOMPENSATIONScheduleofStockOptionsValuationAssumptionsUsingaBlackScholesOptionPricingModelDetails" roleURI="http://precisionbiosciences.com/role/SHAREBASEDCOMPENSATIONScheduleofStockOptionsValuationAssumptionsUsingaBlackScholesOptionPricingModelDetails">
        <link:definition>9955529 - Disclosure - SHARE-BASED COMPENSATION - Schedule of Stock Options Valuation Assumptions Using a Black-Scholes Option Pricing Model (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SHAREBASEDCOMPENSATIONSummaryofActivityofOptionPlansDetails" roleURI="http://precisionbiosciences.com/role/SHAREBASEDCOMPENSATIONSummaryofActivityofOptionPlansDetails">
        <link:definition>9955530 - Disclosure - SHARE-BASED COMPENSATION - Summary of Activity of Option Plans (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SHAREBASEDCOMPENSATIONSummaryofActivityofRSUsDetails" roleURI="http://precisionbiosciences.com/role/SHAREBASEDCOMPENSATIONSummaryofActivityofRSUsDetails">
        <link:definition>9955531 - Disclosure - SHARE-BASED COMPENSATION - Summary of Activity of RSUs (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SHAREBASEDCOMPENSATIONSummaryofStockOptionsGrantedundertheStockOptionPlansareVestedorExpectedtoVestDetails" roleURI="http://precisionbiosciences.com/role/SHAREBASEDCOMPENSATIONSummaryofStockOptionsGrantedundertheStockOptionPlansareVestedorExpectedtoVestDetails">
        <link:definition>9955532 - Disclosure - SHARE-BASED COMPENSATION - Summary of Stock Options Granted under the Stock Option Plans are Vested or Expected to Vest (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SHAREBASEDCOMPENSATIONSummaryofStockOptionOutstandingundertheStockOptionPlansDetails" roleURI="http://precisionbiosciences.com/role/SHAREBASEDCOMPENSATIONSummaryofStockOptionOutstandingundertheStockOptionPlansDetails">
        <link:definition>9955533 - Disclosure - SHARE-BASED COMPENSATION - Summary of Stock Option Outstanding under the Stock Option Plans (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RETIREMENTPLANDetails" roleURI="http://precisionbiosciences.com/role/RETIREMENTPLANDetails">
        <link:definition>9955534 - Disclosure - RETIREMENT PLAN (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IMPAIRMENTCHARGESDetails" roleURI="http://precisionbiosciences.com/role/IMPAIRMENTCHARGESDetails">
        <link:definition>9955535 - Disclosure - IMPAIRMENT CHARGES (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DISCONTINUEDOPERATIONSNarrativeDetails" roleURI="http://precisionbiosciences.com/role/DISCONTINUEDOPERATIONSNarrativeDetails">
        <link:definition>9955536 - Disclosure - DISCONTINUED OPERATIONS - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DISCONTINUEDOPERATIONSScheduleofAssetsandLiabilitiesofDiscontinuedOperationsonCompanysBalanceSheetDetails" roleURI="http://precisionbiosciences.com/role/DISCONTINUEDOPERATIONSScheduleofAssetsandLiabilitiesofDiscontinuedOperationsonCompanysBalanceSheetDetails">
        <link:definition>9955537 - Disclosure - DISCONTINUED OPERATIONS - Schedule of Assets and Liabilities of Discontinued Operations on Company's Balance Sheet (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DISCONTINUEDOPERATIONSScheduleofResultsofOperationsofDiscontinuedOperationsDetails" roleURI="http://precisionbiosciences.com/role/DISCONTINUEDOPERATIONSScheduleofResultsofOperationsofDiscontinuedOperationsDetails">
        <link:definition>9955538 - Disclosure - DISCONTINUED OPERATIONS - Schedule of Results of Operations of Discontinued Operations (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DISCONTINUEDOPERATIONSScheduleofSignificantNoncashItemsRelatedtoDiscontinuedOperationsDetails" roleURI="http://precisionbiosciences.com/role/DISCONTINUEDOPERATIONSScheduleofSignificantNoncashItemsRelatedtoDiscontinuedOperationsDetails">
        <link:definition>9955539 - Disclosure - DISCONTINUED OPERATIONS - Schedule of Significant Non-cash Items Related to Discontinued Operations (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EARNINGSPERSHAREDetails" roleURI="http://precisionbiosciences.com/role/EARNINGSPERSHAREDetails">
        <link:definition>9955540 - Disclosure - EARNINGS PER SHARE (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="PROPERTYEQUIPMENTANDSOFTWAREANDASSETSHELDFORSALEScheduleofPropertyEquipmentandSoftwareDetails" roleURI="http://precisionbiosciences.com/role/PROPERTYEQUIPMENTANDSOFTWAREANDASSETSHELDFORSALEScheduleofPropertyEquipmentandSoftwareDetails">
        <link:definition>9955541 - Disclosure - PROPERTY, EQUIPMENT AND SOFTWARE AND ASSETS HELD FOR SALE - Schedule of Property, Equipment, and Software (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="PROPERTYEQUIPMENTANDSOFTWAREANDASSETSHELDFORSALEAdditionalInformationDetails" roleURI="http://precisionbiosciences.com/role/PROPERTYEQUIPMENTANDSOFTWAREANDASSETSHELDFORSALEAdditionalInformationDetails">
        <link:definition>9955542 - Disclosure - PROPERTY, EQUIPMENT AND SOFTWARE AND ASSETS HELD FOR SALE - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INTANGIBLEASSETSScheduleofIntangibleAssetsNetDetails" roleURI="http://precisionbiosciences.com/role/INTANGIBLEASSETSScheduleofIntangibleAssetsNetDetails">
        <link:definition>9955543 - Disclosure - INTANGIBLE ASSETS - Schedule of Intangible Assets, Net (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INTANGIBLEASSETSAdditionalInformationDetails" roleURI="http://precisionbiosciences.com/role/INTANGIBLEASSETSAdditionalInformationDetails">
        <link:definition>9955544 - Disclosure - INTANGIBLE ASSETS - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSScheduleofAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails" roleURI="http://precisionbiosciences.com/role/FAIRVALUEMEASUREMENTSScheduleofAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails">
        <link:definition>9955545 - Disclosure - FAIR VALUE MEASUREMENTS - Schedule of Assets and Liabilities Measured at Fair Value on Recurring Basis (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSSummaryofFinancialAssetsMeasuredatFairValueonRecurringBasisUsingSignificantUnobservableInputsDetails" roleURI="http://precisionbiosciences.com/role/FAIRVALUEMEASUREMENTSSummaryofFinancialAssetsMeasuredatFairValueonRecurringBasisUsingSignificantUnobservableInputsDetails">
        <link:definition>9955546 - Disclosure - FAIR VALUE MEASUREMENTS - Summary of Financial Assets Measured at Fair Value on Recurring Basis Using Significant Unobservable Inputs (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSAdditionalinformationDetails" roleURI="http://precisionbiosciences.com/role/FAIRVALUEMEASUREMENTSAdditionalinformationDetails">
        <link:definition>9955547 - Disclosure - FAIR VALUE MEASUREMENTS - Additional information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ELOTRANSACTIONDetails" roleURI="http://precisionbiosciences.com/role/ELOTRANSACTIONDetails">
        <link:definition>9955548 - Disclosure - ELO TRANSACTION (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DEBTDetails" roleURI="http://precisionbiosciences.com/role/DEBTDetails">
        <link:definition>9955549 - Disclosure - DEBT (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="WARRANTSAdditionalInformationDetails" roleURI="http://precisionbiosciences.com/role/WARRANTSAdditionalInformationDetails">
        <link:definition>9955550 - Disclosure - WARRANTS - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="WARRANTSScheduleofEstimatedFairValueofWarrantsDetails" roleURI="http://precisionbiosciences.com/role/WARRANTSScheduleofEstimatedFairValueofWarrantsDetails">
        <link:definition>9955551 - Disclosure - WARRANTS - Schedule of Estimated Fair Value of Warrants (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="WARRANTSSummaryofWarrantLiabilityDetails" roleURI="http://precisionbiosciences.com/role/WARRANTSSummaryofWarrantLiabilityDetails">
        <link:definition>9955552 - Disclosure - WARRANTS - Summary of Warrant Liability (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSANDCONTINGENCIESAdditionalInformationDetails" roleURI="http://precisionbiosciences.com/role/COMMITMENTSANDCONTINGENCIESAdditionalInformationDetails">
        <link:definition>9955553 - Disclosure - COMMITMENTS AND CONTINGENCIES - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSANDCONTINGENCIESComponentsofLeaseExpenseDetails" roleURI="http://precisionbiosciences.com/role/COMMITMENTSANDCONTINGENCIESComponentsofLeaseExpenseDetails">
        <link:definition>9955554 - Disclosure - COMMITMENTS AND CONTINGENCIES - Components of Lease Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSANDCONTINGENCIESScheduleofFutureLeasePaymentsunderNonCancelableLeasesDetails" roleURI="http://precisionbiosciences.com/role/COMMITMENTSANDCONTINGENCIESScheduleofFutureLeasePaymentsunderNonCancelableLeasesDetails">
        <link:definition>9955555 - Disclosure - COMMITMENTS AND CONTINGENCIES - Schedule of Future Lease Payments under Non-Cancelable Leases (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSANDCONTINGENCIESScheduleofFutureLeasePaymentsunderNonCancelableLeasesDetails_1" roleURI="http://precisionbiosciences.com/role/COMMITMENTSANDCONTINGENCIESScheduleofFutureLeasePaymentsunderNonCancelableLeasesDetails_1">
        <link:definition>9955555 - Disclosure - COMMITMENTS AND CONTINGENCIES - Schedule of Future Lease Payments under Non-Cancelable Leases (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockholdersEquityAdditionalInformationDetails" roleURI="http://precisionbiosciences.com/role/StockholdersEquityAdditionalInformationDetails">
        <link:definition>9955556 - Disclosure - Stockholders' Equity - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESScheduleofComponentsofLossIncomeBeforeTaxesDetails" roleURI="http://precisionbiosciences.com/role/INCOMETAXESScheduleofComponentsofLossIncomeBeforeTaxesDetails">
        <link:definition>9955557 - Disclosure - INCOME TAXES - Schedule of Components of Loss (Income) Before Taxes (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESScheduleofDeferredTaxAssetsandLiabilitiesDetails" roleURI="http://precisionbiosciences.com/role/INCOMETAXESScheduleofDeferredTaxAssetsandLiabilitiesDetails">
        <link:definition>9955558 - Disclosure - INCOME TAXES - Schedule of Deferred Tax Assets and Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESAdditionalInformationDetails" roleURI="http://precisionbiosciences.com/role/INCOMETAXESAdditionalInformationDetails">
        <link:definition>9955559 - Disclosure - INCOME TAXES - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESReconciliationofFederalStatutoryIncomeTaxRateandIncomeTaxBenefitDetails" roleURI="http://precisionbiosciences.com/role/INCOMETAXESReconciliationofFederalStatutoryIncomeTaxRateandIncomeTaxBenefitDetails">
        <link:definition>9955560 - Disclosure - INCOME TAXES - Reconciliation of Federal Statutory Income Tax Rate and Income Tax Benefit (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESScheduleofCashIncomeTaxesPaidReceivedDetails" roleURI="http://precisionbiosciences.com/role/INCOMETAXESScheduleofCashIncomeTaxesPaidReceivedDetails">
        <link:definition>9955561 - Disclosure - INCOME TAXES - Schedule of Cash Income Taxes Paid (Received) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SEGMENTREPORTINGAdditionalInformationDetails" roleURI="http://precisionbiosciences.com/role/SEGMENTREPORTINGAdditionalInformationDetails">
        <link:definition>9955562 - Disclosure - SEGMENT REPORTING - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SEGMENTREPORTINGSummaryofSignificantResearchandDevelopmentandGeneralandAdministrativeExpensetoCODMDetails" roleURI="http://precisionbiosciences.com/role/SEGMENTREPORTINGSummaryofSignificantResearchandDevelopmentandGeneralandAdministrativeExpensetoCODMDetails">
        <link:definition>9955563 - Disclosure - SEGMENT REPORTING - Summary of Significant Research and Development and General and Administrative Expense to CODM (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:element id="dtil_AuditInformationAbstract" abstract="true" name="AuditInformationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="dtil_ContractAssetCurrent" abstract="false" name="ContractAssetCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_AccruedResearchAndDevelopmentExpenses" abstract="false" name="AccruedResearchAndDevelopmentExpenses" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_WarrantLiabilityNoncurrent" abstract="false" name="WarrantLiabilityNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_GainLossOnChangeInFairValueOfWarrantLiability" abstract="false" name="GainLossOnChangeInFairValueOfWarrantLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_StockAndWarrantsIssuedDuringPeriodThroughUnderwrittenOfferingNetOfIssuanceCostShares" abstract="false" name="StockAndWarrantsIssuedDuringPeriodThroughUnderwrittenOfferingNetOfIssuanceCostShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="dtil_StockAndWarrantsIssuedDuringPeriodValueThroughUnderwrittenOfferingNetOfIssuanceCost" abstract="false" name="StockAndWarrantsIssuedDuringPeriodValueThroughUnderwrittenOfferingNetOfIssuanceCost" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_StockIssuedDuringPeriodCollaborationPartnersAndLicensesShares" abstract="false" name="StockIssuedDuringPeriodCollaborationPartnersAndLicensesShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="dtil_StockIssuedDuringPeriodValueCollaborationPartnersAndLicenses" abstract="false" name="StockIssuedDuringPeriodValueCollaborationPartnersAndLicenses" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_StockIssuedDuringPeriodThroughATMFacilityNetOfIssuanceCostShares" abstract="false" name="StockIssuedDuringPeriodThroughATMFacilityNetOfIssuanceCostShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="dtil_StockIssuedDuringPeriodValueThroughATMFacilityNetOfIssuanceCost" abstract="false" name="StockIssuedDuringPeriodValueThroughATMFacilityNetOfIssuanceCost" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_AmortizationOfDiscountOnNoteReceivable" abstract="false" name="AmortizationOfDiscountOnNoteReceivable" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_GainOnChangeInFairValueOfWarrantLiability" abstract="false" name="GainOnChangeInFairValueOfWarrantLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_IncreaseDecreaseInOtherAssetsAndOtherCurrentAssets" abstract="false" name="IncreaseDecreaseInOtherAssetsAndOtherCurrentAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_IncreaseDecreaseInAccruedOtherExpensesAndOtherCurrentLiabilities" abstract="false" name="IncreaseDecreaseInAccruedOtherExpensesAndOtherCurrentLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_PaymentsToPurchaseIntangibleAssets" abstract="false" name="PaymentsToPurchaseIntangibleAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_ProceedsFromEmployeeStockPurchasePlan" abstract="false" name="ProceedsFromEmployeeStockPurchasePlan" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_ProceedsFromIssuanceOfCommonStockAndWarrantsThroughUnderwrittenOfferingNetOfIssuanceCost" abstract="false" name="ProceedsFromIssuanceOfCommonStockAndWarrantsThroughUnderwrittenOfferingNetOfIssuanceCost" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_ProceedsFromIssuanceOfCommonStockThroughATMFacilityNetOfIssuanceCost" abstract="false" name="ProceedsFromIssuanceOfCommonStockThroughATMFacilityNetOfIssuanceCost" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_WarrantsTextBlock" abstract="false" name="WarrantsTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="dtil_ReverseStockSplitPolicyTextBlock" abstract="false" name="ReverseStockSplitPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="dtil_DescriptionOfBusinessAndSummaryOfSignificantAccountingPoliciesTable" abstract="true" name="DescriptionOfBusinessAndSummaryOfSignificantAccountingPoliciesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="dtil_IECUREMember" abstract="true" name="IECUREMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_November2025PublicOfferingMember" abstract="true" name="November2025PublicOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_March2024PublicOfferingMember" abstract="true" name="March2024PublicOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_NovartisPharmaAGMember" abstract="true" name="NovartisPharmaAGMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_ImugeneMember" abstract="true" name="ImugeneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_PrevailMember" abstract="true" name="PrevailMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_TGTherapeuticsMember" abstract="true" name="TGTherapeuticsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_DescriptionOfBusinessAndSummaryOfSignificantAccountingPoliciesLineItems" abstract="true" name="DescriptionOfBusinessAndSummaryOfSignificantAccountingPoliciesLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="dtil_TgLicenseMember" abstract="true" name="TgLicenseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_DiscoveryAndDevelopmentMember" abstract="true" name="DiscoveryAndDevelopmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_DevelopmentAndLicenseMember" abstract="true" name="DevelopmentAndLicenseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_PaymentTrancheAxis" abstract="true" name="PaymentTrancheAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="dtil_PaymentTrancheDomain" abstract="true" name="PaymentTrancheDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_PaymentTrancheOneMember" abstract="true" name="PaymentTrancheOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_PaymentTrancheTwoMember" abstract="true" name="PaymentTrancheTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_RevenueRemainingPerformanceObligationVariableConsiderationClinicalMilestoneAmount" abstract="false" name="RevenueRemainingPerformanceObligationVariableConsiderationClinicalMilestoneAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_RevenueRemainingPerformanceObligationVariableConsiderationAdditionalMilestoneAmount" abstract="false" name="RevenueRemainingPerformanceObligationVariableConsiderationAdditionalMilestoneAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_PercentageOfPremiumOverVolumeWeightedAveragePriceOfCompanysCommonStock" abstract="false" name="PercentageOfPremiumOverVolumeWeightedAveragePriceOfCompanysCommonStock" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="dtil_StockIssuedPricePerShareNumberOfTradingDaysPriorToAgreement" abstract="false" name="StockIssuedPricePerShareNumberOfTradingDaysPriorToAgreement" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="dtil_CollaborativeArrangementSharesAvailableForExchange" abstract="false" name="CollaborativeArrangementSharesAvailableForExchange" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="dtil_PercentageOfValueOfEachAdditionalMilestonePayment" abstract="false" name="PercentageOfValueOfEachAdditionalMilestonePayment" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="dtil_PeriodOfExpirationOfPatents" abstract="false" name="PeriodOfExpirationOfPatents" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="dtil_ConversionOfSharesNumberOfDaysVolumeWeightedAveragePrice" abstract="false" name="ConversionOfSharesNumberOfDaysVolumeWeightedAveragePrice" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="dtil_NumberOfAdditionalResearchPrograms" abstract="false" name="NumberOfAdditionalResearchPrograms" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="dtil_TwoThousandFifteenStockIncentivePlanMember" abstract="true" name="TwoThousandFifteenStockIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_TwoThousandNineteenIncentiveAwardPlanMember" abstract="true" name="TwoThousandNineteenIncentiveAwardPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_AmendedPlanMember" abstract="true" name="AmendedPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_TwoThousandNineteenEmployeeStockPurchasePlanMember" abstract="true" name="TwoThousandNineteenEmployeeStockPurchasePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_InducementAwardPlanMember" abstract="true" name="InducementAwardPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_EmployeeStockPurchasePlanMember" abstract="true" name="EmployeeStockPurchasePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForIssuance" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForIssuance" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="dtil_AllowedAnnualPercentageIncreaseInSharesAuthorizedAsPercentageOfOutstandingSharesOfCommonStock" abstract="false" name="AllowedAnnualPercentageIncreaseInSharesAuthorizedAsPercentageOfOutstandingSharesOfCommonStock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="dtil_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAvailableForIssuance" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAvailableForIssuance" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="dtil_IncreaseInCommonStockAvailableForIssuance" abstract="false" name="IncreaseInCommonStockAvailableForIssuance" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="dtil_NumberofSharesIssuedUnderEmployeeStockPurchasePlans" abstract="false" name="NumberofSharesIssuedUnderEmployeeStockPurchasePlans" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="dtil_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGrantDateFairValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGrantDateFairValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsWeightedAverageFairValuePerOption" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsWeightedAverageFairValuePerOption" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="dtil_PriceRangeOneMember" abstract="true" name="PriceRangeOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_PriceRangeTwoMember" abstract="true" name="PriceRangeTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_PriceRangeThreeMember" abstract="true" name="PriceRangeThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_PriceRangeFourMember" abstract="true" name="PriceRangeFourMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_PriceRangeFiveMember" abstract="true" name="PriceRangeFiveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_PriceRangeSixMember" abstract="true" name="PriceRangeSixMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_PriceRangeSevenMember" abstract="true" name="PriceRangeSevenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_PriceRangeEightMember" abstract="true" name="PriceRangeEightMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_PriceRangeNineMember" abstract="true" name="PriceRangeNineMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_PriceRangeTenMember" abstract="true" name="PriceRangeTenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_DisposalGroupIncludingDiscontinuedOperationsAssetImpairmentCharges" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationsAssetImpairmentCharges" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_CellTherapyOperationsMember" abstract="true" name="CellTherapyOperationsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_DisposalGroupIncludingDiscontinuedOperationAccruedResearchAndDevelopmentExpensesCurrent" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationAccruedResearchAndDevelopmentExpensesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_LaboratoryEquipmentMember" abstract="true" name="LaboratoryEquipmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_IntangibleAssetsFiniteLivedAccumulatedImpairmentLoss" abstract="false" name="IntangibleAssetsFiniteLivedAccumulatedImpairmentLoss" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_FiniteLivedIntangibleAssetExpectedAmortizationExpenseAfterYearFiveAndThereafter" abstract="false" name="FiniteLivedIntangibleAssetExpectedAmortizationExpenseAfterYearFiveAndThereafter" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_InvestmentInIECUREMember" abstract="true" name="InvestmentInIECUREMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_AssetsHeldForSaleMember" abstract="true" name="AssetsHeldForSaleMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_ConsiderationReceivedAxis" abstract="true" name="ConsiderationReceivedAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="dtil_ConsiderationReceivedDomain" abstract="true" name="ConsiderationReceivedDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_OrdinarySharesMember" abstract="true" name="OrdinarySharesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_BancOfCaliforniaRevolvingLineMember" abstract="true" name="BancOfCaliforniaRevolvingLineMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_FinalPaymentFee" abstract="false" name="FinalPaymentFee" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_ChangeInFairValueOfFinalPaymentFee" abstract="false" name="ChangeInFairValueOfFinalPaymentFee" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_EloMember" abstract="true" name="EloMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_PromissoryNoteMember" abstract="true" name="PromissoryNoteMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_FinancingReceivableInterestRatePercentage" abstract="false" name="FinancingReceivableInterestRatePercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="dtil_TwoThousandTwentyFourLoanAndSecurityAgreementMember" abstract="true" name="TwoThousandTwentyFourLoanAndSecurityAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_DebtInstrumentInterestRateIncreaseEventOfDefault" abstract="false" name="DebtInstrumentInterestRateIncreaseEventOfDefault" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="dtil_WarrantsOrRightsOutstandingOwnershipOfCommonStockOutstandingPercentageConditionForCompanyRepurchase" abstract="false" name="WarrantsOrRightsOutstandingOwnershipOfCommonStockOutstandingPercentageConditionForCompanyRepurchase" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="dtil_MeasurementInputWeightedAverageFairValuePerOptionMember" abstract="true" name="MeasurementInputWeightedAverageFairValuePerOptionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_FairValueWarrantLiabilityRollForward" abstract="true" name="FairValueWarrantLiabilityRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="dtil_WarrantsAndRightsIssued" abstract="false" name="WarrantsAndRightsIssued" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_OperatingLeaseLiabilityObtainedInExchangeForRightOfUseAsset" abstract="false" name="OperatingLeaseLiabilityObtainedInExchangeForRightOfUseAsset" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_DeferredTaxAssetsLeaseLiability" abstract="false" name="DeferredTaxAssetsLeaseLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_DeferredTaxLiabilitiesRightOfUseAsset" abstract="false" name="DeferredTaxLiabilitiesRightOfUseAsset" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_IncomeTaxDisclosureTable" abstract="true" name="IncomeTaxDisclosureTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="dtil_OrphanDrugTaxCreditCarryforwardMember" abstract="true" name="OrphanDrugTaxCreditCarryforwardMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_TwoThousandTwentyOneAppropriationsActMember" abstract="true" name="TwoThousandTwentyOneAppropriationsActMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_IncomeTaxDisclosureLineItems" abstract="true" name="IncomeTaxDisclosureLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="dtil_FederalContributionCarryforwards" abstract="false" name="FederalContributionCarryforwards" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_OwnershipPercentageChangeInOutstandingCommonStockPeriod" abstract="false" name="OwnershipPercentageChangeInOutstandingCommonStockPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="dtil_OwnershipPercentageChangeOfOutstandingCommonStock" abstract="false" name="OwnershipPercentageChangeOfOutstandingCommonStock" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="dtil_EffectiveIncomeTaxRateReconciliationTaxExpenseBenefitChangeInWarrantLiabilityAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationTaxExpenseBenefitChangeInWarrantLiabilityAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_EffectiveIncomeTaxRateReconciliationTaxExemptIncomeOtherAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationTaxExemptIncomeOtherAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_EffectiveIncomeTaxRateReconciliationTaxExpenseBenefitChangeInWarrantLiabilityPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationTaxExpenseBenefitChangeInWarrantLiabilityPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="dtil_EffectiveIncomeTaxRateReconciliationTaxExemptIncomeOtherPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationTaxExemptIncomeOtherPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="dtil_PBGENEHepatitisBVirusMember" abstract="true" name="PBGENEHepatitisBVirusMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_PBGENEDuchenneMuscularDystrophyProgramMember" abstract="true" name="PBGENEDuchenneMuscularDystrophyProgramMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_PBGENE3243ProgramMember" abstract="true" name="PBGENE3243ProgramMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_OperatingSegmentMember" abstract="true" name="OperatingSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_ExternalDevelopmentCostsCredits" abstract="false" name="ExternalDevelopmentCostsCredits" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_PlatformDevelopmentAndEarly-StageResearchExpensesAbstract" abstract="true" name="PlatformDevelopmentAndEarly-StageResearchExpensesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="dtil_EmployeeRelatedCostsResearchAndDevelopmentIncludingShare-BasedCompensation" abstract="false" name="EmployeeRelatedCostsResearchAndDevelopmentIncludingShare-BasedCompensation" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_LaboratorySuppliesAndServices" abstract="false" name="LaboratorySuppliesAndServices" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_CMOsAndOutsourcedResearchAndDevelopment" abstract="false" name="CMOsAndOutsourcedResearchAndDevelopment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_FacilityRelatedCostsLaboratoryEquipmentAndMaintenance" abstract="false" name="FacilityRelatedCostsLaboratoryEquipmentAndMaintenance" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_LicensingFeesAndOtherResearchAndDevelopmentCosts" abstract="false" name="LicensingFeesAndOtherResearchAndDevelopmentCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_EmployeeRelatedCostsGeneralAndAdminstrativeExpense" abstract="false" name="EmployeeRelatedCostsGeneralAndAdminstrativeExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_ConsultingAndProfessionalServices" abstract="false" name="ConsultingAndProfessionalServices" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
