v3.25.4
SEGMENT REPORTING - Summary of Significant Research and Development and General and Administrative Expense to CODM (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Segment Reporting Information [Line Items]    
Revenue $ 34,264 $ 68,696
Platform development and early-stage research expenses:    
Depreciation and amortization 1,468 3,404
Total research and development expenses 54,172 59,559
General and administrative expense    
Total general and administrative expenses 32,240 35,299
Total operating expenses 86,412 94,858
Operating loss (52,148) (26,162)
Total other income 5,539 33,329
(Loss) income from continuing operations (46,609) 7,167
Gain from discontinued operations 885 0
Net (loss) income (45,724) 7,167
Operating Segment    
Segment Reporting Information [Line Items]    
Revenue 34,264 68,696
Platform development and early-stage research expenses:    
Employee-related costs (including share-based compensation) 19,939 21,313
Laboratory supplies and services 1,798 2,621
CMOs and outsourced research and development 504 247
Facility-related costs, laboratory equipment, and maintenance 2,841 3,082
Depreciation and amortization 1,299 2,718
Licensing fees and other research and development costs 2,238 2,429
Total research and development expenses 54,172 59,559
General and administrative expense    
Employee-related costs (including share-based compensation) 19,904 21,861
Consulting and professional services 6,106 6,327
Other operating expenses and all other costs 6,230 7,111
Total general and administrative expenses 32,240 35,299
Total operating expenses 86,412 94,858
Operating loss (52,148) (26,162)
Total other income 5,539 33,329
(Loss) income from continuing operations (46,609) 7,167
Gain from discontinued operations 885 0
Net (loss) income (45,724) 7,167
PBGENE-HBV external development costs | Operating Segment    
Direct research and development expenses by product candidate:    
External development costs (credits) 7,152 16,111
PBGENE-DMD external development costs | Operating Segment    
Direct research and development expenses by product candidate:    
External development costs (credits) 15,298 1,230
PBGENE-3243 external development costs | Operating Segment    
Direct research and development expenses by product candidate:    
External development costs (credits) $ 3,103 $ 9,808