Commitments and Contingencies, Type of Agreement (Details) - USD ($) $ in Thousands						12 Months Ended
	Dec. 23, 2022	Jun. 15, 2022	Nov. 09, 2021	Apr. 10, 2019	Jun. 06, 2018	Dec. 31, 2025	Dec. 31, 2024
Type of Arrangement [Abstract]
Research and development expense						$ 30,812	$ 26,851
LCA5/RDH12 Agreement [Member] \| Development, Regulatory and Commercial Milestone [Member]
Type of Arrangement [Abstract]
Research and development expense						100
LCA5/RDH12 Agreement [Member] \| Development, Regulatory and Commercial Milestone [Member] \| Maximum [Member]
Type of Arrangement [Abstract]
Milestone payments		$ 2,600
Iveric Agreement [Member] \| Commercial Milestones [Member] \| BEST1 Program [Member]
Type of Arrangement [Abstract]
Research and development expense						400
Iveric Agreement [Member] \| Commercial Milestones [Member] \| Maximum [Member] \| BEST1 Program [Member]
Type of Arrangement [Abstract]
Milestone payments	$ 111,700
BEST1 License Agreement [Member] \| Commercial Milestones [Member] \| First Licensed Product [Member]
Type of Arrangement [Abstract]
Research and development expense						$ 700
BEST1 License Agreement [Member] \| Commercial Milestones [Member] \| Maximum [Member] \| First Licensed Product [Member]
Type of Arrangement [Abstract]
Milestone payments				$ 76,400
Penn and UF RHO License Agreement [Member] \| Development, Regulatory and Commercial Milestone [Member] \| Maximum [Member]
Type of Arrangement [Abstract]
Milestone payments					$ 93,500
Massachusetts Eye and Ear Infirmary License Agreement [Member] \| Development, Regulatory and Commercial Milestone [Member] \| Maximum [Member]
Type of Arrangement [Abstract]
Milestone payments			$ 400