Class of Stock [Axis]
Series B Preferred Stock [Member]
Equity Components [Axis]
Preferred Stock [Member]
Common Stock [Member]
Additional Paid-in Capital [Member]
Retained Earnings [Member]
AOCI Attributable to Parent [Member]
Treasury Stock, Common [Member]
Statement of Financial Position Location, Balance [Axis]
Research And Development Expenses [Member]
Counterparty Name [Axis]
Takeda [Member]
Product and Service [Axis]
Royalty Revenue [Member]
Catalent Pharma Solutions [Member]
Scripps Research [Member]
Transaction Type [Axis]
D Nase Technology [Member]
Subsequent Event Type [Axis]
Subsequent Event [Member]
Scripps Agreement [Member]
University Of Virginia [Member]
U V A Agreement [Member]
Investment, Name [Axis]
Pharmsynthez [Member]
Separation Agreements [Member]
Geographical [Axis]
UNITED STATES
UNITED KINGDOM
GERMANY
SWITZERLAND
Income Tax Jurisdiction [Axis]
Domestic Tax Jurisdiction [Member]
Foreign Tax Jurisdiction [Member]
State and Local Jurisdiction [Member]
Securities Financing Transaction [Axis]
Canaccord Underwriting Agreement [Member]
Series A Warrants [Member]
Award Type [Axis]
Other Warrants [Member]
Publicly Traded Warrants [Member]
Share-Based Payment Arrangement, Option [Member]
Restricted Stock Units (RSUs) [Member]
Non Employee Stock Options [Member]
JSOP [Member]
Statement of Income Location, Balance [Axis]
Research and Development Expense [Member]
General and Administrative Expense [Member]
Non Vested Employee Stock Option [Member]
Retirement Plan Name [Axis]
Plan 401 K [Member]
Property Subject to or Available for Operating Lease [Axis]
Office Space [Member]
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
DNase I Technology [Member]
Related Party Transaction [Axis]
Clinical Trial Services [Member]
Related and Nonrelated Parties [Axis]
Dr Genkin [Member]
Cover [Abstract]
Document Type
Amendment Flag
Amendment Description
Document Registration Statement
Document Annual Report
Document Quarterly Report
Document Transition Report
Document Shell Company Report
Document Shell Company Event Date
Document Period Start Date
Document Period End Date
Document Fiscal Period Focus
Document Fiscal Year Focus
Current Fiscal Year End Date
Entity File Number
Entity Registrant Name
Entity Central Index Key
Entity Primary SIC Number
Entity Tax Identification Number
Entity Incorporation, State or Country Code
Entity Address, Address Line One
Entity Address, Address Line Two
Entity Address, Address Line Three
Entity Address, City or Town
Entity Address, State or Province
Entity Address, Country
Entity Address, Postal Zip Code
Country Region
City Area Code
Local Phone Number
Extension
Written Communications
Soliciting Material
Pre-commencement Tender Offer
Pre-commencement Issuer Tender Offer
Title of 12(b) Security
No Trading Symbol Flag
Trading Symbol
Security Exchange Name
Title of 12(g) Security
Security Reporting Obligation
Annual Information Form
Audited Annual Financial Statements
Entity Well-known Seasoned Issuer
Entity Voluntary Filers
Entity Current Reporting Status
Entity Interactive Data Current
Entity Filer Category
Entity Small Business
Entity Emerging Growth Company
Elected Not To Use the Extended Transition Period
Document Accounting Standard
Other Reporting Standard Item Number
Entity Shell Company
Entity Public Float
Entity Bankruptcy Proceedings, Reporting Current
Entity Common Stock, Shares Outstanding
Documents Incorporated by Reference [Text Block]
ICFR Auditor Attestation Flag
Document Financial Statement Error Correction [Flag]
Auditor Firm ID
Auditor Name
Auditor Location
Statement [Table]
Statement [Line Items]
ASSETS
Current assets:
Cash
Prepaid expenses and other
Total current assets
Other assets
Total assets
LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
Accounts payable
Accrued expenses and other current liabilities
Total current liabilities
Total liabilities
Commitments and contingencies (Note 11)
Stockholders' equity:
Preferred stock, value
Common stock, $0.001 par value; 10,000,000 shares authorized as of December 31, 2025 and December 31, 2024; 2,293,757 and 1,544,840 shares issued as of December 31, 2025 and December 31, 2024, respectively; 2,291,056 and 1,542,139 shares outstanding as of December 31, 2025 and December 31, 2024, respectively
Additional paid in capital
Accumulated deficit
Accumulated other comprehensive income
Treasury stock
Total stockholders' equity
Total liabilities and stockholders' equity
Preferred stock, shares authorized
Preferred stock, par value
Preferred stock, shares issued
Preferred stock, shares outstanding
Common stock, par value
Common stock, shares authorized
Common stock, shares, issued
Common stock, shares, outstanding
Income Statement [Abstract]
Revenue
Royalty revenue
Total revenue
Operating costs and expenses:
Research and development
General and administrative
Total operating costs and expenses
Loss from operations
Other income (expense):
Other income (expense)
Interest income, net
Total other income, net
Net loss
Basic net loss per share
Diluted net loss per share
Weighted-average shares of common stock outstanding, basic
Weighted-average shares of common stock outstanding, diluted
Beginning balance, value
Beginning balance, shares
Issuance of common stock in October 2025 underwritten public offering, net of issuance costs
Conversion of Series B preferred stock to shares of common stock
Conversion of Series B preferred stock to shares of common stock, shares
Conversion of Series B preferred stock to shares of common stock, shares
Issuance of common stock in October 2025 underwritten public offering, net of issuance costs, shares
Issuance of common stock in connection with restricted stock units
Issuance of common stock in connection with restricted stock units, shares
Exercise of purchase warrants
Exercise of purchase warrants, shares
Share-based expense
Net loss
Ending balance, value
Ending balance, shares
Statement of Cash Flows [Abstract]
CASH FLOWS FROM OPERATING ACTIVITIES:
Adjustments to reconcile net loss to net cash used in operating activities:
Share-based expense
Changes in operating assets and liabilities:
Prepaid expenses and other
Other long-term assets
Accounts payable, accrued expenses and other current liabilities
Net cash used in operating activities
CASH FLOWS FROM FINANCING ACTIVITIES:
Net proceeds from issuance of common stock in October 2025 underwritten public offering
Net cash provided by financing activities
Net change in cash
Cash at beginning of period
Cash at end of period
SUPPLEMENTAL CASH FLOW INFORMATION:
Cash paid for interest
SUPPLEMENTAL SCHEDULE OF NON-CASH INVESTING AND FINANCING ACTIVITIES:
Issuance of common stock from cashless exercise of purchase warrants
Conversion of Series B preferred stock to common stock
Pay vs Performance Disclosure [Table]
Executive Category [Axis]
Individual [Axis]
Adjustment to Compensation [Axis]
Measure [Axis]
Pay vs Performance Disclosure, Table
Company Selected Measure Name
Named Executive Officers, Footnote
Peer Group Issuers, Footnote
Changed Peer Group, Footnote
PEO Total Compensation Amount
PEO Actually Paid Compensation Amount
Adjustment To PEO Compensation, Footnote
Non-PEO NEO Average Total Compensation Amount
Non-PEO NEO Average Compensation Actually Paid Amount
Adjustment to Non-PEO NEO Compensation Footnote
Equity Valuation Assumption Difference, Footnote
Compensation Actually Paid vs. Total Shareholder Return
Compensation Actually Paid vs. Net Income
Compensation Actually Paid vs. Company Selected Measure
Total Shareholder Return Vs Peer Group
Compensation Actually Paid vs. Other Measure
Tabular List, Table
Total Shareholder Return Amount
Peer Group Total Shareholder Return Amount
Net Income (Loss)
Company Selected Measure Amount
Other Performance Measure, Amount
Adjustment to Compensation, Amount
PEO Name
Name
Non-GAAP Measure Description
Additional 402(v) Disclosure
Pension Benefits Adjustments, Footnote
Equity Awards Adjustments, Footnote
Erroneously Awarded Compensation Recovery [Table]
Restatement Determination Date [Axis]
Restatement Determination Date
Aggregate Erroneous Compensation Amount
Erroneous Compensation Analysis
Stock Price or TSR Estimation Method
Outstanding Aggregate Erroneous Compensation Amount
Aggregate Erroneous Compensation Not Yet Determined
Name
Forgone Recovery due to Expense of Enforcement, Amount
Forgone Recovery due to Violation of Home Country Law, Amount
Forgone Recovery due to Disqualification of Tax Benefits, Amount
Forgone Recovery, Explanation of Impracticability
Name
Compensation Amount
Restatement does not require Recovery
Awards Close in Time to MNPI Disclosures [Table]
Award Timing MNPI Disclosure
Award Timing Method
Award Timing Predetermined
Award Timing MNPI Considered
Award Timing, How MNPI Considered
MNPI Disclosure Timed for Compensation Value
Awards Close in Time to MNPI Disclosures, Table
Name
Underlying Securities
Exercise Price
Fair Value as of Grant Date
Underlying Security Market Price Change
Insider Trading Arrangements [Line Items]
Material Terms of Trading Arrangement
Name
Title
Rule 10b5-1 Arrangement Adopted
Non-Rule 10b5-1 Arrangement Adopted
Adoption Date
Rule 10b5-1 Arrangement Terminated
Non-Rule 10b5-1 Arrangement Terminated
Termination Date
Expiration Date
Arrangement Duration
Aggregate Available
Insider Trading Policies and Procedures [Line Items]
Insider Trading Policies and Procedures Adopted
Insider Trading Policies and Procedures Not Adopted
Cybersecurity Risk Management, Strategy, and Governance [Abstract]
Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block]
Cybersecurity Risk Management Processes Integrated [Flag]
Cybersecurity Risk Management Processes Integrated [Text Block]
Cybersecurity Risk Management Third Party Engaged [Flag]
Cybersecurity Risk Third Party Oversight and Identification Processes [Flag]
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Flag]
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Text Block]
Cybersecurity Risk Board of Directors Oversight [Text Block]
Cybersecurity Risk Board Committee or Subcommittee Responsible for Oversight [Text Block]
Cybersecurity Risk Process for Informing Board Committee or Subcommittee Responsible for Oversight [Text Block]
Cybersecurity Risk Role of Management [Text Block]
Cybersecurity Risk Management Positions or Committees Responsible [Flag]
Cybersecurity Risk Management Positions or Committees Responsible [Text Block]
Cybersecurity Risk Management Expertise of Management Responsible [Text Block]
Cybersecurity Risk Process for Informing Management or Committees Responsible [Text Block]
Cybersecurity Risk Management Positions or Committees Responsible Report to Board [Flag]
Material Cybersecurity Incident [Abstract]
Material Cybersecurity Incident Nature [Text Block]
Material Cybersecurity Incident Scope [Text Block]
Material Cybersecurity Incident Timing [Text Block]
Material Cybersecurity Incident Material Impact or Reasonably Likely Material Impact [Text Block]
Material Cybersecurity Incident Information Not Available or Undetermined [Text Block]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
The Company
Risks and Uncertainties [Abstract]
Risks and Uncertainties
Accounting Policies [Abstract]
Summary of Significant Accounting Policies
Significant Strategic Collaborations
Payables and Accruals [Abstract]
Accrued Expenses and other current liabilities
Fair Value Disclosures [Abstract]
Fair Value Measurements
Income Tax Disclosure [Abstract]
Income Taxes
Equity [Abstract]
Stockholders’ Equity
Share-Based Payment Arrangement [Abstract]
Share-Based Expense
Retirement Benefits [Abstract]
Employee Benefit Plans
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies
Related Party Transactions [Abstract]
Related Party Transactions
Subsequent Events [Abstract]
Subsequent Events
Principles of Consolidation
Use of Estimates
Functional Currency Change
Foreign Currency Transactions
Fair Value of Financial Instruments
Cash and Concentrations of Credit Risk
Indefinite-Lived Intangible Assets
Impairment of Long-Lived Assets
Revenue Recognition
Research and Development Expenses
Share-based Expense
Warrants
Income Taxes
Basic and Diluted Net Loss per Share
Segment Information
Leases
Recent Accounting Standards
Schedule of consolidated net loss
Schedule of accrued expenses
Schedule of components of loss before income taxes
Schedule of components of loss before income taxes
Schedule of deferred tax assets and liabilities
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Schedule of share-based compensation expense
Schedule of assumptions used
Schedule of option activity
Schedule of non-vested options
Revenue
Program expenses
Non-program expenses
Salaries and wages
Other segment items
DisclosureTable [Table]
DisclosureLineElements [Line Items]
Asset impairment charge
Prepaid expenses and other current assets
Accrued research costs
Antidilutive shares
Operating segment
Reporting segment
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue
Research and development expenses
Prepaid expenses and other current assets
Other assets
Contractual obligation
Contractual obligation addition
Percent ownership in Xenetic
Accrued payroll and benefits
Accrued professional fees
Accrued research costs
Other
Total accrued expenses
Offsetting Assets [Table]
Offsetting Assets [Line Items]
Labor and related expenses
Share based compensation
Accounts Payable and Other Accrued Liabilities, Current
Net income (loss)
Effective Income Tax Rate Reconciliation [Table]
Effective Income Tax Rate Reconciliation [Line Items]
Federal
Federal, percentage
Tax credits
Tax credits, percentage
Effect of cross-border tax laws
Effect of cross-border tax laws, percentage
Valuation allowance
Valuation allowance, percentage
Share-based expense, net
Share-based expense, net, percentage
Other foreign
Other foreign, percentage
Rate differential
Rate differential, percentage
Attribute adjustments
Attribute adjustments, percentage
Other
Other, percentage
Net benefit for income taxes
Net benefit for income taxes, percentage
Foreign net operating loss carryforwards
Foreign capital loss carryforwards
Foreign net operating loss carryforwards
IPR&D
Share-based expense
Enhanced research and development tax credits
Capitalized research and experimental expenditure
U.S. state net operating loss carryforwards
Depreciation
Total deferred tax assets before valuation allowance
Valuation allowance for deferred tax assets
Net deferred tax assets
Total deferred tax liabilities
Net deferred tax assets and liabilities
Net operating loss carryforwards
Operating loss carryforwards expiration date
Uncertain tax positions
Unrecognized tax benefits
Interest and penalties
Stock, Class of Stock [Table]
Class of Stock [Line Items]
Stock issued new, shares
Stock share price
Proceeds from Issuance of Common Stock
Payments of Stock Issuance Costs
Preferred Stock, Shares Authorized
Preferred Stock, Shares Outstanding
Preferred Stock, Shares Issued
Convertible Preferred Stock, Shares Issued upon Conversion
Conversion of Stock, Shares Converted
Conversion of Stock, Shares Issued
Warrant Outstanding
Expired date
Warrants forfeited
Exercise price
Maturity date
Warrants forfeited shares
Warrants exercised shares
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-based compensation
Weighted-average expected dividend yield
Weighted-average expected volatility
Weighted-average risk-free interest rate
Weighted-average expected life of option
Weighted-average exercise price
Options outstanding, beginning balance
Weighted-average exercise price outstanding, beginning balance
Weighted-average remaining life outstanding ending
Aggregate intrinsic value, outstanding beginning balance
Options granted
Weighted-average exercise price, granted
Options expired
Weighted-average exercise price, expired
Options outstanding, ending balance
Weighted-average exercise price, ending balance
Aggregate intrinsic value, outstanding ending balance
Options vested or expected to vest
Weighted-average exercise price, vested or expected to vest
Weighted-average remaining life, vested or expected to vest
Aggregate intrinsic value, vested or expected to vest
Options exercisable
Weighted-average exercise price, exercisable
Weighted-average remaining life, exercisable
Aggregate intrinsic value, exercisable
Non-vested options outstanding, beginning balance
Non-vested weighted-average grant date fair value per share, beginning balance
Weighted-average grant date fair value per share, options granted
Options forfeited
Weighted-average grant date fair value per share, options forfeited
Options vested
Weighted-average grant date fair value per share, options vested
Non-vested options outstanding, ending balance
Non-vested weighted-average grant date fair value per share, ending balance
Weighted-average remaining life outstanding beginning
Weighted-average exercise price, forfeited/expired
Share-based compensation expense
Weighted average grant date fair value
Options exercised
Option forfeited
Weighted average forfeited per share
Options vested
Fair value of options vested
Unrecognized compensation expense
Unrecognized compensation expense recognition period
Other than options granted, shares
Other than options, grant date fair value per share
Other than options, shares expired
Outstanding option grants
Stock option grants outstanding
Other than options, shares outstanding
Share-based compensation expense
Defined Benefit Plan [Table]
Defined Benefit Plan Disclosure [Line Items]
Contribution to defined contribution plan
Lease term
Future minimum rental payments
Outstanding letter of credit
Related Party Transaction [Table]
Related Party Transaction [Line Items]
Research and Development Expense
Prepaid Expense and Other Assets, Current
Accounts Payable, Current
Professional and Contract Services Expense
Assets, Current
Assets
Liabilities, Current
Liabilities
Treasury Stock, Common, Value
Equity, Attributable to Parent
Liabilities and Equity
Revenues
General and Administrative Expense
Operating Expenses
Operating Income (Loss)
Nonoperating Income (Expense)
Shares, Outstanding
Employee Benefits and Share-Based Compensation
Increase (Decrease) in Accounts and Other Receivables
Increase (Decrease) in Other Noncurrent Assets
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Excluding Exchange Rate Effect, Including Discontinued Operation
Forgone Recovery, Individual Name
Outstanding Recovery, Individual Name
Awards Close in Time to MNPI Disclosures, Individual Name
Trading Arrangement, Individual Name
Income Tax, Policy [Policy Text Block]
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Other Assets
Accrued Liabilities, Current
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
Effective Income Tax Rate Reconciliation, Tax Credit, Amount
Effective Income Tax Rate Reconciliation, Tax Settlement, Other, Amount
Deferred Tax Assets, Operating Loss Carryforwards, Domestic
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Deferred Tax Assets, Valuation Allowance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Expirations in Period
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Nonvested, Number of Shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Option, Nonvested, Weighted Average Exercise Price
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Nonvested Options Forfeited, Weighted Average Grant Date Fair Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested, Weighted Average Grant Date Fair Value