00000001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink 00000002 - Statement - CONSOLIDATED BALANCE SHEETS link:presentationLink link:calculationLink link:definitionLink 00000003 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 00000004 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS link:presentationLink link:calculationLink link:definitionLink 00000005 - Statement - CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY link:presentationLink link:calculationLink link:definitionLink 00000006 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS link:presentationLink link:calculationLink link:definitionLink 999014 - Disclosure - The Company link:presentationLink link:calculationLink link:definitionLink 999015 - Disclosure - Risks and Uncertainties link:presentationLink link:calculationLink link:definitionLink 999016 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 999017 - Disclosure - Significant Strategic Collaborations link:presentationLink link:calculationLink link:definitionLink 999018 - Disclosure - Accrued Expenses and other current liabilities link:presentationLink link:calculationLink link:definitionLink 999019 - Disclosure - Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 999020 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 999021 - Disclosure - Stockholders’ Equity link:presentationLink link:calculationLink link:definitionLink 999022 - Disclosure - Share-Based Expense link:presentationLink link:calculationLink link:definitionLink 999023 - Disclosure - Employee Benefit Plans link:presentationLink link:calculationLink link:definitionLink 999024 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 999025 - Disclosure - Related Party Transactions link:presentationLink link:calculationLink link:definitionLink 999026 - Disclosure - Subsequent Events link:presentationLink link:calculationLink link:definitionLink 999027 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 999028 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 999029 - Disclosure - Accrued Expenses and other current liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 999030 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 999031 - Disclosure - Share-Based Expense (Tables) link:presentationLink link:calculationLink link:definitionLink 999032 - Disclosure - Summary of Significant Accounting Policies (Details - Consolidated net loss) link:presentationLink link:calculationLink link:definitionLink 999033 - Disclosure - Summary of Significant Accounting Policies (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 999034 - Disclosure - Significant Strategic Collaborations (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 999035 - Disclosure - Accrued Expenses and other current liabilities (Details - Accrued expenses and other current liabilities) link:presentationLink link:calculationLink link:definitionLink 999036 - Disclosure - Accrued Expenses and other current liabilities (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 999037 - Disclosure - Income Taxes (Details - Income by geographic regions) link:presentationLink link:calculationLink link:definitionLink 999038 - Disclosure - Income Taxes (Details - Income tax benefit) link:presentationLink link:calculationLink link:definitionLink 999039 - Disclosure - Income Taxes (Details - Deferred Tax Assets) link:presentationLink link:calculationLink link:definitionLink 999040 - Disclosure - Income Taxes (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 999041 - Disclosure - Stockholders’ Equity (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 999042 - Disclosure - Share-Based Expense (Details - Share based expense) link:presentationLink link:calculationLink link:definitionLink 999043 - Disclosure - Share-Based Expense (Details - Assumptions Employee) link:presentationLink link:calculationLink link:definitionLink 999044 - Disclosure - Share-Based Expense (Details - Employee stock option activity) link:presentationLink link:calculationLink link:definitionLink 999045 - Disclosure - Share-Based Expense (Details - Non-Vested employee Option activity) link:presentationLink link:calculationLink link:definitionLink 999046 - Disclosure - Share-Based Expense (Details - Non-employee option activity) link:presentationLink link:calculationLink link:definitionLink 999047 - Disclosure - Share-Based Expense (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 999048 - Disclosure - Employee Benefit Plans (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 999049 - Disclosure - Commitments and Contingencies (Details Narrative) link:presentationLink link:calculationLink link:definitionLink 999050 - Disclosure - Related Party Transactions (Details Narrative) link:presentationLink link:calculationLink link:definitionLink