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Contract With Customer Liability Additions Deferred revenue, Additions Proceeds From Sale Of Restricted Investment Proceeds From Sale Of Restricted Investment Sales of restricted investments Document Transition Report Document Transition Report Deferred Tax Assets, Net Net deferred tax assets Operating Expenses Total operating expenses Operating Expenses Phase 2b Study. Phase Two B Study [Member] Phase 2b [Member] Research and Development Expense Research and Development Expense, Total Research and development expenses R&D personnel-related (including stock-based compensation) After two thousand seventeen. After Two Thousand Seventeen [Member] After 2017 [Member] Asset Impairment Charges Asset Impairment Charges, Total Impairment loss Lessee, Operating Leases [Text Block] Leases Employee 1 [Member] Employee One [Member] Employee one. 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Contract With Customer Liability Revenue Recognized With Related Party Deferred revenue - related party, Deductions Amounts included in the contract liability at the beginning of the period Deferred revenue - related party, Deductions Live Biotherapeutics Platform [Member] Live biotherapeutics platform. Live Biotherapeutics Platform [Member] Earnings Per Share [Text Block] Net Income (Loss) per Share Revenue Recognition [Abstract] Revenue recognized in the period from: Discontinued Operations and Disposal Groups [Abstract] Maximum amount to be received on achievement of sales milestones Maximum amount to be received on achievement of sales milestones. 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Commitments and Contingencies Disclosure [Abstract] Non cash operating lease costs Non cash operating lease costs Non-cash operating lease costs Lessee, Operating Lease, Liability, to be Paid, Year One 2026 Bacthera [Member] Bacthera Agreement [Member] BacThera Agreement. BacThera Agreement [Member] Net Income (Loss) Available to Common Stockholders, Basic Net income (loss) attributable to common stockholders Disposal Group, Including Discontinued Operation, Liabilities Liabilities of discontinued operations Stock Issued During Period To Related Party Shares Stock issued during period to related party, shares. Issuance of common stock from Securities Purchase Agreement - related party, shares Debt Instrument [Axis] Debt Instrument Lessee, Operating Lease, Liability, to be Paid, after Year Five 2031 and thereafter Share-Based Payment Arrangement [Abstract] Assets, Fair Value Disclosure Total assets Sale of Stock [Axis] Sale of Stock Research and Development Personnel Expense Research and development personnel expense. R&D personnel-related (including stock-based compensation) VOWST Business [Member] VOWST Business. VOWST Business [Member] Unvested restricted stock units Incremental Common Shares Attributable to Dilutive Effect of Unvested Restricted Stock Units Incremental common shares attributable to dilutive effect of unvested restricted stock units Issuance of common stock from at the market equity offering, value Stock issued during period value at market equity offerings. 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Sublease income1 Money Market Funds [Member] Money Market Funds [Member] Related and Nonrelated Parties [Domain] Related Party Income Tax Disclosure [Text Block] Income Taxes Grant revenue. Grant Revenue Policy [Text Block] Grant Revenue Collaborative Arrangement and Arrangement Other than Collaborative [Table] Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table] Two thousand twelve stock incentive plan. Two Thousand Twelve Stock Incentive Plan [Member] 2012 Stock Incentive Plan [Member] Document Information [Table] Other Liabilities, Noncurrent Other long-term liabilities Other Liabilities, Noncurrent, Total Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract] Changes in operating assets and liabilities: Property, Plant and Equipment [Table Text Block] Schedule of Property and Equipment, Net Tax credit carryforward expiration year. Tax Credit Carryforward Expiration Year Tax credit carryforwards, expiration year, start Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price Weighted Average Exercise Price, Ending Balance Weighted Average Exercise Price, Beginning Balance Preferred Stock Preferred Stock [Text Block] Income Tax Disclosure [Abstract] Fair Value, Recurring and Nonrecurring [Table] Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table] Balance at end of year Unrecognized Tax Benefits Unrecognized tax benefits Balance at beginning of year Additional Paid-in Capital [Member] Additional Paid-in Capital [Member] Tranche B Loan [Member] TrancheB Loan [Member] TrancheB Loan [Member] Measurement Frequency [Domain] Measurement Frequency Statement of Income Location, Balance [Axis] Income Statement Location 80.1% of lease cost of Waltham facility Lease Cost of Waltham Facility Lease cost of waltham facility Trading Symbol Trading Symbol Nature Of Business And Basis Of Presentation [Line Items] Nature Of Business And Basis Of Presentation [Line Items] Nature of business and basis of presentation. 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Aggregate fair value of common stock issued Issuance of common stock from Securities Purchase Agreement - related party, value Collaborative Arrangement, Accounting Policy [Policy Text Block] Collaborative Revenue Effective Income Tax Rate Reconciliation, Tax Contingency, Amount Effective Income Tax Rate Reconciliation, Tax Contingency, Amount, Total Changes in unrecognized tax benefits Statement of Comprehensive Income [Abstract] Increase Decrease Accrued Liabilities Due To SPN-Related Party Increase decrease accrued liabilities due to SPN-related party. Accrued liabilities due to SPN - related party Accrued liabilities due to SPN - related party Effective Income Tax Rate Reconciliation, Nondeductible Expense, Meals and Entertainment, Percent Meals and entertainment percent Maximum [Member] Maximum [Member] Total liabilities Liabilities, Fair Value Disclosure Statistical Measurement [Axis] Statistical Measurement Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Weighted Average Exercise Price, Exercised Passthrough Expenses [Member] Passthrough Expenses [Member] Passthrough Expenses [Member] Common Stock, Value, Issued Common Stock, Value, Issued, Total Common Stock, Value, Issued, Beginning Balance Common Stock, Value, Issued, Ending Balance Common stock, $0.001 par value; 360,000,000 shares authorized at December 31, 2025 and 2024, respectively; 9,556,446 and 8,650,227 shares issued and outstanding at December 31, 2025 and 2024, respectively Gross proceeds from issuance of common stock. 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Payment of outstanding amount Maximum amount to be received on achievement of regulatory and sales milestones Maximum amount to be received on achievement of regulatory and sales milestones. Maximum Amount To Be Received On Achievement Of Regulatory and Sales Milestones SER One Hundred And Fifty Five [Member] SER one hundred and fifty five. SER-155 [Member] RSU and PSU [Member] Restricted Stock Units And Performance Stock Units [Member] Restricted Stock Units and Performance Stock Units. Secured Overnight Financing Rate (SOFR) [Member] Secured Overnight Financing Rate (SOFR) [Member] Fourth Tranche Available Upon Satisfaction of Conditions Including Approval by U.S. Food and Drug Administration [Member] Debt Instrument Tranche Four [Member] Debt instrument tranche four. Increase decrease in operating lease liabilities. Increase Decrease In Operating Lease Liabilities Operating lease liabilities Income (Loss) from Continuing Operations, Per Diluted Share Net income (loss) from continuing operations per share attributable to common stockholders - diluted Net income from discontinued operations per share attributable to common stockholders - diluted Deferred Tax Assets, Operating Loss Carryforwards Net operating loss carryforwards Deferred Tax Assets, Operating Loss Carryforwards, Total Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block] Tax Credit Carryforward [Axis] Tax Credit Carryforward Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block] Impairment of Long-Lived Assets Contract with customer liability with related party. Contract With Customer Liability With Related Party Deferred revenue - related party, Balance at end of period Deferred revenue - related party, Balance at beginning of period Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent State taxes, net of federal benefit State and local income taxes, net of federal income tax effect percent Amortization of Debt Issuance Costs Amortization of debt issuance costs Other Nonoperating Income (Expense) [Abstract] Entity Public Float Entity Public Float Expected volatility Volatility Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate Preferred Stock, Shares Authorized Preferred stock, shares authorized Preferred stock, shares authorized Disposal Group, Including Discontinued Operation, Total Fair Value Transferred for Business Disposal group, including discontinued operation, total fair value transferred for business. Total fair value transferred for business Proceeds from Collaborators Proceeds on achievement of development milestone Phase three study. Phase Three Study [Member] Phase 3 [Member] Lender Name [Axis] Lender Name Related Party Transaction [Line Items] Related Party Transaction [Line Items] Employee Stock [Member] Employee Stock [Member] AstraZeneca, Incorporated. Astra Zeneca Incorporated [Member] AstraZeneca Inc. [Member] Revenue from Contracts with Customers Revenue from Contract with Customer [Text Block] Business Combination [Table] Entity Registrant Name Entity Registrant Name Debt Disclosure [Text Block] Notes Payable Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax Gross Unrealized Loss Entity Voluntary Filers Entity Voluntary Filers Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table] Other Nonoperating Income (Expense) Other Nonoperating Income (Expense), Total Other Expense Other (expense) income, net Other income (expense), net Fair values assets level 2 To level 1 transfer amount 1. Fair Values Assets Level 2 To Level 1 Transfer Amount 1 Fair value, assets transfers from Level 2 to Level 1 measurement Subsequent Events [Abstract] Cybersecurity Risk Management Positions or Committees Responsible [Flag] Collaboration (profit) loss sharing - related party Profit (loss) from research agreement related party. Profit (Loss) from Research Agreement Related Party Collaboration (profit) loss sharing - related party Income Tax Expense (Benefit) Income tax expense (benefit) Effective income tax rate Tranche C Warrant [Member] Tranche C Warrant [Member] Tranche c warrant. Market equity offering. Market Equity Offering [Member] Market Equity Offering [Member] Measurement Frequency [Axis] Measurement Frequency Payments to acquire under agreement Payments to Acquire Productive Assets Payments to Acquire Productive Assets, Total Capital expenditures Minimum percentage of likelihood of tax benefit being realized upon settlement. Minimum Percentage Of Likelihood Of Tax Benefit Being Realized Upon Settlement Minimum percentage of likelihood of tax benefit being realized upon settlement Proceeds from issuance of common stock Proceeds from issuance of common stock, net of issuance costs Proceeds from Issuance of Common Stock Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Discontinued Operation, Income (Loss) from Discontinued Operation, Net of Tax, Per Basic Share Net income from discontinued operations per share attributable to common stockholders - basic Net income (loss) from discontinued operations per share attributable to common stockholders, basic Net income from discontinued operations per share attributable to common stockholders - basic Hercules Capital, Inc. Hercules Capital Inc [Member] Hercules Capital, Inc. [Member] Entity Common Stock, Shares Outstanding Entity Common Stock Shares Outstanding Concentration Risk, Credit Risk, Policy [Policy Text Block] Concentration of Credit Risk Disposal Group Classification [Axis] Consolidation Items [Axis] Subsequent event, date Subsequent Event, Date Payments to Acquire Property, Plant, and Equipment Purchases of property and equipment Payments to Acquire Property, Plant, and Equipment, Total Related Party Partial Payments Related party partial payments. Related party partial payments Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period Number of Shares, Granted Number of shares granted Upfront payment Disposal Group, Including Discontinued Operation,Upfront payment Disposal Group, including discontinued operation,upfront payment. Assets Total assets Inventories Inventory, Policy [Policy Text Block] Property, Plant and Equipment [Table] Schedule Of Property Plant And Equipment [Table] Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term Weighted Average Remaining Contractual Term, Options exercisable Restructuring Cost [Table] Schedule Of Restructuring And Related Costs [Table] Interest Rate Cap [Member] Interest rate cap [Member] Unrecognized Tax Benefits, Decrease Resulting from Prior Period Tax Positions Reduction to unrecognized tax benefits Share-Based Payment Arrangement [Policy Text Block] Accounting for Stock-Based Compensation Closing Period Milestone Payment One Closing period milestone payment one. Closing period milestone payment one Third Tranche [Member] Debt instrument tranche three. Debt Instrument Tranche Three [Member] Third Tranche Available Upon Approval on or Prior to June 30, 2021 [Member] Milestone Prepayment Milestone prepayment. Milestone Prepayment Milestone prepayment Stock Issued During Period, Shares, New Issues Common stock, shares issued Stock issued during period, shares, new Issues Stock issued during period, shares, new Issues Construction [Member] Construction [Member] Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period Number of Shares, Vested Number of shares, vested Number of Shares, Vested Offering period under the plan. 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Effective Income Tax Rate Reconciliation Uncertain Tax Position Reserves Uncertain tax position reserves Uncertain tax position reserves percent Fair Value, Option, Quantitative Disclosures [Line Items] Schedule of Segment Reporting Information, by Segment [Table Text Block] Schedule of reportable segment net income (loss) Operating Segments [Member] Operating Segments [Member] Derivative Liability Expected Volatility Derivative LiabilitDerivative Liability Expected Volatilityy Expected Volatility Volatility Title and Position [Domain] Property, Plant, and Equipment, Useful Life, Term, Description [Extensible Enumeration] Disposal Group, Including Discontinued Operation, Assets Assets of discontinued operations City Area Code City Area Code Auditor Name Income tax Discontinued Operation, Tax Effect of Discontinued Operation Net proceeds received from credit facility Proceeds from Lines of Credit Proceeds from Lines of Credit, Total Income (Loss) from Discontinued Operations, Net of Tax, Including Portion Attributable to Noncontrolling Interest Net income (loss) from discontinued operations, net of tax Net income from discontinued operations, net of tax Net income from discontinuing operations attributable to common stockholders Net income from discontinuing operations attributable to common stockholders Line of Credit Facility, Maximum Borrowing Capacity Credit facility, aggregate principal amount Business Combination [Line Items] Equity, Fair Value Disclosure [Abstract] Counterparty Name [Domain] Counterparty Name Research and development tax credits Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount Lessee operating lease remaining term of contract. Lessee Operating Lease Remaining Term Of Contract Operating lease, remaining term Interest Rate Floor [Member] Interest Rate Floor [Member] Variable Lease, Cost Variable lease costs Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Aggregate Intrinsic Value, Vested Aggregate intrinsic value, vested Issuance of common stock under ESPP, value Stock Issued During Period, Value, Employee Stock Purchase Plan Proceeds from at the market equity offering, net of issuance costs Proceeds From Issuance of Common Stock From at the Market Equity Offering Proceeds from issuance of common stock from at the market equity offering. Cambridge Massachusetts [Member] Cambridge massachusetts. Cambridge Massachusetts [Member] Operating Lease, Weighted Average Remaining Lease Term Weighted average remaining lease term Fair Value, Liability, Recurring Basis, Unobservable Input Reconciliation, Gain (Loss), Statement of Income or Comprehensive Income [Extensible Enumeration] Segment Reporting Information [Line Items] Stockholders equity note stock split, conversion ratio Stockholders' Equity Note, Stock Split, Conversion Ratio Disposal Group Name [Axis] Lease, Cost Total lease costs G&A personnel-related (including stock-based compensation) General and Administrative Personnel Expense General and administrative personnel expense. 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Operating Lease, Weighted Average Discount Rate, Percent Weighted average incremental borrowing rate Operating Lease, Liability, Noncurrent Operating lease liabilities, net of current portion Fair Value, Inputs, Level 1 [Member] Level 1 [Member] Cash Provided by (Used in) Financing Activity, Including Discontinued Operation Net cash provided by (used in) financing activities Lease, Cost [Table Text Block] Summary of Lease Costs Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent [Abstract] Nontaxable or nondeductible items Auditor Location Collaboration payable - related party (Note 16) Transaction price allocated under collaborative arrangement Transaction price allocated under collaborative arrangement Transaction price allocated under collaborative arrangement Restructuring Charges [Member] Restructuring Charges [Member] Nonoperating Income (Expense) [Abstract] Other income (expense): Derivative Liability, Noncurrent Derivative Liability, Noncurrent Warrant liabilities Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items] Percentage of commission on sale of common stock. Percentage Of Commission On Sale Of Common Stock Percentage of commission on sale of common stock Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Summary of Potential Common Shares Excluded from Calculation of Diluted Net Loss per Share Income Tax Jurisdiction [Domain] Income Tax Authority Debt Securities, Available-for-Sale [Table] Debt Securities Available For Sale [Table] Entity Interactive Data Current Entity Interactive Data Current Cowen and Company, LLC and Piper Sandler & Co. Cowen And Company L L C And Piper Sandler Co [Member] Cowen and Company, LLC and Piper Sandler & Co. [Member] Statement of Income Location, Balance [Domain] Income Statement Location Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract] Cash flows from operating activities: Repayments of existing credit facility Repayments of Lines of Credit Accretion (Amortization) of Discounts and Premiums, Investments Net (accretion) amortization of (discounts) premiums on investments Unbilled receivable Unbilled Receivables, Current Adjustment to fair value Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) Included in Earnings Lease payment over sublease term Payments to Acquire Lease Receivables Increase Decrease Accounts Receivable Due From SPN - Related Party Increase decrease accounts receivable due from SPN - related party. Accounts receivable due from SPN - related party Option Indexed to Issuer's Equity, Type [Domain] Entity Tax Identification Number Entity Tax Identification Number Percentage of Performance-Based Stock Options Vesting Percentage of Performance-Based Stock Options Vesting Percentage of performance-based stock options vesting. Revenues [Abstract] Revenue: Share Price Share Price Repayment of notes payable Repayments of Notes Payable Repayments of notes payable Long-Term Debt, Type [Axis] Long-term Debt, Type Collaboration loss sharing Collaboration Loss Sharing Collaboration loss sharing. Operating loss carryforwards expiration year. Operating Loss Carryforwards Expiration Year Net operating loss carry forwards, expiration year, start Share of VOWST net loss Share of VOWST net loss Share of Related Party Net Loss Share of related party net loss. Local Phone Number Local Phone Number Related Party Transaction [Domain] Related Party Transaction Maximum development milestone payments to be received. Maximum Development Milestone Payments To Be Received Maximum development milestone payments to be received Original Credit Facility [Member] Original Credit Facility [Member] Original Credit Facility. Other Liabilities Current Related parties, current Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount Unrecognized stock-based compensation cost Short-Term Lease, Cost Short-term lease costs Denominator: Weighted Average Number of Shares Outstanding, Diluted [Abstract] Auditor Opinion [Text Block] Exit Fee [Member] Exit fee. Exit Fee [Member] Before two thousand eighteen. Before Two Thousand Eighteen [Member] Before 2018 [Member] Accrued Liabilities Due to Spn Related Party Accrued liabilities due to spn related party. Total accrued liabilities due to SPN Deferred income from termination of 2021 License Agreement Disposal Group, Including Discontinued Operation, Deferred Income From Termination of 2021 License Agreement Disposal group, including discontinued operation, deferred income from termination of 2021 license agreement. Weighted Average Number of Shares Outstanding, Basic [Abstract] Denominator: Denominator: Accounting Policies [Abstract] Trading days prior to the funding date Debt Instrument, Convertible, Threshold Trading Days Gain on sale, net of tax Gain Loss On Sale Of Business After Tax Gain loss on sale of business after tax Revenue from Contract with Customer, Excluding Assessed Tax Collaboration revenue - related party Collaboration revenue - related party Revenue from Contract with Customer, Excluding Assessed Tax, Total Upfront Payment Upfront Payment Upfront payment Net Assets Transferred Abstract Net assets transferred. Net assets transferred Increase Decrease In Accrued Expenses And Other Current And Long Term Liabilities Increase (decrease) in accrued expenses and other current and long-term liabilities. Accrued expenses and other current and long-term liabilities Lessee, Operating Lease, Liability, to be Paid, Year Four 2029 Restricted Investments, Current Commercial Paper [Member] Commercial Paper [Member] Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant Shares available for future grant Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition Weighted average period over which unrecognized compensation cost is expected to be recognized Defined Contribution Plan, Maximum Annual Contributions Per Employee, Percent Percentage of eligible earning contributed toward semi-annual purchase of common stock Net Income (Loss) Available to Common Stockholders, Diluted [Abstract] Numerator: Entity Emerging Growth Company Entity Emerging Growth Company Revision of Prior Period, Accounting Standards Update, Adjustment [Member] Revision of Prior Period, Accounting Standards Update, Adjustment [Member] Weighted Average Remaining Contractual Term Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term Tax Credit Carryforward, Name [Domain] Tax Credit Carryforward, Name