Income Taxes - Schedule of Net Deferred Tax Assets (Detail) - USD ($) $ in Thousands |
Dec. 31, 2025 |
Dec. 31, 2024 |
Dec. 31, 2023 |
Dec. 31, 2022 |
|---|---|---|---|---|
| Deferred tax assets: | ||||
| Net operating loss carryforwards | $ 167,203 | $ 156,157 | ||
| Research and development tax credit carryforwards | 54,149 | 54,648 | ||
| Section 174 capitalized research and development expenses | 39,759 | 53,600 | ||
| Stock-based compensation expense | 28,594 | 28,819 | ||
| Lease liability | 22,689 | 23,917 | ||
| Contingent consideration | 13,437 | 0 | ||
| Accrued expenses | 1,788 | 7,032 | ||
| Section 163(j) limitation | 1,843 | 5,599 | ||
| Depreciation and amortization | 1,223 | 953 | ||
| Other | 98 | 132 | ||
| Total deferred tax assets | 330,783 | 330,857 | ||
| Deferred tax liabilities: | ||||
| Depreciation and amortization | 0 | 0 | ||
| Right of use assets | (19,822) | (21,115) | ||
| Total deferred tax liabilities | (19,822) | (21,115) | ||
| Valuation allowance | (310,961) | (309,742) | $ (312,809) | $ (277,370) |
| Net deferred tax assets | $ 0 | $ 0 |
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- Definition Deferred tax assets contingent consideration. No definition available.
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- Definition Deferred tax assets deferred expense capitalized research and development costs. No definition available.
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- Definition Deferred tax assets lease liability. No definition available.
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- Definition Deferred tax assets section 163(j) limitation CARES act. No definition available.
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- Definition Deferred tax liabilities, right of use assets. No definition available.
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- Definition Amount of deferred tax liability attributable to taxable temporary differences. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences and carryforwards. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- Definition Amount, after allocation of valuation allowances and deferred tax liability, of deferred tax asset attributable to deductible differences and carryforwards, without jurisdictional netting. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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- References No definition available.
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- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible operating loss carryforwards. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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- Definition Amount, before allocation of valuation allowance, of deferred tax asset attributable to deductible temporary differences, classified as other. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from property, plant, and equipment. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible research tax credit carryforwards. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from share-based compensation. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from accrued liabilities. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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- Definition Amount of deferred tax assets for which it is more likely than not that a tax benefit will not be realized. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- References No definition available.
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- Definition Amount of deferred tax liability attributable to taxable temporary differences from property, plant, and equipment. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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