v3.25.4
Income Taxes - Schedule of Reconciliation of U.S Federal Statutory Income Tax Rate to Company's Effective Income Tax Rate (Detail) - USD ($)
12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Dec. 31, 2023
Income Tax Disclosure [Abstract]      
Federal statutory income tax rate $ 1,202,000    
Federal statutory income tax rate percent (21.00%) (21.00%) (21.00%)
Research and development tax credits $ 334,000    
Research and development tax credits percent 5.80% (1.80%) (2.50%)
State and local income taxes, net of federal income tax effect [1] $ 0    
State and local income taxes, net of federal income tax effect percent 0.00% [1] (3.60%) (7.20%)
Nontaxable or nondeductible items      
Meals and entertainment $ 14,000    
Meals and entertainment percent 0.30%    
Stock-based compensation $ 3,094,000    
Stock-based compensation percent 54.10% 1.00% 0.80%
Adjustment to gain on sale of VOWST business $ (1,133,000)    
Adjustment to gain on sale of VOWST business percent (19.80%)    
Uncertain tax position reserves percent   0.40% 0.50%
Changes in unrecognized tax benefits $ (67,000)    
Changes in unrecognized tax benefits percent (1.20%)    
Other adjustments $ 1,000    
Other adjustments percent 0.00% (0.40%) (0.10%)
Change in deferred tax asset valuation allowance $ (3,445,000)    
Change in deferred tax asset valuation allowance percent (60.20%) 25.40% 29.50%
Effective income tax rate $ 0 $ 0 $ 0
Effective income tax rate percent 0.00% 0.00% 0.00%
[1] State and local taxes in Massachusetts comprise the majority of this category.