v3.25.4
Restructuring - Additional Information (Detail)
$ in Thousands
12 Months Ended
Sep. 23, 2025
Nov. 02, 2023
Employee
Dec. 31, 2025
USD ($)
Dec. 31, 2024
USD ($)
Dec. 31, 2023
USD ($)
Restructuring Cost And Reserve [Line Items]          
Restructuring and related cost, number of positions eliminated, period percent 25.00%        
Workforce Reduction Rate   41.00%      
Number of positions eliminated | Employee   160      
Restructuring Charges     $ 1,027   $ 5,606
Restructuring Incurred Cost Statement of Income or Comprehensive Income Extensible Enumeration Not Disclosed Flag     true    
Research and development expenses     $ 49,060 $ 64,600 117,597
General and administrative expenses     39,156 53,183 77,500
Accrued Expenses and Other Current Liabilities [Member]          
Restructuring Cost And Reserve [Line Items]          
Outstanding restructuring liabilities     $ 0 $ 20  
Restructuring Charges [Member]          
Restructuring Cost And Reserve [Line Items]          
Research and development expenses         3,481
General and administrative expenses         2,125
Severance and other employee costs          
Restructuring Cost And Reserve [Line Items]          
Restructuring Charges         5,345
Acceleration of unvested equity awards          
Restructuring Cost And Reserve [Line Items]          
Restructuring Charges         $ 261