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  <xs:element id="skye_SharesAvailableForGrantRollForward" abstract="true" name="SharesAvailableForGrantRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="skye_AmendedAndRestatedPlanAnd2024InducementPlanMember" abstract="true" name="AmendedAndRestatedPlanAnd2024InducementPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_MarketBasedRestrictedStockUnitsMember" abstract="true" name="MarketBasedRestrictedStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_DeferredTaxAssetsDepreciation" abstract="false" name="DeferredTaxAssetsDepreciation" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_DeferredTaxAssetsAmortization" abstract="false" name="DeferredTaxAssetsAmortization" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_DeferredTaxAssetsResearchAndDevelopmentCredits" abstract="false" name="DeferredTaxAssetsResearchAndDevelopmentCredits" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_DeferredTaxAssetsSRAndEDCredits" abstract="false" name="DeferredTaxAssetsSRAndEDCredits" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_DeferredTaxAssetsLeasingArrangements" abstract="false" name="DeferredTaxAssetsLeasingArrangements" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseExecutiveCompensationAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationNondeductibleExpenseExecutiveCompensationAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_EffectiveIncomeTaxRateReconciliationCapitalLossCarryforwardUnavailableAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationCapitalLossCarryforwardUnavailableAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseExecutiveCompensationPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationNondeductibleExpenseExecutiveCompensationPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="skye_EffectiveIncomeTaxRateReconciliationCapitalLossCarryforwardUnavailablePercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationCapitalLossCarryforwardUnavailablePercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="skye_EffectiveIncomeTaxRateReconciliationUncertainTaxPositionsAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationUncertainTaxPositionsAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_EffectiveIncomeTaxRateReconciliationChangeInDerivativeAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationChangeInDerivativeAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_EffectiveIncomeTaxRateReconciliationOfficerCompensationAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationOfficerCompensationAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_WendyCunningVsSkyeBioscienceIncMember" abstract="true" name="WendyCunningVsSkyeBioscienceIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_EconomicDamagesMember" abstract="true" name="EconomicDamagesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_NonEconomicDamagesMember" abstract="true" name="NonEconomicDamagesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_PunitiveDamagesMember" abstract="true" name="PunitiveDamagesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_CorporateHeadquartersMember" abstract="true" name="CorporateHeadquartersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_SanFranciscoOfficeMember" abstract="true" name="SanFranciscoOfficeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_LesseeOperatingLeaseAbatementTerm" abstract="false" name="LesseeOperatingLeaseAbatementTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="skye_LesseeOperatingLeaseInitialMonthlyRent" abstract="false" name="LesseeOperatingLeaseInitialMonthlyRent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_LesseeOperatingLeaseAnnualRentIncreasePercent" abstract="false" name="LesseeOperatingLeaseAnnualRentIncreasePercent" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="skye_LesseeOperatingLeaseSquareFootageOfOfficeSpace" abstract="false" name="LesseeOperatingLeaseSquareFootageOfOfficeSpace" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:areaItemType"/>
  <xs:element id="skye_LesseeOperatingLeaseMonthlyRentExpense" abstract="false" name="LesseeOperatingLeaseMonthlyRentExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_LossContingencyAppealBond" abstract="false" name="LossContingencyAppealBond" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_LossContingencyNetCashReceivedToCoverLegalExpenses" abstract="false" name="LossContingencyNetCashReceivedToCoverLegalExpenses" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_ResearchAndDevelopmentActivitiesSegmentMember" abstract="true" name="ResearchAndDevelopmentActivitiesSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_SBI100Member" abstract="true" name="SBI100Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_NimacimabMember" abstract="true" name="NimacimabMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="skye_ExternalClinicalDevelopmentExpenses" abstract="false" name="ExternalClinicalDevelopmentExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_InProcessResearchAndDevelopment" abstract="false" name="InProcessResearchAndDevelopment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="skye_ShareBasedCompensationArrangementByShareBasedPaymentAwardPostTerminationExercisePeriod" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPostTerminationExercisePeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="skye_ShareBasedCompensationArrangementByShareBasedPaymentAwardChangeInControlPeriodFromSeparationDate" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardChangeInControlPeriodFromSeparationDate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="skye_OperatingLeaseTerminationPeriodFollowingNotice" abstract="false" name="OperatingLeaseTerminationPeriodFollowingNotice" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
</xs:schema>
