v3.25.4
Cover - USD ($)
 12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Mar. 09, 2026
Jun. 30, 2025
Cover [Abstract]        
Document Type 10-K      
Document Annual Report true      
Document Period End Date Dec. 31, 2025      
Current Fiscal Year End Date --12-31      
Document Transition Report false      
Entity File Number 000-55136      
Entity Registrant Name Skye Bioscience, Inc.      
Entity Incorporation, State or Country Code NV      
Entity Tax Identification Number 45-0692882      
Entity Address, Address Line One 11250 El Camino Real      
Entity Address, Address Line Two Suite 100      
Entity Address, City or Town San Diego      
Entity Address, State or Province CA      
Entity Address, Postal Zip Code 92130      
City Area Code 858      
Local Phone Number 410-0266      
Title of 12(b) Security Common Stock, par value $0.001      
Trading Symbol SKYE      
Security Exchange Name NASDAQ      
Entity Well-known Seasoned Issuer No      
Entity Voluntary Filers No      
Entity Current Reporting Status Yes      
Entity Interactive Data Current Yes      
Entity Filer Category Non-accelerated Filer      
Entity Small Business true      
Entity Emerging Growth Company false      
ICFR Auditor Attestation Flag true      
Document Financial Statement Error Correction [Flag] false      
Entity Shell Company false      
Entity Public Float       $ 129,530,291
Entity Common Stock, Shares Outstanding     33,378,764  
Documents Incorporated by Reference
DOCUMENTS INCORPORATED BY REFERENCE
Portions of the registrant’s proxy statement to be filed with the Securities and Exchange Commission pursuant to Regulation 14A in connection with the registrant’s 2026 Annual Meeting of Stockholders, which will be filed subsequent to the date hereof, are incorporated by reference into Part III of this Form 10-K. Such proxy statement will be filed with the Securities and Exchange Commission not later than 120 days following the end of the registrant’s fiscal year ended December 31, 2025. 		     
Entity Central Index Key 0001516551      
Amendment Flag false      
Document Fiscal Year Focus 2025      
Document Fiscal Period Focus FY      
Auditor Firm ID 199 688