The principal business address for each of the Bain Capital Life Sciences Entities is 200 Clarendon Street, Boston, MA 02116.

Each of the Bain Capital Life Sciences Entities is principally engaged in the business of investment in securities.

During the last five years, none of the Bain Capital Life Sciences Entities has been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors).

During the last five years, none of the Bain Capital Life Sciences Entities has been a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.

See Item 2(a) hereof.

Item 3 of the Initial Statement is hereby amended and supplemented to add the following: On March 6, 2026, the Issuer entered into a securities purchase agreement (the "March 2026 Securities Purchase Agreement") with certain institutional accredited investors (the "March 2026 PIPE Investors"), pursuant to which the Issuer agreed to issue and sell to the March 2026 PIPE Investors in a private placement an aggregate of 14,973,257 shares of Common Stock, at a price of $5.61 per share, and, to certain investors, pre-funded warrants (the "March 2026 Pre-Funded Warrants") to purchase an aggregate of 27,807,482 shares of Common Stock, at a price of $5.609 per pre-funded warant (the "March 2026 Private Placement"). The March 2026 Private Placement closed on March 9, 2026. BCLS Fund IV Opportunities purchased a March 2026 Pre-Funded Warrant to purchase 5,347,593 shares of Common Stock in the March 2026 Private Placement, for total consideration of $29,994,649.14. BCLS Fund IV Opportunities used its own working capital to acquire the securities. References to and the description of the March 2026 Securities Purchase Agreement set forth above in this Item 3 do not purport to be complete and are qualified in their entirety by reference to the full text of the March 2026 Securities Purchase Agreement, which is filed as an exhibit hereto and incorporated by reference herein.

The information set forth in Items 2, 3 and 6 and on the cover pages of this Schedule 13D is incorporated by reference in its entirety into this Item 5. As of the date hereof, (i) BCLS SB holds no shares of Common Stock, (ii) BCLS Fund II holds 267,257 shares of Common Stock, (iii) BCLS II Investco holds 3,301,955 shares of Common Stock and a Pre-Funded Warrant to purchase 6,444,170 shares of Common Stock, (iv) BCIPLS holds 32,550 shares of Common Stock, (v) BCLS II Equity holds 904,160 shares of Common Stock and (vi) BCLS Fund IV Opportunities holds a March 2026 Pre-Funded Warrant to purchase 5,347,593 shares of Common Stock. As a result of the Beneficial Ownership Blocker and the March 2026 Beneficial Ownership Blocker, BCLS II Investco and BCLS Fund IV Opportunities are prohibited from exercising the Pre-Funded Warrant and the March 2026 Pre-Funded Warrant to the extent that the Reporting Persons would, after such exercise, collectively beneficially own in excess of 9.99% of the outstanding Common Stock. Accordingly, pursuant to Rule 13d-3 of the Act and the relationships described in Item 2 of this Schedule 13D, the Reporting Persons may be deemed to collectively beneficially own 9.99% of the outstanding Common Stock, representing 9,808,819 shares of Common Stock as of the date hereof. The calculation of the beneficial ownership of the Reporting Persons is based on (i) 77,910,239 shares of Common Stock issued and outstanding as of October 29, 2025, as disclosed by the Issuer in its quarterly report on Form 10-Q filed with the Securities and Exchange Commission on November 3, 2025, (ii) 14,973,257 shares of Common Stock issued in the March 2026 Private Placement and (iii) 5,302,897 shares of Common Stock to be issued upon the exercise of the Pre-Funded Warrant and/or March 2026 Pre-Funded Warrant held by BCLS II Investco and BCLS Fund IV Opportunities, which reflects the Beneficial Ownership Blocker and the March 2026 Beneficial Ownership Blocker.

See Item 5(a) hereof.

See Item 3 hereof.

Except as otherwise described in this Item 5, no one other than the Reporting Persons has the right to receive, or the power to direct the receipt of, dividends from, or the proceeds from the sale of, any of the Common Stock beneficially owned by the Reporting Persons as described in this Item 5.

Not applicable.

Item 6 of the Initial Statement is hereby amended and supplemented to add the following: Each March 2026 Pre-Funded Warrant is exercisable at any time after its original issuance. The holder of a March 2026 Pre-Funded Warrant is prohibited from exercising the March 2026 Pre-Funded Warrant into Common Stock if, as a result of such exercise, the holder, together with its affiliates and any other persons whose beneficial ownership would be aggregated with the holder's for purposes of Section 13(d) of the Act, would beneficially own more than 9.99% of the total number of shares of Common Stock issued and outstanding immediately after giving effect to such exercise (the "Beneficial Ownership Blocker"). The exercise price per share of Common Stock purchasable upon the exercise of the March 2026 Pre-Funded Warrant is $0.001 per share. The exercise price is subject to appropriate adjustment in the event of certain stock dividends and distributions, stock splits, stock combinations, or reclassifications affecting the Common Stock. If a Fundamental Transaction (as defined in the March 2026 Pre-Funded Warrant) occurs while a March 2026 Pre-Funded Warrant is outstanding, then upon any subsequent exercise of the March 2026 Pre-Funded Warrant, the holder thereof has the right to receive the same amount and kind of securities, cash or property as such holder would have been entitled to receive upon the occurrence of such Fundamental Transaction if it had been, immediately prior to such Fundamental Transaction, the holder of the number of shares of Common Stock then issuable upon exercise in full of the March 2026 Pre-Funded Warrant (without regard to any limitations on exercise). Subject to compliance with applicable securities laws, each March 2026 Pre-Funded Warrant may be transferred or assigned by the holder thereof without the Issuer's consent. Except as otherwise provided in the March 2026 Pre-Funded Warrant or by virture of the holder's ownership of Common Stock, the holder of a March 2026 Pre-Funded Warrant does not have the rights or privileges of a holder of Common Stock, including any voting rights, until the holder exercises the March 2026 Pre-Funded Warrant. The foregoing summary of the March 2026 Pre-Funded Warrant does not purport to be complete and is qualified in its entirety by reference to the form of March 2026 Pre-Funded Warrant, which is filed as an exhibit hereto and incorporated by reference herein. On March 6, 2026, the Issuer entered into a registration rights agreement (the "March 2026 Registration Rights Agreement") with the March 2026 PIPE Investors, including BCLS Fund IV Opportunities, pursuant to which the Issuer agreed to register for resale the shares of Common Stock issued in the March 2026 Private Placement and the shares of Common Stock issuable upon exercise of the pre-funded warrants issued in the March 2026 Private Placement (collectively, the "March 2026 Registrable Securities"). Under theMarch 2026 Registration Rights Agreement, the Issuer agreed to file a registration statement covering the resale by the March 2026 PIPE Investors of their March 2026 Registrable Securities no later than 30 days following the closing of the March 2026 Private Placement (the "March 2026 Filing Date"). The Issuer agreed to use commercially reasonable efforts to cause such registration statement to be declared effective as soon as reasonably practicable and to keep such registration statement effective until the date all March 2026 Registrable Securities covered by such registration statement have been sold or cease to be registrable securities under the March 2026 Registration Rights Agreement. The foregoing summary of the March 2026 Registration Rights Agreement does not purport to be complete and is qualified in its entirety by reference to the full text of the March 2026 Registration Rights Agreement, which is filed as an exhibit hereto and incorporated by reference herein.

Exhibit A-11 - March 2026 Securities Purchase Agreement (incorporated by reference from Exhibit 10.1 to the Issuer's Current Report on Form 8-K filed with the Securities and Exchange Commission on March 6, 2026 (File No. 001-38360)) Exhibit B-11 - Form of March 2026 Pre-Funded Warrant (incorproated by reference from Exhibit 4.1 to the Issuer's Current Report on Form 8-K filed with the Securities and Exchange Commission on March 6, 2026 (File No. 001-38360)) Exhibit C-11 - March 2026 Registration Rights Agreement (incorporated by reference from Exhibit 10.2 to the Issuer's Current Report on Form 8-K filed with the Securities and Exchange Commission on March 6, 2026 (File No. 001-38360)) Exhibit D-11 Joint Filing Agreement, dated March 10, 2026